Amino acid dipepetide frequency for Streptococcus phage Javan102

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.155AlaAla: 4.155 ± 0.671
0.662AlaCys: 0.662 ± 0.2
4.216AlaAsp: 4.216 ± 0.514
4.155AlaGlu: 4.155 ± 0.493
2.71AlaPhe: 2.71 ± 0.433
5.239AlaGly: 5.239 ± 0.546
0.903AlaHis: 0.903 ± 0.206
5.54AlaIle: 5.54 ± 0.87
5.059AlaLys: 5.059 ± 0.466
4.878AlaLeu: 4.878 ± 0.685
1.445AlaMet: 1.445 ± 0.299
3.192AlaAsn: 3.192 ± 0.513
1.385AlaPro: 1.385 ± 0.277
2.228AlaGln: 2.228 ± 0.331
3.011AlaArg: 3.011 ± 0.492
3.553AlaSer: 3.553 ± 0.425
2.529AlaThr: 2.529 ± 0.432
3.674AlaVal: 3.674 ± 0.478
0.602AlaTrp: 0.602 ± 0.16
2.77AlaTyr: 2.77 ± 0.495
0.0AlaXaa: 0.0 ± 0.0
Cys
0.301CysAla: 0.301 ± 0.148
0.361CysCys: 0.361 ± 0.121
0.723CysAsp: 0.723 ± 0.189
1.024CysGlu: 1.024 ± 0.279
0.662CysPhe: 0.662 ± 0.175
1.024CysGly: 1.024 ± 0.24
0.12CysHis: 0.12 ± 0.081
0.602CysIle: 0.602 ± 0.173
0.903CysLys: 0.903 ± 0.196
1.024CysLeu: 1.024 ± 0.202
0.12CysMet: 0.12 ± 0.121
0.602CysAsn: 0.602 ± 0.17
0.482CysPro: 0.482 ± 0.149
0.422CysGln: 0.422 ± 0.18
0.602CysArg: 0.602 ± 0.202
0.662CysSer: 0.662 ± 0.157
0.783CysThr: 0.783 ± 0.27
0.723CysVal: 0.723 ± 0.167
0.06CysTrp: 0.06 ± 0.056
0.662CysTyr: 0.662 ± 0.197
0.0CysXaa: 0.0 ± 0.0
Asp
4.456AspAla: 4.456 ± 0.476
0.843AspCys: 0.843 ± 0.227
2.83AspAsp: 2.83 ± 0.516
5.54AspGlu: 5.54 ± 0.62
3.071AspPhe: 3.071 ± 0.471
4.758AspGly: 4.758 ± 0.555
0.843AspHis: 0.843 ± 0.229
5.781AspIle: 5.781 ± 0.525
5.902AspLys: 5.902 ± 0.436
4.697AspLeu: 4.697 ± 0.577
1.506AspMet: 1.506 ± 0.316
2.77AspAsn: 2.77 ± 0.482
1.927AspPro: 1.927 ± 0.281
0.602AspGln: 0.602 ± 0.166
3.312AspArg: 3.312 ± 0.405
3.312AspSer: 3.312 ± 0.435
3.071AspThr: 3.071 ± 0.529
3.192AspVal: 3.192 ± 0.428
0.903AspTrp: 0.903 ± 0.209
2.529AspTyr: 2.529 ± 0.384
0.0AspXaa: 0.0 ± 0.0
Glu
3.613GluAla: 3.613 ± 0.411
0.964GluCys: 0.964 ± 0.209
4.155GluAsp: 4.155 ± 0.494
7.648GluGlu: 7.648 ± 0.984
2.951GluPhe: 2.951 ± 0.517
5.059GluGly: 5.059 ± 0.516
1.024GluHis: 1.024 ± 0.255
7.468GluIle: 7.468 ± 0.661
8.251GluLys: 8.251 ± 0.681
8.13GluLeu: 8.13 ± 0.604
3.132GluMet: 3.132 ± 0.381
5.3GluAsn: 5.3 ± 0.546
1.566GluPro: 1.566 ± 0.303
2.288GluGln: 2.288 ± 0.371
3.071GluArg: 3.071 ± 0.602
3.674GluSer: 3.674 ± 0.495
3.553GluThr: 3.553 ± 0.425
5.54GluVal: 5.54 ± 0.695
0.964GluTrp: 0.964 ± 0.239
3.132GluTyr: 3.132 ± 0.434
0.0GluXaa: 0.0 ± 0.0
Phe
2.409PheAla: 2.409 ± 0.376
0.482PheCys: 0.482 ± 0.17
3.252PheAsp: 3.252 ± 0.46
3.312PheGlu: 3.312 ± 0.441
1.204PhePhe: 1.204 ± 0.241
2.65PheGly: 2.65 ± 0.434
0.783PheHis: 0.783 ± 0.257
3.132PheIle: 3.132 ± 0.382
3.613PheLys: 3.613 ± 0.399
3.071PheLeu: 3.071 ± 0.42
1.024PheMet: 1.024 ± 0.228
2.168PheAsn: 2.168 ± 0.412
1.204PhePro: 1.204 ± 0.323
0.783PheGln: 0.783 ± 0.195
1.927PheArg: 1.927 ± 0.396
2.409PheSer: 2.409 ± 0.269
1.626PheThr: 1.626 ± 0.3
2.409PheVal: 2.409 ± 0.42
0.482PheTrp: 0.482 ± 0.156
1.746PheTyr: 1.746 ± 0.367
0.0PheXaa: 0.0 ± 0.0
Gly
3.914GlyAla: 3.914 ± 0.629
0.662GlyCys: 0.662 ± 0.196
3.613GlyAsp: 3.613 ± 0.469
4.276GlyGlu: 4.276 ± 0.427
2.409GlyPhe: 2.409 ± 0.336
4.276GlyGly: 4.276 ± 0.576
1.204GlyHis: 1.204 ± 0.244
5.059GlyIle: 5.059 ± 0.43
6.926GlyLys: 6.926 ± 0.597
5.42GlyLeu: 5.42 ± 0.56
1.987GlyMet: 1.987 ± 0.291
3.734GlyAsn: 3.734 ± 0.593
0.783GlyPro: 0.783 ± 0.244
1.265GlyGln: 1.265 ± 0.262
2.65GlyArg: 2.65 ± 0.418
3.011GlySer: 3.011 ± 0.497
4.336GlyThr: 4.336 ± 0.46
3.613GlyVal: 3.613 ± 0.528
0.662GlyTrp: 0.662 ± 0.173
2.77GlyTyr: 2.77 ± 0.35
0.0GlyXaa: 0.0 ± 0.0
His
0.903HisAla: 0.903 ± 0.225
0.0HisCys: 0.0 ± 0.0
0.964HisAsp: 0.964 ± 0.259
0.843HisGlu: 0.843 ± 0.227
0.602HisPhe: 0.602 ± 0.157
1.325HisGly: 1.325 ± 0.273
0.542HisHis: 0.542 ± 0.172
1.385HisIle: 1.385 ± 0.277
1.144HisLys: 1.144 ± 0.265
1.746HisLeu: 1.746 ± 0.238
0.301HisMet: 0.301 ± 0.138
0.723HisAsn: 0.723 ± 0.206
0.964HisPro: 0.964 ± 0.219
0.482HisGln: 0.482 ± 0.17
0.662HisArg: 0.662 ± 0.189
1.084HisSer: 1.084 ± 0.232
0.662HisThr: 0.662 ± 0.238
0.903HisVal: 0.903 ± 0.205
0.181HisTrp: 0.181 ± 0.106
0.843HisTyr: 0.843 ± 0.2
0.0HisXaa: 0.0 ± 0.0
Ile
5.661IleAla: 5.661 ± 0.556
1.265IleCys: 1.265 ± 0.262
5.36IleAsp: 5.36 ± 0.496
7.106IleGlu: 7.106 ± 0.721
3.854IlePhe: 3.854 ± 0.37
3.674IleGly: 3.674 ± 0.491
1.325IleHis: 1.325 ± 0.266
5.42IleIle: 5.42 ± 0.67
7.046IleLys: 7.046 ± 0.814
6.444IleLeu: 6.444 ± 0.564
1.867IleMet: 1.867 ± 0.462
4.818IleAsn: 4.818 ± 0.577
2.65IlePro: 2.65 ± 0.398
2.168IleGln: 2.168 ± 0.324
3.312IleArg: 3.312 ± 0.546
5.962IleSer: 5.962 ± 0.513
4.637IleThr: 4.637 ± 0.522
3.734IleVal: 3.734 ± 0.437
1.325IleTrp: 1.325 ± 0.333
2.71IleTyr: 2.71 ± 0.346
0.0IleXaa: 0.0 ± 0.0
Lys
5.661LysAla: 5.661 ± 0.534
1.204LysCys: 1.204 ± 0.27
6.323LysAsp: 6.323 ± 0.639
8.07LysGlu: 8.07 ± 0.657
3.372LysPhe: 3.372 ± 0.322
4.998LysGly: 4.998 ± 0.53
0.964LysHis: 0.964 ± 0.221
6.926LysIle: 6.926 ± 0.64
7.468LysLys: 7.468 ± 0.653
7.106LysLeu: 7.106 ± 0.672
1.807LysMet: 1.807 ± 0.392
3.975LysAsn: 3.975 ± 0.581
3.192LysPro: 3.192 ± 0.501
3.553LysGln: 3.553 ± 0.426
3.734LysArg: 3.734 ± 0.518
5.962LysSer: 5.962 ± 0.608
4.276LysThr: 4.276 ± 0.546
5.36LysVal: 5.36 ± 0.514
1.265LysTrp: 1.265 ± 0.262
3.975LysTyr: 3.975 ± 0.55
0.0LysXaa: 0.0 ± 0.0
Leu
4.456LeuAla: 4.456 ± 0.636
0.903LeuCys: 0.903 ± 0.224
5.42LeuAsp: 5.42 ± 0.593
7.769LeuGlu: 7.769 ± 0.871
3.071LeuPhe: 3.071 ± 0.506
4.998LeuGly: 4.998 ± 0.576
0.903LeuHis: 0.903 ± 0.256
6.926LeuIle: 6.926 ± 0.824
6.504LeuLys: 6.504 ± 0.634
6.865LeuLeu: 6.865 ± 0.535
2.349LeuMet: 2.349 ± 0.511
4.095LeuAsn: 4.095 ± 0.443
2.951LeuPro: 2.951 ± 0.36
2.71LeuGln: 2.71 ± 0.483
3.071LeuArg: 3.071 ± 0.345
7.468LeuSer: 7.468 ± 0.618
3.975LeuThr: 3.975 ± 0.466
4.818LeuVal: 4.818 ± 0.494
0.542LeuTrp: 0.542 ± 0.126
3.493LeuTyr: 3.493 ± 0.548
0.0LeuXaa: 0.0 ± 0.0
Met
1.506MetAla: 1.506 ± 0.266
0.361MetCys: 0.361 ± 0.145
1.867MetAsp: 1.867 ± 0.372
2.228MetGlu: 2.228 ± 0.309
0.783MetPhe: 0.783 ± 0.216
1.506MetGly: 1.506 ± 0.302
0.181MetHis: 0.181 ± 0.099
1.566MetIle: 1.566 ± 0.31
2.71MetLys: 2.71 ± 0.385
2.048MetLeu: 2.048 ± 0.338
0.602MetMet: 0.602 ± 0.191
1.927MetAsn: 1.927 ± 0.28
0.723MetPro: 0.723 ± 0.2
0.723MetGln: 0.723 ± 0.192
0.964MetArg: 0.964 ± 0.197
2.048MetSer: 2.048 ± 0.276
1.566MetThr: 1.566 ± 0.34
1.566MetVal: 1.566 ± 0.283
0.301MetTrp: 0.301 ± 0.138
1.144MetTyr: 1.144 ± 0.281
0.0MetXaa: 0.0 ± 0.0
Asn
4.336AsnAla: 4.336 ± 0.579
0.602AsnCys: 0.602 ± 0.203
3.372AsnAsp: 3.372 ± 0.637
3.975AsnGlu: 3.975 ± 0.55
1.927AsnPhe: 1.927 ± 0.406
5.119AsnGly: 5.119 ± 0.57
1.325AsnHis: 1.325 ± 0.281
4.697AsnIle: 4.697 ± 0.57
4.577AsnLys: 4.577 ± 0.417
3.914AsnLeu: 3.914 ± 0.387
1.325AsnMet: 1.325 ± 0.271
2.529AsnAsn: 2.529 ± 0.324
1.927AsnPro: 1.927 ± 0.323
1.686AsnGln: 1.686 ± 0.313
2.77AsnArg: 2.77 ± 0.476
3.493AsnSer: 3.493 ± 0.598
3.011AsnThr: 3.011 ± 0.432
2.71AsnVal: 2.71 ± 0.313
0.301AsnTrp: 0.301 ± 0.139
1.927AsnTyr: 1.927 ± 0.369
0.0AsnXaa: 0.0 ± 0.0
Pro
1.024ProAla: 1.024 ± 0.237
0.422ProCys: 0.422 ± 0.208
1.626ProAsp: 1.626 ± 0.284
2.288ProGlu: 2.288 ± 0.362
1.686ProPhe: 1.686 ± 0.298
1.084ProGly: 1.084 ± 0.225
0.723ProHis: 0.723 ± 0.212
2.288ProIle: 2.288 ± 0.366
2.349ProLys: 2.349 ± 0.333
1.686ProLeu: 1.686 ± 0.326
1.084ProMet: 1.084 ± 0.257
2.048ProAsn: 2.048 ± 0.377
1.204ProPro: 1.204 ± 0.223
1.204ProGln: 1.204 ± 0.236
1.144ProArg: 1.144 ± 0.236
2.288ProSer: 2.288 ± 0.333
1.987ProThr: 1.987 ± 0.306
1.506ProVal: 1.506 ± 0.289
0.361ProTrp: 0.361 ± 0.169
1.867ProTyr: 1.867 ± 0.399
0.0ProXaa: 0.0 ± 0.0
Gln
2.349GlnAla: 2.349 ± 0.291
0.422GlnCys: 0.422 ± 0.149
1.325GlnAsp: 1.325 ± 0.282
2.048GlnGlu: 2.048 ± 0.437
1.084GlnPhe: 1.084 ± 0.198
1.385GlnGly: 1.385 ± 0.306
0.662GlnHis: 0.662 ± 0.207
2.349GlnIle: 2.349 ± 0.353
3.192GlnLys: 3.192 ± 0.377
2.168GlnLeu: 2.168 ± 0.381
1.204GlnMet: 1.204 ± 0.282
2.048GlnAsn: 2.048 ± 0.309
1.204GlnPro: 1.204 ± 0.237
1.325GlnGln: 1.325 ± 0.269
1.265GlnArg: 1.265 ± 0.254
1.385GlnSer: 1.385 ± 0.341
0.964GlnThr: 0.964 ± 0.224
1.746GlnVal: 1.746 ± 0.315
0.482GlnTrp: 0.482 ± 0.187
0.783GlnTyr: 0.783 ± 0.201
0.0GlnXaa: 0.0 ± 0.0
Arg
2.59ArgAla: 2.59 ± 0.416
0.662ArgCys: 0.662 ± 0.164
2.59ArgAsp: 2.59 ± 0.375
3.252ArgGlu: 3.252 ± 0.368
1.566ArgPhe: 1.566 ± 0.25
1.686ArgGly: 1.686 ± 0.343
0.542ArgHis: 0.542 ± 0.161
3.553ArgIle: 3.553 ± 0.589
4.035ArgLys: 4.035 ± 0.429
3.493ArgLeu: 3.493 ± 0.436
1.686ArgMet: 1.686 ± 0.246
2.228ArgAsn: 2.228 ± 0.38
1.084ArgPro: 1.084 ± 0.249
1.626ArgGln: 1.626 ± 0.324
1.867ArgArg: 1.867 ± 0.462
2.168ArgSer: 2.168 ± 0.375
2.59ArgThr: 2.59 ± 0.335
3.011ArgVal: 3.011 ± 0.474
0.723ArgTrp: 0.723 ± 0.247
1.445ArgTyr: 1.445 ± 0.241
0.0ArgXaa: 0.0 ± 0.0
Ser
4.456SerAla: 4.456 ± 0.557
0.361SerCys: 0.361 ± 0.136
4.216SerAsp: 4.216 ± 0.526
4.697SerGlu: 4.697 ± 0.472
2.469SerPhe: 2.469 ± 0.404
4.818SerGly: 4.818 ± 0.406
1.265SerHis: 1.265 ± 0.292
5.3SerIle: 5.3 ± 0.727
4.818SerLys: 4.818 ± 0.6
5.902SerLeu: 5.902 ± 0.596
1.867SerMet: 1.867 ± 0.472
3.192SerAsn: 3.192 ± 0.452
1.626SerPro: 1.626 ± 0.295
1.626SerGln: 1.626 ± 0.317
1.927SerArg: 1.927 ± 0.258
5.661SerSer: 5.661 ± 0.847
3.493SerThr: 3.493 ± 0.446
3.794SerVal: 3.794 ± 0.502
0.964SerTrp: 0.964 ± 0.258
2.65SerTyr: 2.65 ± 0.572
0.0SerXaa: 0.0 ± 0.0
Thr
3.312ThrAla: 3.312 ± 0.665
0.301ThrCys: 0.301 ± 0.159
3.071ThrAsp: 3.071 ± 0.428
3.975ThrGlu: 3.975 ± 0.492
1.566ThrPhe: 1.566 ± 0.329
3.132ThrGly: 3.132 ± 0.38
1.024ThrHis: 1.024 ± 0.282
4.818ThrIle: 4.818 ± 0.538
4.577ThrLys: 4.577 ± 0.533
4.396ThrLeu: 4.396 ± 0.448
1.144ThrMet: 1.144 ± 0.239
3.132ThrAsn: 3.132 ± 0.412
1.746ThrPro: 1.746 ± 0.352
0.843ThrGln: 0.843 ± 0.227
1.807ThrArg: 1.807 ± 0.375
3.854ThrSer: 3.854 ± 0.524
2.77ThrThr: 2.77 ± 0.531
3.734ThrVal: 3.734 ± 0.732
0.422ThrTrp: 0.422 ± 0.161
1.867ThrTyr: 1.867 ± 0.344
0.0ThrXaa: 0.0 ± 0.0
Val
3.433ValAla: 3.433 ± 0.511
0.482ValCys: 0.482 ± 0.165
4.216ValAsp: 4.216 ± 0.511
4.577ValGlu: 4.577 ± 0.492
2.168ValPhe: 2.168 ± 0.398
2.409ValGly: 2.409 ± 0.544
0.903ValHis: 0.903 ± 0.203
4.095ValIle: 4.095 ± 0.562
5.119ValLys: 5.119 ± 0.607
5.42ValLeu: 5.42 ± 0.45
0.843ValMet: 0.843 ± 0.205
3.674ValAsn: 3.674 ± 0.433
1.746ValPro: 1.746 ± 0.24
1.867ValGln: 1.867 ± 0.344
2.951ValArg: 2.951 ± 0.365
3.975ValSer: 3.975 ± 0.444
3.132ValThr: 3.132 ± 0.393
3.372ValVal: 3.372 ± 0.399
0.843ValTrp: 0.843 ± 0.263
2.891ValTyr: 2.891 ± 0.422
0.0ValXaa: 0.0 ± 0.0
Trp
0.602TrpAla: 0.602 ± 0.187
0.301TrpCys: 0.301 ± 0.148
0.602TrpAsp: 0.602 ± 0.175
1.024TrpGlu: 1.024 ± 0.273
0.482TrpPhe: 0.482 ± 0.154
0.723TrpGly: 0.723 ± 0.204
0.482TrpHis: 0.482 ± 0.167
0.301TrpIle: 0.301 ± 0.143
0.843TrpLys: 0.843 ± 0.204
1.204TrpLeu: 1.204 ± 0.243
0.361TrpMet: 0.361 ± 0.136
0.903TrpAsn: 0.903 ± 0.246
0.12TrpPro: 0.12 ± 0.082
0.422TrpGln: 0.422 ± 0.158
0.662TrpArg: 0.662 ± 0.179
0.723TrpSer: 0.723 ± 0.179
0.422TrpThr: 0.422 ± 0.131
0.783TrpVal: 0.783 ± 0.246
0.06TrpTrp: 0.06 ± 0.064
0.662TrpTyr: 0.662 ± 0.168
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.77TyrAla: 2.77 ± 0.446
0.602TyrCys: 0.602 ± 0.169
2.108TyrAsp: 2.108 ± 0.367
3.674TyrGlu: 3.674 ± 0.521
2.048TyrPhe: 2.048 ± 0.371
2.71TyrGly: 2.71 ± 0.392
0.542TyrHis: 0.542 ± 0.164
3.132TyrIle: 3.132 ± 0.487
4.216TyrLys: 4.216 ± 0.462
3.674TyrLeu: 3.674 ± 0.508
0.602TyrMet: 0.602 ± 0.181
2.469TyrAsn: 2.469 ± 0.434
1.385TyrPro: 1.385 ± 0.3
1.566TyrGln: 1.566 ± 0.231
1.686TyrArg: 1.686 ± 0.317
2.409TyrSer: 2.409 ± 0.374
2.108TyrThr: 2.108 ± 0.41
1.927TyrVal: 1.927 ± 0.343
0.241TyrTrp: 0.241 ± 0.123
1.807TyrTyr: 1.807 ± 0.436
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (16606 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski