Amino acid dipepetide frequency for Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.831AlaAla: 3.831 ± 1.64
0.697AlaCys: 0.697 ± 0.324
3.831AlaAsp: 3.831 ± 2.139
2.09AlaGlu: 2.09 ± 1.052
3.135AlaPhe: 3.135 ± 0.703
3.135AlaGly: 3.135 ± 0.761
0.0AlaHis: 0.0 ± 0.0
5.921AlaIle: 5.921 ± 0.727
3.135AlaLys: 3.135 ± 1.8
4.18AlaLeu: 4.18 ± 1.512
0.697AlaMet: 0.697 ± 0.543
2.786AlaAsn: 2.786 ± 0.991
3.483AlaPro: 3.483 ± 2.112
1.393AlaGln: 1.393 ± 0.531
1.045AlaArg: 1.045 ± 0.925
4.18AlaSer: 4.18 ± 0.956
4.18AlaThr: 4.18 ± 0.98
5.225AlaVal: 5.225 ± 1.608
1.045AlaTrp: 1.045 ± 0.511
2.786AlaTyr: 2.786 ± 0.509
0.0AlaXaa: 0.0 ± 0.0
Cys
1.393CysAla: 1.393 ± 0.673
1.393CysCys: 1.393 ± 0.657
1.742CysAsp: 1.742 ± 0.711
0.697CysGlu: 0.697 ± 0.444
2.438CysPhe: 2.438 ± 0.62
1.742CysGly: 1.742 ± 0.85
1.045CysHis: 1.045 ± 0.546
1.742CysIle: 1.742 ± 0.636
1.045CysLys: 1.045 ± 0.416
2.438CysLeu: 2.438 ± 0.83
0.0CysMet: 0.0 ± 0.0
2.438CysAsn: 2.438 ± 0.928
2.09CysPro: 2.09 ± 0.804
1.742CysGln: 1.742 ± 0.758
1.393CysArg: 1.393 ± 0.821
1.393CysSer: 1.393 ± 0.583
2.786CysThr: 2.786 ± 0.554
2.438CysVal: 2.438 ± 0.797
0.348CysTrp: 0.348 ± 0.222
0.697CysTyr: 0.697 ± 0.324
0.0CysXaa: 0.0 ± 0.0
Asp
2.786AspAla: 2.786 ± 0.739
1.393AspCys: 1.393 ± 0.583
2.438AspAsp: 2.438 ± 0.832
2.09AspGlu: 2.09 ± 1.159
2.09AspPhe: 2.09 ± 1.122
2.786AspGly: 2.786 ± 0.972
0.0AspHis: 0.0 ± 0.0
3.483AspIle: 3.483 ± 1.257
1.393AspLys: 1.393 ± 0.55
5.225AspLeu: 5.225 ± 1.787
1.045AspMet: 1.045 ± 0.538
1.393AspAsn: 1.393 ± 1.088
1.393AspPro: 1.393 ± 0.671
1.742AspGln: 1.742 ± 1.525
2.09AspArg: 2.09 ± 0.94
3.831AspSer: 3.831 ± 1.412
3.831AspThr: 3.831 ± 0.773
5.225AspVal: 5.225 ± 1.386
0.348AspTrp: 0.348 ± 0.368
2.786AspTyr: 2.786 ± 0.991
0.0AspXaa: 0.0 ± 0.0
Glu
3.483GluAla: 3.483 ± 0.623
0.697GluCys: 0.697 ± 0.444
2.438GluAsp: 2.438 ± 1.16
1.393GluGlu: 1.393 ± 0.55
2.786GluPhe: 2.786 ± 0.773
2.786GluGly: 2.786 ± 1.02
0.0GluHis: 0.0 ± 0.0
1.742GluIle: 1.742 ± 0.767
0.697GluLys: 0.697 ± 0.411
3.831GluLeu: 3.831 ± 1.144
