Amino acid dipepetide frequency for Treponema brennaborense (strain DSM 12168 / CIP 105900 / DD5/3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.467AlaAla: 15.467 ± 0.245	1.302AlaCys: 1.302 ± 0.049	6.619AlaAsp: 6.619 ± 0.106	8.021AlaGlu: 8.021 ± 0.115	4.023AlaPhe: 4.023 ± 0.078	8.637AlaGly: 8.637 ± 0.126	1.431AlaHis: 1.431 ± 0.044	4.228AlaIle: 4.228 ± 0.074	4.33AlaLys: 4.33 ± 0.097	9.176AlaLeu: 9.176 ± 0.125	1.768AlaMet: 1.768 ± 0.048	2.598AlaAsn: 2.598 ± 0.061	3.221AlaPro: 3.221 ± 0.067	3.315AlaGln: 3.315 ± 0.07	4.514AlaArg: 4.514 ± 0.087	5.634AlaSer: 5.634 ± 0.097	3.259AlaThr: 3.259 ± 0.058	9.359AlaVal: 9.359 ± 0.126	0.79AlaTrp: 0.79 ± 0.032	3.071AlaTyr: 3.071 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.705CysAla: 1.705 ± 0.052	0.268CysCys: 0.268 ± 0.018	0.781CysAsp: 0.781 ± 0.03	0.676CysGlu: 0.676 ± 0.029	0.664CysPhe: 0.664 ± 0.029	1.518CysGly: 1.518 ± 0.046	0.204CysHis: 0.204 ± 0.016	1.004CysIle: 1.004 ± 0.035	0.574CysLys: 0.574 ± 0.025	1.117CysLeu: 1.117 ± 0.037	0.303CysMet: 0.303 ± 0.017	0.449CysAsn: 0.449 ± 0.023	0.571CysPro: 0.571 ± 0.031	0.242CysGln: 0.242 ± 0.017	0.895CysArg: 0.895 ± 0.033	0.996CysSer: 0.996 ± 0.032	0.921CysThr: 0.921 ± 0.036	1.155CysVal: 1.155 ± 0.038	0.124CysTrp: 0.124 ± 0.012	0.395CysTyr: 0.395 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.51AspAla: 5.51 ± 0.087	0.756AspCys: 0.756 ± 0.033	2.693AspAsp: 2.693 ± 0.07	3.586AspGlu: 3.586 ± 0.076	3.033AspPhe: 3.033 ± 0.057	4.737AspGly: 4.737 ± 0.083	0.596AspHis: 0.596 ± 0.027	3.951AspIle: 3.951 ± 0.069	2.674AspLys: 2.674 ± 0.058	4.013AspLeu: 4.013 ± 0.072	1.505AspMet: 1.505 ± 0.041	1.58AspAsn: 1.58 ± 0.044	2.292AspPro: 2.292 ± 0.054	0.99AspGln: 0.99 ± 0.035	2.544AspArg: 2.544 ± 0.052	3.856AspSer: 3.856 ± 0.076	3.673AspThr: 3.673 ± 0.083	3.814AspVal: 3.814 ± 0.061	0.656AspTrp: 0.656 ± 0.028	1.95AspTyr: 1.95 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.144GluAla: 5.144 ± 0.098	0.768GluCys: 0.768 ± 0.031	2.583GluAsp: 2.583 ± 0.062	3.251GluGlu: 3.251 ± 0.079	2.298GluPhe: 2.298 ± 0.054	2.921GluGly: 2.921 ± 0.063	1.037GluHis: 1.037 ± 0.034	4.35GluIle: 4.35 ± 0.077	4.694GluLys: 4.694 ± 0.079	6.198GluLeu: 6.198 ± 0.088	1.465GluMet: 1.465 ± 0.042	3.393GluAsn: 3.393 ± 0.075	2.395GluPro: 2.395 ± 0.071	2.374GluGln: 2.374 ± 0.065	4.024GluArg: 4.024 ± 0.082	4.105GluSer: 4.105 ± 0.075	4.439GluThr: 4.439 ± 0.085	2.873GluVal: 2.873 ± 0.059	0.626GluTrp: 0.626 ± 0.026	2.425GluTyr: 2.425 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	4.612PheAla: 4.612 ± 0.082	0.877PheCys: 0.877 ± 0.033	2.866PheAsp: 2.866 ± 0.06	2.422PheGlu: 2.422 ± 0.061	2.641PhePhe: 2.641 ± 0.074	3.422PheGly: 3.422 ± 0.065	0.662PheHis: 0.662 ± 0.029	3.149PheIle: 3.149 ± 0.072	2.035PheLys: 2.035 ± 0.052	4.179PheLeu: 4.179 ± 0.084	1.088PheMet: 1.088 ± 0.038	1.578PheAsn: 1.578 ± 0.044	1.915PhePro: 1.915 ± 0.059	1.034PheGln: 1.034 ± 0.039	2.248PheArg: 2.248 ± 0.06	4.197PheSer: 4.197 ± 0.079	3.159PheThr: 3.159 ± 0.064	3.003PheVal: 3.003 ± 0.068	0.439PheTrp: 0.439 ± 0.024	1.67PheTyr: 1.67 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	6.547GlyAla: 6.547 ± 0.109	1.176GlyCys: 1.176 ± 0.041	3.292GlyAsp: 3.292 ± 0.073	3.712GlyGlu: 3.712 ± 0.086	3.73GlyPhe: 3.73 ± 0.07	5.522GlyGly: 5.522 ± 0.12	0.903GlyHis: 0.903 ± 0.035	5.522GlyIle: 5.522 ± 0.089	4.694GlyLys: 4.694 ± 0.066	5.748GlyLeu: 5.748 ± 0.082	1.998GlyMet: 1.998 ± 0.049	2.897GlyAsn: 2.897 ± 0.07	1.427GlyPro: 1.427 ± 0.041	1.711GlyGln: 1.711 ± 0.05	3.36GlyArg: 3.36 ± 0.065	5.239GlySer: 5.239 ± 0.109	5.702GlyThr: 5.702 ± 0.112	5.051GlyVal: 5.051 ± 0.077	0.771GlyTrp: 0.771 ± 0.033	2.595GlyTyr: 2.595 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.259HisAla: 1.259 ± 0.038	0.249HisCys: 0.249 ± 0.018	0.757HisAsp: 0.757 ± 0.03	0.842HisGlu: 0.842 ± 0.029	0.748HisPhe: 0.748 ± 0.029	1.142HisGly: 1.142 ± 0.039	0.247HisHis: 0.247 ± 0.016	1.152HisIle: 1.152 ± 0.034	0.652HisLys: 0.652 ± 0.027	1.268HisLeu: 1.268 ± 0.038	0.313HisMet: 0.313 ± 0.018	0.563HisAsn: 0.563 ± 0.02	0.863HisPro: 0.863 ± 0.031	0.366HisGln: 0.366 ± 0.022	0.811HisArg: 0.811 ± 0.031	0.886HisSer: 0.886 ± 0.034	0.988HisThr: 0.988 ± 0.035	1.002HisVal: 1.002 ± 0.035	0.131HisTrp: 0.131 ± 0.011	0.564HisTyr: 0.564 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.373IleAla: 6.373 ± 0.087	0.996IleCys: 0.996 ± 0.042	3.718IleAsp: 3.718 ± 0.065	3.894IleGlu: 3.894 ± 0.074	2.581IlePhe: 2.581 ± 0.064	4.468IleGly: 4.468 ± 0.086	0.981IleHis: 0.981 ± 0.031	4.075IleIle: 4.075 ± 0.098	3.24IleLys: 3.24 ± 0.067	5.847IleLeu: 5.847 ± 0.091	1.33IleMet: 1.33 ± 0.037	2.181IleAsn: 2.181 ± 0.05	3.375IlePro: 3.375 ± 0.061	1.797IleGln: 1.797 ± 0.052	3.841IleArg: 3.841 ± 0.075	4.382IleSer: 4.382 ± 0.08	4.053IleThr: 4.053 ± 0.074	4.468IleVal: 4.468 ± 0.079	0.482IleTrp: 0.482 ± 0.023	1.82IleTyr: 1.82 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.274LysAla: 4.274 ± 0.088	0.499LysCys: 0.499 ± 0.025	2.871LysAsp: 2.871 ± 0.06	3.491LysGlu: 3.491 ± 0.066	1.61LysPhe: 1.61 ± 0.04	3.023LysGly: 3.023 ± 0.064	0.74LysHis: 0.74 ± 0.027	4.211LysIle: 4.211 ± 0.067	4.548LysLys: 4.548 ± 0.088	4.901LysLeu: 4.901 ± 0.079	1.448LysMet: 1.448 ± 0.038	3.258LysAsn: 3.258 ± 0.066	2.086LysPro: 2.086 ± 0.05	1.823LysGln: 1.823 ± 0.047	2.98LysArg: 2.98 ± 0.058	3.281LysSer: 3.281 ± 0.067	4.148LysThr: 4.148 ± 0.07	2.549LysVal: 2.549 ± 0.065	0.446LysTrp: 0.446 ± 0.021	1.876LysTyr: 1.876 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	8.409LeuAla: 8.409 ± 0.1	1.661LeuCys: 1.661 ± 0.045	4.9LeuAsp: 4.9 ± 0.077	5.354LeuGlu: 5.354 ± 0.094	4.875LeuPhe: 4.875 ± 0.095	5.335LeuGly: 5.335 ± 0.082	1.617LeuHis: 1.617 ± 0.043	5.737LeuIle: 5.737 ± 0.091	5.127LeuLys: 5.127 ± 0.081	9.285LeuLeu: 9.285 ± 0.15	1.926LeuMet: 1.926 ± 0.059	3.616LeuAsn: 3.616 ± 0.074	4.59LeuPro: 4.59 ± 0.075	2.878LeuGln: 2.878 ± 0.061	4.651LeuArg: 4.651 ± 0.087	6.962LeuSer: 6.962 ± 0.082	5.296LeuThr: 5.296 ± 0.087	5.517LeuVal: 5.517 ± 0.085	0.796LeuTrp: 0.796 ± 0.031	3.603LeuTyr: 3.603 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.752MetAla: 1.752 ± 0.046	0.254MetCys: 0.254 ± 0.017	1.081MetAsp: 1.081 ± 0.036	1.426MetGlu: 1.426 ± 0.039	0.865MetPhe: 0.865 ± 0.037	1.384MetGly: 1.384 ± 0.04	0.379MetHis: 0.379 ± 0.02	1.574MetIle: 1.574 ± 0.044	1.891MetLys: 1.891 ± 0.045	2.24MetLeu: 2.24 ± 0.051	0.546MetMet: 0.546 ± 0.026	1.389MetAsn: 1.389 ± 0.043	1.004MetPro: 1.004 ± 0.033	0.955MetGln: 0.955 ± 0.033	1.018MetArg: 1.018 ± 0.034	1.443MetSer: 1.443 ± 0.044	1.294MetThr: 1.294 ± 0.038	1.199MetVal: 1.199 ± 0.05	0.145MetTrp: 0.145 ± 0.014	0.705MetTyr: 0.705 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.704AsnAla: 3.704 ± 0.064	0.517AsnCys: 0.517 ± 0.026	2.05AsnAsp: 2.05 ± 0.051	2.19AsnGlu: 2.19 ± 0.052	1.495AsnPhe: 1.495 ± 0.041	3.612AsnGly: 3.612 ± 0.077	0.501AsnHis: 0.501 ± 0.025	2.475AsnIle: 2.475 ± 0.07	1.867AsnLys: 1.867 ± 0.05	3.314AsnLeu: 3.314 ± 0.064	0.991AsnMet: 0.991 ± 0.032	1.218AsnAsn: 1.218 ± 0.042	1.997AsnPro: 1.997 ± 0.051	0.984AsnGln: 0.984 ± 0.037	2.189AsnArg: 2.189 ± 0.053	2.194AsnSer: 2.194 ± 0.052	2.354AsnThr: 2.354 ± 0.062	2.611AsnVal: 2.611 ± 0.058	0.461AsnTrp: 0.461 ± 0.024	1.343AsnTyr: 1.343 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.843ProAla: 4.843 ± 0.1	0.538ProCys: 0.538 ± 0.027	2.935ProAsp: 2.935 ± 0.058	3.613ProGlu: 3.613 ± 0.085	2.146ProPhe: 2.146 ± 0.056	2.782ProGly: 2.782 ± 0.061	0.722ProHis: 0.722 ± 0.03	1.875ProIle: 1.875 ± 0.049	1.397ProLys: 1.397 ± 0.037	3.911ProLeu: 3.911 ± 0.067	0.704ProMet: 0.704 ± 0.029	1.137ProAsn: 1.137 ± 0.041	1.494ProPro: 1.494 ± 0.046	1.324ProGln: 1.324 ± 0.039	1.557ProArg: 1.557 ± 0.043	2.294ProSer: 2.294 ± 0.055	1.389ProThr: 1.389 ± 0.036	4.132ProVal: 4.132 ± 0.075	0.35ProTrp: 0.35 ± 0.021	1.655ProTyr: 1.655 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.477GlnAla: 2.477 ± 0.057	0.325GlnCys: 0.325 ± 0.021	1.375GlnAsp: 1.375 ± 0.041	1.706GlnGlu: 1.706 ± 0.05	1.343GlnPhe: 1.343 ± 0.04	1.533GlnGly: 1.533 ± 0.042	0.439GlnHis: 0.439 ± 0.022	2.216GlnIle: 2.216 ± 0.05	2.081GlnLys: 2.081 ± 0.048	2.944GlnLeu: 2.944 ± 0.063	0.732GlnMet: 0.732 ± 0.028	1.6GlnAsn: 1.6 ± 0.039	1.197GlnPro: 1.197 ± 0.041	1.097GlnGln: 1.097 ± 0.043	1.492GlnArg: 1.492 ± 0.042	2.009GlnSer: 2.009 ± 0.055	2.047GlnThr: 2.047 ± 0.053	1.552GlnVal: 1.552 ± 0.048	0.277GlnTrp: 0.277 ± 0.019	1.109GlnTyr: 1.109 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.14ArgAla: 4.14 ± 0.09	0.716ArgCys: 0.716 ± 0.027	2.437ArgAsp: 2.437 ± 0.059	3.13ArgGlu: 3.13 ± 0.075	2.781ArgPhe: 2.781 ± 0.06	2.853ArgGly: 2.853 ± 0.063	0.77ArgHis: 0.77 ± 0.03	4.177ArgIle: 4.177 ± 0.072	3.262ArgLys: 3.262 ± 0.07	4.88ArgLeu: 4.88 ± 0.078	1.415ArgMet: 1.415 ± 0.044	2.461ArgAsn: 2.461 ± 0.054	1.695ArgPro: 1.695 ± 0.042	1.747ArgGln: 1.747 ± 0.049	3.091ArgArg: 3.091 ± 0.078	3.173ArgSer: 3.173 ± 0.056	3.404ArgThr: 3.404 ± 0.069	3.04ArgVal: 3.04 ± 0.069	0.487ArgTrp: 0.487 ± 0.022	2.038ArgTyr: 2.038 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	7.937SerAla: 7.937 ± 0.127	0.968SerCys: 0.968 ± 0.03	3.811SerAsp: 3.811 ± 0.078	3.871SerGlu: 3.871 ± 0.062	3.656SerPhe: 3.656 ± 0.072	6.42SerGly: 6.42 ± 0.112	0.828SerHis: 0.828 ± 0.029	3.842SerIle: 3.842 ± 0.077	2.719SerLys: 2.719 ± 0.06	6.082SerLeu: 6.082 ± 0.09	1.414SerMet: 1.414 ± 0.04	1.846SerAsn: 1.846 ± 0.049	2.4SerPro: 2.4 ± 0.049	1.585SerGln: 1.585 ± 0.045	3.249SerArg: 3.249 ± 0.066	4.043SerSer: 4.043 ± 0.084	2.724SerThr: 2.724 ± 0.07	6.161SerVal: 6.161 ± 0.095	0.696SerTrp: 0.696 ± 0.03	2.518SerTyr: 2.518 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	7.155ThrAla: 7.155 ± 0.113	0.615ThrCys: 0.615 ± 0.031	3.908ThrAsp: 3.908 ± 0.086	4.141ThrGlu: 4.141 ± 0.077	2.44ThrPhe: 2.44 ± 0.06	5.485ThrGly: 5.485 ± 0.087	0.858ThrHis: 0.858 ± 0.032	3.286ThrIle: 3.286 ± 0.068	2.234ThrLys: 2.234 ± 0.06	5.43ThrLeu: 5.43 ± 0.085	1.11ThrMet: 1.11 ± 0.039	1.7ThrAsn: 1.7 ± 0.056	2.48ThrPro: 2.48 ± 0.055	1.628ThrGln: 1.628 ± 0.044	2.254ThrArg: 2.254 ± 0.051	2.913ThrSer: 2.913 ± 0.063	2.425ThrThr: 2.425 ± 0.057	6.258ThrVal: 6.258 ± 0.12	0.516ThrTrp: 0.516 ± 0.025	2.005ThrTyr: 2.005 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	5.323ValAla: 5.323 ± 0.084	1.442ValCys: 1.442 ± 0.039	3.033ValAsp: 3.033 ± 0.066	3.218ValGlu: 3.218 ± 0.072	4.042ValPhe: 4.042 ± 0.082	3.445ValGly: 3.445 ± 0.064	1.17ValHis: 1.17 ± 0.034	4.36ValIle: 4.36 ± 0.084	3.749ValLys: 3.749 ± 0.065	7.563ValLeu: 7.563 ± 0.112	1.56ValMet: 1.56 ± 0.045	2.549ValAsn: 2.549 ± 0.054	3.977ValPro: 3.977 ± 0.073	2.355ValGln: 2.355 ± 0.049	4.262ValArg: 4.262 ± 0.066	6.509ValSer: 6.509 ± 0.107	4.686ValThr: 4.686 ± 0.105	4.795ValVal: 4.795 ± 0.096	0.771ValTrp: 0.771 ± 0.03	2.716ValTyr: 2.716 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.628TrpAla: 0.628 ± 0.026	0.138TrpCys: 0.138 ± 0.013	0.504TrpAsp: 0.504 ± 0.026	0.549TrpGlu: 0.549 ± 0.024	0.515TrpPhe: 0.515 ± 0.025	0.632TrpGly: 0.632 ± 0.03	0.194TrpHis: 0.194 ± 0.014	0.675TrpIle: 0.675 ± 0.028	0.63TrpLys: 0.63 ± 0.025	0.888TrpLeu: 0.888 ± 0.034	0.21TrpMet: 0.21 ± 0.015	0.667TrpAsn: 0.667 ± 0.028	0.246TrpPro: 0.246 ± 0.016	0.447TrpGln: 0.447 ± 0.025	0.454TrpArg: 0.454 ± 0.024	0.522TrpSer: 0.522 ± 0.027	0.558TrpThr: 0.558 ± 0.03	0.466TrpVal: 0.466 ± 0.022	0.131TrpTrp: 0.131 ± 0.012	0.432TrpTyr: 0.432 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.505TyrAla: 3.505 ± 0.071	0.497TyrCys: 0.497 ± 0.023	2.193TyrAsp: 2.193 ± 0.054	2.27TyrGlu: 2.27 ± 0.06	1.71TyrPhe: 1.71 ± 0.042	2.728TyrGly: 2.728 ± 0.062	0.524TyrHis: 0.524 ± 0.024	2.042TyrIle: 2.042 ± 0.048	1.665TyrLys: 1.665 ± 0.045	3.149TyrLeu: 3.149 ± 0.067	0.72TyrMet: 0.72 ± 0.029	1.389TyrAsn: 1.389 ± 0.046	1.573TyrPro: 1.573 ± 0.042	0.899TyrGln: 0.899 ± 0.033	2.261TyrArg: 2.261 ± 0.062	2.13TyrSer: 2.13 ± 0.047	2.325TyrThr: 2.325 ± 0.062	2.519TyrVal: 2.519 ± 0.056	0.388TyrTrp: 0.388 ± 0.023	1.442TyrTyr: 1.442 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2522 proteins (908311 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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