Amino acid dipepetide frequency for Gordonia sp. HNM0687

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.11AlaAla: 19.11 ± 0.171	0.939AlaCys: 0.939 ± 0.024	9.799AlaAsp: 9.799 ± 0.095	7.857AlaGlu: 7.857 ± 0.085	3.454AlaPhe: 3.454 ± 0.056	11.679AlaGly: 11.679 ± 0.11	2.717AlaHis: 2.717 ± 0.048	5.573AlaIle: 5.573 ± 0.063	2.646AlaLys: 2.646 ± 0.056	11.933AlaLeu: 11.933 ± 0.131	2.884AlaMet: 2.884 ± 0.044	2.303AlaAsn: 2.303 ± 0.041	5.95AlaPro: 5.95 ± 0.084	3.849AlaGln: 3.849 ± 0.051	8.666AlaArg: 8.666 ± 0.084	5.889AlaSer: 5.889 ± 0.051	7.756AlaThr: 7.756 ± 0.078	11.431AlaVal: 11.431 ± 0.111	1.528AlaTrp: 1.528 ± 0.03	2.218AlaTyr: 2.218 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.078CysAla: 1.078 ± 0.03	0.099CysCys: 0.099 ± 0.009	0.523CysAsp: 0.523 ± 0.02	0.38CysGlu: 0.38 ± 0.016	0.226CysPhe: 0.226 ± 0.012	0.883CysGly: 0.883 ± 0.024	0.2CysHis: 0.2 ± 0.01	0.271CysIle: 0.271 ± 0.013	0.094CysLys: 0.094 ± 0.008	0.606CysLeu: 0.606 ± 0.019	0.125CysMet: 0.125 ± 0.008	0.143CysAsn: 0.143 ± 0.01	0.44CysPro: 0.44 ± 0.019	0.179CysGln: 0.179 ± 0.011	0.57CysArg: 0.57 ± 0.019	0.45CysSer: 0.45 ± 0.016	0.481CysThr: 0.481 ± 0.017	0.65CysVal: 0.65 ± 0.02	0.111CysTrp: 0.111 ± 0.009	0.158CysTyr: 0.158 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.433AspAla: 8.433 ± 0.086	0.43AspCys: 0.43 ± 0.016	5.716AspAsp: 5.716 ± 0.07	4.639AspGlu: 4.639 ± 0.052	1.838AspPhe: 1.838 ± 0.042	6.316AspGly: 6.316 ± 0.068	1.728AspHis: 1.728 ± 0.034	2.867AspIle: 2.867 ± 0.043	1.227AspLys: 1.227 ± 0.034	6.934AspLeu: 6.934 ± 0.068	1.111AspMet: 1.111 ± 0.025	1.35AspAsn: 1.35 ± 0.03	4.587AspPro: 4.587 ± 0.053	1.803AspGln: 1.803 ± 0.034	5.278AspArg: 5.278 ± 0.063	3.189AspSer: 3.189 ± 0.043	3.769AspThr: 3.769 ± 0.052	5.798AspVal: 5.798 ± 0.056	0.954AspTrp: 0.954 ± 0.024	1.345AspTyr: 1.345 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.796GluAla: 5.796 ± 0.069	0.379GluCys: 0.379 ± 0.017	2.354GluAsp: 2.354 ± 0.047	2.512GluGlu: 2.512 ± 0.053	1.863GluPhe: 1.863 ± 0.038	3.285GluGly: 3.285 ± 0.057	1.551GluHis: 1.551 ± 0.031	3.016GluIle: 3.016 ± 0.046	1.297GluLys: 1.297 ± 0.039	6.454GluLeu: 6.454 ± 0.07	1.235GluMet: 1.235 ± 0.032	1.156GluAsn: 1.156 ± 0.028	3.031GluPro: 3.031 ± 0.049	2.252GluGln: 2.252 ± 0.042	4.467GluArg: 4.467 ± 0.06	3.125GluSer: 3.125 ± 0.05	2.757GluThr: 2.757 ± 0.043	4.746GluVal: 4.746 ± 0.06	0.847GluTrp: 0.847 ± 0.026	1.159GluTyr: 1.159 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.073PheAla: 4.073 ± 0.057	0.299PheCys: 0.299 ± 0.013	2.526PheAsp: 2.526 ± 0.047	1.522PheGlu: 1.522 ± 0.029	0.982PhePhe: 0.982 ± 0.026	3.47PheGly: 3.47 ± 0.046	0.648PheHis: 0.648 ± 0.02	1.102PheIle: 1.102 ± 0.03	0.392PheLys: 0.392 ± 0.017	2.5PheLeu: 2.5 ± 0.045	0.46PheMet: 0.46 ± 0.019	0.637PheAsn: 0.637 ± 0.02	1.291PhePro: 1.291 ± 0.028	0.629PheGln: 0.629 ± 0.021	1.757PheArg: 1.757 ± 0.034	1.628PheSer: 1.628 ± 0.037	2.034PheThr: 2.034 ± 0.042	2.623PheVal: 2.623 ± 0.044	0.407PheTrp: 0.407 ± 0.018	0.666PheTyr: 0.666 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.147GlyAla: 10.147 ± 0.101	0.737GlyCys: 0.737 ± 0.021	5.55GlyAsp: 5.55 ± 0.061	4.621GlyGlu: 4.621 ± 0.057	3.016GlyPhe: 3.016 ± 0.05	7.786GlyGly: 7.786 ± 0.113	2.133GlyHis: 2.133 ± 0.044	4.176GlyIle: 4.176 ± 0.052	2.149GlyLys: 2.149 ± 0.046	8.537GlyLeu: 8.537 ± 0.082	2.078GlyMet: 2.078 ± 0.041	1.895GlyAsn: 1.895 ± 0.04	4.449GlyPro: 4.449 ± 0.061	2.612GlyGln: 2.612 ± 0.046	6.581GlyArg: 6.581 ± 0.072	5.465GlySer: 5.465 ± 0.063	5.307GlyThr: 5.307 ± 0.066	7.789GlyVal: 7.789 ± 0.088	1.566GlyTrp: 1.566 ± 0.035	2.298GlyTyr: 2.298 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.552HisAla: 2.552 ± 0.041	0.201HisCys: 0.201 ± 0.011	1.491HisAsp: 1.491 ± 0.036	1.093HisGlu: 1.093 ± 0.027	0.611HisPhe: 0.611 ± 0.021	2.116HisGly: 2.116 ± 0.043	0.764HisHis: 0.764 ± 0.024	0.845HisIle: 0.845 ± 0.025	0.353HisLys: 0.353 ± 0.016	2.271HisLeu: 2.271 ± 0.04	0.386HisMet: 0.386 ± 0.015	0.471HisAsn: 0.471 ± 0.019	1.696HisPro: 1.696 ± 0.036	0.65HisGln: 0.65 ± 0.021	2.084HisArg: 2.084 ± 0.041	1.112HisSer: 1.112 ± 0.028	1.269HisThr: 1.269 ± 0.025	1.708HisVal: 1.708 ± 0.034	0.337HisTrp: 0.337 ± 0.014	0.482HisTyr: 0.482 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.677IleAla: 6.677 ± 0.073	0.385IleCys: 0.385 ± 0.014	3.82IleAsp: 3.82 ± 0.057	2.632IleGlu: 2.632 ± 0.042	1.08IlePhe: 1.08 ± 0.026	4.735IleGly: 4.735 ± 0.059	0.844IleHis: 0.844 ± 0.023	1.666IleIle: 1.666 ± 0.036	0.786IleLys: 0.786 ± 0.023	3.334IleLeu: 3.334 ± 0.051	0.692IleMet: 0.692 ± 0.022	1.086IleAsn: 1.086 ± 0.03	2.437IlePro: 2.437 ± 0.045	0.839IleGln: 0.839 ± 0.025	2.945IleArg: 2.945 ± 0.037	2.513IleSer: 2.513 ± 0.038	3.003IleThr: 3.003 ± 0.047	4.098IleVal: 4.098 ± 0.053	0.489IleTrp: 0.489 ± 0.019	0.794IleTyr: 0.794 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.357LysAla: 2.357 ± 0.05	0.107LysCys: 0.107 ± 0.008	0.982LysAsp: 0.982 ± 0.03	0.895LysGlu: 0.895 ± 0.03	0.536LysPhe: 0.536 ± 0.017	1.433LysGly: 1.433 ± 0.035	0.452LysHis: 0.452 ± 0.017	0.965LysIle: 0.965 ± 0.025	0.666LysLys: 0.666 ± 0.033	1.815LysLeu: 1.815 ± 0.039	0.438LysMet: 0.438 ± 0.017	0.484LysAsn: 0.484 ± 0.017	1.186LysPro: 1.186 ± 0.035	0.644LysGln: 0.644 ± 0.022	1.518LysArg: 1.518 ± 0.036	1.179LysSer: 1.179 ± 0.029	1.201LysThr: 1.201 ± 0.033	1.828LysVal: 1.828 ± 0.037	0.247LysTrp: 0.247 ± 0.013	0.449LysTyr: 0.449 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.157LeuAla: 13.157 ± 0.111	0.787LeuCys: 0.787 ± 0.025	7.001LeuAsp: 7.001 ± 0.086	4.28LeuGlu: 4.28 ± 0.065	2.622LeuPhe: 2.622 ± 0.044	8.728LeuGly: 8.728 ± 0.086	1.95LeuHis: 1.95 ± 0.043	4.314LeuIle: 4.314 ± 0.057	1.474LeuLys: 1.474 ± 0.037	8.806LeuLeu: 8.806 ± 0.091	1.776LeuMet: 1.776 ± 0.035	1.815LeuAsn: 1.815 ± 0.035	5.367LeuPro: 5.367 ± 0.062	2.261LeuGln: 2.261 ± 0.037	7.358LeuArg: 7.358 ± 0.081	5.467LeuSer: 5.467 ± 0.074	6.422LeuThr: 6.422 ± 0.067	8.229LeuVal: 8.229 ± 0.082	1.146LeuTrp: 1.146 ± 0.03	1.608LeuTyr: 1.608 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.569MetAla: 2.569 ± 0.041	0.19MetCys: 0.19 ± 0.012	0.952MetAsp: 0.952 ± 0.023	0.771MetGlu: 0.771 ± 0.025	0.639MetPhe: 0.639 ± 0.02	1.505MetGly: 1.505 ± 0.032	0.435MetHis: 0.435 ± 0.018	1.025MetIle: 1.025 ± 0.028	0.469MetLys: 0.469 ± 0.019	2.028MetLeu: 2.028 ± 0.037	0.476MetMet: 0.476 ± 0.018	0.521MetAsn: 0.521 ± 0.015	1.181MetPro: 1.181 ± 0.026	0.565MetGln: 0.565 ± 0.018	1.588MetArg: 1.588 ± 0.031	1.832MetSer: 1.832 ± 0.037	1.958MetThr: 1.958 ± 0.035	1.687MetVal: 1.687 ± 0.035	0.266MetTrp: 0.266 ± 0.013	0.311MetTyr: 0.311 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.478AsnAla: 2.478 ± 0.04	0.178AsnCys: 0.178 ± 0.011	1.178AsnAsp: 1.178 ± 0.03	0.991AsnGlu: 0.991 ± 0.028	0.618AsnPhe: 0.618 ± 0.021	1.971AsnGly: 1.971 ± 0.039	0.423AsnHis: 0.423 ± 0.016	0.921AsnIle: 0.921 ± 0.025	0.429AsnLys: 0.429 ± 0.018	1.939AsnLeu: 1.939 ± 0.037	0.409AsnMet: 0.409 ± 0.018	0.521AsnAsn: 0.521 ± 0.02	1.7AsnPro: 1.7 ± 0.035	0.598AsnGln: 0.598 ± 0.021	1.539AsnArg: 1.539 ± 0.033	1.142AsnSer: 1.142 ± 0.03	1.246AsnThr: 1.246 ± 0.034	1.664AsnVal: 1.664 ± 0.033	0.365AsnTrp: 0.365 ± 0.015	0.479AsnTyr: 0.479 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.87ProAla: 6.87 ± 0.075	0.267ProCys: 0.267 ± 0.013	4.791ProAsp: 4.791 ± 0.057	3.585ProGlu: 3.585 ± 0.05	1.545ProPhe: 1.545 ± 0.033	5.346ProGly: 5.346 ± 0.068	1.238ProHis: 1.238 ± 0.032	2.314ProIle: 2.314 ± 0.043	1.119ProLys: 1.119 ± 0.032	4.467ProLeu: 4.467 ± 0.057	1.189ProMet: 1.189 ± 0.027	1.205ProAsn: 1.205 ± 0.032	3.027ProPro: 3.027 ± 0.074	1.594ProGln: 1.594 ± 0.034	3.482ProArg: 3.482 ± 0.051	3.102ProSer: 3.102 ± 0.052	3.862ProThr: 3.862 ± 0.058	4.792ProVal: 4.792 ± 0.062	0.788ProTrp: 0.788 ± 0.026	1.086ProTyr: 1.086 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.254GlnAla: 3.254 ± 0.047	0.199GlnCys: 0.199 ± 0.013	1.066GlnAsp: 1.066 ± 0.027	1.122GlnGlu: 1.122 ± 0.029	0.934GlnPhe: 0.934 ± 0.028	1.902GlnGly: 1.902 ± 0.033	0.63GlnHis: 0.63 ± 0.019	1.557GlnIle: 1.557 ± 0.033	0.56GlnLys: 0.56 ± 0.022	3.086GlnLeu: 3.086 ± 0.055	0.734GlnMet: 0.734 ± 0.021	0.612GlnAsn: 0.612 ± 0.019	1.567GlnPro: 1.567 ± 0.038	1.238GlnGln: 1.238 ± 0.032	2.573GlnArg: 2.573 ± 0.042	1.498GlnSer: 1.498 ± 0.031	1.608GlnThr: 1.608 ± 0.032	2.566GlnVal: 2.566 ± 0.043	0.526GlnTrp: 0.526 ± 0.017	0.596GlnTyr: 0.596 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.421ArgAla: 8.421 ± 0.086	0.555ArgCys: 0.555 ± 0.02	4.69ArgAsp: 4.69 ± 0.056	3.959ArgGlu: 3.959 ± 0.059	2.405ArgPhe: 2.405 ± 0.038	5.221ArgGly: 5.221 ± 0.064	1.827ArgHis: 1.827 ± 0.037	3.5ArgIle: 3.5 ± 0.047	1.503ArgLys: 1.503 ± 0.035	7.208ArgLeu: 7.208 ± 0.078	1.881ArgMet: 1.881 ± 0.036	1.616ArgAsn: 1.616 ± 0.033	4.173ArgPro: 4.173 ± 0.056	2.112ArgGln: 2.112 ± 0.043	7.006ArgArg: 7.006 ± 0.094	4.569ArgSer: 4.569 ± 0.055	4.582ArgThr: 4.582 ± 0.052	5.791ArgVal: 5.791 ± 0.062	1.337ArgTrp: 1.337 ± 0.03	1.816ArgTyr: 1.816 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	7.503SerAla: 7.503 ± 0.071	0.391SerCys: 0.391 ± 0.016	3.583SerAsp: 3.583 ± 0.052	2.729SerGlu: 2.729 ± 0.047	1.602SerPhe: 1.602 ± 0.025	5.884SerGly: 5.884 ± 0.066	1.074SerHis: 1.074 ± 0.027	2.357SerIle: 2.357 ± 0.039	1.031SerLys: 1.031 ± 0.024	4.746SerLeu: 4.746 ± 0.06	1.494SerMet: 1.494 ± 0.031	1.083SerAsn: 1.083 ± 0.026	3.129SerPro: 3.129 ± 0.047	1.389SerGln: 1.389 ± 0.034	3.873SerArg: 3.873 ± 0.056	3.56SerSer: 3.56 ± 0.058	3.824SerThr: 3.824 ± 0.049	5.003SerVal: 5.003 ± 0.071	0.889SerTrp: 0.889 ± 0.025	1.131SerTyr: 1.131 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.043ThrAla: 8.043 ± 0.084	0.437ThrCys: 0.437 ± 0.015	4.61ThrAsp: 4.61 ± 0.061	3.45ThrGlu: 3.45 ± 0.05	1.835ThrPhe: 1.835 ± 0.036	5.999ThrGly: 5.999 ± 0.063	1.272ThrHis: 1.272 ± 0.027	2.769ThrIle: 2.769 ± 0.047	1.181ThrLys: 1.181 ± 0.037	5.519ThrLeu: 5.519 ± 0.052	1.315ThrMet: 1.315 ± 0.032	1.16ThrAsn: 1.16 ± 0.03	4.022ThrPro: 4.022 ± 0.062	1.479ThrGln: 1.479 ± 0.034	3.976ThrArg: 3.976 ± 0.052	3.657ThrSer: 3.657 ± 0.054	4.397ThrThr: 4.397 ± 0.063	6.021ThrVal: 6.021 ± 0.074	0.85ThrTrp: 0.85 ± 0.024	1.318ThrTyr: 1.318 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	11.875ValAla: 11.875 ± 0.117	0.75ValCys: 0.75 ± 0.024	6.545ValAsp: 6.545 ± 0.064	4.606ValGlu: 4.606 ± 0.057	2.572ValPhe: 2.572 ± 0.037	7.682ValGly: 7.682 ± 0.083	1.823ValHis: 1.823 ± 0.041	4.329ValIle: 4.329 ± 0.051	1.388ValLys: 1.388 ± 0.034	8.52ValLeu: 8.52 ± 0.095	1.626ValMet: 1.626 ± 0.04	1.894ValAsn: 1.894 ± 0.038	4.526ValPro: 4.526 ± 0.052	1.927ValGln: 1.927 ± 0.037	5.88ValArg: 5.88 ± 0.058	4.855ValSer: 4.855 ± 0.061	5.812ValThr: 5.812 ± 0.061	9.006ValVal: 9.006 ± 0.095	1.044ValTrp: 1.044 ± 0.031	1.469ValTyr: 1.469 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.487TrpAla: 1.487 ± 0.032	0.138TrpCys: 0.138 ± 0.009	0.793TrpAsp: 0.793 ± 0.024	0.625TrpGlu: 0.625 ± 0.022	0.548TrpPhe: 0.548 ± 0.02	1.011TrpGly: 1.011 ± 0.026	0.352TrpHis: 0.352 ± 0.017	0.647TrpIle: 0.647 ± 0.02	0.297TrpLys: 0.297 ± 0.014	1.618TrpLeu: 1.618 ± 0.042	0.363TrpMet: 0.363 ± 0.015	0.379TrpAsn: 0.379 ± 0.016	0.736TrpPro: 0.736 ± 0.023	0.583TrpGln: 0.583 ± 0.021	1.196TrpArg: 1.196 ± 0.028	0.95TrpSer: 0.95 ± 0.027	0.917TrpThr: 0.917 ± 0.021	1.075TrpVal: 1.075 ± 0.028	0.365TrpTrp: 0.365 ± 0.016	0.33TrpTyr: 0.33 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.301TyrAla: 2.301 ± 0.034	0.198TyrCys: 0.198 ± 0.01	1.34TyrAsp: 1.34 ± 0.031	1.015TyrGlu: 1.015 ± 0.026	0.72TyrPhe: 0.72 ± 0.023	1.94TyrGly: 1.94 ± 0.041	0.431TyrHis: 0.431 ± 0.016	0.643TyrIle: 0.643 ± 0.021	0.321TyrLys: 0.321 ± 0.016	2.246TyrLeu: 2.246 ± 0.041	0.295TyrMet: 0.295 ± 0.013	0.455TyrAsn: 0.455 ± 0.018	1.172TyrPro: 1.172 ± 0.031	0.625TyrGln: 0.625 ± 0.019	1.832TyrArg: 1.832 ± 0.035	1.094TyrSer: 1.094 ± 0.027	1.107TyrThr: 1.107 ± 0.032	1.625TyrVal: 1.625 ± 0.033	0.348TyrTrp: 0.348 ± 0.015	0.46TyrTyr: 0.46 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4687 proteins (1589854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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