Amino acid dipepetide frequency for Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.056AlaAla: 9.056 ± 0.31
0.936AlaCys: 0.936 ± 0.04
5.705AlaAsp: 5.705 ± 0.216
5.233AlaGlu: 5.233 ± 0.103
3.098AlaPhe: 3.098 ± 0.072
6.995AlaGly: 6.995 ± 0.358
2.029AlaHis: 2.029 ± 0.063
6.432AlaIle: 6.432 ± 0.119
5.08AlaLys: 5.08 ± 0.117
9.63AlaLeu: 9.63 ± 0.159
2.984AlaMet: 2.984 ± 0.093
3.983AlaAsn: 3.983 ± 0.088
3.4AlaPro: 3.4 ± 0.181
4.448AlaGln: 4.448 ± 0.098
3.963AlaArg: 3.963 ± 0.092
5.575AlaSer: 5.575 ± 0.104
5.473AlaThr: 5.473 ± 0.155
6.259AlaVal: 6.259 ± 0.142
0.985AlaTrp: 0.985 ± 0.035
2.493AlaTyr: 2.493 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.769CysAla: 0.769 ± 0.033
0.131CysCys: 0.131 ± 0.015
0.524CysAsp: 0.524 ± 0.03
0.529CysGlu: 0.529 ± 0.028
0.355CysPhe: 0.355 ± 0.026
0.709CysGly: 0.709 ± 0.036
0.328CysHis: 0.328 ± 0.027
0.549CysIle: 0.549 ± 0.03
0.318CysLys: 0.318 ± 0.022
0.854CysLeu: 0.854 ± 0.035
0.221CysMet: 0.221 ± 0.017
0.287CysAsn: 0.287 ± 0.019
0.431CysPro: 0.431 ± 0.028
0.507CysGln: 0.507 ± 0.031
0.455CysArg: 0.455 ± 0.029
0.534CysSer: 0.534 ± 0.029
0.386CysThr: 0.386 ± 0.025
0.575CysVal: 0.575 ± 0.031
0.085CysTrp: 0.085 ± 0.011
0.308CysTyr: 0.308 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
5.454AspAla: 5.454 ± 0.093
0.507AspCys: 0.507 ± 0.028
3.926AspAsp: 3.926 ± 0.086
3.949AspGlu: 3.949 ± 0.089
2.304AspPhe: 2.304 ± 0.056
3.871AspGly: 3.871 ± 0.101
1.095AspHis: 1.095 ± 0.048
5.007AspIle: 5.007 ± 0.156
3.838AspLys: 3.838 ± 0.094
5.012AspLeu: 5.012 ± 0.094
1.815AspMet: 1.815 ± 0.064
3.36AspAsn: 3.36 ± 0.069
1.994AspPro: 1.994 ± 0.052
1.717AspGln: 1.717 ± 0.048
2.232AspArg: 2.232 ± 0.067
3.969AspSer: 3.969 ± 0.083
3.62AspThr: 3.62 ± 0.166
4.086AspVal: 4.086 ± 0.096
0.917AspTrp: 0.917 ± 0.039
2.206AspTyr: 2.206 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
5.078GluAla: 5.078 ± 0.1
0.402GluCys: 0.402 ± 0.025
2.99GluAsp: 2.99 ± 0.086
2.842GluGlu: 2.842 ± 0.076
1.967GluPhe: 1.967 ± 0.063
3.262GluGly: 3.262 ± 0.092
1.574GluHis: 1.574 ± 0.055
3.404GluIle: 3.404 ± 0.086
3.042GluLys: 3.042 ± 0.078
5.881GluLeu: 5.881 ± 0.115
1.504GluMet: 1.504 ± 0.052
2.433GluAsn: 2.433 ± 0.063
1.88GluPro: 1.88 ± 0.045
3.824GluGln: 3.824 ± 0.091
3.185GluArg: 3.185 ± 0.087
3.154GluSer: 3.154 ± 0.076
2.963GluThr: 2.963 ± 0.078
3.83GluVal: 3.83 ± 0.08
0.688GluTrp: 0.688 ± 0.033
1.622GluTyr: 1.622 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.561PheAla: 3.561 ± 0.083
0.368PheCys: 0.368 ± 0.021
2.886PheAsp: 2.886 ± 0.073
2.292PheGlu: 2.292 ± 0.057
1.491PhePhe: 1.491 ± 0.063
2.98PheGly: 2.98 ± 0.074
0.67PheHis: 0.67 ± 0.033
2.663PheIle: 2.663 ± 0.071
1.703PheLys: 1.703 ± 0.056
2.92PheLeu: 2.92 ± 0.076
1.043PheMet: 1.043 ± 0.041
1.835PheAsn: 1.835 ± 0.057
1.108PhePro: 1.108 ± 0.043
0.894PheGln: 0.894 ± 0.04
1.183PheArg: 1.183 ± 0.039
2.536PheSer: 2.536 ± 0.059
2.093PheThr: 2.093 ± 0.058
2.377PheVal: 2.377 ± 0.06
0.448PheTrp: 0.448 ± 0.033
1.278PheTyr: 1.278 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
5.371GlyAla: 5.371 ± 0.153
0.796GlyCys: 0.796 ± 0.038
3.686GlyAsp: 3.686 ± 0.159
3.686GlyGlu: 3.686 ± 0.089
3.062GlyPhe: 3.062 ± 0.09
4.724GlyGly: 4.724 ± 0.135
1.463GlyHis: 1.463 ± 0.052
4.89GlyIle: 4.89 ± 0.113
3.733GlyLys: 3.733 ± 0.094
6.666GlyLeu: 6.666 ± 0.114
2.239GlyMet: 2.239 ± 0.069
2.741GlyAsn: 2.741 ± 0.116
1.137GlyPro: 1.137 ± 0.049
3.025GlyGln: 3.025 ± 0.092
3.052GlyArg: 3.052 ± 0.08
4.132GlySer: 4.132 ± 0.103
3.857GlyThr: 3.857 ± 0.319
4.883GlyVal: 4.883 ± 0.089
0.904GlyTrp: 0.904 ± 0.039
2.375GlyTyr: 2.375 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.845HisAla: 1.845 ± 0.055
0.267HisCys: 0.267 ± 0.021
1.269HisAsp: 1.269 ± 0.048
1.253HisGlu: 1.253 ± 0.052
0.82HisPhe: 0.82 ± 0.038
1.409HisGly: 1.409 ± 0.045
0.718HisHis: 0.718 ± 0.037
1.504HisIle: 1.504 ± 0.048
1.056HisLys: 1.056 ± 0.038
2.204HisLeu: 2.204 ± 0.068
0.526HisMet: 0.526 ± 0.024
1.0HisAsn: 1.0 ± 0.043
1.196HisPro: 1.196 ± 0.05
1.132HisGln: 1.132 ± 0.045
1.05HisArg: 1.05 ± 0.037
1.48HisSer: 1.48 ± 0.057
1.232HisThr: 1.232 ± 0.047
1.374HisVal: 1.374 ± 0.045
0.309HisTrp: 0.309 ± 0.024
0.823HisTyr: 0.823 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.808IleAla: 6.808 ± 0.12
0.626IleCys: 0.626 ± 0.032
5.088IleAsp: 5.088 ± 0.085
4.631IleGlu: 4.631 ± 0.106
2.231IlePhe: 2.231 ± 0.072
5.043IleGly: 5.043 ± 0.125
1.358IleHis: 1.358 ± 0.051
4.427IleIle: 4.427 ± 0.096
3.722IleLys: 3.722 ± 0.089
5.48IleLeu: 5.48 ± 0.101
1.639IleMet: 1.639 ± 0.053
3.557IleAsn: 3.557 ± 0.097
2.564IlePro: 2.564 ± 0.067
2.218IleGln: 2.218 ± 0.061
2.784IleArg: 2.784 ± 0.067
4.44IleSer: 4.44 ± 0.084
4.146IleThr: 4.146 ± 0.092
4.372IleVal: 4.372 ± 0.121
0.653IleTrp: 0.653 ± 0.032
1.9IleTyr: 1.9 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.88LysAla: 4.88 ± 0.104
