Amino acid dipepetide frequency for Lachnospiraceae bacterium XPB1003

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.563AlaAla: 7.563 ± 0.134	1.023AlaCys: 1.023 ± 0.034	5.512AlaAsp: 5.512 ± 0.088	5.767AlaGlu: 5.767 ± 0.095	3.203AlaPhe: 3.203 ± 0.071	6.346AlaGly: 6.346 ± 0.064	1.088AlaHis: 1.088 ± 0.037	4.95AlaIle: 4.95 ± 0.089	4.617AlaLys: 4.617 ± 0.098	6.695AlaLeu: 6.695 ± 0.094	2.232AlaMet: 2.232 ± 0.052	2.376AlaAsn: 2.376 ± 0.049	2.136AlaPro: 2.136 ± 0.068	1.792AlaGln: 1.792 ± 0.046	2.805AlaArg: 2.805 ± 0.054	4.352AlaSer: 4.352 ± 0.088	3.064AlaThr: 3.064 ± 0.077	6.506AlaVal: 6.506 ± 0.081	0.575AlaTrp: 0.575 ± 0.023	2.888AlaTyr: 2.888 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.0CysAla: 1.0 ± 0.034	0.257CysCys: 0.257 ± 0.016	0.971CysAsp: 0.971 ± 0.032	0.945CysGlu: 0.945 ± 0.031	0.733CysPhe: 0.733 ± 0.031	1.551CysGly: 1.551 ± 0.044	0.276CysHis: 0.276 ± 0.02	1.121CysIle: 1.121 ± 0.036	0.74CysLys: 0.74 ± 0.037	1.115CysLeu: 1.115 ± 0.035	0.394CysMet: 0.394 ± 0.023	0.61CysAsn: 0.61 ± 0.028	0.56CysPro: 0.56 ± 0.027	0.24CysGln: 0.24 ± 0.017	0.699CysArg: 0.699 ± 0.029	0.881CysSer: 0.881 ± 0.03	0.619CysThr: 0.619 ± 0.024	1.001CysVal: 1.001 ± 0.038	0.113CysTrp: 0.113 ± 0.011	0.549CysTyr: 0.549 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.836AspAla: 4.836 ± 0.088	0.855AspCys: 0.855 ± 0.034	4.583AspAsp: 4.583 ± 0.104	5.768AspGlu: 5.768 ± 0.086	2.91AspPhe: 2.91 ± 0.053	4.878AspGly: 4.878 ± 0.095	1.166AspHis: 1.166 ± 0.034	5.393AspIle: 5.393 ± 0.078	4.756AspLys: 4.756 ± 0.071	5.1AspLeu: 5.1 ± 0.078	2.204AspMet: 2.204 ± 0.049	2.981AspAsn: 2.981 ± 0.067	2.583AspPro: 2.583 ± 0.054	1.26AspGln: 1.26 ± 0.034	3.099AspArg: 3.099 ± 0.054	3.685AspSer: 3.685 ± 0.065	3.308AspThr: 3.308 ± 0.061	4.092AspVal: 4.092 ± 0.07	0.559AspTrp: 0.559 ± 0.024	3.074AspTyr: 3.074 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	5.742GluAla: 5.742 ± 0.102	0.858GluCys: 0.858 ± 0.029	4.831GluAsp: 4.831 ± 0.083	6.85GluGlu: 6.85 ± 0.102	2.836GluPhe: 2.836 ± 0.053	4.645GluGly: 4.645 ± 0.07	1.239GluHis: 1.239 ± 0.035	5.678GluIle: 5.678 ± 0.074	6.777GluLys: 6.777 ± 0.087	6.371GluLeu: 6.371 ± 0.088	2.396GluMet: 2.396 ± 0.051	3.911GluAsn: 3.911 ± 0.069	1.764GluPro: 1.764 ± 0.042	2.075GluGln: 2.075 ± 0.048	3.476GluArg: 3.476 ± 0.067	3.874GluSer: 3.874 ± 0.072	3.5GluThr: 3.5 ± 0.071	4.286GluVal: 4.286 ± 0.07	0.665GluTrp: 0.665 ± 0.031	3.467GluTyr: 3.467 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	3.119PheAla: 3.119 ± 0.068	0.757PheCys: 0.757 ± 0.031	3.151PheAsp: 3.151 ± 0.066	2.888PheGlu: 2.888 ± 0.056	2.206PhePhe: 2.206 ± 0.064	3.181PheGly: 3.181 ± 0.068	0.723PheHis: 0.723 ± 0.029	3.355PheIle: 3.355 ± 0.063	2.329PheLys: 2.329 ± 0.049	3.651PheLeu: 3.651 ± 0.077	1.328PheMet: 1.328 ± 0.043	1.746PheAsn: 1.746 ± 0.045	1.396PhePro: 1.396 ± 0.033	0.77PheGln: 0.77 ± 0.03	1.768PheArg: 1.768 ± 0.049	3.176PheSer: 3.176 ± 0.059	2.396PheThr: 2.396 ± 0.058	2.843PheVal: 2.843 ± 0.065	0.437PheTrp: 0.437 ± 0.023	1.919PheTyr: 1.919 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.919GlyAla: 4.919 ± 0.075	1.256GlyCys: 1.256 ± 0.037	4.286GlyAsp: 4.286 ± 0.068	4.583GlyGlu: 4.583 ± 0.071	3.33GlyPhe: 3.33 ± 0.066	4.76GlyGly: 4.76 ± 0.12	1.275GlyHis: 1.275 ± 0.043	6.054GlyIle: 6.054 ± 0.092	5.571GlyLys: 5.571 ± 0.067	5.696GlyLeu: 5.696 ± 0.088	2.494GlyMet: 2.494 ± 0.056	3.217GlyAsn: 3.217 ± 0.068	1.325GlyPro: 1.325 ± 0.037	1.8GlyGln: 1.8 ± 0.063	3.423GlyArg: 3.423 ± 0.063	4.658GlySer: 4.658 ± 0.081	4.033GlyThr: 4.033 ± 0.074	4.803GlyVal: 4.803 ± 0.102	0.699GlyTrp: 0.699 ± 0.027	3.328GlyTyr: 3.328 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.044HisAla: 1.044 ± 0.032	0.253HisCys: 0.253 ± 0.016	1.061HisAsp: 1.061 ± 0.035	1.033HisGlu: 1.033 ± 0.036	0.831HisPhe: 0.831 ± 0.031	1.271HisGly: 1.271 ± 0.042	0.38HisHis: 0.38 ± 0.037	1.294HisIle: 1.294 ± 0.037	0.87HisLys: 0.87 ± 0.028	1.273HisLeu: 1.273 ± 0.038	0.506HisMet: 0.506 ± 0.027	0.684HisAsn: 0.684 ± 0.028	0.835HisPro: 0.835 ± 0.032	0.313HisGln: 0.313 ± 0.018	0.692HisArg: 0.692 ± 0.027	0.974HisSer: 0.974 ± 0.033	0.852HisThr: 0.852 ± 0.031	1.029HisVal: 1.029 ± 0.035	0.151HisTrp: 0.151 ± 0.012	0.708HisTyr: 0.708 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.808IleAla: 5.808 ± 0.082	1.353IleCys: 1.353 ± 0.037	4.703IleAsp: 4.703 ± 0.066	5.069IleGlu: 5.069 ± 0.087	3.334IlePhe: 3.334 ± 0.068	5.13IleGly: 5.13 ± 0.084	1.146IleHis: 1.146 ± 0.033	5.809IleIle: 5.809 ± 0.093	4.977IleLys: 4.977 ± 0.06	6.721IleLeu: 6.721 ± 0.109	2.104IleMet: 2.104 ± 0.052	3.371IleAsn: 3.371 ± 0.067	3.311IlePro: 3.311 ± 0.065	1.61IleGln: 1.61 ± 0.046	3.942IleArg: 3.942 ± 0.078	5.446IleSer: 5.446 ± 0.078	4.234IleThr: 4.234 ± 0.075	4.932IleVal: 4.932 ± 0.072	0.65IleTrp: 0.65 ± 0.029	3.051IleTyr: 3.051 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.513LysAla: 5.513 ± 0.104	0.822LysCys: 0.822 ± 0.036	4.867LysAsp: 4.867 ± 0.076	6.284LysGlu: 6.284 ± 0.094	2.014LysPhe: 2.014 ± 0.051	4.402LysGly: 4.402 ± 0.064	1.036LysHis: 1.036 ± 0.031	4.978LysIle: 4.978 ± 0.071	6.749LysLys: 6.749 ± 0.115	5.319LysLeu: 5.319 ± 0.081	2.082LysMet: 2.082 ± 0.044	3.82LysAsn: 3.82 ± 0.067	2.118LysPro: 2.118 ± 0.05	1.781LysGln: 1.781 ± 0.044	3.167LysArg: 3.167 ± 0.063	3.642LysSer: 3.642 ± 0.061	3.648LysThr: 3.648 ± 0.066	4.049LysVal: 4.049 ± 0.058	0.607LysTrp: 0.607 ± 0.028	3.024LysTyr: 3.024 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	6.117LeuAla: 6.117 ± 0.099	1.279LeuCys: 1.279 ± 0.043	5.212LeuAsp: 5.212 ± 0.071	5.506LeuGlu: 5.506 ± 0.082	3.8LeuPhe: 3.8 ± 0.074	5.422LeuGly: 5.422 ± 0.089	1.291LeuHis: 1.291 ± 0.038	6.571LeuIle: 6.571 ± 0.112	6.25LeuLys: 6.25 ± 0.085	7.556LeuLeu: 7.556 ± 0.119	2.538LeuMet: 2.538 ± 0.057	3.538LeuAsn: 3.538 ± 0.059	3.172LeuPro: 3.172 ± 0.065	1.941LeuGln: 1.941 ± 0.04	3.609LeuArg: 3.609 ± 0.071	6.34LeuSer: 6.34 ± 0.087	4.662LeuThr: 4.662 ± 0.075	4.901LeuVal: 4.901 ± 0.064	0.688LeuTrp: 0.688 ± 0.031	3.357LeuTyr: 3.357 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.319MetAla: 2.319 ± 0.051	0.383MetCys: 0.383 ± 0.019	1.947MetAsp: 1.947 ± 0.045	2.12MetGlu: 2.12 ± 0.056	1.141MetPhe: 1.141 ± 0.035	1.912MetGly: 1.912 ± 0.048	0.463MetHis: 0.463 ± 0.022	2.6MetIle: 2.6 ± 0.062	2.468MetLys: 2.468 ± 0.049	2.757MetLeu: 2.757 ± 0.056	0.969MetMet: 0.969 ± 0.035	1.579MetAsn: 1.579 ± 0.04	1.213MetPro: 1.213 ± 0.04	0.897MetGln: 0.897 ± 0.03	1.311MetArg: 1.311 ± 0.038	1.896MetSer: 1.896 ± 0.045	1.791MetThr: 1.791 ± 0.043	1.753MetVal: 1.753 ± 0.046	0.223MetTrp: 0.223 ± 0.015	0.918MetTyr: 0.918 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.398AsnAla: 3.398 ± 0.058	0.622AsnCys: 0.622 ± 0.025	2.876AsnAsp: 2.876 ± 0.061	3.146AsnGlu: 3.146 ± 0.059	1.54AsnPhe: 1.54 ± 0.037	3.477AsnGly: 3.477 ± 0.062	0.658AsnHis: 0.658 ± 0.028	3.655AsnIle: 3.655 ± 0.056	2.699AsnLys: 2.699 ± 0.057	3.255AsnLeu: 3.255 ± 0.067	1.428AsnMet: 1.428 ± 0.039	2.004AsnAsn: 2.004 ± 0.052	1.806AsnPro: 1.806 ± 0.045	0.919AsnGln: 0.919 ± 0.039	2.047AsnArg: 2.047 ± 0.048	2.579AsnSer: 2.579 ± 0.06	2.353AsnThr: 2.353 ± 0.053	2.972AsnVal: 2.972 ± 0.052	0.369AsnTrp: 0.369 ± 0.019	1.796AsnTyr: 1.796 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.564ProAla: 2.564 ± 0.076	0.374ProCys: 0.374 ± 0.02	2.925ProAsp: 2.925 ± 0.057	3.561ProGlu: 3.561 ± 0.061	1.488ProPhe: 1.488 ± 0.039	2.419ProGly: 2.419 ± 0.055	0.516ProHis: 0.516 ± 0.024	1.963ProIle: 1.963 ± 0.043	1.752ProLys: 1.752 ± 0.05	2.546ProLeu: 2.546 ± 0.057	0.861ProMet: 0.861 ± 0.028	1.074ProAsn: 1.074 ± 0.035	0.643ProPro: 0.643 ± 0.027	0.847ProGln: 0.847 ± 0.035	0.995ProArg: 0.995 ± 0.039	1.873ProSer: 1.873 ± 0.048	1.408ProThr: 1.408 ± 0.05	3.076ProVal: 3.076 ± 0.061	0.325ProTrp: 0.325 ± 0.02	1.42ProTyr: 1.42 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.829GlnAla: 1.829 ± 0.049	0.272GlnCys: 0.272 ± 0.017	1.357GlnAsp: 1.357 ± 0.037	1.53GlnGlu: 1.53 ± 0.044	0.9GlnPhe: 0.9 ± 0.035	1.64GlnGly: 1.64 ± 0.057	0.343GlnHis: 0.343 ± 0.018	1.987GlnIle: 1.987 ± 0.048	1.774GlnLys: 1.774 ± 0.041	1.836GlnLeu: 1.836 ± 0.051	0.975GlnMet: 0.975 ± 0.034	1.167GlnAsn: 1.167 ± 0.042	0.676GlnPro: 0.676 ± 0.04	0.74GlnGln: 0.74 ± 0.049	0.982GlnArg: 0.982 ± 0.032	1.385GlnSer: 1.385 ± 0.042	1.337GlnThr: 1.337 ± 0.035	1.479GlnVal: 1.479 ± 0.041	0.203GlnTrp: 0.203 ± 0.014	1.049GlnTyr: 1.049 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.728ArgAla: 2.728 ± 0.059	0.571ArgCys: 0.571 ± 0.028	2.631ArgAsp: 2.631 ± 0.053	3.56ArgGlu: 3.56 ± 0.075	2.097ArgPhe: 2.097 ± 0.044	2.542ArgGly: 2.542 ± 0.056	0.751ArgHis: 0.751 ± 0.03	3.841ArgIle: 3.841 ± 0.071	3.457ArgLys: 3.457 ± 0.063	3.932ArgLeu: 3.932 ± 0.064	1.529ArgMet: 1.529 ± 0.044	2.063ArgAsn: 2.063 ± 0.047	1.208ArgPro: 1.208 ± 0.046	1.287ArgGln: 1.287 ± 0.034	2.157ArgArg: 2.157 ± 0.06	2.632ArgSer: 2.632 ± 0.05	2.154ArgThr: 2.154 ± 0.051	2.756ArgVal: 2.756 ± 0.06	0.331ArgTrp: 0.331 ± 0.02	1.976ArgTyr: 1.976 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.74SerAla: 4.74 ± 0.081	0.838SerCys: 0.838 ± 0.031	4.795SerAsp: 4.795 ± 0.081	4.733SerGlu: 4.733 ± 0.103	3.065SerPhe: 3.065 ± 0.06	5.477SerGly: 5.477 ± 0.089	0.976SerHis: 0.976 ± 0.031	4.273SerIle: 4.273 ± 0.066	3.641SerLys: 3.641 ± 0.067	5.167SerLeu: 5.167 ± 0.074	1.777SerMet: 1.777 ± 0.047	2.336SerAsn: 2.336 ± 0.052	1.762SerPro: 1.762 ± 0.049	1.409SerGln: 1.409 ± 0.041	2.686SerArg: 2.686 ± 0.051	3.963SerSer: 3.963 ± 0.087	2.755SerThr: 2.755 ± 0.058	4.907SerVal: 4.907 ± 0.065	0.501SerTrp: 0.501 ± 0.024	2.621SerTyr: 2.621 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	4.325ThrAla: 4.325 ± 0.076	0.594ThrCys: 0.594 ± 0.031	3.9ThrAsp: 3.9 ± 0.075	4.005ThrGlu: 4.005 ± 0.068	2.106ThrPhe: 2.106 ± 0.051	4.804ThrGly: 4.804 ± 0.081	0.785ThrHis: 0.785 ± 0.03	3.549ThrIle: 3.549 ± 0.064	2.712ThrLys: 2.712 ± 0.057	4.23ThrLeu: 4.23 ± 0.07	1.268ThrMet: 1.268 ± 0.038	1.761ThrAsn: 1.761 ± 0.038	2.064ThrPro: 2.064 ± 0.053	1.172ThrGln: 1.172 ± 0.04	1.829ThrArg: 1.829 ± 0.041	2.913ThrSer: 2.913 ± 0.055	2.481ThrThr: 2.481 ± 0.061	4.491ThrVal: 4.491 ± 0.074	0.401ThrTrp: 0.401 ± 0.02	1.935ThrTyr: 1.935 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.673ValAla: 4.673 ± 0.075	1.168ValCys: 1.168 ± 0.038	3.849ValAsp: 3.849 ± 0.067	4.186ValGlu: 4.186 ± 0.067	3.254ValPhe: 3.254 ± 0.062	4.068ValGly: 4.068 ± 0.093	0.921ValHis: 0.921 ± 0.033	5.815ValIle: 5.815 ± 0.086	4.635ValLys: 4.635 ± 0.071	6.181ValLeu: 6.181 ± 0.095	2.098ValMet: 2.098 ± 0.045	2.967ValAsn: 2.967 ± 0.063	2.381ValPro: 2.381 ± 0.05	1.415ValGln: 1.415 ± 0.039	3.08ValArg: 3.08 ± 0.064	4.82ValSer: 4.82 ± 0.076	4.139ValThr: 4.139 ± 0.064	4.526ValVal: 4.526 ± 0.074	0.598ValTrp: 0.598 ± 0.027	2.803ValTyr: 2.803 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.483TrpAla: 0.483 ± 0.02	0.139TrpCys: 0.139 ± 0.013	0.549TrpAsp: 0.549 ± 0.025	0.555TrpGlu: 0.555 ± 0.027	0.442TrpPhe: 0.442 ± 0.023	0.605TrpGly: 0.605 ± 0.03	0.184TrpHis: 0.184 ± 0.015	0.696TrpIle: 0.696 ± 0.027	0.633TrpLys: 0.633 ± 0.028	0.783TrpLeu: 0.783 ± 0.028	0.291TrpMet: 0.291 ± 0.017	0.485TrpAsn: 0.485 ± 0.02	0.193TrpPro: 0.193 ± 0.016	0.273TrpGln: 0.273 ± 0.018	0.348TrpArg: 0.348 ± 0.019	0.465TrpSer: 0.465 ± 0.023	0.421TrpThr: 0.421 ± 0.02	0.481TrpVal: 0.481 ± 0.023	0.089TrpTrp: 0.089 ± 0.01	0.413TrpTyr: 0.413 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.773TyrAla: 2.773 ± 0.063	0.702TyrCys: 0.702 ± 0.029	3.083TyrAsp: 3.083 ± 0.066	3.154TyrGlu: 3.154 ± 0.065	1.911TyrPhe: 1.911 ± 0.05	2.981TyrGly: 2.981 ± 0.059	0.834TyrHis: 0.834 ± 0.032	3.119TyrIle: 3.119 ± 0.063	2.516TyrLys: 2.516 ± 0.056	3.565TyrLeu: 3.565 ± 0.06	1.185TyrMet: 1.185 ± 0.035	1.907TyrAsn: 1.907 ± 0.046	1.482TyrPro: 1.482 ± 0.043	0.922TyrGln: 0.922 ± 0.037	2.086TyrArg: 2.086 ± 0.055	2.866TyrSer: 2.866 ± 0.07	2.169TyrThr: 2.169 ± 0.056	2.694TyrVal: 2.694 ± 0.051	0.345TyrTrp: 0.345 ± 0.021	2.028TyrTyr: 2.028 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2824 proteins (956784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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