Amino acid dipepetide frequency for Amycolatopsis sulphurea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.14AlaAla: 20.14 ± 0.196	1.032AlaCys: 1.032 ± 0.027	8.063AlaAsp: 8.063 ± 0.077	9.607AlaGlu: 9.607 ± 0.092	3.372AlaPhe: 3.372 ± 0.046	13.808AlaGly: 13.808 ± 0.101	2.631AlaHis: 2.631 ± 0.036	4.129AlaIle: 4.129 ± 0.056	3.397AlaLys: 3.397 ± 0.051	13.367AlaLeu: 13.367 ± 0.131	2.446AlaMet: 2.446 ± 0.038	2.286AlaAsn: 2.286 ± 0.037	6.491AlaPro: 6.491 ± 0.079	3.95AlaGln: 3.95 ± 0.061	9.785AlaArg: 9.785 ± 0.094	5.635AlaSer: 5.635 ± 0.06	7.123AlaThr: 7.123 ± 0.076	11.457AlaVal: 11.457 ± 0.102	1.709AlaTrp: 1.709 ± 0.032	2.3AlaTyr: 2.3 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.035CysAla: 1.035 ± 0.027	0.086CysCys: 0.086 ± 0.007	0.4CysAsp: 0.4 ± 0.018	0.371CysGlu: 0.371 ± 0.015	0.236CysPhe: 0.236 ± 0.012	0.92CysGly: 0.92 ± 0.027	0.205CysHis: 0.205 ± 0.011	0.164CysIle: 0.164 ± 0.01	0.11CysLys: 0.11 ± 0.008	0.726CysLeu: 0.726 ± 0.021	0.104CysMet: 0.104 ± 0.007	0.135CysAsn: 0.135 ± 0.009	0.527CysPro: 0.527 ± 0.018	0.184CysGln: 0.184 ± 0.011	0.638CysArg: 0.638 ± 0.026	0.476CysSer: 0.476 ± 0.017	0.532CysThr: 0.532 ± 0.017	0.622CysVal: 0.622 ± 0.02	0.133CysTrp: 0.133 ± 0.009	0.168CysTyr: 0.168 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.006AspAla: 7.006 ± 0.073	0.401AspCys: 0.401 ± 0.017	3.274AspAsp: 3.274 ± 0.051	4.062AspGlu: 4.062 ± 0.06	1.597AspPhe: 1.597 ± 0.033	5.804AspGly: 5.804 ± 0.071	1.371AspHis: 1.371 ± 0.026	1.664AspIle: 1.664 ± 0.034	1.12AspLys: 1.12 ± 0.024	6.409AspLeu: 6.409 ± 0.064	0.678AspMet: 0.678 ± 0.018	0.947AspAsn: 0.947 ± 0.024	4.468AspPro: 4.468 ± 0.054	1.817AspGln: 1.817 ± 0.035	4.78AspArg: 4.78 ± 0.055	2.604AspSer: 2.604 ± 0.072	2.99AspThr: 2.99 ± 0.043	4.865AspVal: 4.865 ± 0.057	0.883AspTrp: 0.883 ± 0.023	1.209AspTyr: 1.209 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.847GluAla: 6.847 ± 0.077	0.352GluCys: 0.352 ± 0.014	2.705GluAsp: 2.705 ± 0.037	2.889GluGlu: 2.889 ± 0.046	1.842GluPhe: 1.842 ± 0.031	3.752GluGly: 3.752 ± 0.047	1.663GluHis: 1.663 ± 0.029	2.446GluIle: 2.446 ± 0.038	1.433GluLys: 1.433 ± 0.032	7.382GluLeu: 7.382 ± 0.081	0.877GluMet: 0.877 ± 0.024	1.118GluAsn: 1.118 ± 0.027	3.604GluPro: 3.604 ± 0.049	2.447GluGln: 2.447 ± 0.041	4.89GluArg: 4.89 ± 0.062	2.726GluSer: 2.726 ± 0.048	3.003GluThr: 3.003 ± 0.045	4.866GluVal: 4.866 ± 0.055	0.766GluTrp: 0.766 ± 0.019	1.115GluTyr: 1.115 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.062PheAla: 4.062 ± 0.045	0.287PheCys: 0.287 ± 0.013	2.113PheAsp: 2.113 ± 0.033	1.366PheGlu: 1.366 ± 0.026	0.904PhePhe: 0.904 ± 0.025	3.402PheGly: 3.402 ± 0.048	0.638PheHis: 0.638 ± 0.018	0.7PheIle: 0.7 ± 0.022	0.439PheLys: 0.439 ± 0.015	2.655PheLeu: 2.655 ± 0.043	0.323PheMet: 0.323 ± 0.013	0.506PheAsn: 0.506 ± 0.018	1.467PhePro: 1.467 ± 0.024	0.669PheGln: 0.669 ± 0.018	1.973PheArg: 1.973 ± 0.034	1.635PheSer: 1.635 ± 0.031	2.17PheThr: 2.17 ± 0.036	2.381PheVal: 2.381 ± 0.038	0.375PheTrp: 0.375 ± 0.015	0.599PheTyr: 0.599 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.514GlyAla: 10.514 ± 0.094	0.848GlyCys: 0.848 ± 0.028	4.927GlyAsp: 4.927 ± 0.064	5.461GlyGlu: 5.461 ± 0.058	3.183GlyPhe: 3.183 ± 0.04	8.81GlyGly: 8.81 ± 0.12	2.171GlyHis: 2.171 ± 0.038	3.634GlyIle: 3.634 ± 0.053	2.767GlyLys: 2.767 ± 0.045	9.419GlyLeu: 9.419 ± 0.079	1.998GlyMet: 1.998 ± 0.038	1.981GlyAsn: 1.981 ± 0.042	4.947GlyPro: 4.947 ± 0.08	3.039GlyGln: 3.039 ± 0.051	7.318GlyArg: 7.318 ± 0.072	5.412GlySer: 5.412 ± 0.07	5.92GlyThr: 5.92 ± 0.062	7.823GlyVal: 7.823 ± 0.075	1.77GlyTrp: 1.77 ± 0.035	2.399GlyTyr: 2.399 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.639HisAla: 2.639 ± 0.04	0.21HisCys: 0.21 ± 0.011	1.332HisAsp: 1.332 ± 0.029	1.282HisGlu: 1.282 ± 0.026	0.649HisPhe: 0.649 ± 0.017	2.43HisGly: 2.43 ± 0.04	0.682HisHis: 0.682 ± 0.02	0.58HisIle: 0.58 ± 0.018	0.343HisLys: 0.343 ± 0.013	2.35HisLeu: 2.35 ± 0.04	0.281HisMet: 0.281 ± 0.013	0.442HisAsn: 0.442 ± 0.016	1.75HisPro: 1.75 ± 0.032	0.729HisGln: 0.729 ± 0.02	2.097HisArg: 2.097 ± 0.041	1.066HisSer: 1.066 ± 0.025	1.23HisThr: 1.23 ± 0.031	1.665HisVal: 1.665 ± 0.03	0.343HisTrp: 0.343 ± 0.015	0.516HisTyr: 0.516 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.132IleAla: 5.132 ± 0.069	0.29IleCys: 0.29 ± 0.012	2.281IleAsp: 2.281 ± 0.042	2.254IleGlu: 2.254 ± 0.037	0.778IlePhe: 0.778 ± 0.022	3.799IleGly: 3.799 ± 0.054	0.583IleHis: 0.583 ± 0.016	0.919IleIle: 0.919 ± 0.027	0.696IleLys: 0.696 ± 0.019	2.528IleLeu: 2.528 ± 0.043	0.454IleMet: 0.454 ± 0.014	0.692IleAsn: 0.692 ± 0.019	1.967IlePro: 1.967 ± 0.035	0.75IleGln: 0.75 ± 0.021	2.461IleArg: 2.461 ± 0.04	1.936IleSer: 1.936 ± 0.033	2.473IleThr: 2.473 ± 0.036	2.984IleVal: 2.984 ± 0.049	0.362IleTrp: 0.362 ± 0.015	0.602IleTyr: 0.602 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.788LysAla: 2.788 ± 0.046	0.114LysCys: 0.114 ± 0.009	1.169LysAsp: 1.169 ± 0.028	1.026LysGlu: 1.026 ± 0.024	0.563LysPhe: 0.563 ± 0.018	1.656LysGly: 1.656 ± 0.03	0.516LysHis: 0.516 ± 0.016	1.012LysIle: 1.012 ± 0.028	0.728LysLys: 0.728 ± 0.022	2.449LysLeu: 2.449 ± 0.04	0.397LysMet: 0.397 ± 0.015	0.53LysAsn: 0.53 ± 0.019	1.592LysPro: 1.592 ± 0.035	0.802LysGln: 0.802 ± 0.024	1.574LysArg: 1.574 ± 0.027	1.122LysSer: 1.122 ± 0.028	1.366LysThr: 1.366 ± 0.03	1.922LysVal: 1.922 ± 0.032	0.284LysTrp: 0.284 ± 0.014	0.497LysTyr: 0.497 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.529LeuAla: 15.529 ± 0.125	0.824LeuCys: 0.824 ± 0.022	6.751LeuAsp: 6.751 ± 0.077	4.63LeuGlu: 4.63 ± 0.057	2.709LeuPhe: 2.709 ± 0.038	9.575LeuGly: 9.575 ± 0.092	2.279LeuHis: 2.279 ± 0.038	3.472LeuIle: 3.472 ± 0.053	1.865LeuLys: 1.865 ± 0.037	10.76LeuLeu: 10.76 ± 0.136	1.382LeuMet: 1.382 ± 0.03	1.75LeuAsn: 1.75 ± 0.034	6.631LeuPro: 6.631 ± 0.063	2.311LeuGln: 2.311 ± 0.038	8.768LeuArg: 8.768 ± 0.08	5.819LeuSer: 5.819 ± 0.065	6.547LeuThr: 6.547 ± 0.062	9.28LeuVal: 9.28 ± 0.079	1.19LeuTrp: 1.19 ± 0.029	1.653LeuTyr: 1.653 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.022MetAla: 2.022 ± 0.036	0.121MetCys: 0.121 ± 0.008	0.774MetAsp: 0.774 ± 0.019	0.587MetGlu: 0.587 ± 0.018	0.458MetPhe: 0.458 ± 0.018	1.1MetGly: 1.1 ± 0.024	0.344MetHis: 0.344 ± 0.013	0.714MetIle: 0.714 ± 0.022	0.423MetLys: 0.423 ± 0.015	1.711MetLeu: 1.711 ± 0.03	0.282MetMet: 0.282 ± 0.011	0.423MetAsn: 0.423 ± 0.016	1.153MetPro: 1.153 ± 0.026	0.435MetGln: 0.435 ± 0.017	1.347MetArg: 1.347 ± 0.025	1.292MetSer: 1.292 ± 0.027	1.543MetThr: 1.543 ± 0.03	1.235MetVal: 1.235 ± 0.026	0.187MetTrp: 0.187 ± 0.01	0.248MetTyr: 0.248 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.346AsnAla: 2.346 ± 0.039	0.159AsnCys: 0.159 ± 0.01	1.007AsnAsp: 1.007 ± 0.022	0.867AsnGlu: 0.867 ± 0.021	0.495AsnPhe: 0.495 ± 0.018	2.012AsnGly: 2.012 ± 0.041	0.429AsnHis: 0.429 ± 0.016	0.634AsnIle: 0.634 ± 0.019	0.395AsnLys: 0.395 ± 0.015	1.891AsnLeu: 1.891 ± 0.035	0.248AsnMet: 0.248 ± 0.011	0.426AsnAsn: 0.426 ± 0.015	1.544AsnPro: 1.544 ± 0.029	0.568AsnGln: 0.568 ± 0.019	1.374AsnArg: 1.374 ± 0.031	0.988AsnSer: 0.988 ± 0.028	1.11AsnThr: 1.11 ± 0.024	1.485AsnVal: 1.485 ± 0.027	0.308AsnTrp: 0.308 ± 0.012	0.431AsnTyr: 0.431 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.848ProAla: 8.848 ± 0.085	0.375ProCys: 0.375 ± 0.015	4.457ProAsp: 4.457 ± 0.061	4.324ProGlu: 4.324 ± 0.056	1.585ProPhe: 1.585 ± 0.029	7.012ProGly: 7.012 ± 0.083	1.284ProHis: 1.284 ± 0.027	1.763ProIle: 1.763 ± 0.032	1.325ProLys: 1.325 ± 0.026	5.056ProLeu: 5.056 ± 0.044	1.017ProMet: 1.017 ± 0.022	1.076ProAsn: 1.076 ± 0.026	3.892ProPro: 3.892 ± 0.093	1.769ProGln: 1.769 ± 0.041	3.94ProArg: 3.94 ± 0.058	3.424ProSer: 3.424 ± 0.061	2.908ProThr: 2.908 ± 0.047	5.505ProVal: 5.505 ± 0.072	0.875ProTrp: 0.875 ± 0.022	1.137ProTyr: 1.137 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.94GlnAla: 3.94 ± 0.051	0.178GlnCys: 0.178 ± 0.01	1.337GlnAsp: 1.337 ± 0.026	1.285GlnGlu: 1.285 ± 0.029	0.808GlnPhe: 0.808 ± 0.022	2.161GlnGly: 2.161 ± 0.036	0.745GlnHis: 0.745 ± 0.02	1.185GlnIle: 1.185 ± 0.026	0.592GlnLys: 0.592 ± 0.018	3.556GlnLeu: 3.556 ± 0.039	0.499GlnMet: 0.499 ± 0.018	0.603GlnAsn: 0.603 ± 0.02	1.978GlnPro: 1.978 ± 0.047	1.39GlnGln: 1.39 ± 0.039	2.685GlnArg: 2.685 ± 0.036	1.399GlnSer: 1.399 ± 0.028	1.389GlnThr: 1.389 ± 0.026	2.723GlnVal: 2.723 ± 0.04	0.513GlnTrp: 0.513 ± 0.016	0.623GlnTyr: 0.623 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.497ArgAla: 9.497 ± 0.089	0.632ArgCys: 0.632 ± 0.02	4.029ArgAsp: 4.029 ± 0.05	4.637ArgGlu: 4.637 ± 0.057	2.505ArgPhe: 2.505 ± 0.046	5.818ArgGly: 5.818 ± 0.06	1.997ArgHis: 1.997 ± 0.04	3.375ArgIle: 3.375 ± 0.044	1.868ArgLys: 1.868 ± 0.029	8.47ArgLeu: 8.47 ± 0.08	1.784ArgMet: 1.784 ± 0.031	1.488ArgAsn: 1.488 ± 0.028	4.886ArgPro: 4.886 ± 0.067	2.422ArgGln: 2.422 ± 0.039	7.627ArgArg: 7.627 ± 0.096	4.091ArgSer: 4.091 ± 0.05	4.943ArgThr: 4.943 ± 0.054	6.026ArgVal: 6.026 ± 0.061	1.385ArgTrp: 1.385 ± 0.026	1.862ArgTyr: 1.862 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.079SerAla: 7.079 ± 0.078	0.428SerCys: 0.428 ± 0.015	2.654SerAsp: 2.654 ± 0.071	2.451SerGlu: 2.451 ± 0.045	1.655SerPhe: 1.655 ± 0.033	6.257SerGly: 6.257 ± 0.073	0.956SerHis: 0.956 ± 0.022	1.669SerIle: 1.669 ± 0.029	1.018SerLys: 1.018 ± 0.026	4.888SerLeu: 4.888 ± 0.055	1.099SerMet: 1.099 ± 0.023	0.918SerAsn: 0.918 ± 0.025	3.314SerPro: 3.314 ± 0.066	1.257SerGln: 1.257 ± 0.026	3.773SerArg: 3.773 ± 0.051	3.092SerSer: 3.092 ± 0.063	3.399SerThr: 3.399 ± 0.052	4.486SerVal: 4.486 ± 0.064	0.985SerTrp: 0.985 ± 0.027	1.156SerTyr: 1.156 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	8.103ThrAla: 8.103 ± 0.087	0.417ThrCys: 0.417 ± 0.017	3.443ThrAsp: 3.443 ± 0.05	3.406ThrGlu: 3.406 ± 0.052	1.666ThrPhe: 1.666 ± 0.032	6.586ThrGly: 6.586 ± 0.07	1.169ThrHis: 1.169 ± 0.026	1.998ThrIle: 1.998 ± 0.036	1.3ThrLys: 1.3 ± 0.032	5.49ThrLeu: 5.49 ± 0.056	0.976ThrMet: 0.976 ± 0.023	1.016ThrAsn: 1.016 ± 0.026	3.974ThrPro: 3.974 ± 0.053	1.452ThrGln: 1.452 ± 0.03	3.93ThrArg: 3.93 ± 0.054	3.278ThrSer: 3.278 ± 0.049	3.98ThrThr: 3.98 ± 0.064	6.042ThrVal: 6.042 ± 0.061	0.873ThrTrp: 0.873 ± 0.024	1.145ThrTyr: 1.145 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	11.196ValAla: 11.196 ± 0.09	0.679ValCys: 0.679 ± 0.021	5.245ValAsp: 5.245 ± 0.06	4.575ValGlu: 4.575 ± 0.059	2.465ValPhe: 2.465 ± 0.044	6.448ValGly: 6.448 ± 0.066	2.035ValHis: 2.035 ± 0.035	2.906ValIle: 2.906 ± 0.046	1.718ValLys: 1.718 ± 0.032	10.455ValLeu: 10.455 ± 0.091	1.11ValMet: 1.11 ± 0.029	1.64ValAsn: 1.64 ± 0.031	5.381ValPro: 5.381 ± 0.06	2.246ValGln: 2.246 ± 0.034	7.192ValArg: 7.192 ± 0.093	4.645ValSer: 4.645 ± 0.057	5.513ValThr: 5.513 ± 0.06	8.489ValVal: 8.489 ± 0.081	1.021ValTrp: 1.021 ± 0.024	1.501ValTyr: 1.501 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.58TrpAla: 1.58 ± 0.032	0.157TrpCys: 0.157 ± 0.01	0.71TrpAsp: 0.71 ± 0.021	0.624TrpGlu: 0.624 ± 0.019	0.508TrpPhe: 0.508 ± 0.019	0.971TrpGly: 0.971 ± 0.023	0.409TrpHis: 0.409 ± 0.016	0.556TrpIle: 0.556 ± 0.02	0.29TrpLys: 0.29 ± 0.013	1.878TrpLeu: 1.878 ± 0.035	0.259TrpMet: 0.259 ± 0.011	0.357TrpAsn: 0.357 ± 0.014	0.827TrpPro: 0.827 ± 0.027	0.655TrpGln: 0.655 ± 0.018	1.318TrpArg: 1.318 ± 0.026	0.863TrpSer: 0.863 ± 0.025	0.977TrpThr: 0.977 ± 0.024	1.042TrpVal: 1.042 ± 0.026	0.372TrpTrp: 0.372 ± 0.016	0.297TrpTyr: 0.297 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.424TyrAla: 2.424 ± 0.035	0.182TyrCys: 0.182 ± 0.01	1.276TyrAsp: 1.276 ± 0.035	1.021TyrGlu: 1.021 ± 0.023	0.685TyrPhe: 0.685 ± 0.021	2.018TyrGly: 2.018 ± 0.035	0.51TyrHis: 0.51 ± 0.018	0.419TyrIle: 0.419 ± 0.015	0.281TyrLys: 0.281 ± 0.011	2.285TyrLeu: 2.285 ± 0.04	0.186TyrMet: 0.186 ± 0.01	0.383TyrAsn: 0.383 ± 0.017	1.178TyrPro: 1.178 ± 0.027	0.698TyrGln: 0.698 ± 0.02	1.872TyrArg: 1.872 ± 0.035	1.034TyrSer: 1.034 ± 0.028	1.127TyrThr: 1.127 ± 0.025	1.563TyrVal: 1.563 ± 0.028	0.318TyrTrp: 0.318 ± 0.015	0.475TyrTyr: 0.475 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5941 proteins (1913325 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---