0.267LysCys: 0.267 ± 0.023
3.015LysAsp: 3.015 ± 0.088
2.713LysGlu: 2.713 ± 0.085
1.422LysPhe: 1.422 ± 0.052
3.073LysGly: 3.073 ± 0.074
1.138LysHis: 1.138 ± 0.041
3.112LysIle: 3.112 ± 0.079
3.049LysLys: 3.049 ± 0.087
4.891LysLeu: 4.891 ± 0.103
1.423LysMet: 1.423 ± 0.049
2.47LysAsn: 2.47 ± 0.075
2.523LysPro: 2.523 ± 0.068
2.907LysGln: 2.907 ± 0.082
2.69LysArg: 2.69 ± 0.073
3.281LysSer: 3.281 ± 0.088
3.133LysThr: 3.133 ± 0.075
3.407LysVal: 3.407 ± 0.084
0.487LysTrp: 0.487 ± 0.03
1.325LysTyr: 1.325 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
10.074LeuAla: 10.074 ± 0.153
0.887LeuCys: 0.887 ± 0.042
5.68LeuAsp: 5.68 ± 0.101
4.915LeuGlu: 4.915 ± 0.112
3.549LeuPhe: 3.549 ± 0.089
6.442LeuGly: 6.442 ± 0.118
1.971LeuHis: 1.971 ± 0.059
6.375LeuIle: 6.375 ± 0.12
4.909LeuLys: 4.909 ± 0.107
9.903LeuLeu: 9.903 ± 0.181
2.699LeuMet: 2.699 ± 0.074
4.331LeuAsn: 4.331 ± 0.089
5.05LeuPro: 5.05 ± 0.111
4.172LeuGln: 4.172 ± 0.09
4.162LeuArg: 4.162 ± 0.092
7.516LeuSer: 7.516 ± 0.14
6.45LeuThr: 6.45 ± 0.227
6.113LeuVal: 6.113 ± 0.114
1.06LeuTrp: 1.06 ± 0.045
2.66LeuTyr: 2.66 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.773MetAla: 2.773 ± 0.067
0.207MetCys: 0.207 ± 0.017
1.354MetAsp: 1.354 ± 0.054
0.983MetGlu: 0.983 ± 0.043
0.813MetPhe: 0.813 ± 0.037
1.94MetGly: 1.94 ± 0.083
0.551MetHis: 0.551 ± 0.032
1.706MetIle: 1.706 ± 0.047
1.266MetLys: 1.266 ± 0.046
2.754MetLeu: 2.754 ± 0.066
0.918MetMet: 0.918 ± 0.039
1.276MetAsn: 1.276 ± 0.046
1.501MetPro: 1.501 ± 0.049
1.473MetGln: 1.473 ± 0.055
1.273MetArg: 1.273 ± 0.037
2.311MetSer: 2.311 ± 0.058
2.066MetThr: 2.066 ± 0.054
1.872MetVal: 1.872 ± 0.052
0.236MetTrp: 0.236 ± 0.02
0.583MetTyr: 0.583 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
4.014AsnAla: 4.014 ± 0.103
0.39AsnCys: 0.39 ± 0.029
2.933AsnAsp: 2.933 ± 0.068
2.58AsnGlu: 2.58 ± 0.069
1.513AsnPhe: 1.513 ± 0.051
2.865AsnGly: 2.865 ± 0.119
1.054AsnHis: 1.054 ± 0.039
3.256AsnIle: 3.256 ± 0.073
2.571AsnLys: 2.571 ± 0.063
4.025AsnLeu: 4.025 ± 0.071
1.043AsnMet: 1.043 ± 0.042
2.553AsnAsn: 2.553 ± 0.081
2.275AsnPro: 2.275 ± 0.057
2.148AsnGln: 2.148 ± 0.059
1.962AsnArg: 1.962 ± 0.053
2.991AsnSer: 2.991 ± 0.088
2.841AsnThr: 2.841 ± 0.085
2.612AsnVal: 2.612 ± 0.066
0.508AsnTrp: 0.508 ± 0.026
1.365AsnTyr: 1.365 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
3.522ProAla: 3.522 ± 0.07
0.277ProCys: 0.277 ± 0.021
2.514ProAsp: 2.514 ± 0.065
2.757ProGlu: 2.757 ± 0.075
1.549ProPhe: 1.549 ± 0.05
1.395ProGly: 1.395 ± 0.05
0.813ProHis: 0.813 ± 0.038
2.842ProIle: 2.842 ± 0.083
2.292ProLys: 2.292 ± 0.072
4.104ProLeu: 4.104 ± 0.078
1.138ProMet: 1.138 ± 0.048
2.155ProAsn: 2.155 ± 0.058
1.229ProPro: 1.229 ± 0.052
1.476ProGln: 1.476 ± 0.057
1.44ProArg: 1.44 ± 0.051
2.655ProSer: 2.655 ± 0.071
2.693ProThr: 2.693 ± 0.159
3.2ProVal: 3.2 ± 0.097
0.458ProTrp: 0.458 ± 0.028
1.293ProTyr: 1.293 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
5.259GlnAla: 5.259 ± 0.12
0.311GlnCys: 0.311 ± 0.02
2.218GlnAsp: 2.218 ± 0.063
2.069GlnGlu: 2.069 ± 0.066
1.547GlnPhe: 1.547 ± 0.05
2.8GlnGly: 2.8 ± 0.063
1.171GlnHis: 1.171 ± 0.044
2.767GlnIle: 2.767 ± 0.084
2.107GlnLys: 2.107 ± 0.064
5.234GlnLeu: 5.234 ± 0.11
1.259GlnMet: 1.259 ± 0.043
1.671GlnAsn: 1.671 ± 0.047
2.14GlnPro: 2.14 ± 0.083
3.292GlnGln: 3.292 ± 0.123
2.363GlnArg: 2.363 ± 0.062
2.931GlnSer: 2.931 ± 0.087
2.777GlnThr: 2.777 ± 0.081
3.337GlnVal: 3.337 ± 0.076
0.501GlnTrp: 0.501 ± 0.031
1.351GlnTyr: 1.351 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.666ArgAla: 3.666 ± 0.085
0.392ArgCys: 0.392 ± 0.025
2.416ArgAsp: 2.416 ± 0.07
2.588ArgGlu: 2.588 ± 0.068
1.935ArgPhe: 1.935 ± 0.052
2.652ArgGly: 2.652 ± 0.076
1.271ArgHis: 1.271 ± 0.046
3.166ArgIle: 3.166 ± 0.083
1.921ArgLys: 1.921 ± 0.06
5.077ArgLeu: 5.077 ± 0.112
1.236ArgMet: 1.236 ± 0.046
1.609ArgAsn: 1.609 ± 0.053
1.725ArgPro: 1.725 ± 0.05
2.526ArgGln: 2.526 ± 0.076
2.337ArgArg: 2.337 ± 0.072
2.456ArgSer: 2.456 ± 0.067
2.205ArgThr: 2.205 ± 0.064
2.861ArgVal: 2.861 ± 0.071
0.59ArgTrp: 0.59 ± 0.03
1.808ArgTyr: 1.808 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
5.859SerAla: 5.859 ± 0.103
0.508SerCys: 0.508 ± 0.03
3.989SerAsp: 3.989 ± 0.08
3.651SerGlu: 3.651 ± 0.091
2.527SerPhe: 2.527 ± 0.07
4.457SerGly: 4.457 ± 0.082
1.531SerHis: 1.531 ± 0.056
4.424SerIle: 4.424 ± 0.08
3.303SerLys: 3.303 ± 0.078
6.414SerLeu: 6.414 ± 0.136
1.778SerMet: 1.778 ± 0.047
3.063SerAsn: 3.063 ± 0.069
2.269SerPro: 2.269 ± 0.061
3.056SerGln: 3.056 ± 0.075
2.914SerArg: 2.914 ± 0.079
4.438SerSer: 4.438 ± 0.106
3.681SerThr: 3.681 ± 0.085
4.216SerVal: 4.216 ± 0.141
0.711SerTrp: 0.711 ± 0.031
2.082SerTyr: 2.082 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
6.192ThrAla: 6.192 ± 0.525
0.437ThrCys: 0.437 ± 0.026
3.976ThrAsp: 3.976 ± 0.102
3.066ThrGlu: 3.066 ± 0.069
1.867ThrPhe: 1.867 ± 0.051
4.444ThrGly: 4.444 ± 0.148
1.375ThrHis: 1.375 ± 0.053
3.821ThrIle: 3.821 ± 0.089
2.5ThrLys: 2.5 ± 0.076
6.462ThrLeu: 6.462 ± 0.206
1.335ThrMet: 1.335 ± 0.044
2.46ThrAsn: 2.46 ± 0.092
3.034ThrPro: 3.034 ± 0.071
2.897ThrGln: 2.897 ± 0.157
2.374ThrArg: 2.374 ± 0.067
3.469ThrSer: 3.469 ± 0.086
3.688ThrThr: 3.688 ± 0.147
4.15ThrVal: 4.15 ± 0.162
0.644ThrTrp: 0.644 ± 0.082
1.548ThrTyr: 1.548 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
6.229ValAla: 6.229 ± 0.127
0.688ValCys: 0.688 ± 0.032
4.174ValAsp: 4.174 ± 0.087
3.685ValGlu: 3.685 ± 0.082
2.506ValPhe: 2.506 ± 0.072
4.524ValGly: 4.524 ± 0.11
1.188ValHis: 1.188 ± 0.047
4.952ValIle: 4.952 ± 0.091
3.154ValLys: 3.154 ± 0.077
6.479ValLeu: 6.479 ± 0.13
2.074ValMet: 2.074 ± 0.064
3.137ValAsn: 3.137 ± 0.093
2.648ValPro: 2.648 ± 0.064
2.402ValGln: 2.402 ± 0.064
2.8ValArg: 2.8 ± 0.075
4.535ValSer: 4.535 ± 0.091
4.481ValThr: 4.481 ± 0.38
4.844ValVal: 4.844 ± 0.096
0.64ValTrp: 0.64 ± 0.03
1.839ValTyr: 1.839 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.816TrpAla: 0.816 ± 0.036
0.119TrpCys: 0.119 ± 0.013
0.532TrpAsp: 0.532 ± 0.026
0.446TrpGlu: 0.446 ± 0.029
0.576TrpPhe: 0.576 ± 0.028
0.702TrpGly: 0.702 ± 0.03
0.345TrpHis: 0.345 ± 0.024
0.643TrpIle: 0.643 ± 0.03
0.341TrpLys: 0.341 ± 0.025
1.791TrpLeu: 1.791 ± 0.07
0.332TrpMet: 0.332 ± 0.021
0.324TrpAsn: 0.324 ± 0.023
0.224TrpPro: 0.224 ± 0.018
1.12TrpGln: 1.12 ± 0.048
0.621TrpArg: 0.621 ± 0.033
0.688TrpSer: 0.688 ± 0.077
0.515TrpThr: 0.515 ± 0.029
0.749TrpVal: 0.749 ± 0.035
0.159TrpTrp: 0.159 ± 0.014
0.363TrpTyr: 0.363 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.531TyrAla: 2.531 ± 0.071
0.341TyrCys: 0.341 ± 0.025
2.004TyrAsp: 2.004 ± 0.058
1.657TyrGlu: 1.657 ± 0.063
1.198TyrPhe: 1.198 ± 0.041
2.135TyrGly: 2.135 ± 0.062
0.824TyrHis: 0.824 ± 0.033
1.745TyrIle: 1.745 ± 0.048
1.301TyrLys: 1.301 ± 0.05
3.137TyrLeu: 3.137 ± 0.081
0.646TyrMet: 0.646 ± 0.035
1.253TyrAsn: 1.253 ± 0.047
1.474TyrPro: 1.474 ± 0.048
1.869TyrGln: 1.869 ± 0.062
1.598TyrArg: 1.598 ± 0.048
1.779TyrSer: 1.779 ± 0.056
1.443TyrThr: 1.443 ± 0.038
1.864TyrVal: 1.864 ± 0.053
0.423TyrTrp: 0.423 ± 0.025
1.05TyrTyr: 1.05 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2099 proteins (704762 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski