Amino acid dipepetide frequency for Corynebacterium jeikeium (strain K411)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.836AlaAla: 14.836 ± 0.213	0.859AlaCys: 0.859 ± 0.034	7.165AlaAsp: 7.165 ± 0.11	8.78AlaGlu: 8.78 ± 0.144	3.349AlaPhe: 3.349 ± 0.077	10.267AlaGly: 10.267 ± 0.144	2.209AlaHis: 2.209 ± 0.071	5.047AlaIle: 5.047 ± 0.093	4.496AlaLys: 4.496 ± 0.117	10.843AlaLeu: 10.843 ± 0.152	2.7AlaMet: 2.7 ± 0.056	3.153AlaAsn: 3.153 ± 0.065	5.21AlaPro: 5.21 ± 0.136	4.195AlaGln: 4.195 ± 0.083	6.548AlaArg: 6.548 ± 0.11	5.96AlaSer: 5.96 ± 0.095	6.6AlaThr: 6.6 ± 0.104	8.885AlaVal: 8.885 ± 0.131	1.501AlaTrp: 1.501 ± 0.051	2.132AlaTyr: 2.132 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.78CysAla: 0.78 ± 0.037	0.087CysCys: 0.087 ± 0.012	0.402CysAsp: 0.402 ± 0.025	0.436CysGlu: 0.436 ± 0.025	0.215CysPhe: 0.215 ± 0.019	0.755CysGly: 0.755 ± 0.034	0.145CysHis: 0.145 ± 0.014	0.321CysIle: 0.321 ± 0.02	0.173CysLys: 0.173 ± 0.013	0.621CysLeu: 0.621 ± 0.029	0.148CysMet: 0.148 ± 0.016	0.204CysAsn: 0.204 ± 0.016	0.376CysPro: 0.376 ± 0.026	0.223CysGln: 0.223 ± 0.017	0.403CysArg: 0.403 ± 0.026	0.455CysSer: 0.455 ± 0.028	0.451CysThr: 0.451 ± 0.028	0.585CysVal: 0.585 ± 0.029	0.109CysTrp: 0.109 ± 0.012	0.148CysTyr: 0.148 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.729AspAla: 6.729 ± 0.102	0.41AspCys: 0.41 ± 0.027	3.479AspAsp: 3.479 ± 0.073	4.503AspGlu: 4.503 ± 0.087	2.023AspPhe: 2.023 ± 0.052	5.339AspGly: 5.339 ± 0.119	1.213AspHis: 1.213 ± 0.045	2.957AspIle: 2.957 ± 0.061	2.343AspLys: 2.343 ± 0.074	5.532AspLeu: 5.532 ± 0.087	1.252AspMet: 1.252 ± 0.042	1.943AspAsn: 1.943 ± 0.058	3.603AspPro: 3.603 ± 0.067	1.939AspGln: 1.939 ± 0.053	3.59AspArg: 3.59 ± 0.075	3.49AspSer: 3.49 ± 0.07	3.038AspThr: 3.038 ± 0.077	4.864AspVal: 4.864 ± 0.092	0.821AspTrp: 0.821 ± 0.032	1.476AspTyr: 1.476 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.211GluAla: 7.211 ± 0.12	0.369GluCys: 0.369 ± 0.023	4.05GluAsp: 4.05 ± 0.085	4.828GluGlu: 4.828 ± 0.105	2.178GluPhe: 2.178 ± 0.062	5.099GluGly: 5.099 ± 0.103	1.554GluHis: 1.554 ± 0.044	3.204GluIle: 3.204 ± 0.071	2.919GluLys: 2.919 ± 0.069	6.929GluLeu: 6.929 ± 0.094	1.451GluMet: 1.451 ± 0.052	2.09GluAsn: 2.09 ± 0.06	2.879GluPro: 2.879 ± 0.082	2.925GluGln: 2.925 ± 0.072	4.198GluArg: 4.198 ± 0.074	3.425GluSer: 3.425 ± 0.076	3.222GluThr: 3.222 ± 0.081	5.224GluVal: 5.224 ± 0.103	0.863GluTrp: 0.863 ± 0.041	1.49GluTyr: 1.49 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.7PheAla: 3.7 ± 0.076	0.262PheCys: 0.262 ± 0.018	2.203PheAsp: 2.203 ± 0.055	1.784PheGlu: 1.784 ± 0.056	1.237PhePhe: 1.237 ± 0.044	3.331PheGly: 3.331 ± 0.071	0.673PheHis: 0.673 ± 0.035	1.597PheIle: 1.597 ± 0.054	0.92PheLys: 0.92 ± 0.038	2.834PheLeu: 2.834 ± 0.064	0.641PheMet: 0.641 ± 0.032	1.042PheAsn: 1.042 ± 0.042	1.375PhePro: 1.375 ± 0.044	0.91PheGln: 0.91 ± 0.035	1.705PheArg: 1.705 ± 0.049	2.079PheSer: 2.079 ± 0.051	2.023PheThr: 2.023 ± 0.06	2.425PheVal: 2.425 ± 0.06	0.429PheTrp: 0.429 ± 0.022	0.73PheTyr: 0.73 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.476GlyAla: 9.476 ± 0.15	0.6GlyCys: 0.6 ± 0.035	4.762GlyAsp: 4.762 ± 0.099	5.631GlyGlu: 5.631 ± 0.089	2.982GlyPhe: 2.982 ± 0.063	7.166GlyGly: 7.166 ± 0.131	1.837GlyHis: 1.837 ± 0.054	4.258GlyIle: 4.258 ± 0.075	3.781GlyLys: 3.781 ± 0.077	7.874GlyLeu: 7.874 ± 0.119	2.267GlyMet: 2.267 ± 0.053	2.514GlyAsn: 2.514 ± 0.064	3.264GlyPro: 3.264 ± 0.073	3.147GlyGln: 3.147 ± 0.083	4.983GlyArg: 4.983 ± 0.081	5.222GlySer: 5.222 ± 0.095	5.244GlyThr: 5.244 ± 0.098	7.235GlyVal: 7.235 ± 0.1	1.431GlyTrp: 1.431 ± 0.056	2.218GlyTyr: 2.218 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.09HisAla: 2.09 ± 0.054	0.202HisCys: 0.202 ± 0.018	1.135HisAsp: 1.135 ± 0.039	1.163HisGlu: 1.163 ± 0.049	0.667HisPhe: 0.667 ± 0.034	1.846HisGly: 1.846 ± 0.049	0.553HisHis: 0.553 ± 0.034	0.952HisIle: 0.952 ± 0.039	0.577HisLys: 0.577 ± 0.029	1.865HisLeu: 1.865 ± 0.051	0.451HisMet: 0.451 ± 0.026	0.646HisAsn: 0.646 ± 0.035	1.392HisPro: 1.392 ± 0.046	0.695HisGln: 0.695 ± 0.031	1.561HisArg: 1.561 ± 0.046	1.329HisSer: 1.329 ± 0.044	1.233HisThr: 1.233 ± 0.045	1.586HisVal: 1.586 ± 0.054	0.276HisTrp: 0.276 ± 0.017	0.521HisTyr: 0.521 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.132IleAla: 6.132 ± 0.104	0.367IleCys: 0.367 ± 0.022	3.405IleAsp: 3.405 ± 0.07	2.993IleGlu: 2.993 ± 0.069	1.431IlePhe: 1.431 ± 0.052	4.283IleGly: 4.283 ± 0.076	0.952IleHis: 0.952 ± 0.038	2.277IleIle: 2.277 ± 0.062	1.462IleLys: 1.462 ± 0.049	3.912IleLeu: 3.912 ± 0.077	0.871IleMet: 0.871 ± 0.034	1.569IleAsn: 1.569 ± 0.048	2.566IlePro: 2.566 ± 0.062	1.321IleGln: 1.321 ± 0.045	2.628IleArg: 2.628 ± 0.06	2.859IleSer: 2.859 ± 0.066	3.003IleThr: 3.003 ± 0.067	4.043IleVal: 4.043 ± 0.081	0.471IleTrp: 0.471 ± 0.021	1.005IleTyr: 1.005 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.116LysAla: 4.116 ± 0.1	0.151LysCys: 0.151 ± 0.011	2.301LysAsp: 2.301 ± 0.073	2.432LysGlu: 2.432 ± 0.069	1.019LysPhe: 1.019 ± 0.034	2.741LysGly: 2.741 ± 0.06	0.688LysHis: 0.688 ± 0.029	1.927LysIle: 1.927 ± 0.058	2.283LysLys: 2.283 ± 0.075	3.362LysLeu: 3.362 ± 0.079	0.968LysMet: 0.968 ± 0.043	1.377LysAsn: 1.377 ± 0.047	2.122LysPro: 2.122 ± 0.079	1.46LysGln: 1.46 ± 0.043	2.404LysArg: 2.404 ± 0.071	2.044LysSer: 2.044 ± 0.061	2.193LysThr: 2.193 ± 0.063	2.931LysVal: 2.931 ± 0.077	0.491LysTrp: 0.491 ± 0.026	0.771LysTyr: 0.771 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.208LeuAla: 11.208 ± 0.133	0.692LeuCys: 0.692 ± 0.031	5.837LeuAsp: 5.837 ± 0.1	5.208LeuGlu: 5.208 ± 0.081	2.692LeuPhe: 2.692 ± 0.074	8.109LeuGly: 8.109 ± 0.121	1.893LeuHis: 1.893 ± 0.054	4.399LeuIle: 4.399 ± 0.084	3.143LeuLys: 3.143 ± 0.067	8.536LeuLeu: 8.536 ± 0.147	1.995LeuMet: 1.995 ± 0.056	2.802LeuAsn: 2.802 ± 0.069	5.019LeuPro: 5.019 ± 0.094	3.012LeuGln: 3.012 ± 0.072	6.234LeuArg: 6.234 ± 0.104	5.821LeuSer: 5.821 ± 0.1	5.103LeuThr: 5.103 ± 0.088	7.726LeuVal: 7.726 ± 0.103	1.15LeuTrp: 1.15 ± 0.049	1.677LeuTyr: 1.677 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.591MetAla: 2.591 ± 0.063	0.162MetCys: 0.162 ± 0.014	1.269MetAsp: 1.269 ± 0.043	1.152MetGlu: 1.152 ± 0.04	0.667MetPhe: 0.667 ± 0.028	1.752MetGly: 1.752 ± 0.055	0.476MetHis: 0.476 ± 0.027	1.124MetIle: 1.124 ± 0.041	0.8MetLys: 0.8 ± 0.034	2.144MetLeu: 2.144 ± 0.06	0.542MetMet: 0.542 ± 0.031	0.762MetAsn: 0.762 ± 0.035	1.173MetPro: 1.173 ± 0.042	0.766MetGln: 0.766 ± 0.035	1.417MetArg: 1.417 ± 0.043	1.684MetSer: 1.684 ± 0.049	1.608MetThr: 1.608 ± 0.046	1.701MetVal: 1.701 ± 0.051	0.286MetTrp: 0.286 ± 0.023	0.401MetTyr: 0.401 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.287AsnAla: 3.287 ± 0.067	0.205AsnCys: 0.205 ± 0.017	1.687AsnAsp: 1.687 ± 0.05	1.723AsnGlu: 1.723 ± 0.06	0.919AsnPhe: 0.919 ± 0.035	2.738AsnGly: 2.738 ± 0.075	0.646AsnHis: 0.646 ± 0.028	1.322AsnIle: 1.322 ± 0.044	1.252AsnLys: 1.252 ± 0.051	2.716AsnLeu: 2.716 ± 0.062	0.679AsnMet: 0.679 ± 0.028	1.197AsnAsn: 1.197 ± 0.054	2.334AsnPro: 2.334 ± 0.054	1.188AsnGln: 1.188 ± 0.044	1.842AsnArg: 1.842 ± 0.059	2.075AsnSer: 2.075 ± 0.055	1.759AsnThr: 1.759 ± 0.053	2.167AsnVal: 2.167 ± 0.052	0.465AsnTrp: 0.465 ± 0.027	0.803AsnTyr: 0.803 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.742ProAla: 5.742 ± 0.121	0.25ProCys: 0.25 ± 0.018	3.183ProAsp: 3.183 ± 0.081	4.596ProGlu: 4.596 ± 0.096	1.53ProPhe: 1.53 ± 0.051	4.631ProGly: 4.631 ± 0.094	1.138ProHis: 1.138 ± 0.049	2.1ProIle: 2.1 ± 0.054	2.036ProLys: 2.036 ± 0.067	4.137ProLeu: 4.137 ± 0.07	0.998ProMet: 0.998 ± 0.041	1.65ProAsn: 1.65 ± 0.05	1.825ProPro: 1.825 ± 0.074	2.105ProGln: 2.105 ± 0.069	2.748ProArg: 2.748 ± 0.072	2.94ProSer: 2.94 ± 0.066	3.239ProThr: 3.239 ± 0.072	4.061ProVal: 4.061 ± 0.082	0.692ProTrp: 0.692 ± 0.034	1.018ProTyr: 1.018 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.116GlnAla: 4.116 ± 0.079	0.186GlnCys: 0.186 ± 0.014	1.795GlnAsp: 1.795 ± 0.051	2.16GlnGlu: 2.16 ± 0.053	0.975GlnPhe: 0.975 ± 0.038	2.577GlnGly: 2.577 ± 0.066	0.75GlnHis: 0.75 ± 0.032	1.772GlnIle: 1.772 ± 0.051	1.255GlnLys: 1.255 ± 0.045	3.746GlnLeu: 3.746 ± 0.078	0.803GlnMet: 0.803 ± 0.033	1.099GlnAsn: 1.099 ± 0.047	2.022GlnPro: 2.022 ± 0.068	1.849GlnGln: 1.849 ± 0.058	2.781GlnArg: 2.781 ± 0.067	1.822GlnSer: 1.822 ± 0.052	1.756GlnThr: 1.756 ± 0.047	2.836GlnVal: 2.836 ± 0.062	0.595GlnTrp: 0.595 ± 0.028	0.695GlnTyr: 0.695 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.312ArgAla: 6.312 ± 0.09	0.403ArgCys: 0.403 ± 0.022	3.492ArgAsp: 3.492 ± 0.075	4.275ArgGlu: 4.275 ± 0.076	2.082ArgPhe: 2.082 ± 0.054	4.748ArgGly: 4.748 ± 0.093	1.335ArgHis: 1.335 ± 0.037	3.24ArgIle: 3.24 ± 0.06	2.488ArgLys: 2.488 ± 0.071	5.438ArgLeu: 5.438 ± 0.09	1.65ArgMet: 1.65 ± 0.049	1.981ArgAsn: 1.981 ± 0.067	3.002ArgPro: 3.002 ± 0.084	2.244ArgGln: 2.244 ± 0.061	4.952ArgArg: 4.952 ± 0.108	3.603ArgSer: 3.603 ± 0.07	3.609ArgThr: 3.609 ± 0.076	4.586ArgVal: 4.586 ± 0.082	1.007ArgTrp: 1.007 ± 0.038	1.52ArgTyr: 1.52 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.928SerAla: 6.928 ± 0.105	0.373SerCys: 0.373 ± 0.023	3.354SerAsp: 3.354 ± 0.068	3.5SerGlu: 3.5 ± 0.078	2.013SerPhe: 2.013 ± 0.054	5.661SerGly: 5.661 ± 0.099	1.132SerHis: 1.132 ± 0.041	2.59SerIle: 2.59 ± 0.064	2.111SerLys: 2.111 ± 0.056	5.227SerLeu: 5.227 ± 0.091	1.36SerMet: 1.36 ± 0.045	1.822SerAsn: 1.822 ± 0.054	2.964SerPro: 2.964 ± 0.065	2.051SerGln: 2.051 ± 0.053	3.517SerArg: 3.517 ± 0.074	4.13SerSer: 4.13 ± 0.094	3.881SerThr: 3.881 ± 0.085	4.408SerVal: 4.408 ± 0.105	0.868SerTrp: 0.868 ± 0.036	1.3SerTyr: 1.3 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.514ThrAla: 6.514 ± 0.101	0.431ThrCys: 0.431 ± 0.027	3.511ThrAsp: 3.511 ± 0.077	3.451ThrGlu: 3.451 ± 0.081	1.938ThrPhe: 1.938 ± 0.057	5.398ThrGly: 5.398 ± 0.099	1.192ThrHis: 1.192 ± 0.049	2.844ThrIle: 2.844 ± 0.056	1.98ThrLys: 1.98 ± 0.056	5.276ThrLeu: 5.276 ± 0.087	1.223ThrMet: 1.223 ± 0.04	1.691ThrAsn: 1.691 ± 0.046	3.753ThrPro: 3.753 ± 0.089	1.811ThrGln: 1.811 ± 0.05	3.18ThrArg: 3.18 ± 0.075	3.49ThrSer: 3.49 ± 0.071	3.743ThrThr: 3.743 ± 0.087	5.238ThrVal: 5.238 ± 0.099	0.829ThrTrp: 0.829 ± 0.037	1.305ThrTyr: 1.305 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	9.381ValAla: 9.381 ± 0.144	0.713ValCys: 0.713 ± 0.033	5.414ValAsp: 5.414 ± 0.09	5.494ValGlu: 5.494 ± 0.107	2.618ValPhe: 2.618 ± 0.061	6.432ValGly: 6.432 ± 0.123	1.663ValHis: 1.663 ± 0.043	3.957ValIle: 3.957 ± 0.086	2.563ValLys: 2.563 ± 0.071	7.707ValLeu: 7.707 ± 0.108	1.721ValMet: 1.721 ± 0.047	2.33ValAsn: 2.33 ± 0.058	4.043ValPro: 4.043 ± 0.097	2.429ValGln: 2.429 ± 0.052	4.737ValArg: 4.737 ± 0.085	4.6ValSer: 4.6 ± 0.097	4.98ValThr: 4.98 ± 0.089	7.097ValVal: 7.097 ± 0.106	0.963ValTrp: 0.963 ± 0.028	1.491ValTyr: 1.491 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.405TrpAla: 1.405 ± 0.051	0.131TrpCys: 0.131 ± 0.014	0.748TrpAsp: 0.748 ± 0.032	0.733TrpGlu: 0.733 ± 0.037	0.579TrpPhe: 0.579 ± 0.03	1.021TrpGly: 1.021 ± 0.04	0.314TrpHis: 0.314 ± 0.02	0.746TrpIle: 0.746 ± 0.034	0.521TrpLys: 0.521 ± 0.028	1.453TrpLeu: 1.453 ± 0.051	0.397TrpMet: 0.397 ± 0.026	0.457TrpAsn: 0.457 ± 0.023	0.588TrpPro: 0.588 ± 0.033	0.56TrpGln: 0.56 ± 0.03	1.002TrpArg: 1.002 ± 0.04	0.73TrpSer: 0.73 ± 0.031	0.799TrpThr: 0.799 ± 0.037	1.124TrpVal: 1.124 ± 0.044	0.359TrpTrp: 0.359 ± 0.027	0.283TrpTyr: 0.283 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.181TyrAla: 2.181 ± 0.058	0.183TyrCys: 0.183 ± 0.018	1.351TyrAsp: 1.351 ± 0.046	1.266TyrGlu: 1.266 ± 0.048	0.786TyrPhe: 0.786 ± 0.039	1.999TyrGly: 1.999 ± 0.055	0.377TyrHis: 0.377 ± 0.024	0.917TyrIle: 0.917 ± 0.036	0.679TyrLys: 0.679 ± 0.03	2.104TyrLeu: 2.104 ± 0.053	0.36TyrMet: 0.36 ± 0.022	0.673TyrAsn: 0.673 ± 0.032	1.11TyrPro: 1.11 ± 0.04	0.757TyrGln: 0.757 ± 0.032	1.54TyrArg: 1.54 ± 0.045	1.431TyrSer: 1.431 ± 0.045	1.315TyrThr: 1.315 ± 0.041	1.613TyrVal: 1.613 ± 0.048	0.342TyrTrp: 0.342 ± 0.023	0.532TyrTyr: 0.532 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2064 proteins (716252 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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