Amino acid dipepetide frequency for Fusarium sp. AF-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.767AlaAla: 8.767 ± 0.081	1.139AlaCys: 1.139 ± 0.015	4.191AlaAsp: 4.191 ± 0.025	5.2AlaGlu: 5.2 ± 0.057	3.193AlaPhe: 3.193 ± 0.024	5.641AlaGly: 5.641 ± 0.033	1.694AlaHis: 1.694 ± 0.016	4.456AlaIle: 4.456 ± 0.031	4.144AlaLys: 4.144 ± 0.03	7.727AlaLeu: 7.727 ± 0.04	2.025AlaMet: 2.025 ± 0.017	2.803AlaAsn: 2.803 ± 0.02	4.763AlaPro: 4.763 ± 0.045	3.255AlaGln: 3.255 ± 0.028	4.659AlaArg: 4.659 ± 0.026	6.987AlaSer: 6.987 ± 0.039	5.14AlaThr: 5.14 ± 0.027	5.36AlaVal: 5.36 ± 0.028	1.282AlaTrp: 1.282 ± 0.013	2.119AlaTyr: 2.119 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.971CysAla: 0.971 ± 0.013	0.264CysCys: 0.264 ± 0.008	0.726CysAsp: 0.726 ± 0.012	0.661CysGlu: 0.661 ± 0.011	0.589CysPhe: 0.589 ± 0.01	0.982CysGly: 0.982 ± 0.016	0.362CysHis: 0.362 ± 0.008	0.791CysIle: 0.791 ± 0.012	0.562CysLys: 0.562 ± 0.01	1.334CysLeu: 1.334 ± 0.015	0.277CysMet: 0.277 ± 0.006	0.452CysAsn: 0.452 ± 0.009	0.705CysPro: 0.705 ± 0.013	0.5CysGln: 0.5 ± 0.009	0.8CysArg: 0.8 ± 0.011	0.953CysSer: 0.953 ± 0.013	0.746CysThr: 0.746 ± 0.013	0.852CysVal: 0.852 ± 0.013	0.244CysTrp: 0.244 ± 0.006	0.379CysTyr: 0.379 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.747AspAla: 4.747 ± 0.031	0.691AspCys: 0.691 ± 0.014	4.66AspAsp: 4.66 ± 0.052	4.696AspGlu: 4.696 ± 0.039	2.295AspPhe: 2.295 ± 0.018	4.252AspGly: 4.252 ± 0.029	1.26AspHis: 1.26 ± 0.014	3.094AspIle: 3.094 ± 0.023	2.654AspLys: 2.654 ± 0.025	5.196AspLeu: 5.196 ± 0.031	1.38AspMet: 1.38 ± 0.013	1.963AspAsn: 1.963 ± 0.019	3.409AspPro: 3.409 ± 0.025	1.963AspGln: 1.963 ± 0.018	3.035AspArg: 3.035 ± 0.027	4.164AspSer: 4.164 ± 0.031	3.019AspThr: 3.019 ± 0.02	3.745AspVal: 3.745 ± 0.025	0.983AspTrp: 0.983 ± 0.012	1.609AspTyr: 1.609 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.699GluAla: 5.699 ± 0.064	0.699GluCys: 0.699 ± 0.011	4.296GluAsp: 4.296 ± 0.035	5.565GluGlu: 5.565 ± 0.06	2.037GluPhe: 2.037 ± 0.02	3.867GluGly: 3.867 ± 0.024	1.403GluHis: 1.403 ± 0.014	3.017GluIle: 3.017 ± 0.024	3.729GluLys: 3.729 ± 0.035	5.233GluLeu: 5.233 ± 0.031	1.535GluMet: 1.535 ± 0.015	2.276GluAsn: 2.276 ± 0.017	3.146GluPro: 3.146 ± 0.052	2.374GluGln: 2.374 ± 0.02	3.795GluArg: 3.795 ± 0.034	4.3GluSer: 4.3 ± 0.031	3.776GluThr: 3.776 ± 0.031	3.685GluVal: 3.685 ± 0.026	0.96GluTrp: 0.96 ± 0.012	1.689GluTyr: 1.689 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.051PheAla: 3.051 ± 0.023	0.614PheCys: 0.614 ± 0.009	2.361PheAsp: 2.361 ± 0.019	2.21PheGlu: 2.21 ± 0.016	1.724PhePhe: 1.724 ± 0.022	2.957PheGly: 2.957 ± 0.025	0.924PheHis: 0.924 ± 0.013	1.966PheIle: 1.966 ± 0.019	1.625PheLys: 1.625 ± 0.015	3.562PheLeu: 3.562 ± 0.032	0.851PheMet: 0.851 ± 0.012	1.49PheAsn: 1.49 ± 0.015	1.975PhePro: 1.975 ± 0.023	1.448PheGln: 1.448 ± 0.013	1.973PheArg: 1.973 ± 0.017	2.982PheSer: 2.982 ± 0.023	2.18PheThr: 2.18 ± 0.017	2.451PheVal: 2.451 ± 0.02	0.725PheTrp: 0.725 ± 0.01	1.135PheTyr: 1.135 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.2GlyAla: 5.2 ± 0.03	0.961GlyCys: 0.961 ± 0.014	3.806GlyAsp: 3.806 ± 0.03	3.684GlyGlu: 3.684 ± 0.025	2.969GlyPhe: 2.969 ± 0.025	5.547GlyGly: 5.547 ± 0.053	1.735GlyHis: 1.735 ± 0.016	3.674GlyIle: 3.674 ± 0.028	3.421GlyLys: 3.421 ± 0.028	6.252GlyLeu: 6.252 ± 0.034	1.635GlyMet: 1.635 ± 0.016	2.569GlyAsn: 2.569 ± 0.025	3.389GlyPro: 3.389 ± 0.025	2.651GlyGln: 2.651 ± 0.025	4.078GlyArg: 4.078 ± 0.029	5.687GlySer: 5.687 ± 0.068	4.033GlyThr: 4.033 ± 0.043	4.391GlyVal: 4.391 ± 0.03	1.277GlyTrp: 1.277 ± 0.018	2.182GlyTyr: 2.182 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.731HisAla: 1.731 ± 0.017	0.344HisCys: 0.344 ± 0.008	1.368HisAsp: 1.368 ± 0.016	1.356HisGlu: 1.356 ± 0.015	0.945HisPhe: 0.945 ± 0.012	1.763HisGly: 1.763 ± 0.019	0.872HisHis: 0.872 ± 0.017	1.214HisIle: 1.214 ± 0.015	0.926HisLys: 0.926 ± 0.012	2.294HisLeu: 2.294 ± 0.022	0.497HisMet: 0.497 ± 0.009	0.804HisAsn: 0.804 ± 0.012	1.564HisPro: 1.564 ± 0.018	0.993HisGln: 0.993 ± 0.012	1.505HisArg: 1.505 ± 0.017	1.681HisSer: 1.681 ± 0.019	1.192HisThr: 1.192 ± 0.016	1.473HisVal: 1.473 ± 0.016	0.379HisTrp: 0.379 ± 0.008	0.682HisTyr: 0.682 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.147IleAla: 4.147 ± 0.026	0.808IleCys: 0.808 ± 0.012	2.932IleAsp: 2.932 ± 0.023	2.952IleGlu: 2.952 ± 0.025	2.06IlePhe: 2.06 ± 0.02	3.31IleGly: 3.31 ± 0.029	1.199IleHis: 1.199 ± 0.014	2.684IleIle: 2.684 ± 0.027	2.268IleLys: 2.268 ± 0.019	4.655IleLeu: 4.655 ± 0.031	1.106IleMet: 1.106 ± 0.014	1.861IleAsn: 1.861 ± 0.017	3.026IlePro: 3.026 ± 0.021	1.94IleGln: 1.94 ± 0.018	2.821IleArg: 2.821 ± 0.019	3.785IleSer: 3.785 ± 0.024	2.948IleThr: 2.948 ± 0.039	3.219IleVal: 3.219 ± 0.023	0.819IleTrp: 0.819 ± 0.012	1.424IleTyr: 1.424 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.357LysAla: 4.357 ± 0.028	0.547LysCys: 0.547 ± 0.01	2.985LysAsp: 2.985 ± 0.026	3.422LysGlu: 3.422 ± 0.031	1.527LysPhe: 1.527 ± 0.014	3.058LysGly: 3.058 ± 0.023	1.161LysHis: 1.161 ± 0.013	2.248LysIle: 2.248 ± 0.019	3.283LysLys: 3.283 ± 0.038	4.112LysLeu: 4.112 ± 0.027	1.068LysMet: 1.068 ± 0.012	1.735LysAsn: 1.735 ± 0.016	2.864LysPro: 2.864 ± 0.029	1.75LysGln: 1.75 ± 0.019	3.201LysArg: 3.201 ± 0.026	3.367LysSer: 3.367 ± 0.027	2.991LysThr: 2.991 ± 0.023	2.907LysVal: 2.907 ± 0.023	0.727LysTrp: 0.727 ± 0.011	1.361LysTyr: 1.361 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.912LeuAla: 7.912 ± 0.042	1.286LeuCys: 1.286 ± 0.015	5.369LeuAsp: 5.369 ± 0.033	5.641LeuGlu: 5.641 ± 0.036	3.448LeuPhe: 3.448 ± 0.029	6.198LeuGly: 6.198 ± 0.041	2.171LeuHis: 2.171 ± 0.02	4.082LeuIle: 4.082 ± 0.028	4.182LeuLys: 4.182 ± 0.033	8.309LeuLeu: 8.309 ± 0.053	1.88LeuMet: 1.88 ± 0.019	3.12LeuAsn: 3.12 ± 0.022	5.292LeuPro: 5.292 ± 0.03	3.665LeuGln: 3.665 ± 0.029	5.541LeuArg: 5.541 ± 0.031	7.098LeuSer: 7.098 ± 0.042	4.835LeuThr: 4.835 ± 0.03	5.632LeuVal: 5.632 ± 0.038	1.312LeuTrp: 1.312 ± 0.016	2.372LeuTyr: 2.372 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.383MetAla: 2.383 ± 0.018	0.269MetCys: 0.269 ± 0.006	1.318MetAsp: 1.318 ± 0.014	1.31MetGlu: 1.31 ± 0.014	0.795MetPhe: 0.795 ± 0.011	1.549MetGly: 1.549 ± 0.017	0.477MetHis: 0.477 ± 0.009	1.059MetIle: 1.059 ± 0.013	1.023MetLys: 1.023 ± 0.011	1.882MetLeu: 1.882 ± 0.018	0.635MetMet: 0.635 ± 0.009	0.791MetAsn: 0.791 ± 0.012	1.326MetPro: 1.326 ± 0.014	0.791MetGln: 0.791 ± 0.01	1.273MetArg: 1.273 ± 0.014	1.933MetSer: 1.933 ± 0.02	1.39MetThr: 1.39 ± 0.014	1.381MetVal: 1.381 ± 0.015	0.295MetTrp: 0.295 ± 0.007	0.523MetTyr: 0.523 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.93AsnAla: 2.93 ± 0.021	0.481AsnCys: 0.481 ± 0.009	1.995AsnAsp: 1.995 ± 0.017	2.004AsnGlu: 2.004 ± 0.02	1.366AsnPhe: 1.366 ± 0.014	2.923AsnGly: 2.923 ± 0.027	0.845AsnHis: 0.845 ± 0.012	1.981AsnIle: 1.981 ± 0.019	1.634AsnLys: 1.634 ± 0.018	3.302AsnLeu: 3.302 ± 0.024	0.878AsnMet: 0.878 ± 0.012	1.471AsnAsn: 1.471 ± 0.022	2.425AsnPro: 2.425 ± 0.02	1.322AsnGln: 1.322 ± 0.016	1.861AsnArg: 1.861 ± 0.018	2.611AsnSer: 2.611 ± 0.021	2.086AsnThr: 2.086 ± 0.019	2.272AsnVal: 2.272 ± 0.02	0.597AsnTrp: 0.597 ± 0.009	1.057AsnTyr: 1.057 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	4.999ProAla: 4.999 ± 0.049	0.562ProCys: 0.562 ± 0.011	3.42ProAsp: 3.42 ± 0.025	4.189ProGlu: 4.189 ± 0.035	2.095ProPhe: 2.095 ± 0.02	4.047ProGly: 4.047 ± 0.049	1.249ProHis: 1.249 ± 0.015	2.569ProIle: 2.569 ± 0.024	2.756ProLys: 2.756 ± 0.025	4.639ProLeu: 4.639 ± 0.03	1.103ProMet: 1.103 ± 0.013	2.172ProAsn: 2.172 ± 0.018	4.765ProPro: 4.765 ± 0.053	2.444ProGln: 2.444 ± 0.027	3.392ProArg: 3.392 ± 0.03	5.655ProSer: 5.655 ± 0.039	3.894ProThr: 3.894 ± 0.037	3.587ProVal: 3.587 ± 0.031	0.836ProTrp: 0.836 ± 0.013	1.475ProTyr: 1.475 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.443GlnAla: 3.443 ± 0.027	0.442GlnCys: 0.442 ± 0.008	2.256GlnAsp: 2.256 ± 0.02	2.448GlnGlu: 2.448 ± 0.023	1.272GlnPhe: 1.272 ± 0.014	2.527GlnGly: 2.527 ± 0.023	1.041GlnHis: 1.041 ± 0.014	1.774GlnIle: 1.774 ± 0.018	1.847GlnLys: 1.847 ± 0.018	3.386GlnLeu: 3.386 ± 0.025	0.86GlnMet: 0.86 ± 0.012	1.413GlnAsn: 1.413 ± 0.015	2.557GlnPro: 2.557 ± 0.034	2.297GlnGln: 2.297 ± 0.04	2.478GlnArg: 2.478 ± 0.02	2.873GlnSer: 2.873 ± 0.027	2.266GlnThr: 2.266 ± 0.021	2.291GlnVal: 2.291 ± 0.019	0.59GlnTrp: 0.59 ± 0.01	1.091GlnTyr: 1.091 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.438ArgAla: 4.438 ± 0.026	0.749ArgCys: 0.749 ± 0.011	3.501ArgAsp: 3.501 ± 0.034	3.682ArgGlu: 3.682 ± 0.031	2.165ArgPhe: 2.165 ± 0.018	3.676ArgGly: 3.676 ± 0.025	1.584ArgHis: 1.584 ± 0.017	2.844ArgIle: 2.844 ± 0.024	3.206ArgLys: 3.206 ± 0.025	5.453ArgLeu: 5.453 ± 0.031	1.294ArgMet: 1.294 ± 0.015	2.169ArgAsn: 2.169 ± 0.019	3.483ArgPro: 3.483 ± 0.032	2.523ArgGln: 2.523 ± 0.023	4.982ArgArg: 4.982 ± 0.042	4.451ArgSer: 4.451 ± 0.035	3.101ArgThr: 3.101 ± 0.023	3.392ArgVal: 3.392 ± 0.024	1.009ArgTrp: 1.009 ± 0.013	1.657ArgTyr: 1.657 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.09SerAla: 6.09 ± 0.034	0.929SerCys: 0.929 ± 0.015	4.264SerAsp: 4.264 ± 0.032	4.164SerGlu: 4.164 ± 0.033	3.058SerPhe: 3.058 ± 0.024	5.45SerGly: 5.45 ± 0.077	1.863SerHis: 1.863 ± 0.02	3.964SerIle: 3.964 ± 0.029	3.658SerLys: 3.658 ± 0.025	7.053SerLeu: 7.053 ± 0.034	1.743SerMet: 1.743 ± 0.016	2.864SerAsn: 2.864 ± 0.022	5.153SerPro: 5.153 ± 0.048	3.127SerGln: 3.127 ± 0.027	4.834SerArg: 4.834 ± 0.033	8.024SerSer: 8.024 ± 0.058	5.365SerThr: 5.365 ± 0.046	4.504SerVal: 4.504 ± 0.028	1.256SerTrp: 1.256 ± 0.016	2.039SerTyr: 2.039 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.043ThrAla: 5.043 ± 0.036	0.819ThrCys: 0.819 ± 0.011	2.906ThrAsp: 2.906 ± 0.025	3.363ThrGlu: 3.363 ± 0.036	2.284ThrPhe: 2.284 ± 0.021	4.182ThrGly: 4.182 ± 0.033	1.233ThrHis: 1.233 ± 0.014	3.187ThrIle: 3.187 ± 0.036	2.739ThrLys: 2.739 ± 0.022	5.262ThrLeu: 5.262 ± 0.028	1.241ThrMet: 1.241 ± 0.013	2.079ThrAsn: 2.079 ± 0.018	4.246ThrPro: 4.246 ± 0.042	2.06ThrGln: 2.06 ± 0.02	3.135ThrArg: 3.135 ± 0.02	5.108ThrSer: 5.108 ± 0.042	4.387ThrThr: 4.387 ± 0.056	3.809ThrVal: 3.809 ± 0.043	0.974ThrTrp: 0.974 ± 0.013	1.623ThrTyr: 1.623 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.289ValAla: 5.289 ± 0.031	0.873ValCys: 0.873 ± 0.013	3.818ValAsp: 3.818 ± 0.024	4.039ValGlu: 4.039 ± 0.028	2.553ValPhe: 2.553 ± 0.024	4.05ValGly: 4.05 ± 0.029	1.364ValHis: 1.364 ± 0.014	3.099ValIle: 3.099 ± 0.026	2.99ValLys: 2.99 ± 0.022	5.579ValLeu: 5.579 ± 0.037	1.357ValMet: 1.357 ± 0.016	2.238ValAsn: 2.238 ± 0.02	3.625ValPro: 3.625 ± 0.028	2.345ValGln: 2.345 ± 0.02	3.365ValArg: 3.365 ± 0.023	4.632ValSer: 4.632 ± 0.027	3.693ValThr: 3.693 ± 0.044	4.446ValVal: 4.446 ± 0.032	0.926ValTrp: 0.926 ± 0.013	1.766ValTyr: 1.766 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.261TrpAla: 1.261 ± 0.016	0.225TrpCys: 0.225 ± 0.006	0.97TrpAsp: 0.97 ± 0.012	0.933TrpGlu: 0.933 ± 0.012	0.622TrpPhe: 0.622 ± 0.01	1.058TrpGly: 1.058 ± 0.014	0.395TrpHis: 0.395 ± 0.009	0.86TrpIle: 0.86 ± 0.013	0.89TrpLys: 0.89 ± 0.012	1.476TrpLeu: 1.476 ± 0.016	0.404TrpMet: 0.404 ± 0.008	0.664TrpAsn: 0.664 ± 0.011	0.686TrpPro: 0.686 ± 0.011	0.595TrpGln: 0.595 ± 0.01	0.998TrpArg: 0.998 ± 0.012	1.135TrpSer: 1.135 ± 0.014	1.047TrpThr: 1.047 ± 0.012	0.998TrpVal: 0.998 ± 0.014	0.314TrpTrp: 0.314 ± 0.006	0.468TrpTyr: 0.468 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.087TyrAla: 2.087 ± 0.018	0.451TyrCys: 0.451 ± 0.008	1.673TyrAsp: 1.673 ± 0.018	1.563TyrGlu: 1.563 ± 0.015	1.204TyrPhe: 1.204 ± 0.012	2.106TyrGly: 2.106 ± 0.019	0.75TyrHis: 0.75 ± 0.01	1.403TyrIle: 1.403 ± 0.018	1.134TyrLys: 1.134 ± 0.015	2.638TyrLeu: 2.638 ± 0.022	0.631TyrMet: 0.631 ± 0.01	1.107TyrAsn: 1.107 ± 0.014	1.453TyrPro: 1.453 ± 0.016	1.106TyrGln: 1.106 ± 0.013	1.633TyrArg: 1.633 ± 0.018	1.978TyrSer: 1.978 ± 0.015	1.589TyrThr: 1.589 ± 0.02	1.653TyrVal: 1.653 ± 0.017	0.494TyrTrp: 0.494 ± 0.009	0.919TyrTyr: 0.919 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 15273 proteins (7097187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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