Amino acid dipepetide frequency for Metarhizium anisopliae BRIP 53293

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.886AlaAla: 9.886 ± 0.055	1.149AlaCys: 1.149 ± 0.017	4.602AlaAsp: 4.602 ± 0.032	5.152AlaGlu: 5.152 ± 0.044	3.193AlaPhe: 3.193 ± 0.028	6.144AlaGly: 6.144 ± 0.045	1.843AlaHis: 1.843 ± 0.021	4.318AlaIle: 4.318 ± 0.035	4.281AlaLys: 4.281 ± 0.032	7.904AlaLeu: 7.904 ± 0.047	2.122AlaMet: 2.122 ± 0.018	3.108AlaAsn: 3.108 ± 0.024	4.61AlaPro: 4.61 ± 0.038	3.435AlaGln: 3.435 ± 0.026	5.148AlaArg: 5.148 ± 0.028	7.428AlaSer: 7.428 ± 0.042	5.376AlaThr: 5.376 ± 0.034	5.9AlaVal: 5.9 ± 0.039	1.25AlaTrp: 1.25 ± 0.017	2.161AlaTyr: 2.161 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.015	0.247CysCys: 0.247 ± 0.007	0.734CysAsp: 0.734 ± 0.013	0.628CysGlu: 0.628 ± 0.012	0.562CysPhe: 0.562 ± 0.01	1.008CysGly: 1.008 ± 0.016	0.356CysHis: 0.356 ± 0.009	0.724CysIle: 0.724 ± 0.012	0.557CysLys: 0.557 ± 0.012	1.331CysLeu: 1.331 ± 0.017	0.279CysMet: 0.279 ± 0.006	0.468CysAsn: 0.468 ± 0.01	0.686CysPro: 0.686 ± 0.014	0.498CysGln: 0.498 ± 0.01	0.821CysArg: 0.821 ± 0.014	0.939CysSer: 0.939 ± 0.015	0.731CysThr: 0.731 ± 0.014	0.835CysVal: 0.835 ± 0.013	0.203CysTrp: 0.203 ± 0.006	0.358CysTyr: 0.358 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.181AspAla: 5.181 ± 0.034	0.701AspCys: 0.701 ± 0.013	4.516AspAsp: 4.516 ± 0.041	4.602AspGlu: 4.602 ± 0.042	2.241AspPhe: 2.241 ± 0.023	4.51AspGly: 4.51 ± 0.032	1.252AspHis: 1.252 ± 0.016	3.135AspIle: 3.135 ± 0.029	2.761AspLys: 2.761 ± 0.028	4.983AspLeu: 4.983 ± 0.034	1.469AspMet: 1.469 ± 0.017	1.987AspAsn: 1.987 ± 0.019	3.074AspPro: 3.074 ± 0.025	1.918AspGln: 1.918 ± 0.019	3.071AspArg: 3.071 ± 0.03	4.173AspSer: 4.173 ± 0.036	2.941AspThr: 2.941 ± 0.025	3.948AspVal: 3.948 ± 0.03	0.914AspTrp: 0.914 ± 0.014	1.579AspTyr: 1.579 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.554GluAla: 5.554 ± 0.04	0.662GluCys: 0.662 ± 0.011	4.028GluAsp: 4.028 ± 0.038	4.879GluGlu: 4.879 ± 0.048	1.952GluPhe: 1.952 ± 0.019	3.477GluGly: 3.477 ± 0.027	1.39GluHis: 1.39 ± 0.016	2.808GluIle: 2.808 ± 0.023	3.45GluLys: 3.45 ± 0.034	5.249GluLeu: 5.249 ± 0.036	1.493GluMet: 1.493 ± 0.016	2.194GluAsn: 2.194 ± 0.022	2.828GluPro: 2.828 ± 0.034	2.486GluGln: 2.486 ± 0.021	3.755GluArg: 3.755 ± 0.032	4.201GluSer: 4.201 ± 0.026	3.416GluThr: 3.416 ± 0.027	3.354GluVal: 3.354 ± 0.029	0.868GluTrp: 0.868 ± 0.012	1.631GluTyr: 1.631 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.096PheAla: 3.096 ± 0.025	0.574PheCys: 0.574 ± 0.01	2.318PheAsp: 2.318 ± 0.02	2.058PheGlu: 2.058 ± 0.023	1.582PhePhe: 1.582 ± 0.021	2.857PheGly: 2.857 ± 0.028	0.913PheHis: 0.913 ± 0.013	1.764PheIle: 1.764 ± 0.021	1.524PheLys: 1.524 ± 0.016	3.388PheLeu: 3.388 ± 0.03	0.801PheMet: 0.801 ± 0.013	1.443PheAsn: 1.443 ± 0.019	1.897PhePro: 1.897 ± 0.021	1.403PheGln: 1.403 ± 0.017	1.957PheArg: 1.957 ± 0.019	2.847PheSer: 2.847 ± 0.026	2.087PheThr: 2.087 ± 0.018	2.439PheVal: 2.439 ± 0.024	0.654PheTrp: 0.654 ± 0.012	1.078PheTyr: 1.078 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.573GlyAla: 5.573 ± 0.039	0.908GlyCys: 0.908 ± 0.015	3.893GlyAsp: 3.893 ± 0.033	3.656GlyGlu: 3.656 ± 0.028	2.794GlyPhe: 2.794 ± 0.025	5.807GlyGly: 5.807 ± 0.055	1.876GlyHis: 1.876 ± 0.024	3.61GlyIle: 3.61 ± 0.028	3.485GlyLys: 3.485 ± 0.034	6.176GlyLeu: 6.176 ± 0.041	1.618GlyMet: 1.618 ± 0.02	2.676GlyAsn: 2.676 ± 0.025	3.459GlyPro: 3.459 ± 0.038	2.773GlyGln: 2.773 ± 0.025	4.33GlyArg: 4.33 ± 0.033	5.809GlySer: 5.809 ± 0.039	4.039GlyThr: 4.039 ± 0.03	4.458GlyVal: 4.458 ± 0.033	1.182GlyTrp: 1.182 ± 0.015	2.097GlyTyr: 2.097 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.922HisAla: 1.922 ± 0.019	0.355HisCys: 0.355 ± 0.009	1.46HisAsp: 1.46 ± 0.018	1.349HisGlu: 1.349 ± 0.017	0.901HisPhe: 0.901 ± 0.012	1.888HisGly: 1.888 ± 0.021	0.88HisHis: 0.88 ± 0.017	1.212HisIle: 1.212 ± 0.014	0.949HisLys: 0.949 ± 0.014	2.261HisLeu: 2.261 ± 0.021	0.524HisMet: 0.524 ± 0.01	0.842HisAsn: 0.842 ± 0.011	1.55HisPro: 1.55 ± 0.02	1.04HisGln: 1.04 ± 0.016	1.55HisArg: 1.55 ± 0.018	1.716HisSer: 1.716 ± 0.019	1.211HisThr: 1.211 ± 0.016	1.624HisVal: 1.624 ± 0.018	0.352HisTrp: 0.352 ± 0.009	0.664HisTyr: 0.664 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.111IleAla: 4.111 ± 0.03	0.781IleCys: 0.781 ± 0.011	2.853IleAsp: 2.853 ± 0.022	2.687IleGlu: 2.687 ± 0.025	1.874IlePhe: 1.874 ± 0.021	3.171IleGly: 3.171 ± 0.027	1.197IleHis: 1.197 ± 0.017	2.437IleIle: 2.437 ± 0.027	2.215IleLys: 2.215 ± 0.024	4.498IleLeu: 4.498 ± 0.032	1.051IleMet: 1.051 ± 0.014	1.782IleAsn: 1.782 ± 0.019	2.906IlePro: 2.906 ± 0.025	1.909IleGln: 1.909 ± 0.018	2.85IleArg: 2.85 ± 0.022	3.725IleSer: 3.725 ± 0.028	2.712IleThr: 2.712 ± 0.02	3.144IleVal: 3.144 ± 0.028	0.727IleTrp: 0.727 ± 0.014	1.32IleTyr: 1.32 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.361LysAla: 4.361 ± 0.038	0.536LysCys: 0.536 ± 0.011	2.892LysAsp: 2.892 ± 0.026	3.1LysGlu: 3.1 ± 0.031	1.513LysPhe: 1.513 ± 0.018	2.962LysGly: 2.962 ± 0.028	1.162LysHis: 1.162 ± 0.017	2.217LysIle: 2.217 ± 0.023	3.165LysLys: 3.165 ± 0.043	4.231LysLeu: 4.231 ± 0.034	1.075LysMet: 1.075 ± 0.015	1.779LysAsn: 1.779 ± 0.018	2.749LysPro: 2.749 ± 0.027	1.902LysGln: 1.902 ± 0.021	3.285LysArg: 3.285 ± 0.03	3.524LysSer: 3.524 ± 0.03	2.961LysThr: 2.961 ± 0.023	2.728LysVal: 2.728 ± 0.024	0.668LysTrp: 0.668 ± 0.012	1.385LysTyr: 1.385 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.235LeuAla: 8.235 ± 0.049	1.324LeuCys: 1.324 ± 0.015	5.42LeuAsp: 5.42 ± 0.033	5.375LeuGlu: 5.375 ± 0.036	3.253LeuPhe: 3.253 ± 0.031	6.175LeuGly: 6.175 ± 0.038	2.224LeuHis: 2.224 ± 0.022	3.759LeuIle: 3.759 ± 0.029	4.067LeuLys: 4.067 ± 0.032	8.416LeuLeu: 8.416 ± 0.062	1.826LeuMet: 1.826 ± 0.018	3.042LeuAsn: 3.042 ± 0.029	5.349LeuPro: 5.349 ± 0.034	3.87LeuGln: 3.87 ± 0.028	5.904LeuArg: 5.904 ± 0.041	7.151LeuSer: 7.151 ± 0.04	4.625LeuThr: 4.625 ± 0.031	5.748LeuVal: 5.748 ± 0.042	1.26LeuTrp: 1.26 ± 0.015	2.314LeuTyr: 2.314 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.441MetAla: 2.441 ± 0.018	0.26MetCys: 0.26 ± 0.007	1.338MetAsp: 1.338 ± 0.015	1.34MetGlu: 1.34 ± 0.015	0.736MetPhe: 0.736 ± 0.013	1.507MetGly: 1.507 ± 0.016	0.479MetHis: 0.479 ± 0.009	0.942MetIle: 0.942 ± 0.014	1.061MetLys: 1.061 ± 0.013	1.95MetLeu: 1.95 ± 0.022	0.598MetMet: 0.598 ± 0.011	0.79MetAsn: 0.79 ± 0.013	1.362MetPro: 1.362 ± 0.017	0.876MetGln: 0.876 ± 0.016	1.317MetArg: 1.317 ± 0.018	1.911MetSer: 1.911 ± 0.018	1.364MetThr: 1.364 ± 0.017	1.382MetVal: 1.382 ± 0.016	0.276MetTrp: 0.276 ± 0.008	0.559MetTyr: 0.559 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.124AsnAla: 3.124 ± 0.024	0.479AsnCys: 0.479 ± 0.01	2.026AsnAsp: 2.026 ± 0.02	1.953AsnGlu: 1.953 ± 0.02	1.37AsnPhe: 1.37 ± 0.015	3.067AsnGly: 3.067 ± 0.033	0.853AsnHis: 0.853 ± 0.013	2.013AsnIle: 2.013 ± 0.018	1.676AsnLys: 1.676 ± 0.02	3.191AsnLeu: 3.191 ± 0.026	0.917AsnMet: 0.917 ± 0.013	1.494AsnAsn: 1.494 ± 0.023	2.32AsnPro: 2.32 ± 0.019	1.335AsnGln: 1.335 ± 0.018	1.983AsnArg: 1.983 ± 0.02	2.655AsnSer: 2.655 ± 0.025	2.149AsnThr: 2.149 ± 0.022	2.309AsnVal: 2.309 ± 0.025	0.564AsnTrp: 0.564 ± 0.01	1.013AsnTyr: 1.013 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.122ProAla: 5.122 ± 0.039	0.576ProCys: 0.576 ± 0.012	3.311ProAsp: 3.311 ± 0.027	3.696ProGlu: 3.696 ± 0.036	1.991ProPhe: 1.991 ± 0.022	4.198ProGly: 4.198 ± 0.033	1.253ProHis: 1.253 ± 0.016	2.407ProIle: 2.407 ± 0.022	2.608ProLys: 2.608 ± 0.026	4.617ProLeu: 4.617 ± 0.034	1.08ProMet: 1.08 ± 0.015	2.12ProAsn: 2.12 ± 0.022	4.86ProPro: 4.86 ± 0.065	2.371ProGln: 2.371 ± 0.03	3.402ProArg: 3.402 ± 0.032	5.605ProSer: 5.605 ± 0.041	3.669ProThr: 3.669 ± 0.03	3.623ProVal: 3.623 ± 0.033	0.784ProTrp: 0.784 ± 0.01	1.409ProTyr: 1.409 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.554GlnAla: 3.554 ± 0.027	0.465GlnCys: 0.465 ± 0.01	2.283GlnAsp: 2.283 ± 0.023	2.346GlnGlu: 2.346 ± 0.022	1.293GlnPhe: 1.293 ± 0.015	2.561GlnGly: 2.561 ± 0.022	1.154GlnHis: 1.154 ± 0.017	1.838GlnIle: 1.838 ± 0.021	1.95GlnLys: 1.95 ± 0.022	3.548GlnLeu: 3.548 ± 0.03	0.917GlnMet: 0.917 ± 0.016	1.503GlnAsn: 1.503 ± 0.02	2.549GlnPro: 2.549 ± 0.028	2.419GlnGln: 2.419 ± 0.047	2.663GlnArg: 2.663 ± 0.026	3.104GlnSer: 3.104 ± 0.029	2.307GlnThr: 2.307 ± 0.021	2.37GlnVal: 2.37 ± 0.023	0.57GlnTrp: 0.57 ± 0.009	1.14GlnTyr: 1.14 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.799ArgAla: 4.799 ± 0.032	0.75ArgCys: 0.75 ± 0.013	3.675ArgAsp: 3.675 ± 0.033	3.731ArgGlu: 3.731 ± 0.031	2.153ArgPhe: 2.153 ± 0.021	3.934ArgGly: 3.934 ± 0.034	1.683ArgHis: 1.683 ± 0.02	2.912ArgIle: 2.912 ± 0.024	3.263ArgLys: 3.263 ± 0.029	5.662ArgLeu: 5.662 ± 0.033	1.336ArgMet: 1.336 ± 0.015	2.307ArgAsn: 2.307 ± 0.019	3.526ArgPro: 3.526 ± 0.031	2.832ArgGln: 2.832 ± 0.024	5.287ArgArg: 5.287 ± 0.044	4.568ArgSer: 4.568 ± 0.042	3.178ArgThr: 3.178 ± 0.024	3.52ArgVal: 3.52 ± 0.028	0.931ArgTrp: 0.931 ± 0.013	1.629ArgTyr: 1.629 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.606SerAla: 6.606 ± 0.036	0.935SerCys: 0.935 ± 0.015	4.203SerAsp: 4.203 ± 0.026	3.975SerGlu: 3.975 ± 0.03	2.93SerPhe: 2.93 ± 0.025	5.583SerGly: 5.583 ± 0.032	1.935SerHis: 1.935 ± 0.02	3.847SerIle: 3.847 ± 0.03	3.692SerLys: 3.692 ± 0.028	7.119SerLeu: 7.119 ± 0.045	1.758SerMet: 1.758 ± 0.019	2.902SerAsn: 2.902 ± 0.026	5.216SerPro: 5.216 ± 0.048	3.315SerGln: 3.315 ± 0.028	5.083SerArg: 5.083 ± 0.04	8.101SerSer: 8.101 ± 0.065	5.216SerThr: 5.216 ± 0.039	4.608SerVal: 4.608 ± 0.03	1.162SerTrp: 1.162 ± 0.016	1.984SerTyr: 1.984 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.322ThrAla: 5.322 ± 0.035	0.761ThrCys: 0.761 ± 0.012	2.825ThrAsp: 2.825 ± 0.024	3.04ThrGlu: 3.04 ± 0.023	2.096ThrPhe: 2.096 ± 0.021	4.203ThrGly: 4.203 ± 0.034	1.24ThrHis: 1.24 ± 0.016	2.964ThrIle: 2.964 ± 0.026	2.633ThrLys: 2.633 ± 0.026	5.073ThrLeu: 5.073 ± 0.031	1.225ThrMet: 1.225 ± 0.015	2.048ThrAsn: 2.048 ± 0.021	4.126ThrPro: 4.126 ± 0.036	2.061ThrGln: 2.061 ± 0.022	3.168ThrArg: 3.168 ± 0.026	5.016ThrSer: 5.016 ± 0.033	4.123ThrThr: 4.123 ± 0.05	3.737ThrVal: 3.737 ± 0.028	0.86ThrTrp: 0.86 ± 0.013	1.556ThrTyr: 1.556 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.707ValAla: 5.707 ± 0.039	0.91ValCys: 0.91 ± 0.012	3.983ValAsp: 3.983 ± 0.032	3.805ValGlu: 3.805 ± 0.031	2.551ValPhe: 2.551 ± 0.024	4.175ValGly: 4.175 ± 0.036	1.436ValHis: 1.436 ± 0.017	2.932ValIle: 2.932 ± 0.031	2.928ValLys: 2.928 ± 0.026	5.785ValLeu: 5.785 ± 0.042	1.385ValMet: 1.385 ± 0.016	2.273ValAsn: 2.273 ± 0.022	3.641ValPro: 3.641 ± 0.029	2.43ValGln: 2.43 ± 0.023	3.519ValArg: 3.519 ± 0.031	4.695ValSer: 4.695 ± 0.031	3.494ValThr: 3.494 ± 0.026	4.583ValVal: 4.583 ± 0.04	0.866ValTrp: 0.866 ± 0.013	1.725ValTyr: 1.725 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.219TrpAla: 1.219 ± 0.016	0.213TrpCys: 0.213 ± 0.007	0.945TrpAsp: 0.945 ± 0.014	0.834TrpGlu: 0.834 ± 0.013	0.535TrpPhe: 0.535 ± 0.01	0.935TrpGly: 0.935 ± 0.013	0.399TrpHis: 0.399 ± 0.008	0.772TrpIle: 0.772 ± 0.014	0.789TrpLys: 0.789 ± 0.012	1.369TrpLeu: 1.369 ± 0.018	0.376TrpMet: 0.376 ± 0.008	0.642TrpAsn: 0.642 ± 0.012	0.636TrpPro: 0.636 ± 0.012	0.602TrpGln: 0.602 ± 0.01	0.963TrpArg: 0.963 ± 0.013	1.043TrpSer: 1.043 ± 0.012	0.943TrpThr: 0.943 ± 0.014	0.916TrpVal: 0.916 ± 0.013	0.296TrpTrp: 0.296 ± 0.008	0.42TrpTyr: 0.42 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.151TyrAla: 2.151 ± 0.023	0.427TyrCys: 0.427 ± 0.009	1.651TyrAsp: 1.651 ± 0.018	1.467TyrGlu: 1.467 ± 0.017	1.159TyrPhe: 1.159 ± 0.016	2.057TyrGly: 2.057 ± 0.02	0.723TyrHis: 0.723 ± 0.012	1.343TyrIle: 1.343 ± 0.014	1.139TyrLys: 1.139 ± 0.016	2.585TyrLeu: 2.585 ± 0.023	0.639TyrMet: 0.639 ± 0.01	1.092TyrAsn: 1.092 ± 0.015	1.358TyrPro: 1.358 ± 0.017	1.06TyrGln: 1.06 ± 0.016	1.621TyrArg: 1.621 ± 0.018	1.959TyrSer: 1.959 ± 0.019	1.535TyrThr: 1.535 ± 0.022	1.599TyrVal: 1.599 ± 0.017	0.458TyrTrp: 0.458 ± 0.01	0.889TyrTyr: 0.889 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11404 proteins (5535669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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