Amino acid dipepetide frequency for Nocardioides sp. K1W22B-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.321AlaAla: 19.321 ± 0.231	1.005AlaCys: 1.005 ± 0.039	8.178AlaAsp: 8.178 ± 0.1	7.791AlaGlu: 7.791 ± 0.14	3.733AlaPhe: 3.733 ± 0.062	12.128AlaGly: 12.128 ± 0.118	2.502AlaHis: 2.502 ± 0.053	5.222AlaIle: 5.222 ± 0.081	3.101AlaLys: 3.101 ± 0.067	13.431AlaLeu: 13.431 ± 0.164	2.776AlaMet: 2.776 ± 0.058	2.386AlaAsn: 2.386 ± 0.05	6.279AlaPro: 6.279 ± 0.115	3.493AlaGln: 3.493 ± 0.06	8.88AlaArg: 8.88 ± 0.111	6.796AlaSer: 6.796 ± 0.092	7.562AlaThr: 7.562 ± 0.112	11.024AlaVal: 11.024 ± 0.132	1.902AlaTrp: 1.902 ± 0.048	2.737AlaTyr: 2.737 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.891CysAla: 0.891 ± 0.029	0.094CysCys: 0.094 ± 0.011	0.443CysAsp: 0.443 ± 0.018	0.369CysGlu: 0.369 ± 0.019	0.221CysPhe: 0.221 ± 0.014	0.917CysGly: 0.917 ± 0.027	0.196CysHis: 0.196 ± 0.013	0.241CysIle: 0.241 ± 0.015	0.142CysLys: 0.142 ± 0.013	0.63CysLeu: 0.63 ± 0.027	0.151CysMet: 0.151 ± 0.01	0.152CysAsn: 0.152 ± 0.012	0.465CysPro: 0.465 ± 0.025	0.177CysGln: 0.177 ± 0.015	0.521CysArg: 0.521 ± 0.023	0.482CysSer: 0.482 ± 0.023	0.45CysThr: 0.45 ± 0.021	0.583CysVal: 0.583 ± 0.025	0.094CysTrp: 0.094 ± 0.009	0.133CysTyr: 0.133 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.72AspAla: 7.72 ± 0.1	0.397AspCys: 0.397 ± 0.02	3.877AspAsp: 3.877 ± 0.072	4.249AspGlu: 4.249 ± 0.071	1.736AspPhe: 1.736 ± 0.038	6.19AspGly: 6.19 ± 0.097	1.45AspHis: 1.45 ± 0.044	2.261AspIle: 2.261 ± 0.054	1.434AspLys: 1.434 ± 0.04	7.049AspLeu: 7.049 ± 0.087	0.939AspMet: 0.939 ± 0.035	1.203AspAsn: 1.203 ± 0.039	4.214AspPro: 4.214 ± 0.072	1.746AspGln: 1.746 ± 0.045	4.552AspArg: 4.552 ± 0.074	2.556AspSer: 2.556 ± 0.046	2.727AspThr: 2.727 ± 0.06	5.665AspVal: 5.665 ± 0.074	0.945AspTrp: 0.945 ± 0.033	1.182AspTyr: 1.182 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.205GluAla: 7.205 ± 0.101	0.358GluCys: 0.358 ± 0.018	2.885GluAsp: 2.885 ± 0.056	3.2GluGlu: 3.2 ± 0.078	1.782GluPhe: 1.782 ± 0.043	4.327GluGly: 4.327 ± 0.076	1.589GluHis: 1.589 ± 0.039	2.803GluIle: 2.803 ± 0.067	1.703GluLys: 1.703 ± 0.049	6.455GluLeu: 6.455 ± 0.101	1.039GluMet: 1.039 ± 0.029	1.056GluAsn: 1.056 ± 0.037	2.871GluPro: 2.871 ± 0.062	2.254GluGln: 2.254 ± 0.059	4.615GluArg: 4.615 ± 0.092	2.782GluSer: 2.782 ± 0.049	2.979GluThr: 2.979 ± 0.052	5.218GluVal: 5.218 ± 0.072	0.789GluTrp: 0.789 ± 0.029	1.045GluTyr: 1.045 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.868PheAla: 3.868 ± 0.068	0.286PheCys: 0.286 ± 0.018	2.165PheAsp: 2.165 ± 0.051	1.616PheGlu: 1.616 ± 0.035	1.0PhePhe: 1.0 ± 0.037	3.305PheGly: 3.305 ± 0.058	0.663PheHis: 0.663 ± 0.028	0.996PheIle: 0.996 ± 0.038	0.632PheLys: 0.632 ± 0.028	2.859PheLeu: 2.859 ± 0.05	0.489PheMet: 0.489 ± 0.021	0.686PheAsn: 0.686 ± 0.026	1.359PhePro: 1.359 ± 0.039	0.722PheGln: 0.722 ± 0.024	1.833PheArg: 1.833 ± 0.043	1.623PheSer: 1.623 ± 0.043	2.004PheThr: 2.004 ± 0.044	2.698PheVal: 2.698 ± 0.05	0.46PheTrp: 0.46 ± 0.024	0.651PheTyr: 0.651 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.337GlyAla: 10.337 ± 0.109	0.8GlyCys: 0.8 ± 0.031	5.386GlyAsp: 5.386 ± 0.082	5.023GlyGlu: 5.023 ± 0.071	3.177GlyPhe: 3.177 ± 0.056	8.039GlyGly: 8.039 ± 0.124	2.125GlyHis: 2.125 ± 0.043	4.039GlyIle: 4.039 ± 0.071	2.7GlyLys: 2.7 ± 0.059	9.317GlyLeu: 9.317 ± 0.109	1.95GlyMet: 1.95 ± 0.043	1.849GlyAsn: 1.849 ± 0.052	4.297GlyPro: 4.297 ± 0.077	2.68GlyGln: 2.68 ± 0.057	6.332GlyArg: 6.332 ± 0.079	5.6GlySer: 5.6 ± 0.088	5.771GlyThr: 5.771 ± 0.089	7.961GlyVal: 7.961 ± 0.091	1.666GlyTrp: 1.666 ± 0.047	2.073GlyTyr: 2.073 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.526HisAla: 2.526 ± 0.057	0.156HisCys: 0.156 ± 0.012	1.386HisAsp: 1.386 ± 0.041	1.238HisGlu: 1.238 ± 0.036	0.648HisPhe: 0.648 ± 0.027	2.171HisGly: 2.171 ± 0.048	0.668HisHis: 0.668 ± 0.027	0.699HisIle: 0.699 ± 0.027	0.41HisLys: 0.41 ± 0.02	2.32HisLeu: 2.32 ± 0.044	0.326HisMet: 0.326 ± 0.016	0.407HisAsn: 0.407 ± 0.018	1.542HisPro: 1.542 ± 0.045	0.638HisGln: 0.638 ± 0.023	1.73HisArg: 1.73 ± 0.04	0.953HisSer: 0.953 ± 0.031	1.171HisThr: 1.171 ± 0.033	1.865HisVal: 1.865 ± 0.046	0.315HisTrp: 0.315 ± 0.017	0.452HisTyr: 0.452 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.105IleAla: 6.105 ± 0.09	0.331IleCys: 0.331 ± 0.018	3.163IleAsp: 3.163 ± 0.053	2.786IleGlu: 2.786 ± 0.059	0.967IlePhe: 0.967 ± 0.03	4.21IleGly: 4.21 ± 0.075	0.752IleHis: 0.752 ± 0.029	1.306IleIle: 1.306 ± 0.042	1.017IleLys: 1.017 ± 0.035	3.038IleLeu: 3.038 ± 0.063	0.526IleMet: 0.526 ± 0.02	1.021IleAsn: 1.021 ± 0.033	2.098IlePro: 2.098 ± 0.053	0.934IleGln: 0.934 ± 0.027	2.506IleArg: 2.506 ± 0.049	2.217IleSer: 2.217 ± 0.051	2.687IleThr: 2.687 ± 0.055	3.693IleVal: 3.693 ± 0.064	0.467IleTrp: 0.467 ± 0.025	0.664IleTyr: 0.664 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.235LysAla: 3.235 ± 0.079	0.124LysCys: 0.124 ± 0.009	1.452LysAsp: 1.452 ± 0.043	1.231LysGlu: 1.231 ± 0.037	0.644LysPhe: 0.644 ± 0.025	1.983LysGly: 1.983 ± 0.047	0.525LysHis: 0.525 ± 0.023	1.096LysIle: 1.096 ± 0.031	1.027LysLys: 1.027 ± 0.047	2.393LysLeu: 2.393 ± 0.057	0.469LysMet: 0.469 ± 0.024	0.588LysAsn: 0.588 ± 0.025	1.483LysPro: 1.483 ± 0.044	0.795LysGln: 0.795 ± 0.028	1.572LysArg: 1.572 ± 0.038	1.359LysSer: 1.359 ± 0.041	1.475LysThr: 1.475 ± 0.044	2.44LysVal: 2.44 ± 0.053	0.272LysTrp: 0.272 ± 0.018	0.584LysTyr: 0.584 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.868LeuAla: 14.868 ± 0.159	0.701LeuCys: 0.701 ± 0.026	6.679LeuAsp: 6.679 ± 0.082	5.614LeuGlu: 5.614 ± 0.081	2.579LeuPhe: 2.579 ± 0.058	9.559LeuGly: 9.559 ± 0.108	2.035LeuHis: 2.035 ± 0.048	3.777LeuIle: 3.777 ± 0.064	2.203LeuLys: 2.203 ± 0.055	10.654LeuLeu: 10.654 ± 0.149	1.694LeuMet: 1.694 ± 0.043	1.843LeuAsn: 1.843 ± 0.042	5.819LeuPro: 5.819 ± 0.084	2.411LeuGln: 2.411 ± 0.054	7.317LeuArg: 7.317 ± 0.106	5.452LeuSer: 5.452 ± 0.073	6.363LeuThr: 6.363 ± 0.084	9.838LeuVal: 9.838 ± 0.121	1.178LeuTrp: 1.178 ± 0.034	1.487LeuTyr: 1.487 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.346MetAla: 2.346 ± 0.049	0.134MetCys: 0.134 ± 0.012	0.934MetAsp: 0.934 ± 0.031	0.816MetGlu: 0.816 ± 0.03	0.491MetPhe: 0.491 ± 0.023	1.436MetGly: 1.436 ± 0.04	0.358MetHis: 0.358 ± 0.02	0.765MetIle: 0.765 ± 0.028	0.542MetLys: 0.542 ± 0.025	1.881MetLeu: 1.881 ± 0.045	0.322MetMet: 0.322 ± 0.018	0.44MetAsn: 0.44 ± 0.02	1.072MetPro: 1.072 ± 0.035	0.535MetGln: 0.535 ± 0.022	1.362MetArg: 1.362 ± 0.035	1.523MetSer: 1.523 ± 0.037	1.697MetThr: 1.697 ± 0.041	1.552MetVal: 1.552 ± 0.039	0.19MetTrp: 0.19 ± 0.014	0.293MetTyr: 0.293 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.442AsnAla: 2.442 ± 0.049	0.172AsnCys: 0.172 ± 0.014	1.177AsnAsp: 1.177 ± 0.035	0.971AsnGlu: 0.971 ± 0.034	0.592AsnPhe: 0.592 ± 0.026	1.995AsnGly: 1.995 ± 0.056	0.417AsnHis: 0.417 ± 0.019	0.808AsnIle: 0.808 ± 0.033	0.526AsnLys: 0.526 ± 0.024	2.063AsnLeu: 2.063 ± 0.044	0.34AsnMet: 0.34 ± 0.02	0.488AsnAsn: 0.488 ± 0.022	1.6AsnPro: 1.6 ± 0.049	0.61AsnGln: 0.61 ± 0.031	1.317AsnArg: 1.317 ± 0.036	0.944AsnSer: 0.944 ± 0.033	1.143AsnThr: 1.143 ± 0.038	1.72AsnVal: 1.72 ± 0.039	0.314AsnTrp: 0.314 ± 0.019	0.433AsnTyr: 0.433 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.359ProAla: 7.359 ± 0.118	0.306ProCys: 0.306 ± 0.019	4.036ProAsp: 4.036 ± 0.061	3.859ProGlu: 3.859 ± 0.066	1.585ProPhe: 1.585 ± 0.036	5.424ProGly: 5.424 ± 0.068	1.192ProHis: 1.192 ± 0.036	1.914ProIle: 1.914 ± 0.044	1.332ProLys: 1.332 ± 0.038	4.866ProLeu: 4.866 ± 0.075	0.953ProMet: 0.953 ± 0.028	0.992ProAsn: 0.992 ± 0.036	2.381ProPro: 2.381 ± 0.062	1.382ProGln: 1.382 ± 0.034	3.321ProArg: 3.321 ± 0.072	3.266ProSer: 3.266 ± 0.059	3.438ProThr: 3.438 ± 0.066	5.154ProVal: 5.154 ± 0.081	0.89ProTrp: 0.89 ± 0.03	1.041ProTyr: 1.041 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.476GlnAla: 3.476 ± 0.06	0.172GlnCys: 0.172 ± 0.012	1.235GlnAsp: 1.235 ± 0.041	1.348GlnGlu: 1.348 ± 0.036	0.83GlnPhe: 0.83 ± 0.029	2.062GlnGly: 2.062 ± 0.043	0.611GlnHis: 0.611 ± 0.023	1.33GlnIle: 1.33 ± 0.037	0.768GlnLys: 0.768 ± 0.03	3.229GlnLeu: 3.229 ± 0.052	0.533GlnMet: 0.533 ± 0.022	0.536GlnAsn: 0.536 ± 0.026	1.634GlnPro: 1.634 ± 0.044	1.109GlnGln: 1.109 ± 0.032	2.281GlnArg: 2.281 ± 0.047	1.333GlnSer: 1.333 ± 0.04	1.456GlnThr: 1.456 ± 0.035	2.773GlnVal: 2.773 ± 0.057	0.424GlnTrp: 0.424 ± 0.023	0.518GlnTyr: 0.518 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.21ArgAla: 8.21 ± 0.112	0.471ArgCys: 0.471 ± 0.019	4.154ArgAsp: 4.154 ± 0.068	4.216ArgGlu: 4.216 ± 0.071	2.207ArgPhe: 2.207 ± 0.053	5.19ArgGly: 5.19 ± 0.079	1.724ArgHis: 1.724 ± 0.042	3.375ArgIle: 3.375 ± 0.058	1.806ArgLys: 1.806 ± 0.046	7.352ArgLeu: 7.352 ± 0.098	1.653ArgMet: 1.653 ± 0.036	1.414ArgAsn: 1.414 ± 0.036	3.895ArgPro: 3.895 ± 0.067	2.048ArgGln: 2.048 ± 0.047	6.353ArgArg: 6.353 ± 0.116	4.078ArgSer: 4.078 ± 0.063	4.39ArgThr: 4.39 ± 0.072	5.768ArgVal: 5.768 ± 0.076	1.166ArgTrp: 1.166 ± 0.038	1.513ArgTyr: 1.513 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.657SerAla: 6.657 ± 0.086	0.43SerCys: 0.43 ± 0.024	3.101SerAsp: 3.101 ± 0.057	2.648SerGlu: 2.648 ± 0.053	1.858SerPhe: 1.858 ± 0.04	5.887SerGly: 5.887 ± 0.084	1.021SerHis: 1.021 ± 0.032	2.166SerIle: 2.166 ± 0.046	1.21SerLys: 1.21 ± 0.036	5.206SerLeu: 5.206 ± 0.073	1.312SerMet: 1.312 ± 0.03	1.1SerAsn: 1.1 ± 0.031	3.152SerPro: 3.152 ± 0.054	1.408SerGln: 1.408 ± 0.038	3.794SerArg: 3.794 ± 0.064	3.361SerSer: 3.361 ± 0.067	3.631SerThr: 3.631 ± 0.082	4.647SerVal: 4.647 ± 0.07	0.936SerTrp: 0.936 ± 0.031	1.364SerTyr: 1.364 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	7.56ThrAla: 7.56 ± 0.101	0.481ThrCys: 0.481 ± 0.022	3.544ThrAsp: 3.544 ± 0.059	3.05ThrGlu: 3.05 ± 0.056	1.977ThrPhe: 1.977 ± 0.043	6.056ThrGly: 6.056 ± 0.089	1.192ThrHis: 1.192 ± 0.034	2.492ThrIle: 2.492 ± 0.046	1.373ThrLys: 1.373 ± 0.037	5.791ThrLeu: 5.791 ± 0.083	1.06ThrMet: 1.06 ± 0.03	1.229ThrAsn: 1.229 ± 0.036	3.876ThrPro: 3.876 ± 0.078	1.539ThrGln: 1.539 ± 0.043	3.848ThrArg: 3.848 ± 0.071	3.731ThrSer: 3.731 ± 0.068	4.26ThrThr: 4.26 ± 0.103	5.595ThrVal: 5.595 ± 0.091	1.076ThrTrp: 1.076 ± 0.036	1.437ThrTyr: 1.437 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	11.835ValAla: 11.835 ± 0.124	0.631ValCys: 0.631 ± 0.025	5.861ValAsp: 5.861 ± 0.072	5.248ValGlu: 5.248 ± 0.089	2.632ValPhe: 2.632 ± 0.049	7.344ValGly: 7.344 ± 0.107	1.933ValHis: 1.933 ± 0.044	4.009ValIle: 4.009 ± 0.065	2.023ValLys: 2.023 ± 0.054	9.683ValLeu: 9.683 ± 0.116	1.585ValMet: 1.585 ± 0.042	1.887ValAsn: 1.887 ± 0.043	4.988ValPro: 4.988 ± 0.059	2.085ValGln: 2.085 ± 0.044	6.26ValArg: 6.26 ± 0.082	4.767ValSer: 4.767 ± 0.067	5.94ValThr: 5.94 ± 0.082	9.345ValVal: 9.345 ± 0.12	1.138ValTrp: 1.138 ± 0.035	1.441ValTyr: 1.441 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.538TrpAla: 1.538 ± 0.04	0.149TrpCys: 0.149 ± 0.012	0.768TrpAsp: 0.768 ± 0.028	0.675TrpGlu: 0.675 ± 0.03	0.576TrpPhe: 0.576 ± 0.023	1.064TrpGly: 1.064 ± 0.039	0.378TrpHis: 0.378 ± 0.018	0.657TrpIle: 0.657 ± 0.025	0.395TrpLys: 0.395 ± 0.019	1.79TrpLeu: 1.79 ± 0.042	0.322TrpMet: 0.322 ± 0.016	0.371TrpAsn: 0.371 ± 0.021	0.692TrpPro: 0.692 ± 0.026	0.531TrpGln: 0.531 ± 0.027	1.142TrpArg: 1.142 ± 0.034	1.009TrpSer: 1.009 ± 0.03	0.975TrpThr: 0.975 ± 0.03	1.172TrpVal: 1.172 ± 0.036	0.351TrpTrp: 0.351 ± 0.019	0.298TrpTyr: 0.298 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.746TyrAla: 2.746 ± 0.056	0.153TyrCys: 0.153 ± 0.011	1.669TyrAsp: 1.669 ± 0.04	1.007TyrGlu: 1.007 ± 0.034	0.679TyrPhe: 0.679 ± 0.027	1.835TyrGly: 1.835 ± 0.041	0.29TyrHis: 0.29 ± 0.018	0.531TyrIle: 0.531 ± 0.024	0.402TyrLys: 0.402 ± 0.021	2.065TyrLeu: 2.065 ± 0.051	0.25TyrMet: 0.25 ± 0.018	0.426TyrAsn: 0.426 ± 0.024	0.975TyrPro: 0.975 ± 0.034	0.562TyrGln: 0.562 ± 0.026	1.449TyrArg: 1.449 ± 0.037	1.053TyrSer: 1.053 ± 0.033	1.048TyrThr: 1.048 ± 0.033	1.928TyrVal: 1.928 ± 0.049	0.28TyrTrp: 0.28 ± 0.016	0.408TyrTyr: 0.408 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3217 proteins (1049921 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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