Amino acid dipepetide frequency for Mesonia algae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.895AlaAla: 3.895 ± 0.09	0.544AlaCys: 0.544 ± 0.026	2.825AlaAsp: 2.825 ± 0.056	4.145AlaGlu: 4.145 ± 0.076	3.216AlaPhe: 3.216 ± 0.07	3.884AlaGly: 3.884 ± 0.076	1.074AlaHis: 1.074 ± 0.033	5.215AlaIle: 5.215 ± 0.079	4.839AlaLys: 4.839 ± 0.096	5.853AlaLeu: 5.853 ± 0.099	1.388AlaMet: 1.388 ± 0.049	3.375AlaAsn: 3.375 ± 0.059	1.774AlaPro: 1.774 ± 0.052	2.601AlaGln: 2.601 ± 0.058	1.854AlaArg: 1.854 ± 0.051	4.16AlaSer: 4.16 ± 0.083	3.485AlaThr: 3.485 ± 0.077	3.731AlaVal: 3.731 ± 0.086	0.533AlaTrp: 0.533 ± 0.025	2.509AlaTyr: 2.509 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.402CysAla: 0.402 ± 0.019	0.1CysCys: 0.1 ± 0.011	0.422CysAsp: 0.422 ± 0.024	0.459CysGlu: 0.459 ± 0.024	0.369CysPhe: 0.369 ± 0.019	0.575CysGly: 0.575 ± 0.026	0.178CysHis: 0.178 ± 0.015	0.546CysIle: 0.546 ± 0.026	0.471CysLys: 0.471 ± 0.022	0.625CysLeu: 0.625 ± 0.029	0.117CysMet: 0.117 ± 0.011	0.413CysAsn: 0.413 ± 0.025	0.296CysPro: 0.296 ± 0.023	0.231CysGln: 0.231 ± 0.017	0.186CysArg: 0.186 ± 0.013	0.543CysSer: 0.543 ± 0.031	0.399CysThr: 0.399 ± 0.026	0.407CysVal: 0.407 ± 0.021	0.068CysTrp: 0.068 ± 0.008	0.293CysTyr: 0.293 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.444AspAla: 3.444 ± 0.076	0.394AspCys: 0.394 ± 0.026	2.844AspAsp: 2.844 ± 0.079	3.896AspGlu: 3.896 ± 0.073	3.616AspPhe: 3.616 ± 0.062	3.161AspGly: 3.161 ± 0.067	0.982AspHis: 0.982 ± 0.031	4.224AspIle: 4.224 ± 0.067	4.074AspLys: 4.074 ± 0.076	5.24AspLeu: 5.24 ± 0.077	1.044AspMet: 1.044 ± 0.034	2.864AspAsn: 2.864 ± 0.068	1.647AspPro: 1.647 ± 0.05	1.711AspGln: 1.711 ± 0.046	1.756AspArg: 1.756 ± 0.044	3.097AspSer: 3.097 ± 0.066	2.584AspThr: 2.584 ± 0.054	3.389AspVal: 3.389 ± 0.08	0.693AspTrp: 0.693 ± 0.035	2.846AspTyr: 2.846 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.563GluAla: 4.563 ± 0.076	0.314GluCys: 0.314 ± 0.021	4.191GluAsp: 4.191 ± 0.076	6.358GluGlu: 6.358 ± 0.114	3.143GluPhe: 3.143 ± 0.058	3.957GluGly: 3.957 ± 0.068	1.208GluHis: 1.208 ± 0.04	6.268GluIle: 6.268 ± 0.083	6.907GluLys: 6.907 ± 0.119	6.369GluLeu: 6.369 ± 0.094	1.661GluMet: 1.661 ± 0.046	5.625GluAsn: 5.625 ± 0.072	1.601GluPro: 1.601 ± 0.047	2.405GluGln: 2.405 ± 0.058	2.491GluArg: 2.491 ± 0.059	3.532GluSer: 3.532 ± 0.061	3.733GluThr: 3.733 ± 0.056	4.944GluVal: 4.944 ± 0.082	0.639GluTrp: 0.639 ± 0.024	2.494GluTyr: 2.494 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.849PheAla: 2.849 ± 0.061	0.452PheCys: 0.452 ± 0.022	2.965PheAsp: 2.965 ± 0.067	3.348PheGlu: 3.348 ± 0.065	2.893PhePhe: 2.893 ± 0.074	3.348PheGly: 3.348 ± 0.069	0.862PheHis: 0.862 ± 0.035	4.227PheIle: 4.227 ± 0.08	4.033PheLys: 4.033 ± 0.073	5.184PheLeu: 5.184 ± 0.091	1.037PheMet: 1.037 ± 0.036	3.307PheAsn: 3.307 ± 0.078	1.744PhePro: 1.744 ± 0.045	1.783PheGln: 1.783 ± 0.044	1.519PheArg: 1.519 ± 0.043	4.191PheSer: 4.191 ± 0.076	3.236PheThr: 3.236 ± 0.063	2.818PheVal: 2.818 ± 0.057	0.548PheTrp: 0.548 ± 0.024	2.274PheTyr: 2.274 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	3.827GlyAla: 3.827 ± 0.073	0.495GlyCys: 0.495 ± 0.028	3.328GlyAsp: 3.328 ± 0.065	3.969GlyGlu: 3.969 ± 0.074	3.59GlyPhe: 3.59 ± 0.062	4.325GlyGly: 4.325 ± 0.112	0.995GlyHis: 0.995 ± 0.034	5.186GlyIle: 5.186 ± 0.082	4.855GlyLys: 4.855 ± 0.08	5.504GlyLeu: 5.504 ± 0.096	1.469GlyMet: 1.469 ± 0.042	3.564GlyAsn: 3.564 ± 0.076	1.199GlyPro: 1.199 ± 0.038	1.711GlyGln: 1.711 ± 0.051	1.835GlyArg: 1.835 ± 0.049	3.855GlySer: 3.855 ± 0.071	3.51GlyThr: 3.51 ± 0.091	4.164GlyVal: 4.164 ± 0.077	0.692GlyTrp: 0.692 ± 0.029	2.543GlyTyr: 2.543 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.881HisAla: 0.881 ± 0.036	0.159HisCys: 0.159 ± 0.013	0.723HisAsp: 0.723 ± 0.027	1.013HisGlu: 1.013 ± 0.033	1.177HisPhe: 1.177 ± 0.039	0.933HisGly: 0.933 ± 0.031	0.511HisHis: 0.511 ± 0.028	1.528HisIle: 1.528 ± 0.047	1.277HisLys: 1.277 ± 0.045	1.986HisLeu: 1.986 ± 0.051	0.344HisMet: 0.344 ± 0.02	0.957HisAsn: 0.957 ± 0.033	0.928HisPro: 0.928 ± 0.035	0.946HisGln: 0.946 ± 0.031	0.672HisArg: 0.672 ± 0.027	1.019HisSer: 1.019 ± 0.035	1.006HisThr: 1.006 ± 0.032	0.867HisVal: 0.867 ± 0.03	0.189HisTrp: 0.189 ± 0.014	0.867HisTyr: 0.867 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.498IleAla: 5.498 ± 0.08	0.639IleCys: 0.639 ± 0.026	4.924IleAsp: 4.924 ± 0.079	6.047IleGlu: 6.047 ± 0.09	3.759IlePhe: 3.759 ± 0.073	4.925IleGly: 4.925 ± 0.075	1.429IleHis: 1.429 ± 0.043	6.133IleIle: 6.133 ± 0.106	6.037IleLys: 6.037 ± 0.087	7.527IleLeu: 7.527 ± 0.115	1.222IleMet: 1.222 ± 0.043	4.843IleAsn: 4.843 ± 0.084	3.236IlePro: 3.236 ± 0.064	2.855IleGln: 2.855 ± 0.062	2.341IleArg: 2.341 ± 0.047	5.884IleSer: 5.884 ± 0.089	4.734IleThr: 4.734 ± 0.083	4.447IleVal: 4.447 ± 0.082	0.675IleTrp: 0.675 ± 0.023	2.933IleTyr: 2.933 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.933LysAla: 4.933 ± 0.079	0.315LysCys: 0.315 ± 0.019	4.67LysAsp: 4.67 ± 0.093	7.691LysGlu: 7.691 ± 0.128	3.068LysPhe: 3.068 ± 0.064	4.319LysGly: 4.319 ± 0.072	1.387LysHis: 1.387 ± 0.042	6.483LysIle: 6.483 ± 0.098	7.876LysLys: 7.876 ± 0.117	6.846LysLeu: 6.846 ± 0.098	2.045LysMet: 2.045 ± 0.049	5.924LysAsn: 5.924 ± 0.084	2.161LysPro: 2.161 ± 0.049	2.878LysGln: 2.878 ± 0.06	2.93LysArg: 2.93 ± 0.056	4.776LysSer: 4.776 ± 0.077	4.643LysThr: 4.643 ± 0.072	4.73LysVal: 4.73 ± 0.075	0.695LysTrp: 0.695 ± 0.027	2.957LysTyr: 2.957 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.811LeuAla: 5.811 ± 0.086	0.627LeuCys: 0.627 ± 0.028	5.018LeuAsp: 5.018 ± 0.084	6.891LeuGlu: 6.891 ± 0.101	4.918LeuPhe: 4.918 ± 0.088	5.929LeuGly: 5.929 ± 0.085	1.669LeuHis: 1.669 ± 0.048	7.376LeuIle: 7.376 ± 0.11	8.299LeuLys: 8.299 ± 0.117	8.763LeuLeu: 8.763 ± 0.124	2.072LeuMet: 2.072 ± 0.052	5.87LeuAsn: 5.87 ± 0.095	3.571LeuPro: 3.571 ± 0.072	3.787LeuGln: 3.787 ± 0.065	3.094LeuArg: 3.094 ± 0.069	6.96LeuSer: 6.96 ± 0.091	5.031LeuThr: 5.031 ± 0.079	5.389LeuVal: 5.389 ± 0.071	0.781LeuTrp: 0.781 ± 0.034	3.178LeuTyr: 3.178 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.446MetAla: 1.446 ± 0.047	0.139MetCys: 0.139 ± 0.012	0.979MetAsp: 0.979 ± 0.036	1.319MetGlu: 1.319 ± 0.037	0.824MetPhe: 0.824 ± 0.043	1.375MetGly: 1.375 ± 0.037	0.366MetHis: 0.366 ± 0.022	1.53MetIle: 1.53 ± 0.048	2.19MetLys: 2.19 ± 0.057	1.976MetLeu: 1.976 ± 0.054	0.588MetMet: 0.588 ± 0.027	1.192MetAsn: 1.192 ± 0.037	0.767MetPro: 0.767 ± 0.032	0.9MetGln: 0.9 ± 0.033	0.833MetArg: 0.833 ± 0.03	1.369MetSer: 1.369 ± 0.037	1.076MetThr: 1.076 ± 0.036	1.326MetVal: 1.326 ± 0.042	0.144MetTrp: 0.144 ± 0.013	0.693MetTyr: 0.693 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.615AsnAla: 3.615 ± 0.065	0.455AsnCys: 0.455 ± 0.026	3.218AsnAsp: 3.218 ± 0.068	4.097AsnGlu: 4.097 ± 0.066	3.396AsnPhe: 3.396 ± 0.069	3.731AsnGly: 3.731 ± 0.084	1.149AsnHis: 1.149 ± 0.03	4.81AsnIle: 4.81 ± 0.084	4.555AsnLys: 4.555 ± 0.074	5.996AsnLeu: 5.996 ± 0.099	1.21AsnMet: 1.21 ± 0.037	3.925AsnAsn: 3.925 ± 0.093	2.655AsnPro: 2.655 ± 0.06	2.608AsnGln: 2.608 ± 0.059	2.099AsnArg: 2.099 ± 0.053	4.016AsnSer: 4.016 ± 0.075	3.577AsnThr: 3.577 ± 0.073	3.461AsnVal: 3.461 ± 0.073	0.798AsnTrp: 0.798 ± 0.034	3.042AsnTyr: 3.042 ± 0.068	0.0AsnXaa: 0.0 ± 0.0
Pro	1.762ProAla: 1.762 ± 0.049	0.211ProCys: 0.211 ± 0.015	1.692ProAsp: 1.692 ± 0.049	2.567ProGlu: 2.567 ± 0.051	1.771ProPhe: 1.771 ± 0.041	1.683ProGly: 1.683 ± 0.047	0.66ProHis: 0.66 ± 0.027	2.662ProIle: 2.662 ± 0.052	2.633ProLys: 2.633 ± 0.055	3.057ProLeu: 3.057 ± 0.056	0.679ProMet: 0.679 ± 0.025	2.141ProAsn: 2.141 ± 0.059	0.785ProPro: 0.785 ± 0.033	1.467ProGln: 1.467 ± 0.041	0.857ProArg: 0.857 ± 0.034	2.192ProSer: 2.192 ± 0.049	1.906ProThr: 1.906 ± 0.047	2.195ProVal: 2.195 ± 0.053	0.291ProTrp: 0.291 ± 0.018	1.463ProTyr: 1.463 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.221GlnAla: 2.221 ± 0.051	0.178GlnCys: 0.178 ± 0.015	1.856GlnAsp: 1.856 ± 0.045	3.144GlnGlu: 3.144 ± 0.067	1.749GlnPhe: 1.749 ± 0.04	1.818GlnGly: 1.818 ± 0.047	0.785GlnHis: 0.785 ± 0.029	2.948GlnIle: 2.948 ± 0.058	3.2GlnLys: 3.2 ± 0.063	4.134GlnLeu: 4.134 ± 0.078	0.814GlnMet: 0.814 ± 0.028	2.315GlnAsn: 2.315 ± 0.058	1.331GlnPro: 1.331 ± 0.033	1.967GlnGln: 1.967 ± 0.061	1.352GlnArg: 1.352 ± 0.043	1.962GlnSer: 1.962 ± 0.057	2.0GlnThr: 2.0 ± 0.049	2.203GlnVal: 2.203 ± 0.052	0.349GlnTrp: 0.349 ± 0.021	1.307GlnTyr: 1.307 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.841ArgAla: 1.841 ± 0.047	0.182ArgCys: 0.182 ± 0.013	1.656ArgAsp: 1.656 ± 0.044	2.428ArgGlu: 2.428 ± 0.058	1.772ArgPhe: 1.772 ± 0.049	1.873ArgGly: 1.873 ± 0.043	0.54ArgHis: 0.54 ± 0.026	2.657ArgIle: 2.657 ± 0.054	2.98ArgLys: 2.98 ± 0.056	3.199ArgLeu: 3.199 ± 0.06	0.853ArgMet: 0.853 ± 0.031	2.079ArgAsn: 2.079 ± 0.051	0.979ArgPro: 0.979 ± 0.036	1.077ArgGln: 1.077 ± 0.038	1.211ArgArg: 1.211 ± 0.036	1.817ArgSer: 1.817 ± 0.048	1.534ArgThr: 1.534 ± 0.039	1.975ArgVal: 1.975 ± 0.045	0.356ArgTrp: 0.356 ± 0.023	1.434ArgTyr: 1.434 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.764SerAla: 3.764 ± 0.065	0.639SerCys: 0.639 ± 0.031	3.087SerAsp: 3.087 ± 0.063	3.938SerGlu: 3.938 ± 0.064	4.023SerPhe: 4.023 ± 0.078	4.303SerGly: 4.303 ± 0.088	1.083SerHis: 1.083 ± 0.034	5.54SerIle: 5.54 ± 0.082	4.953SerLys: 4.953 ± 0.086	6.595SerLeu: 6.595 ± 0.09	1.27SerMet: 1.27 ± 0.034	3.917SerAsn: 3.917 ± 0.083	2.078SerPro: 2.078 ± 0.041	2.382SerGln: 2.382 ± 0.058	2.032SerArg: 2.032 ± 0.051	4.703SerSer: 4.703 ± 0.088	3.649SerThr: 3.649 ± 0.065	4.064SerVal: 4.064 ± 0.076	0.658SerTrp: 0.658 ± 0.028	2.908SerTyr: 2.908 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.465ThrAla: 3.465 ± 0.077	0.362ThrCys: 0.362 ± 0.023	2.796ThrAsp: 2.796 ± 0.077	3.513ThrGlu: 3.513 ± 0.071	2.875ThrPhe: 2.875 ± 0.053	3.743ThrGly: 3.743 ± 0.077	1.087ThrHis: 1.087 ± 0.038	4.442ThrIle: 4.442 ± 0.083	3.654ThrLys: 3.654 ± 0.072	5.371ThrLeu: 5.371 ± 0.075	0.916ThrMet: 0.916 ± 0.028	3.206ThrAsn: 3.206 ± 0.084	2.37ThrPro: 2.37 ± 0.049	2.345ThrGln: 2.345 ± 0.055	1.614ThrArg: 1.614 ± 0.048	4.003ThrSer: 4.003 ± 0.066	3.477ThrThr: 3.477 ± 0.077	3.384ThrVal: 3.384 ± 0.072	0.531ThrTrp: 0.531 ± 0.03	2.54ThrTyr: 2.54 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	3.816ValAla: 3.816 ± 0.078	0.477ValCys: 0.477 ± 0.023	3.371ValAsp: 3.371 ± 0.064	4.328ValGlu: 4.328 ± 0.079	3.333ValPhe: 3.333 ± 0.073	3.662ValGly: 3.662 ± 0.071	0.975ValHis: 0.975 ± 0.03	4.816ValIle: 4.816 ± 0.078	4.566ValLys: 4.566 ± 0.083	5.849ValLeu: 5.849 ± 0.085	1.3ValMet: 1.3 ± 0.037	3.752ValAsn: 3.752 ± 0.072	1.927ValPro: 1.927 ± 0.047	1.772ValGln: 1.772 ± 0.043	1.836ValArg: 1.836 ± 0.045	4.28ValSer: 4.28 ± 0.079	3.413ValThr: 3.413 ± 0.087	3.93ValVal: 3.93 ± 0.075	0.539ValTrp: 0.539 ± 0.027	2.351ValTyr: 2.351 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.516TrpAla: 0.516 ± 0.024	0.094TrpCys: 0.094 ± 0.01	0.596TrpAsp: 0.596 ± 0.036	0.659TrpGlu: 0.659 ± 0.028	0.58TrpPhe: 0.58 ± 0.029	0.571TrpGly: 0.571 ± 0.028	0.185TrpHis: 0.185 ± 0.013	0.692TrpIle: 0.692 ± 0.031	0.777TrpLys: 0.777 ± 0.03	1.009TrpLeu: 1.009 ± 0.038	0.303TrpMet: 0.303 ± 0.019	0.613TrpAsn: 0.613 ± 0.028	0.231TrpPro: 0.231 ± 0.018	0.413TrpGln: 0.413 ± 0.022	0.351TrpArg: 0.351 ± 0.019	0.622TrpSer: 0.622 ± 0.027	0.428TrpThr: 0.428 ± 0.025	0.585TrpVal: 0.585 ± 0.022	0.15TrpTrp: 0.15 ± 0.013	0.387TrpTyr: 0.387 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.349TyrAla: 2.349 ± 0.055	0.323TyrCys: 0.323 ± 0.02	2.347TyrAsp: 2.347 ± 0.055	2.593TyrGlu: 2.593 ± 0.054	2.549TyrPhe: 2.549 ± 0.06	2.5TyrGly: 2.5 ± 0.06	0.856TyrHis: 0.856 ± 0.032	2.804TyrIle: 2.804 ± 0.055	3.149TyrLys: 3.149 ± 0.066	3.953TyrLeu: 3.953 ± 0.074	0.7TyrMet: 0.7 ± 0.029	2.535TyrAsn: 2.535 ± 0.058	1.393TyrPro: 1.393 ± 0.036	1.795TyrGln: 1.795 ± 0.049	1.581TyrArg: 1.581 ± 0.042	2.604TyrSer: 2.604 ± 0.058	2.273TyrThr: 2.273 ± 0.053	2.28TyrVal: 2.28 ± 0.053	0.434TyrTrp: 0.434 ± 0.025	1.878TyrTyr: 1.878 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2856 proteins (933224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---