Amino acid dipepetide frequency for Histophilus somni (strain 2336) (Haemophilus somnus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.198AlaAla: 5.198 ± 0.125
0.798AlaCys: 0.798 ± 0.038
4.132AlaAsp: 4.132 ± 0.088
5.608AlaGlu: 5.608 ± 0.108
3.166AlaPhe: 3.166 ± 0.086
5.511AlaGly: 5.511 ± 0.129
1.313AlaHis: 1.313 ± 0.048
6.347AlaIle: 6.347 ± 0.13
5.996AlaLys: 5.996 ± 0.111
8.958AlaLeu: 8.958 ± 0.155
2.116AlaMet: 2.116 ± 0.064
3.825AlaAsn: 3.825 ± 0.084
2.11AlaPro: 2.11 ± 0.063
3.685AlaGln: 3.685 ± 0.09
3.029AlaArg: 3.029 ± 0.079
3.813AlaSer: 3.813 ± 0.094
4.419AlaThr: 4.419 ± 0.109
6.069AlaVal: 6.069 ± 0.119
0.774AlaTrp: 0.774 ± 0.034
2.29AlaTyr: 2.29 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.734CysAla: 0.734 ± 0.035
0.169CysCys: 0.169 ± 0.015
0.542CysAsp: 0.542 ± 0.034
0.566CysGlu: 0.566 ± 0.033
0.469CysPhe: 0.469 ± 0.027
0.975CysGly: 0.975 ± 0.044
0.308CysHis: 0.308 ± 0.026
0.597CysIle: 0.597 ± 0.034
0.453CysLys: 0.453 ± 0.031
0.948CysLeu: 0.948 ± 0.041
0.163CysMet: 0.163 ± 0.017
0.376CysAsn: 0.376 ± 0.027
0.391CysPro: 0.391 ± 0.03
0.478CysGln: 0.478 ± 0.031
0.455CysArg: 0.455 ± 0.026
0.6CysSer: 0.6 ± 0.033
0.476CysThr: 0.476 ± 0.031
0.621CysVal: 0.621 ± 0.037
0.114CysTrp: 0.114 ± 0.014
0.362CysTyr: 0.362 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.268AspAla: 3.268 ± 0.076
0.537AspCys: 0.537 ± 0.033
2.377AspAsp: 2.377 ± 0.071
3.622AspGlu: 3.622 ± 0.084
2.551AspPhe: 2.551 ± 0.063
3.297AspGly: 3.297 ± 0.115
0.939AspHis: 0.939 ± 0.071
4.276AspIle: 4.276 ± 0.095
3.67AspLys: 3.67 ± 0.112
5.063AspLeu: 5.063 ± 0.09
1.099AspMet: 1.099 ± 0.038
2.74AspAsn: 2.74 ± 0.09
1.844AspPro: 1.844 ± 0.058
1.603AspGln: 1.603 ± 0.046
2.09AspArg: 2.09 ± 0.057
2.635AspSer: 2.635 ± 0.079
2.416AspThr: 2.416 ± 0.071
3.458AspVal: 3.458 ± 0.082
0.753AspTrp: 0.753 ± 0.03
2.004AspTyr: 2.004 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
4.16GluAla: 4.16 ± 0.095
0.473GluCys: 0.473 ± 0.031
2.607GluAsp: 2.607 ± 0.073
3.871GluGlu: 3.871 ± 0.102
2.468GluPhe: 2.468 ± 0.066
3.239GluGly: 3.239 ± 0.091
1.372GluHis: 1.372 ± 0.047
5.263GluIle: 5.263 ± 0.093
5.723GluLys: 5.723 ± 0.107
6.469GluLeu: 6.469 ± 0.127
1.739GluMet: 1.739 ± 0.047
4.109GluAsn: 4.109 ± 0.079
1.678GluPro: 1.678 ± 0.055
4.273GluGln: 4.273 ± 0.101
3.114GluArg: 3.114 ± 0.091
2.853GluSer: 2.853 ± 0.058
3.244GluThr: 3.244 ± 0.079
3.85GluVal: 3.85 ± 0.09
0.635GluTrp: 0.635 ± 0.034
1.893GluTyr: 1.893 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.505PheAla: 3.505 ± 0.08
0.579PheCys: 0.579 ± 0.028
2.598PheAsp: 2.598 ± 0.064
2.38PheGlu: 2.38 ± 0.067
2.001PhePhe: 2.001 ± 0.065
3.151PheGly: 3.151 ± 0.076
0.788PheHis: 0.788 ± 0.037
3.166PheIle: 3.166 ± 0.096
2.514PheLys: 2.514 ± 0.077
3.789PheLeu: 3.789 ± 0.098
0.969PheMet: 0.969 ± 0.042
2.511PheAsn: 2.511 ± 0.063
1.385PhePro: 1.385 ± 0.054
1.331PheGln: 1.331 ± 0.048
1.533PheArg: 1.533 ± 0.058
3.393PheSer: 3.393 ± 0.078
2.355PheThr: 2.355 ± 0.06
2.768PheVal: 2.768 ± 0.081
0.502PheTrp: 0.502 ± 0.032
1.556PheTyr: 1.556 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.241GlyAla: 5.241 ± 0.147
0.757GlyCys: 0.757 ± 0.04
3.338GlyAsp: 3.338 ± 0.107
4.187GlyGlu: 4.187 ± 0.093
3.084GlyPhe: 3.084 ± 0.074
4.766GlyGly: 4.766 ± 0.112
1.284GlyHis: 1.284 ± 0.046
5.63GlyIle: 5.63 ± 0.104
5.407GlyLys: 5.407 ± 0.136
6.755GlyLeu: 6.755 ± 0.131
1.774GlyMet: 1.774 ± 0.064
3.439GlyAsn: 3.439 ± 0.15
1.101GlyPro: 1.101 ± 0.047
2.565GlyGln: 2.565 ± 0.078
2.774GlyArg: 2.774 ± 0.073
4.253GlySer: 4.253 ± 0.162
3.774GlyThr: 3.774 ± 0.143
4.686GlyVal: 4.686 ± 0.102
0.8GlyTrp: 0.8 ± 0.034
2.604GlyTyr: 2.604 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.293HisAla: 1.293 ± 0.04
0.392HisCys: 0.392 ± 0.027
0.872HisAsp: 0.872 ± 0.067
0.901HisGlu: 0.901 ± 0.046
1.198HisPhe: 1.198 ± 0.046
1.235HisGly: 1.235 ± 0.048
0.63HisHis: 0.63 ± 0.035
1.639HisIle: 1.639 ± 0.055
1.212HisLys: 1.212 ± 0.042
2.326HisLeu: 2.326 ± 0.064
0.336HisMet: 0.336 ± 0.022
1.012HisAsn: 1.012 ± 0.043
0.864HisPro: 0.864 ± 0.039
1.153HisGln: 1.153 ± 0.05
0.988HisArg: 0.988 ± 0.046
1.334HisSer: 1.334 ± 0.047
0.975HisThr: 0.975 ± 0.039
1.003HisVal: 1.003 ± 0.036
0.289HisTrp: 0.289 ± 0.019
0.919HisTyr: 0.919 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.958IleAla: 6.958 ± 0.125
0.8IleCys: 0.8 ± 0.033
4.186IleAsp: 4.186 ± 0.085
5.021IleGlu: 5.021 ± 0.087
2.952IlePhe: 2.952 ± 0.073
5.737IleGly: 5.737 ± 0.146
1.372IleHis: 1.372 ± 0.055
4.963IleIle: 4.963 ± 0.113
4.599IleLys: 4.599 ± 0.098
6.793IleLeu: 6.793 ± 0.148
1.391IleMet: 1.391 ± 0.053
3.932IleAsn: 3.932 ± 0.083
2.876IlePro: 2.876 ± 0.081
2.946IleGln: 2.946 ± 0.076
2.984IleArg: 2.984 ± 0.071
5.025IleSer: 5.025 ± 0.087
4.318IleThr: 4.318 ± 0.114
4.641IleVal: 4.641 ± 0.098
0.637IleTrp: 0.637 ± 0.035
2.14IleTyr: 2.14 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.46LysAla: 5.46 ± 0.132
0.441LysCys: 0.441 ± 0.03
3.418LysAsp: 3.418 ± 0.124
4.502LysGlu: 4.502 ± 0.112
2.239LysPhe: 2.239 ± 0.067
4.433LysGly: 4.433 ± 0.132
1.265LysHis: 1.265 ± 0.04
4.999LysIle: 4.999 ± 0.11
4.7LysLys: 4.7 ± 0.104
6.582LysLeu: 6.582 ± 0.104
1.89LysMet: 1.89 ± 0.059
3.973LysAsn: 3.973 ± 0.109
2.329LysPro: 2.329 ± 0.058
3.624LysGln: 3.624 ± 0.08
2.903LysArg: 2.903 ± 0.066
3.871LysSer: 3.871 ± 0.093
3.775LysThr: 3.775 ± 0.081
4.456LysVal: 4.456 ± 0.103
0.659LysTrp: 0.659 ± 0.034
2.133LysTyr: 2.133 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
8.732LeuAla: 8.732 ± 0.145
1.052LeuCys: 1.052 ± 0.051
5.276LeuAsp: 5.276 ± 0.086
5.863LeuGlu: 5.863 ± 0.103
4.358LeuPhe: 4.358 ± 0.114
7.197LeuGly: 7.197 ± 0.129
1.995LeuHis: 1.995 ± 0.054
6.878LeuIle: 6.878 ± 0.144
6.456LeuLys: 6.456 ± 0.112
10.174LeuLeu: 10.174 ± 0.229
2.32LeuMet: 2.32 ± 0.074
5.241LeuAsn: 5.241 ± 0.091
4.413LeuPro: 4.413 ± 0.097
4.497LeuGln: 4.497 ± 0.118
4.338LeuArg: 4.338 ± 0.102
7.504LeuSer: 7.504 ± 0.126
5.897LeuThr: 5.897 ± 0.095
6.19LeuVal: 6.19 ± 0.12
0.963LeuTrp: 0.963 ± 0.042
2.688LeuTyr: 2.688 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.143MetAla: 2.143 ± 0.059
0.189MetCys: 0.189 ± 0.018
0.945MetAsp: 0.945 ± 0.043
1.192MetGlu: 1.192 ± 0.047
0.841MetPhe: 0.841 ± 0.042
1.505MetGly: 1.505 ± 0.047
0.354MetHis: 0.354 ± 0.023
1.505MetIle: 1.505 ± 0.058
1.681MetLys: 1.681 ± 0.045
2.468MetLeu: 2.468 ± 0.07
0.692MetMet: 0.692 ± 0.036
1.175MetAsn: 1.175 ± 0.042
1.029MetPro: 1.029 ± 0.042
1.236MetGln: 1.236 ± 0.054
1.026MetArg: 1.026 ± 0.045
1.58MetSer: 1.58 ± 0.054
1.479MetThr: 1.479 ± 0.046
1.284MetVal: 1.284 ± 0.049
0.195MetTrp: 0.195 ± 0.018
0.479MetTyr: 0.479 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.998AsnAla: 3.998 ± 0.09
0.434AsnCys: 0.434 ± 0.03
2.453AsnAsp: 2.453 ± 0.073
3.079AsnGlu: 3.079 ± 0.075
1.931AsnPhe: 1.931 ± 0.054
3.864AsnGly: 3.864 ± 0.154
0.982AsnHis: 0.982 ± 0.044
4.128AsnIle: 4.128 ± 0.086
3.571AsnLys: 3.571 ± 0.113
4.976AsnLeu: 4.976 ± 0.088
1.142AsnMet: 1.142 ± 0.044
2.725AsnAsn: 2.725 ± 0.094
2.362AsnPro: 2.362 ± 0.063
2.508AsnGln: 2.508 ± 0.074
2.088AsnArg: 2.088 ± 0.062
3.074AsnSer: 3.074 ± 0.1
2.569AsnThr: 2.569 ± 0.074
3.247AsnVal: 3.247 ± 0.084
0.614AsnTrp: 0.614 ± 0.032
1.722AsnTyr: 1.722 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
2.416ProAla: 2.416 ± 0.068
0.311ProCys: 0.311 ± 0.024
1.745ProAsp: 1.745 ± 0.058
2.736ProGlu: 2.736 ± 0.075
1.647ProPhe: 1.647 ± 0.059
1.404ProGly: 1.404 ± 0.051
0.985ProHis: 0.985 ± 0.044
2.674ProIle: 2.674 ± 0.074
2.329ProLys: 2.329 ± 0.065
3.531ProLeu: 3.531 ± 0.093
0.895ProMet: 0.895 ± 0.038
1.937ProAsn: 1.937 ± 0.054
0.943ProPro: 0.943 ± 0.039
1.704ProGln: 1.704 ± 0.058
1.125ProArg: 1.125 ± 0.049
1.98ProSer: 1.98 ± 0.06
2.296ProThr: 2.296 ± 0.059
2.34ProVal: 2.34 ± 0.063
0.319ProTrp: 0.319 ± 0.023
1.307ProTyr: 1.307 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
4.193GlnAla: 4.193 ± 0.096
0.33GlnCys: 0.33 ± 0.022
2.133GlnAsp: 2.133 ± 0.063
2.852GlnGlu: 2.852 ± 0.077
1.966GlnPhe: 1.966 ± 0.056
3.233GlnGly: 3.233 ± 0.079
1.226GlnHis: 1.226 ± 0.048
3.314GlnIle: 3.314 ± 0.073
3.134GlnLys: 3.134 ± 0.097
4.958GlnLeu: 4.958 ± 0.108
0.962GlnMet: 0.962 ± 0.044
2.458GlnAsn: 2.458 ± 0.068
1.668GlnPro: 1.668 ± 0.062
3.375GlnGln: 3.375 ± 0.106
2.305GlnArg: 2.305 ± 0.077
2.729GlnSer: 2.729 ± 0.074
2.29GlnThr: 2.29 ± 0.065
2.858GlnVal: 2.858 ± 0.079
0.585GlnTrp: 0.585 ± 0.036
1.586GlnTyr: 1.586 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
2.896ArgAla: 2.896 ± 0.063
0.405ArgCys: 0.405 ± 0.026
2.056ArgAsp: 2.056 ± 0.064
2.862ArgGlu: 2.862 ± 0.072
2.1ArgPhe: 2.1 ± 0.057
2.497ArgGly: 2.497 ± 0.073
1.043ArgHis: 1.043 ± 0.038
3.172ArgIle: 3.172 ± 0.079
2.674ArgLys: 2.674 ± 0.068
4.593ArgLeu: 4.593 ± 0.112
0.913ArgMet: 0.913 ± 0.039
1.995ArgAsn: 1.995 ± 0.06
1.414ArgPro: 1.414 ± 0.052
2.252ArgGln: 2.252 ± 0.062
2.096ArgArg: 2.096 ± 0.066
2.329ArgSer: 2.329 ± 0.058
2.122ArgThr: 2.122 ± 0.074
2.525ArgVal: 2.525 ± 0.074
0.534ArgTrp: 0.534 ± 0.035
1.684ArgTyr: 1.684 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
5.273SerAla: 5.273 ± 0.101
0.54SerCys: 0.54 ± 0.031
3.137SerAsp: 3.137 ± 0.094
3.67SerGlu: 3.67 ± 0.075
2.677SerPhe: 2.677 ± 0.077
4.697SerGly: 4.697 ± 0.116
1.322SerHis: 1.322 ± 0.046
4.412SerIle: 4.412 ± 0.102
3.598SerLys: 3.598 ± 0.108
6.225SerLeu: 6.225 ± 0.114
1.291SerMet: 1.291 ± 0.049
2.826SerAsn: 2.826 ± 0.1
2.136SerPro: 2.136 ± 0.064
2.781SerGln: 2.781 ± 0.073
2.435SerArg: 2.435 ± 0.068
3.917SerSer: 3.917 ± 0.105
3.383SerThr: 3.383 ± 0.109
4.004SerVal: 4.004 ± 0.086
0.673SerTrp: 0.673 ± 0.032
1.96SerTyr: 1.96 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.955ThrAla: 4.955 ± 0.106
0.411ThrCys: 0.411 ± 0.025
2.871ThrAsp: 2.871 ± 0.088
3.525ThrGlu: 3.525 ± 0.084
2.351ThrPhe: 2.351 ± 0.076
4.079ThrGly: 4.079 ± 0.115
1.192ThrHis: 1.192 ± 0.046
3.682ThrIle: 3.682 ± 0.096
3.181ThrLys: 3.181 ± 0.096
6.036ThrLeu: 6.036 ± 0.11
1.018ThrMet: 1.018 ± 0.043
2.354ThrAsn: 2.354 ± 0.078
2.363ThrPro: 2.363 ± 0.069
2.56ThrGln: 2.56 ± 0.064
1.904ThrArg: 1.904 ± 0.057
3.158ThrSer: 3.158 ± 0.104
3.181ThrThr: 3.181 ± 0.123
3.54ThrVal: 3.54 ± 0.086
0.531ThrTrp: 0.531 ± 0.029
1.54ThrTyr: 1.54 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.593ValAla: 5.593 ± 0.116
0.663ValCys: 0.663 ± 0.031
3.432ValAsp: 3.432 ± 0.085
4.439ValGlu: 4.439 ± 0.092
2.551ValPhe: 2.551 ± 0.072
4.612ValGly: 4.612 ± 0.104
1.07ValHis: 1.07 ± 0.042
4.938ValIle: 4.938 ± 0.099
4.323ValLys: 4.323 ± 0.087
6.344ValLeu: 6.344 ± 0.125
1.527ValMet: 1.527 ± 0.052
3.064ValAsn: 3.064 ± 0.072
2.183ValPro: 2.183 ± 0.064
2.522ValGln: 2.522 ± 0.07
2.729ValArg: 2.729 ± 0.076
4.227ValSer: 4.227 ± 0.077
3.502ValThr: 3.502 ± 0.08
4.576ValVal: 4.576 ± 0.102
0.563ValTrp: 0.563 ± 0.03
1.798ValTyr: 1.798 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.743TrpAla: 0.743 ± 0.034
0.124TrpCys: 0.124 ± 0.014
0.485TrpAsp: 0.485 ± 0.029
0.525TrpGlu: 0.525 ± 0.025
0.536TrpPhe: 0.536 ± 0.029
0.646TrpGly: 0.646 ± 0.033
0.296TrpHis: 0.296 ± 0.02
0.719TrpIle: 0.719 ± 0.038
0.679TrpLys: 0.679 ± 0.026
1.501TrpLeu: 1.501 ± 0.06
0.198TrpMet: 0.198 ± 0.016
0.469TrpAsn: 0.469 ± 0.029
0.15TrpPro: 0.15 ± 0.016
0.922TrpGln: 0.922 ± 0.045
0.569TrpArg: 0.569 ± 0.031
0.582TrpSer: 0.582 ± 0.033
0.461TrpThr: 0.461 ± 0.027
0.637TrpVal: 0.637 ± 0.032
0.147TrpTrp: 0.147 ± 0.019
0.342TrpTyr: 0.342 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.398TyrAla: 2.398 ± 0.061
0.394TyrCys: 0.394 ± 0.026
1.639TyrAsp: 1.639 ± 0.055
1.633TyrGlu: 1.633 ± 0.052
1.685TyrPhe: 1.685 ± 0.065
2.14TyrGly: 2.14 ± 0.061
0.835TyrHis: 0.835 ± 0.04
1.968TyrIle: 1.968 ± 0.065
1.754TyrLys: 1.754 ± 0.059
3.543TyrLeu: 3.543 ± 0.083
0.565TyrMet: 0.565 ± 0.025
1.304TyrAsn: 1.304 ± 0.045
1.388TyrPro: 1.388 ± 0.05
2.14TyrGln: 2.14 ± 0.073
1.678TyrArg: 1.678 ± 0.056
2.097TyrSer: 2.097 ± 0.063
1.499TyrThr: 1.499 ± 0.048
1.904TyrVal: 1.904 ± 0.053
0.443TyrTrp: 0.443 ± 0.031
1.064TyrTyr: 1.064 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1971 proteins (655091 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski