Amino acid dipepetide frequency for Streptococcus satellite phage Javan211

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.489AlaAla: 0.489 ± 0.498
0.489AlaCys: 0.489 ± 0.386
6.846AlaAsp: 6.846 ± 1.72
4.401AlaGlu: 4.401 ± 1.955
2.934AlaPhe: 2.934 ± 0.974
3.912AlaGly: 3.912 ± 1.081
0.0AlaHis: 0.0 ± 0.0
4.89AlaIle: 4.89 ± 1.237
8.313AlaLys: 8.313 ± 3.185
6.846AlaLeu: 6.846 ± 1.632
0.978AlaMet: 0.978 ± 0.772
4.401AlaAsn: 4.401 ± 1.263
0.978AlaPro: 0.978 ± 0.734
1.467AlaGln: 1.467 ± 0.6
3.423AlaArg: 3.423 ± 1.339
2.934AlaSer: 2.934 ± 1.047
4.401AlaThr: 4.401 ± 2.111
2.445AlaVal: 2.445 ± 0.759
0.978AlaTrp: 0.978 ± 0.695
2.934AlaTyr: 2.934 ± 1.216
0.0AlaXaa: 0.0 ± 0.0
Cys
0.978CysAla: 0.978 ± 0.621
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.489CysGlu: 0.489 ± 0.507
0.489CysPhe: 0.489 ± 0.612
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.489CysIle: 0.489 ± 0.538
0.489CysLys: 0.489 ± 0.507
0.0CysLeu: 0.0 ± 0.0
0.489CysMet: 0.489 ± 0.471
0.489CysAsn: 0.489 ± 0.386
1.467CysPro: 1.467 ± 1.002
1.467CysGln: 1.467 ± 1.535
0.978CysArg: 0.978 ± 1.023
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.978CysTyr: 0.978 ± 0.8
0.0CysXaa: 0.0 ± 0.0
Asp
0.489AspAla: 0.489 ± 0.498
1.956AspCys: 1.956 ± 1.384
3.423AspAsp: 3.423 ± 1.316
4.401AspGlu: 4.401 ± 1.58
5.379AspPhe: 5.379 ± 1.239
1.956AspGly: 1.956 ± 1.317
0.0AspHis: 0.0 ± 0.0
4.89AspIle: 4.89 ± 1.212
8.313AspLys: 8.313 ± 2.231
6.357AspLeu: 6.357 ± 1.846
1.467AspMet: 1.467 ± 0.845
2.445AspAsn: 2.445 ± 1.783
1.467AspPro: 1.467 ± 0.92
1.467AspGln: 1.467 ± 0.73
2.445AspArg: 2.445 ± 1.103
2.445AspSer: 2.445 ± 0.958
0.978AspThr: 0.978 ± 0.603
0.978AspVal: 0.978 ± 0.579
0.489AspTrp: 0.489 ± 0.475
4.89AspTyr: 4.89 ± 1.2
0.0AspXaa: 0.0 ± 0.0
Glu
9.291GluAla: 9.291 ± 2.017
0.489GluCys: 0.489 ± 0.475
3.423GluAsp: 3.423 ± 1.488
7.824GluGlu: 7.824 ± 2.449
3.423GluPhe: 3.423 ± 1.448
2.445GluGly: 2.445 ± 1.319
0.0GluHis: 0.0 ± 0.0
6.357GluIle: 6.357 ± 1.685
7.824GluLys: 7.824 ± 1.71
12.225GluLeu: 12.225 ± 2.429
0.978GluMet: 0.978 ± 0.593
6.357GluAsn: 6.357 ± 1.619
2.934GluPro: 2.934 ± 1.352
4.401GluGln: 4.401 ± 1.647
5.868GluArg: 5.868 ± 1.774
4.89GluSer: 4.89 ± 1.519
0.978GluThr: 0.978 ± 0.961
3.423GluVal: 3.423 ± 1.285
0.978GluTrp: 0.978 ± 0.527
1.956GluTyr: 1.956 ± 0.82
0.0GluXaa: 0.0 ± 0.0
Phe
1.956PheAla: 1.956 ± 0.864
0.0PheCys: 0.0 ± 0.0
4.89PheAsp: 4.89 ± 1.518
2.934PheGlu: 2.934 ± 0.847
2.445PhePhe: 2.445 ± 0.999
1.467PheGly: 1.467 ± 0.803
1.956PheHis: 1.956 ± 1.033
2.445PheIle: 2.445 ± 0.912
1.467PheLys: 1.467 ± 0.699
6.357PheLeu: 6.357 ± 1.029
0.978PheMet: 0.978 ± 0.736
0.489PheAsn: 0.489 ± 0.612
1.956PhePro: 1.956 ± 1.088
0.978PheGln: 0.978 ± 0.826
0.489PheArg: 0.489 ± 0.512
3.912PheSer: 3.912 ± 1.146
1.467PheThr: 1.467 ± 0.678
0.978PheVal: 0.978 ± 0.579
0.489PheTrp: 0.489 ± 0.534
1.956PheTyr: 1.956 ± 0.927
0.0PheXaa: 0.0 ± 0.0
Gly
2.934GlyAla: 2.934 ± 0.921
0.0GlyCys: 0.0 ± 0.0
1.956GlyAsp: 1.956 ± 0.684
3.423GlyGlu: 3.423 ± 1.353
1.467GlyPhe: 1.467 ± 1.109
1.956GlyGly: 1.956 ± 1.148
0.489GlyHis: 0.489 ± 0.386
4.89GlyIle: 4.89 ± 0.92
1.956GlyLys: 1.956 ± 0.772
3.423GlyLeu: 3.423 ± 1.28
0.978GlyMet: 0.978 ± 0.584
1.956GlyAsn: 1.956 ± 1.197
0.0GlyPro: 0.0 ± 0.0
0.978GlyGln: 0.978 ± 0.763
0.978GlyArg: 0.978 ± 0.479
1.467GlySer: 1.467 ± 0.79
2.934GlyThr: 2.934 ± 1.165
4.401GlyVal: 4.401 ± 1.36
0.489GlyTrp: 0.489 ± 0.475
5.379GlyTyr: 5.379 ± 1.008
0.0GlyXaa: 0.0 ± 0.0
His
0.978HisAla: 0.978 ± 0.772
0.0HisCys: 0.0 ± 0.0
0.489HisAsp: 0.489 ± 0.448
0.489HisGlu: 0.489 ± 0.465
0.489HisPhe: 0.489 ± 0.386
0.489HisGly: 0.489 ± 0.386
0.0HisHis: 0.0 ± 0.0
0.978HisIle: 0.978 ± 0.479
0.489HisLys: 0.489 ± 0.512
1.956HisLeu: 1.956 ± 1.243
0.0HisMet: 0.0 ± 0.0
2.934HisAsn: 2.934 ± 1.01
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.489HisArg: 0.489 ± 0.386
0.489HisSer: 0.489 ± 0.386
0.489HisThr: 0.489 ± 0.386
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.489HisTyr: 0.489 ± 0.512
0.0HisXaa: 0.0 ± 0.0
Ile
4.89IleAla: 4.89 ± 2.231
0.0IleCys: 0.0 ± 0.0
4.89IleAsp: 4.89 ± 1.127
5.379IleGlu: 5.379 ± 2.006
0.978IlePhe: 0.978 ± 0.651
1.467IleGly: 1.467 ± 0.99
0.489IleHis: 0.489 ± 0.512
3.423IleIle: 3.423 ± 1.424
5.868IleLys: 5.868 ± 1.659
6.846IleLeu: 6.846 ± 1.521
0.978IleMet: 0.978 ± 0.596
5.379IleAsn: 5.379 ± 0.933
1.467IlePro: 1.467 ± 0.628
2.934IleGln: 2.934 ± 1.38
2.445IleArg: 2.445 ± 0.708
8.313IleSer: 8.313 ± 2.88
3.423IleThr: 3.423 ± 1.376
3.423IleVal: 3.423 ± 1.243
0.489IleTrp: 0.489 ± 0.534
3.912IleTyr: 3.912 ± 1.116
0.0IleXaa: 0.0 ± 0.0
Lys
7.824LysAla: 7.824 ± 2.573
0.489LysCys: 0.489 ± 0.465
4.89LysAsp: 4.89 ± 1.621
10.758LysGlu: 10.758 ± 1.938
2.445LysPhe: 2.445 ± 1.536
6.846LysGly: 6.846 ± 2.171
1.956LysHis: 1.956 ± 0.661
6.846LysIle: 6.846 ± 2.455
9.291LysLys: 9.291 ± 2.406
9.78LysLeu: 9.78 ± 2.033
1.956LysMet: 1.956 ± 1.044
7.335LysAsn: 7.335 ± 1.73
1.956LysPro: 1.956 ± 0.908
6.357LysGln: 6.357 ± 0.978
5.379LysArg: 5.379 ± 2.317
4.89LysSer: 4.89 ± 1.811
4.89LysThr: 4.89 ± 1.169
2.934LysVal: 2.934 ± 0.844
0.978LysTrp: 0.978 ± 0.596
4.89LysTyr: 4.89 ± 1.125
0.0LysXaa: 0.0 ± 0.0
Leu
6.846LeuAla: 6.846 ± 1.657
0.978LeuCys: 0.978 ± 0.739
7.335LeuAsp: 7.335 ± 1.542
10.758LeuGlu: 10.758 ± 2.922
3.912LeuPhe: 3.912 ± 1.127
7.335LeuGly: 7.335 ± 1.408
0.489LeuHis: 0.489 ± 0.386
3.423LeuIle: 3.423 ± 0.904
12.225LeuLys: 12.225 ± 2.27
7.335LeuLeu: 7.335 ± 1.177
1.956LeuMet: 1.956 ± 0.91
6.357LeuAsn: 6.357 ± 1.94
1.956LeuPro: 1.956 ± 1.417
3.423LeuGln: 3.423 ± 0.912
5.379LeuArg: 5.379 ± 1.652
8.313LeuSer: 8.313 ± 5.372
6.846LeuThr: 6.846 ± 1.591
4.89LeuVal: 4.89 ± 2.158
0.978LeuTrp: 0.978 ± 0.61
2.445LeuTyr: 2.445 ± 0.819
0.0LeuXaa: 0.0 ± 0.0
Met
0.978MetAla: 0.978 ± 1.075
0.489MetCys: 0.489 ± 0.512
1.467MetAsp: 1.467 ± 0.792
1.467MetGlu: 1.467 ± 1.063
0.489MetPhe: 0.489 ± 0.512
0.978MetGly: 0.978 ± 0.689
0.489MetHis: 0.489 ± 0.498
1.956MetIle: 1.956 ± 1.08
2.445MetLys: 2.445 ± 0.927
1.467MetLeu: 1.467 ± 0.897
0.0MetMet: 0.0 ± 0.0
0.978MetAsn: 0.978 ± 0.584
0.0MetPro: 0.0 ± 0.0
0.978MetGln: 0.978 ± 0.584
0.489MetArg: 0.489 ± 0.512
1.467MetSer: 1.467 ± 1.119
0.978MetThr: 0.978 ± 0.651
1.467MetVal: 1.467 ± 0.708
0.489MetTrp: 0.489 ± 0.612
0.489MetTyr: 0.489 ± 0.48
0.0MetXaa: 0.0 ± 0.0
Asn
5.379AsnAla: 5.379 ± 1.341
0.489AsnCys: 0.489 ± 0.498
1.956AsnAsp: 1.956 ± 1.128
4.89AsnGlu: 4.89 ± 1.233
2.445AsnPhe: 2.445 ± 1.021
2.445AsnGly: 2.445 ± 1.08
0.0AsnHis: 0.0 ± 0.0
4.401AsnIle: 4.401 ± 2.029
4.89AsnLys: 4.89 ± 2.407
6.357AsnLeu: 6.357 ± 1.202
0.978AsnMet: 0.978 ± 0.659
4.401AsnAsn: 4.401 ± 0.933
3.423AsnPro: 3.423 ± 1.418
1.956AsnGln: 1.956 ± 1.308
3.912AsnArg: 3.912 ± 1.007
2.934AsnSer: 2.934 ± 0.89
7.335AsnThr: 7.335 ± 2.154
2.934AsnVal: 2.934 ± 1.153
0.978AsnTrp: 0.978 ± 0.665
2.445AsnTyr: 2.445 ± 0.991
0.0AsnXaa: 0.0 ± 0.0
Pro
1.956ProAla: 1.956 ± 0.8
0.0ProCys: 0.0 ± 0.0
0.489ProAsp: 0.489 ± 0.465
2.445ProGlu: 2.445 ± 0.949
1.956ProPhe: 1.956 ± 0.914
0.0ProGly: 0.0 ± 0.0
0.489ProHis: 0.489 ± 0.534
0.978ProIle: 0.978 ± 0.579
5.379ProLys: 5.379 ± 1.746
2.445ProLeu: 2.445 ± 1.366
0.978ProMet: 0.978 ± 0.659
1.956ProAsn: 1.956 ± 1.086
0.489ProPro: 0.489 ± 0.386
0.489ProGln: 0.489 ± 0.48
1.956ProArg: 1.956 ± 0.644
0.978ProSer: 0.978 ± 0.564
0.489ProThr: 0.489 ± 0.507
0.978ProVal: 0.978 ± 0.479
0.0ProTrp: 0.0 ± 0.0
1.467ProTyr: 1.467 ± 0.698
0.0ProXaa: 0.0 ± 0.0
Gln
4.401GlnAla: 4.401 ± 1.261
0.0GlnCys: 0.0 ± 0.0
0.978GlnAsp: 0.978 ± 0.672
3.912GlnGlu: 3.912 ± 1.395
0.978GlnPhe: 0.978 ± 0.651
0.978GlnGly: 0.978 ± 0.673
0.978GlnHis: 0.978 ± 0.772
2.445GlnIle: 2.445 ± 1.199
3.423GlnLys: 3.423 ± 1.173
4.401GlnLeu: 4.401 ± 0.99
0.0GlnMet: 0.0 ± 0.0
3.423GlnAsn: 3.423 ± 1.938
0.978GlnPro: 0.978 ± 0.579
3.912GlnGln: 3.912 ± 1.591
0.978GlnArg: 0.978 ± 0.641
3.912GlnSer: 3.912 ± 1.288
2.934GlnThr: 2.934 ± 1.048
2.934GlnVal: 2.934 ± 0.951
0.0GlnTrp: 0.0 ± 0.0
1.467GlnTyr: 1.467 ± 0.743
0.0GlnXaa: 0.0 ± 0.0
Arg
2.934ArgAla: 2.934 ± 0.864
0.978ArgCys: 0.978 ± 1.023
0.978ArgAsp: 0.978 ± 0.479
1.956ArgGlu: 1.956 ± 0.644
1.956ArgPhe: 1.956 ± 0.727
2.934ArgGly: 2.934 ± 1.444
0.489ArgHis: 0.489 ± 0.386
3.912ArgIle: 3.912 ± 1.284
6.357ArgLys: 6.357 ± 0.995
5.379ArgLeu: 5.379 ± 2.198
1.467ArgMet: 1.467 ± 0.708
1.956ArgAsn: 1.956 ± 0.961
0.978ArgPro: 0.978 ± 0.641
3.912ArgGln: 3.912 ± 0.816
3.423ArgArg: 3.423 ± 1.174
2.445ArgSer: 2.445 ± 0.741
2.445ArgThr: 2.445 ± 1.047
1.956ArgVal: 1.956 ± 1.258
0.0ArgTrp: 0.0 ± 0.0
2.445ArgTyr: 2.445 ± 0.654
0.0ArgXaa: 0.0 ± 0.0
Ser
1.956SerAla: 1.956 ± 1.063
0.0SerCys: 0.0 ± 0.0
5.868SerAsp: 5.868 ± 2.28
6.846SerGlu: 6.846 ± 1.441
1.467SerPhe: 1.467 ± 0.765
1.467SerGly: 1.467 ± 0.766
0.489SerHis: 0.489 ± 0.475
5.379SerIle: 5.379 ± 1.253
7.824SerLys: 7.824 ± 2.915
4.89SerLeu: 4.89 ± 1.85
0.978SerMet: 0.978 ± 0.556
2.445SerAsn: 2.445 ± 1.842
0.978SerPro: 0.978 ± 0.564
2.445SerGln: 2.445 ± 0.726
1.956SerArg: 1.956 ± 1.077
0.978SerSer: 0.978 ± 0.672
4.401SerThr: 4.401 ± 0.901
3.423SerVal: 3.423 ± 1.216
0.489SerTrp: 0.489 ± 0.386
2.934SerTyr: 2.934 ± 0.653
0.0SerXaa: 0.0 ± 0.0
Thr
3.423ThrAla: 3.423 ± 0.831
0.0ThrCys: 0.0 ± 0.0
4.89ThrAsp: 4.89 ± 1.517
5.379ThrGlu: 5.379 ± 1.505
2.445ThrPhe: 2.445 ± 1.337
2.445ThrGly: 2.445 ± 0.982
0.489ThrHis: 0.489 ± 0.386
4.401ThrIle: 4.401 ± 1.167
5.868ThrLys: 5.868 ± 2.221
6.357ThrLeu: 6.357 ± 0.949
1.467ThrMet: 1.467 ± 1.119
1.956ThrAsn: 1.956 ± 0.575
3.423ThrPro: 3.423 ± 0.955
1.467ThrGln: 1.467 ± 0.978
0.489ThrArg: 0.489 ± 0.507
0.978ThrSer: 0.978 ± 0.593
3.423ThrThr: 3.423 ± 1.554
3.912ThrVal: 3.912 ± 0.899
0.0ThrTrp: 0.0 ± 0.0
2.445ThrTyr: 2.445 ± 0.876
0.0ThrXaa: 0.0 ± 0.0
Val
0.978ValAla: 0.978 ± 0.61
0.978ValCys: 0.978 ± 0.667
0.0ValAsp: 0.0 ± 0.0
3.423ValGlu: 3.423 ± 1.264
1.956ValPhe: 1.956 ± 1.203
1.467ValGly: 1.467 ± 0.742
1.956ValHis: 1.956 ± 0.959
3.423ValIle: 3.423 ± 1.136
4.89ValLys: 4.89 ± 1.52
4.401ValLeu: 4.401 ± 1.233
0.489ValMet: 0.489 ± 0.51
3.912ValAsn: 3.912 ± 1.744
0.489ValPro: 0.489 ± 0.386
1.467ValGln: 1.467 ± 0.693
2.934ValArg: 2.934 ± 1.405
2.934ValSer: 2.934 ± 1.054
3.912ValThr: 3.912 ± 1.047
1.956ValVal: 1.956 ± 0.644
0.978ValTrp: 0.978 ± 0.763
2.934ValTyr: 2.934 ± 1.115
0.0ValXaa: 0.0 ± 0.0
Trp
0.978TrpAla: 0.978 ± 0.651
0.0TrpCys: 0.0 ± 0.0
0.978TrpAsp: 0.978 ± 0.664
1.956TrpGlu: 1.956 ± 0.734
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.489TrpLys: 0.489 ± 0.498
1.467TrpLeu: 1.467 ± 0.974
0.0TrpMet: 0.0 ± 0.0
0.978TrpAsn: 0.978 ± 0.696
0.0TrpPro: 0.0 ± 0.0
0.978TrpGln: 0.978 ± 0.596
0.489TrpArg: 0.489 ± 0.465
0.489TrpSer: 0.489 ± 0.386
0.0TrpThr: 0.0 ± 0.0
0.489TrpVal: 0.489 ± 0.534
0.978TrpTrp: 0.978 ± 0.651
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.401TyrAla: 4.401 ± 1.994
1.467TyrCys: 1.467 ± 0.8
0.489TyrAsp: 0.489 ± 0.48
2.934TyrGlu: 2.934 ± 1.079
2.445TyrPhe: 2.445 ± 1.226
1.467TyrGly: 1.467 ± 0.629
0.489TyrHis: 0.489 ± 0.448
1.467TyrIle: 1.467 ± 0.61
4.89TyrLys: 4.89 ± 1.527
4.89TyrLeu: 4.89 ± 1.252
1.956TyrMet: 1.956 ± 1.247
4.401TyrAsn: 4.401 ± 1.253
0.978TyrPro: 0.978 ± 0.691
1.956TyrGln: 1.956 ± 0.578
4.401TyrArg: 4.401 ± 1.72
2.445TyrSer: 2.445 ± 0.889
2.934TyrThr: 2.934 ± 1.245
1.956TyrVal: 1.956 ± 0.793
0.489TyrTrp: 0.489 ± 0.512
2.445TyrTyr: 2.445 ± 1.099
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (2046 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski