Amino acid dipepetide frequency for Trueperella bialowiezensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.174AlaAla: 14.174 ± 0.266
0.78AlaCys: 0.78 ± 0.044
7.931AlaAsp: 7.931 ± 0.138
7.634AlaGlu: 7.634 ± 0.13
3.42AlaPhe: 3.42 ± 0.087
10.584AlaGly: 10.584 ± 0.147
2.377AlaHis: 2.377 ± 0.063
6.046AlaIle: 6.046 ± 0.135
4.156AlaLys: 4.156 ± 0.106
11.042AlaLeu: 11.042 ± 0.189
2.784AlaMet: 2.784 ± 0.074
3.189AlaAsn: 3.189 ± 0.079
5.135AlaPro: 5.135 ± 0.155
4.414AlaGln: 4.414 ± 0.109
7.623AlaArg: 7.623 ± 0.143
6.014AlaSer: 6.014 ± 0.096
6.367AlaThr: 6.367 ± 0.118
9.072AlaVal: 9.072 ± 0.148
1.478AlaTrp: 1.478 ± 0.052
2.443AlaTyr: 2.443 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.658CysAla: 0.658 ± 0.036
0.071CysCys: 0.071 ± 0.012
0.364CysAsp: 0.364 ± 0.026
0.396CysGlu: 0.396 ± 0.026
0.181CysPhe: 0.181 ± 0.018
0.672CysGly: 0.672 ± 0.037
0.144CysHis: 0.144 ± 0.016
0.259CysIle: 0.259 ± 0.021
0.126CysLys: 0.126 ± 0.015
0.465CysLeu: 0.465 ± 0.027
0.087CysMet: 0.087 ± 0.011
0.162CysAsn: 0.162 ± 0.017
0.368CysPro: 0.368 ± 0.028
0.208CysGln: 0.208 ± 0.018
0.32CysArg: 0.32 ± 0.022
0.388CysSer: 0.388 ± 0.025
0.362CysThr: 0.362 ± 0.025
0.496CysVal: 0.496 ± 0.025
0.068CysTrp: 0.068 ± 0.01
0.152CysTyr: 0.152 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
7.334AspAla: 7.334 ± 0.134
0.302AspCys: 0.302 ± 0.026
4.658AspAsp: 4.658 ± 0.102
4.422AspGlu: 4.422 ± 0.1
2.029AspPhe: 2.029 ± 0.062
5.593AspGly: 5.593 ± 0.141
1.286AspHis: 1.286 ± 0.049
3.031AspIle: 3.031 ± 0.071
1.787AspLys: 1.787 ± 0.062
5.972AspLeu: 5.972 ± 0.111
1.296AspMet: 1.296 ± 0.042
1.498AspAsn: 1.498 ± 0.058
3.742AspPro: 3.742 ± 0.08
1.928AspGln: 1.928 ± 0.066
3.406AspArg: 3.406 ± 0.077
3.567AspSer: 3.567 ± 0.071
3.155AspThr: 3.155 ± 0.077
6.057AspVal: 6.057 ± 0.123
0.935AspTrp: 0.935 ± 0.047
1.753AspTyr: 1.753 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
7.211GluAla: 7.211 ± 0.12
0.346GluCys: 0.346 ± 0.026
3.388GluAsp: 3.388 ± 0.091
4.196GluGlu: 4.196 ± 0.099
2.036GluPhe: 2.036 ± 0.057
4.204GluGly: 4.204 ± 0.092
1.543GluHis: 1.543 ± 0.051
3.642GluIle: 3.642 ± 0.091
2.22GluLys: 2.22 ± 0.075
7.238GluLeu: 7.238 ± 0.137
1.351GluMet: 1.351 ± 0.047
1.906GluAsn: 1.906 ± 0.057
3.663GluPro: 3.663 ± 0.16
2.747GluGln: 2.747 ± 0.076
4.781GluArg: 4.781 ± 0.106
3.335GluSer: 3.335 ± 0.078
3.13GluThr: 3.13 ± 0.08
4.832GluVal: 4.832 ± 0.102
0.826GluTrp: 0.826 ± 0.036
1.488GluTyr: 1.488 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.803PheAla: 3.803 ± 0.086
0.174PheCys: 0.174 ± 0.018
2.339PheAsp: 2.339 ± 0.064
1.881PheGlu: 1.881 ± 0.055
1.154PhePhe: 1.154 ± 0.051
3.078PheGly: 3.078 ± 0.082
0.648PheHis: 0.648 ± 0.033
1.603PheIle: 1.603 ± 0.062
0.759PheLys: 0.759 ± 0.035
2.685PheLeu: 2.685 ± 0.08
0.612PheMet: 0.612 ± 0.034
0.872PheAsn: 0.872 ± 0.038
1.554PhePro: 1.554 ± 0.052
0.816PheGln: 0.816 ± 0.035
1.629PheArg: 1.629 ± 0.048
2.1PheSer: 2.1 ± 0.055
2.288PheThr: 2.288 ± 0.067
2.627PheVal: 2.627 ± 0.073
0.412PheTrp: 0.412 ± 0.03
0.784PheTyr: 0.784 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
8.718GlyAla: 8.718 ± 0.147
0.58GlyCys: 0.58 ± 0.038
4.584GlyAsp: 4.584 ± 0.091
5.603GlyGlu: 5.603 ± 0.108
2.869GlyPhe: 2.869 ± 0.069
6.86GlyGly: 6.86 ± 0.148
1.756GlyHis: 1.756 ± 0.053
4.574GlyIle: 4.574 ± 0.096
3.43GlyLys: 3.43 ± 0.083
7.686GlyLeu: 7.686 ± 0.127
2.146GlyMet: 2.146 ± 0.061
2.302GlyAsn: 2.302 ± 0.066
3.138GlyPro: 3.138 ± 0.064
3.118GlyGln: 3.118 ± 0.076
4.963GlyArg: 4.963 ± 0.106
4.986GlySer: 4.986 ± 0.097
5.222GlyThr: 5.222 ± 0.1
7.08GlyVal: 7.08 ± 0.141
1.419GlyTrp: 1.419 ± 0.056
2.427GlyTyr: 2.427 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
2.217HisAla: 2.217 ± 0.062
0.128HisCys: 0.128 ± 0.013
1.398HisAsp: 1.398 ± 0.046
1.302HisGlu: 1.302 ± 0.046
0.59HisPhe: 0.59 ± 0.033
1.91HisGly: 1.91 ± 0.061
0.512HisHis: 0.512 ± 0.034
1.053HisIle: 1.053 ± 0.042
0.62HisLys: 0.62 ± 0.031
1.869HisLeu: 1.869 ± 0.055
0.454HisMet: 0.454 ± 0.029
0.632HisAsn: 0.632 ± 0.031
1.22HisPro: 1.22 ± 0.041
0.544HisGln: 0.544 ± 0.029
1.32HisArg: 1.32 ± 0.049
1.154HisSer: 1.154 ± 0.046
1.255HisThr: 1.255 ± 0.046
1.864HisVal: 1.864 ± 0.051
0.27HisTrp: 0.27 ± 0.026
0.538HisTyr: 0.538 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.733IleAla: 6.733 ± 0.111
0.37IleCys: 0.37 ± 0.025
3.894IleAsp: 3.894 ± 0.082
3.34IleGlu: 3.34 ± 0.079
1.65IlePhe: 1.65 ± 0.056
4.626IleGly: 4.626 ± 0.11
1.045IleHis: 1.045 ± 0.042
2.684IleIle: 2.684 ± 0.075
1.495IleLys: 1.495 ± 0.061
4.16IleLeu: 4.16 ± 0.093
1.071IleMet: 1.071 ± 0.048
1.595IleAsn: 1.595 ± 0.048
2.771IlePro: 2.771 ± 0.072
1.259IleGln: 1.259 ± 0.044
2.952IleArg: 2.952 ± 0.083
3.201IleSer: 3.201 ± 0.074
3.479IleThr: 3.479 ± 0.088
4.802IleVal: 4.802 ± 0.113
0.514IleTrp: 0.514 ± 0.029
1.139IleTyr: 1.139 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
3.456LysAla: 3.456 ± 0.093
0.139LysCys: 0.139 ± 0.015
1.874LysAsp: 1.874 ± 0.061
2.037LysGlu: 2.037 ± 0.065
0.903LysPhe: 0.903 ± 0.044
2.036LysGly: 2.036 ± 0.067
0.667LysHis: 0.667 ± 0.035
1.949LysIle: 1.949 ± 0.055
1.59LysLys: 1.59 ± 0.056
3.07LysLeu: 3.07 ± 0.073
0.827LysMet: 0.827 ± 0.036
1.247LysAsn: 1.247 ± 0.046
1.932LysPro: 1.932 ± 0.074
1.095LysGln: 1.095 ± 0.043
2.243LysArg: 2.243 ± 0.059
1.629LysSer: 1.629 ± 0.05
1.881LysThr: 1.881 ± 0.071
2.769LysVal: 2.769 ± 0.076
0.394LysTrp: 0.394 ± 0.025
0.813LysTyr: 0.813 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
12.433LeuAla: 12.433 ± 0.206
0.548LeuCys: 0.548 ± 0.029
6.293LeuAsp: 6.293 ± 0.112
5.461LeuGlu: 5.461 ± 0.117
2.769LeuPhe: 2.769 ± 0.085
7.846LeuGly: 7.846 ± 0.128
1.64LeuHis: 1.64 ± 0.052
4.858LeuIle: 4.858 ± 0.108
2.577LeuLys: 2.577 ± 0.07
8.075LeuLeu: 8.075 ± 0.14
1.966LeuMet: 1.966 ± 0.059
2.52LeuAsn: 2.52 ± 0.064
4.839LeuPro: 4.839 ± 0.088
2.22LeuGln: 2.22 ± 0.056
6.059LeuArg: 6.059 ± 0.12
5.327LeuSer: 5.327 ± 0.1
6.054LeuThr: 6.054 ± 0.118
7.589LeuVal: 7.589 ± 0.128
1.05LeuTrp: 1.05 ± 0.037
1.816LeuTyr: 1.816 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.579MetAla: 2.579 ± 0.063
0.132MetCys: 0.132 ± 0.015
1.191MetAsp: 1.191 ± 0.047
1.074MetGlu: 1.074 ± 0.042
0.716MetPhe: 0.716 ± 0.035
1.629MetGly: 1.629 ± 0.057
0.412MetHis: 0.412 ± 0.026
1.204MetIle: 1.204 ± 0.05
0.808MetLys: 0.808 ± 0.036
2.081MetLeu: 2.081 ± 0.066
0.477MetMet: 0.477 ± 0.031
0.761MetAsn: 0.761 ± 0.035
1.207MetPro: 1.207 ± 0.041
0.582MetGln: 0.582 ± 0.026
1.551MetArg: 1.551 ± 0.055
1.743MetSer: 1.743 ± 0.047
1.719MetThr: 1.719 ± 0.056
1.688MetVal: 1.688 ± 0.057
0.32MetTrp: 0.32 ± 0.021
0.439MetTyr: 0.439 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.848AsnAla: 2.848 ± 0.068
0.145AsnCys: 0.145 ± 0.015
1.609AsnAsp: 1.609 ± 0.046
1.643AsnGlu: 1.643 ± 0.055
0.929AsnPhe: 0.929 ± 0.045
2.281AsnGly: 2.281 ± 0.07
0.551AsnHis: 0.551 ± 0.029
1.461AsnIle: 1.461 ± 0.05
0.981AsnLys: 0.981 ± 0.05
2.637AsnLeu: 2.637 ± 0.065
0.737AsnMet: 0.737 ± 0.035
0.958AsnAsn: 0.958 ± 0.066
2.199AsnPro: 2.199 ± 0.085
0.916AsnGln: 0.916 ± 0.043
1.774AsnArg: 1.774 ± 0.057
1.491AsnSer: 1.491 ± 0.048
1.696AsnThr: 1.696 ± 0.066
2.412AsnVal: 2.412 ± 0.056
0.485AsnTrp: 0.485 ± 0.029
0.83AsnTyr: 0.83 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
6.285ProAla: 6.285 ± 0.161
0.217ProCys: 0.217 ± 0.018
3.895ProAsp: 3.895 ± 0.086
4.183ProGlu: 4.183 ± 0.14
1.533ProPhe: 1.533 ± 0.052
4.58ProGly: 4.58 ± 0.104
1.142ProHis: 1.142 ± 0.041
2.375ProIle: 2.375 ± 0.063
1.54ProLys: 1.54 ± 0.059
3.97ProLeu: 3.97 ± 0.079
1.016ProMet: 1.016 ± 0.038
1.575ProAsn: 1.575 ± 0.065
1.889ProPro: 1.889 ± 0.075
1.837ProGln: 1.837 ± 0.06
2.766ProArg: 2.766 ± 0.078
2.839ProSer: 2.839 ± 0.071
3.057ProThr: 3.057 ± 0.099
4.298ProVal: 4.298 ± 0.087
0.721ProTrp: 0.721 ± 0.039
1.281ProTyr: 1.281 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
4.248GlnAla: 4.248 ± 0.106
0.152GlnCys: 0.152 ± 0.016
1.344GlnAsp: 1.344 ± 0.051
1.85GlnGlu: 1.85 ± 0.057
0.976GlnPhe: 0.976 ± 0.036
2.196GlnGly: 2.196 ± 0.08
0.706GlnHis: 0.706 ± 0.032
2.22GlnIle: 2.22 ± 0.061
0.945GlnLys: 0.945 ± 0.04
3.498GlnLeu: 3.498 ± 0.082
0.868GlnMet: 0.868 ± 0.037
0.8GlnAsn: 0.8 ± 0.033
1.818GlnPro: 1.818 ± 0.065
1.367GlnGln: 1.367 ± 0.065
2.529GlnArg: 2.529 ± 0.068
1.569GlnSer: 1.569 ± 0.053
1.727GlnThr: 1.727 ± 0.054
2.766GlnVal: 2.766 ± 0.061
0.553GlnTrp: 0.553 ± 0.032
0.764GlnTyr: 0.764 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
7.086ArgAla: 7.086 ± 0.135
0.288ArgCys: 0.288 ± 0.024
3.658ArgAsp: 3.658 ± 0.08
4.59ArgGlu: 4.59 ± 0.097
2.07ArgPhe: 2.07 ± 0.06
4.689ArgGly: 4.689 ± 0.104
1.381ArgHis: 1.381 ± 0.048
3.503ArgIle: 3.503 ± 0.089
2.377ArgLys: 2.377 ± 0.076
5.791ArgLeu: 5.791 ± 0.114
1.608ArgMet: 1.608 ± 0.049
1.769ArgAsn: 1.769 ± 0.055
2.966ArgPro: 2.966 ± 0.084
2.388ArgGln: 2.388 ± 0.061
5.025ArgArg: 5.025 ± 0.112
3.537ArgSer: 3.537 ± 0.081
3.564ArgThr: 3.564 ± 0.086
4.776ArgVal: 4.776 ± 0.106
0.897ArgTrp: 0.897 ± 0.037
1.604ArgTyr: 1.604 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
6.715SerAla: 6.715 ± 0.131
0.313SerCys: 0.313 ± 0.022
3.554SerAsp: 3.554 ± 0.075
3.488SerGlu: 3.488 ± 0.075
1.9SerPhe: 1.9 ± 0.056
5.581SerGly: 5.581 ± 0.103
1.179SerHis: 1.179 ± 0.044
2.742SerIle: 2.742 ± 0.089
1.706SerLys: 1.706 ± 0.066
5.026SerLeu: 5.026 ± 0.093
1.32SerMet: 1.32 ± 0.049
1.53SerAsn: 1.53 ± 0.046
2.798SerPro: 2.798 ± 0.074
2.013SerGln: 2.013 ± 0.059
3.495SerArg: 3.495 ± 0.071
3.269SerSer: 3.269 ± 0.082
3.301SerThr: 3.301 ± 0.082
4.435SerVal: 4.435 ± 0.089
0.863SerTrp: 0.863 ± 0.039
1.407SerTyr: 1.407 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
6.505ThrAla: 6.505 ± 0.112
0.409ThrCys: 0.409 ± 0.029
3.601ThrAsp: 3.601 ± 0.088
3.212ThrGlu: 3.212 ± 0.074
2.066ThrPhe: 2.066 ± 0.057
5.448ThrGly: 5.448 ± 0.082
1.27ThrHis: 1.27 ± 0.044
3.338ThrIle: 3.338 ± 0.083
1.845ThrLys: 1.845 ± 0.068
5.304ThrLeu: 5.304 ± 0.1
1.284ThrMet: 1.284 ± 0.049
1.727ThrAsn: 1.727 ± 0.058
3.698ThrPro: 3.698 ± 0.1
1.826ThrGln: 1.826 ± 0.059
3.285ThrArg: 3.285 ± 0.076
3.524ThrSer: 3.524 ± 0.08
3.789ThrThr: 3.789 ± 0.091
5.039ThrVal: 5.039 ± 0.112
0.85ThrTrp: 0.85 ± 0.04
1.503ThrTyr: 1.503 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
9.799ValAla: 9.799 ± 0.143
0.606ValCys: 0.606 ± 0.035
5.812ValAsp: 5.812 ± 0.108
5.317ValGlu: 5.317 ± 0.105
2.695ValPhe: 2.695 ± 0.077
6.543ValGly: 6.543 ± 0.111
1.713ValHis: 1.713 ± 0.062
4.511ValIle: 4.511 ± 0.098
2.49ValLys: 2.49 ± 0.066
7.637ValLeu: 7.637 ± 0.136
1.583ValMet: 1.583 ± 0.058
2.361ValAsn: 2.361 ± 0.073
4.21ValPro: 4.21 ± 0.078
2.17ValGln: 2.17 ± 0.058
5.198ValArg: 5.198 ± 0.112
4.821ValSer: 4.821 ± 0.097
5.377ValThr: 5.377 ± 0.102
8.187ValVal: 8.187 ± 0.143
1.061ValTrp: 1.061 ± 0.041
1.855ValTyr: 1.855 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
1.373TrpAla: 1.373 ± 0.05
0.087TrpCys: 0.087 ± 0.01
0.864TrpAsp: 0.864 ± 0.039
0.816TrpGlu: 0.816 ± 0.034
0.498TrpPhe: 0.498 ± 0.028
0.874TrpGly: 0.874 ± 0.036
0.352TrpHis: 0.352 ± 0.024
0.743TrpIle: 0.743 ± 0.037
0.467TrpLys: 0.467 ± 0.028
1.467TrpLeu: 1.467 ± 0.062
0.339TrpMet: 0.339 ± 0.024
0.485TrpAsn: 0.485 ± 0.034
0.638TrpPro: 0.638 ± 0.034
0.627TrpGln: 0.627 ± 0.032
0.932TrpArg: 0.932 ± 0.041
0.725TrpSer: 0.725 ± 0.036
0.729TrpThr: 0.729 ± 0.04
1.076TrpVal: 1.076 ± 0.04
0.275TrpTrp: 0.275 ± 0.022
0.359TrpTyr: 0.359 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.49TyrAla: 2.49 ± 0.062
0.158TyrCys: 0.158 ± 0.015
1.499TyrAsp: 1.499 ± 0.049
1.635TyrGlu: 1.635 ± 0.055
0.835TyrPhe: 0.835 ± 0.04
2.231TyrGly: 2.231 ± 0.074
0.525TyrHis: 0.525 ± 0.03
0.982TyrIle: 0.982 ± 0.041
0.633TyrLys: 0.633 ± 0.037
2.267TyrLeu: 2.267 ± 0.069
0.485TyrMet: 0.485 ± 0.027
0.695TyrAsn: 0.695 ± 0.028
1.213TyrPro: 1.213 ± 0.046
0.819TyrGln: 0.819 ± 0.037
1.717TyrArg: 1.717 ± 0.056
1.42TyrSer: 1.42 ± 0.047
1.372TyrThr: 1.372 ± 0.059
2.079TyrVal: 2.079 ± 0.056
0.338TyrTrp: 0.338 ± 0.021
0.58TyrTyr: 0.58 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1821 proteins (618937 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski