Amino acid dipepetide frequency for Marinomonas pollencensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.541AlaAla: 8.541 ± 0.111	1.066AlaCys: 1.066 ± 0.032	4.694AlaAsp: 4.694 ± 0.072	5.389AlaGlu: 5.389 ± 0.088	3.777AlaPhe: 3.777 ± 0.057	6.194AlaGly: 6.194 ± 0.082	1.819AlaHis: 1.819 ± 0.042	6.128AlaIle: 6.128 ± 0.078	5.016AlaLys: 5.016 ± 0.075	10.944AlaLeu: 10.944 ± 0.105	2.731AlaMet: 2.731 ± 0.049	3.54AlaAsn: 3.54 ± 0.063	3.242AlaPro: 3.242 ± 0.061	4.207AlaGln: 4.207 ± 0.075	3.871AlaArg: 3.871 ± 0.062	5.986AlaSer: 5.986 ± 0.078	4.522AlaThr: 4.522 ± 0.065	5.945AlaVal: 5.945 ± 0.083	1.032AlaTrp: 1.032 ± 0.034	2.521AlaTyr: 2.521 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.834CysAla: 0.834 ± 0.03	0.157CysCys: 0.157 ± 0.011	0.593CysAsp: 0.593 ± 0.024	0.597CysGlu: 0.597 ± 0.023	0.505CysPhe: 0.505 ± 0.021	0.848CysGly: 0.848 ± 0.028	0.343CysHis: 0.343 ± 0.017	0.635CysIle: 0.635 ± 0.026	0.344CysLys: 0.344 ± 0.019	1.181CysLeu: 1.181 ± 0.033	0.209CysMet: 0.209 ± 0.014	0.297CysAsn: 0.297 ± 0.017	0.444CysPro: 0.444 ± 0.023	0.523CysGln: 0.523 ± 0.022	0.489CysArg: 0.489 ± 0.02	0.668CysSer: 0.668 ± 0.022	0.453CysThr: 0.453 ± 0.021	0.74CysVal: 0.74 ± 0.027	0.133CysTrp: 0.133 ± 0.01	0.342CysTyr: 0.342 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.746AspAla: 4.746 ± 0.066	0.547AspCys: 0.547 ± 0.02	2.895AspAsp: 2.895 ± 0.068	3.722AspGlu: 3.722 ± 0.07	2.393AspPhe: 2.393 ± 0.047	3.446AspGly: 3.446 ± 0.057	1.279AspHis: 1.279 ± 0.034	3.745AspIle: 3.745 ± 0.064	2.907AspLys: 2.907 ± 0.055	5.385AspLeu: 5.385 ± 0.067	1.469AspMet: 1.469 ± 0.035	2.057AspAsn: 2.057 ± 0.041	2.151AspPro: 2.151 ± 0.044	2.263AspGln: 2.263 ± 0.053	2.335AspArg: 2.335 ± 0.042	3.274AspSer: 3.274 ± 0.057	2.702AspThr: 2.702 ± 0.042	3.778AspVal: 3.778 ± 0.061	0.845AspTrp: 0.845 ± 0.024	2.023AspTyr: 2.023 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.744GluAla: 5.744 ± 0.08	0.511GluCys: 0.511 ± 0.021	2.919GluAsp: 2.919 ± 0.061	4.055GluGlu: 4.055 ± 0.066	2.294GluPhe: 2.294 ± 0.041	3.701GluGly: 3.701 ± 0.058	1.573GluHis: 1.573 ± 0.039	3.508GluIle: 3.508 ± 0.048	3.72GluLys: 3.72 ± 0.06	6.276GluLeu: 6.276 ± 0.08	1.659GluMet: 1.659 ± 0.035	2.558GluAsn: 2.558 ± 0.052	1.877GluPro: 1.877 ± 0.045	3.648GluGln: 3.648 ± 0.061	3.359GluArg: 3.359 ± 0.053	3.828GluSer: 3.828 ± 0.061	2.909GluThr: 2.909 ± 0.057	4.071GluVal: 4.071 ± 0.067	0.763GluTrp: 0.763 ± 0.025	1.641GluTyr: 1.641 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.64PheAla: 3.64 ± 0.057	0.605PheCys: 0.605 ± 0.026	2.652PheAsp: 2.652 ± 0.052	2.304PheGlu: 2.304 ± 0.046	1.83PhePhe: 1.83 ± 0.045	3.122PheGly: 3.122 ± 0.063	0.869PheHis: 0.869 ± 0.028	2.78PheIle: 2.78 ± 0.055	1.808PheLys: 1.808 ± 0.041	3.807PheLeu: 3.807 ± 0.072	1.068PheMet: 1.068 ± 0.031	1.709PheAsn: 1.709 ± 0.042	1.584PhePro: 1.584 ± 0.035	1.374PheGln: 1.374 ± 0.031	1.597PheArg: 1.597 ± 0.036	3.537PheSer: 3.537 ± 0.06	2.233PheThr: 2.233 ± 0.047	2.937PheVal: 2.937 ± 0.055	0.539PheTrp: 0.539 ± 0.022	1.341PheTyr: 1.341 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.564GlyAla: 5.564 ± 0.083	0.837GlyCys: 0.837 ± 0.032	3.463GlyAsp: 3.463 ± 0.057	4.081GlyGlu: 4.081 ± 0.061	3.374GlyPhe: 3.374 ± 0.054	4.72GlyGly: 4.72 ± 0.086	1.58GlyHis: 1.58 ± 0.041	4.646GlyIle: 4.646 ± 0.073	3.751GlyLys: 3.751 ± 0.063	7.446GlyLeu: 7.446 ± 0.095	2.031GlyMet: 2.031 ± 0.049	2.376GlyAsn: 2.376 ± 0.044	1.8GlyPro: 1.8 ± 0.041	2.836GlyGln: 2.836 ± 0.051	3.23GlyArg: 3.23 ± 0.051	4.098GlySer: 4.098 ± 0.07	3.159GlyThr: 3.159 ± 0.056	5.578GlyVal: 5.578 ± 0.083	0.936GlyTrp: 0.936 ± 0.028	2.43GlyTyr: 2.43 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.766HisAla: 1.766 ± 0.041	0.318HisCys: 0.318 ± 0.017	1.184HisAsp: 1.184 ± 0.036	1.157HisGlu: 1.157 ± 0.031	1.16HisPhe: 1.16 ± 0.033	1.55HisGly: 1.55 ± 0.033	0.693HisHis: 0.693 ± 0.029	1.357HisIle: 1.357 ± 0.038	1.042HisLys: 1.042 ± 0.033	2.503HisLeu: 2.503 ± 0.046	0.542HisMet: 0.542 ± 0.02	0.89HisAsn: 0.89 ± 0.03	1.255HisPro: 1.255 ± 0.034	1.252HisGln: 1.252 ± 0.037	1.076HisArg: 1.076 ± 0.03	1.521HisSer: 1.521 ± 0.043	1.197HisThr: 1.197 ± 0.032	1.249HisVal: 1.249 ± 0.032	0.372HisTrp: 0.372 ± 0.02	0.924HisTyr: 0.924 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.308IleAla: 6.308 ± 0.072	0.683IleCys: 0.683 ± 0.026	4.004IleAsp: 4.004 ± 0.064	4.291IleGlu: 4.291 ± 0.079	2.178IlePhe: 2.178 ± 0.054	4.689IleGly: 4.689 ± 0.078	1.32IleHis: 1.32 ± 0.037	3.599IleIle: 3.599 ± 0.065	3.278IleLys: 3.278 ± 0.057	5.691IleLeu: 5.691 ± 0.081	1.412IleMet: 1.412 ± 0.036	2.702IleAsn: 2.702 ± 0.045	2.658IlePro: 2.658 ± 0.042	2.421IleGln: 2.421 ± 0.044	3.018IleArg: 3.018 ± 0.059	4.617IleSer: 4.617 ± 0.068	3.415IleThr: 3.415 ± 0.062	4.162IleVal: 4.162 ± 0.075	0.644IleTrp: 0.644 ± 0.026	1.551IleTyr: 1.551 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	5.138LysAla: 5.138 ± 0.077	0.313LysCys: 0.313 ± 0.019	2.814LysAsp: 2.814 ± 0.052	3.568LysGlu: 3.568 ± 0.064	1.329LysPhe: 1.329 ± 0.039	3.459LysGly: 3.459 ± 0.056	1.286LysHis: 1.286 ± 0.04	2.885LysIle: 2.885 ± 0.054	3.137LysLys: 3.137 ± 0.061	4.708LysLeu: 4.708 ± 0.074	1.477LysMet: 1.477 ± 0.036	2.099LysAsn: 2.099 ± 0.05	2.159LysPro: 2.159 ± 0.044	2.807LysGln: 2.807 ± 0.056	2.865LysArg: 2.865 ± 0.049	3.206LysSer: 3.206 ± 0.055	2.87LysThr: 2.87 ± 0.052	3.847LysVal: 3.847 ± 0.058	0.524LysTrp: 0.524 ± 0.022	1.226LysTyr: 1.226 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	10.743LeuAla: 10.743 ± 0.105	1.146LeuCys: 1.146 ± 0.028	5.895LeuAsp: 5.895 ± 0.081	6.27LeuGlu: 6.27 ± 0.082	4.387LeuPhe: 4.387 ± 0.074	7.284LeuGly: 7.284 ± 0.097	2.107LeuHis: 2.107 ± 0.039	6.586LeuIle: 6.586 ± 0.09	5.397LeuLys: 5.397 ± 0.077	11.365LeuLeu: 11.365 ± 0.147	2.804LeuMet: 2.804 ± 0.052	4.375LeuAsn: 4.375 ± 0.063	5.002LeuPro: 5.002 ± 0.073	3.91LeuGln: 3.91 ± 0.064	4.271LeuArg: 4.271 ± 0.067	8.554LeuSer: 8.554 ± 0.105	5.957LeuThr: 5.957 ± 0.082	7.427LeuVal: 7.427 ± 0.082	1.157LeuTrp: 1.157 ± 0.035	2.75LeuTyr: 2.75 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.732MetAla: 2.732 ± 0.047	0.179MetCys: 0.179 ± 0.014	1.336MetAsp: 1.336 ± 0.033	1.304MetGlu: 1.304 ± 0.034	0.856MetPhe: 0.856 ± 0.028	1.831MetGly: 1.831 ± 0.044	0.503MetHis: 0.503 ± 0.021	1.542MetIle: 1.542 ± 0.037	1.489MetLys: 1.489 ± 0.034	2.686MetLeu: 2.686 ± 0.047	0.789MetMet: 0.789 ± 0.03	1.094MetAsn: 1.094 ± 0.034	1.267MetPro: 1.267 ± 0.033	1.066MetGln: 1.066 ± 0.032	1.275MetArg: 1.275 ± 0.035	2.107MetSer: 2.107 ± 0.041	1.721MetThr: 1.721 ± 0.041	1.834MetVal: 1.834 ± 0.038	0.236MetTrp: 0.236 ± 0.016	0.497MetTyr: 0.497 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.448AsnAla: 3.448 ± 0.058	0.34AsnCys: 0.34 ± 0.017	2.17AsnAsp: 2.17 ± 0.049	2.309AsnGlu: 2.309 ± 0.05	1.359AsnPhe: 1.359 ± 0.032	2.678AsnGly: 2.678 ± 0.048	0.939AsnHis: 0.939 ± 0.028	2.63AsnIle: 2.63 ± 0.049	2.238AsnLys: 2.238 ± 0.046	3.875AsnLeu: 3.875 ± 0.056	0.939AsnMet: 0.939 ± 0.028	1.748AsnAsn: 1.748 ± 0.045	1.947AsnPro: 1.947 ± 0.044	1.876AsnGln: 1.876 ± 0.04	1.834AsnArg: 1.834 ± 0.048	2.413AsnSer: 2.413 ± 0.052	2.308AsnThr: 2.308 ± 0.05	2.354AsnVal: 2.354 ± 0.047	0.594AsnTrp: 0.594 ± 0.023	1.199AsnTyr: 1.199 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.32ProAla: 3.32 ± 0.062	0.322ProCys: 0.322 ± 0.017	2.44ProAsp: 2.44 ± 0.048	3.197ProGlu: 3.197 ± 0.058	1.797ProPhe: 1.797 ± 0.039	2.367ProGly: 2.367 ± 0.054	0.949ProHis: 0.949 ± 0.032	2.671ProIle: 2.671 ± 0.05	2.173ProLys: 2.173 ± 0.051	4.158ProLeu: 4.158 ± 0.069	1.085ProMet: 1.085 ± 0.031	1.817ProAsn: 1.817 ± 0.041	1.227ProPro: 1.227 ± 0.037	1.508ProGln: 1.508 ± 0.04	1.417ProArg: 1.417 ± 0.041	2.733ProSer: 2.733 ± 0.047	2.186ProThr: 2.186 ± 0.049	3.062ProVal: 3.062 ± 0.059	0.564ProTrp: 0.564 ± 0.024	1.276ProTyr: 1.276 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.827GlnAla: 4.827 ± 0.073	0.386GlnCys: 0.386 ± 0.019	2.208GlnAsp: 2.208 ± 0.048	2.566GlnGlu: 2.566 ± 0.056	1.597GlnPhe: 1.597 ± 0.034	3.075GlnGly: 3.075 ± 0.051	1.221GlnHis: 1.221 ± 0.033	2.54GlnIle: 2.54 ± 0.044	2.282GlnLys: 2.282 ± 0.052	4.937GlnLeu: 4.937 ± 0.081	1.005GlnMet: 1.005 ± 0.025	1.609GlnAsn: 1.609 ± 0.037	1.701GlnPro: 1.701 ± 0.044	2.932GlnGln: 2.932 ± 0.064	2.389GlnArg: 2.389 ± 0.057	2.808GlnSer: 2.808 ± 0.045	2.437GlnThr: 2.437 ± 0.049	3.192GlnVal: 3.192 ± 0.057	0.684GlnTrp: 0.684 ± 0.026	1.295GlnTyr: 1.295 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.663ArgAla: 3.663 ± 0.066	0.489ArgCys: 0.489 ± 0.024	2.278ArgAsp: 2.278 ± 0.049	2.8ArgGlu: 2.8 ± 0.052	2.451ArgPhe: 2.451 ± 0.046	2.6ArgGly: 2.6 ± 0.051	1.268ArgHis: 1.268 ± 0.035	3.139ArgIle: 3.139 ± 0.059	2.271ArgLys: 2.271 ± 0.045	5.54ArgLeu: 5.54 ± 0.075	1.238ArgMet: 1.238 ± 0.032	1.737ArgAsn: 1.737 ± 0.037	1.804ArgPro: 1.804 ± 0.044	2.243ArgGln: 2.243 ± 0.049	2.532ArgArg: 2.532 ± 0.051	2.861ArgSer: 2.861 ± 0.048	2.111ArgThr: 2.111 ± 0.041	3.272ArgVal: 3.272 ± 0.058	0.669ArgTrp: 0.669 ± 0.025	1.699ArgTyr: 1.699 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.984SerAla: 5.984 ± 0.078	0.612SerCys: 0.612 ± 0.023	3.627SerAsp: 3.627 ± 0.062	3.871SerGlu: 3.871 ± 0.061	2.919SerPhe: 2.919 ± 0.046	4.834SerGly: 4.834 ± 0.075	1.634SerHis: 1.634 ± 0.04	4.351SerIle: 4.351 ± 0.071	3.285SerLys: 3.285 ± 0.058	7.77SerLeu: 7.77 ± 0.092	1.85SerMet: 1.85 ± 0.043	2.577SerAsn: 2.577 ± 0.055	2.643SerPro: 2.643 ± 0.049	3.212SerGln: 3.212 ± 0.059	3.177SerArg: 3.177 ± 0.056	4.776SerSer: 4.776 ± 0.077	3.36SerThr: 3.36 ± 0.065	4.852SerVal: 4.852 ± 0.074	0.895SerTrp: 0.895 ± 0.03	2.029SerTyr: 2.029 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.273ThrAla: 4.273 ± 0.069	0.434ThrCys: 0.434 ± 0.023	2.679ThrAsp: 2.679 ± 0.05	2.916ThrGlu: 2.916 ± 0.051	2.052ThrPhe: 2.052 ± 0.045	3.909ThrGly: 3.909 ± 0.069	1.207ThrHis: 1.207 ± 0.032	3.098ThrIle: 3.098 ± 0.054	2.39ThrLys: 2.39 ± 0.047	6.5ThrLeu: 6.5 ± 0.071	1.181ThrMet: 1.181 ± 0.034	1.916ThrAsn: 1.916 ± 0.044	2.938ThrPro: 2.938 ± 0.051	2.518ThrGln: 2.518 ± 0.054	2.34ThrArg: 2.34 ± 0.044	3.411ThrSer: 3.411 ± 0.064	2.704ThrThr: 2.704 ± 0.05	3.583ThrVal: 3.583 ± 0.06	0.575ThrTrp: 0.575 ± 0.021	1.343ThrTyr: 1.343 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.72ValAla: 6.72 ± 0.088	0.86ValCys: 0.86 ± 0.028	3.948ValAsp: 3.948 ± 0.066	4.119ValGlu: 4.119 ± 0.068	3.045ValPhe: 3.045 ± 0.056	4.762ValGly: 4.762 ± 0.067	1.259ValHis: 1.259 ± 0.036	4.596ValIle: 4.596 ± 0.076	3.413ValLys: 3.413 ± 0.064	7.269ValLeu: 7.269 ± 0.094	1.973ValMet: 1.973 ± 0.045	2.75ValAsn: 2.75 ± 0.049	2.678ValPro: 2.678 ± 0.053	2.258ValGln: 2.258 ± 0.041	3.182ValArg: 3.182 ± 0.058	5.182ValSer: 5.182 ± 0.065	3.93ValThr: 3.93 ± 0.056	5.298ValVal: 5.298 ± 0.096	0.759ValTrp: 0.759 ± 0.027	1.802ValTyr: 1.802 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.856TrpAla: 0.856 ± 0.029	0.166TrpCys: 0.166 ± 0.013	0.556TrpAsp: 0.556 ± 0.024	0.538TrpGlu: 0.538 ± 0.022	0.641TrpPhe: 0.641 ± 0.027	0.787TrpGly: 0.787 ± 0.025	0.374TrpHis: 0.374 ± 0.019	0.676TrpIle: 0.676 ± 0.028	0.514TrpLys: 0.514 ± 0.021	1.877TrpLeu: 1.877 ± 0.044	0.326TrpMet: 0.326 ± 0.014	0.41TrpAsn: 0.41 ± 0.018	0.5TrpPro: 0.5 ± 0.019	0.9TrpGln: 0.9 ± 0.032	0.725TrpArg: 0.725 ± 0.026	0.79TrpSer: 0.79 ± 0.03	0.477TrpThr: 0.477 ± 0.021	0.933TrpVal: 0.933 ± 0.031	0.178TrpTrp: 0.178 ± 0.014	0.322TrpTyr: 0.322 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.316TyrAla: 2.316 ± 0.044	0.366TyrCys: 0.366 ± 0.017	1.61TyrAsp: 1.61 ± 0.036	1.561TyrGlu: 1.561 ± 0.039	1.396TyrPhe: 1.396 ± 0.036	2.077TyrGly: 2.077 ± 0.041	0.786TyrHis: 0.786 ± 0.024	1.532TyrIle: 1.532 ± 0.036	1.264TyrLys: 1.264 ± 0.04	3.469TyrLeu: 3.469 ± 0.053	0.555TyrMet: 0.555 ± 0.024	0.934TyrAsn: 0.934 ± 0.028	1.392TyrPro: 1.392 ± 0.041	1.939TyrGln: 1.939 ± 0.042	1.683TyrArg: 1.683 ± 0.035	1.888TyrSer: 1.888 ± 0.052	1.315TyrThr: 1.315 ± 0.033	1.685TyrVal: 1.685 ± 0.043	0.445TyrTrp: 0.445 ± 0.019	0.941TyrTyr: 0.941 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3539 proteins (1124909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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