1.045GluMet: 1.045 ± 0.484
1.393GluAsn: 1.393 ± 0.298
3.483GluPro: 3.483 ± 1.268
0.348GluGln: 0.348 ± 0.49
0.697GluArg: 0.697 ± 0.453
0.697GluSer: 0.697 ± 0.98
1.393GluThr: 1.393 ± 0.526
1.393GluVal: 1.393 ± 0.578
0.348GluTrp: 0.348 ± 0.487
1.742GluTyr: 1.742 ± 0.778
0.0GluXaa: 0.0 ± 0.0
Phe
2.786PheAla: 2.786 ± 0.979
1.742PheCys: 1.742 ± 0.81
2.09PheAsp: 2.09 ± 0.582
1.393PheGlu: 1.393 ± 0.671
1.393PhePhe: 1.393 ± 0.701
4.528PheGly: 4.528 ± 1.192
1.393PheHis: 1.393 ± 0.696
4.18PheIle: 4.18 ± 1.35
3.831PheLys: 3.831 ± 0.79
4.18PheLeu: 4.18 ± 1.207
1.393PheMet: 1.393 ± 0.817
5.921PheAsn: 5.921 ± 1.374
2.09PhePro: 2.09 ± 0.704
0.348PheGln: 0.348 ± 0.406
2.786PheArg: 2.786 ± 1.273
3.831PheSer: 3.831 ± 0.773
5.225PheThr: 5.225 ± 1.287
2.786PheVal: 2.786 ± 1.191
0.348PheTrp: 0.348 ± 0.406
3.483PheTyr: 3.483 ± 1.132
0.0PheXaa: 0.0 ± 0.0
Gly
2.09GlyAla: 2.09 ± 0.847
2.09GlyCys: 2.09 ± 0.985
2.438GlyAsp: 2.438 ± 0.932
0.697GlyGlu: 0.697 ± 0.484
5.573GlyPhe: 5.573 ± 1.691
2.786GlyGly: 2.786 ± 1.16
0.697GlyHis: 0.697 ± 0.412
5.225GlyIle: 5.225 ± 0.721
2.786GlyLys: 2.786 ± 1.578
5.225GlyLeu: 5.225 ± 1.806
1.742GlyMet: 1.742 ± 0.831
6.27GlyAsn: 6.27 ± 1.19
1.045GlyPro: 1.045 ± 0.9
2.438GlyGln: 2.438 ± 1.079
2.786GlyArg: 2.786 ± 0.816
5.921GlySer: 5.921 ± 0.693
6.966GlyThr: 6.966 ± 1.416
6.27GlyVal: 6.27 ± 1.012
0.348GlyTrp: 0.348 ± 0.222
4.18GlyTyr: 4.18 ± 1.05
0.0GlyXaa: 0.0 ± 0.0
His
1.393HisAla: 1.393 ± 0.298
0.348HisCys: 0.348 ± 0.222
1.393HisAsp: 1.393 ± 0.531
0.0HisGlu: 0.0 ± 0.0
1.393HisPhe: 1.393 ± 0.647
0.348HisGly: 0.348 ± 0.368
0.0HisHis: 0.0 ± 0.0
0.697HisIle: 0.697 ± 0.674
0.348HisLys: 0.348 ± 0.487
1.045HisLeu: 1.045 ± 1.151
0.0HisMet: 0.0 ± 0.0
0.348HisAsn: 0.348 ± 0.406
0.697HisPro: 0.697 ± 0.453
1.393HisGln: 1.393 ± 0.908
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
1.045HisThr: 1.045 ± 0.448
0.697HisVal: 0.697 ± 0.324
0.0HisTrp: 0.0 ± 0.0
2.09HisTyr: 2.09 ± 0.83
0.0HisXaa: 0.0 ± 0.0
Ile
1.742IleAla: 1.742 ± 0.579
2.438IleCys: 2.438 ± 0.941
2.438IleAsp: 2.438 ± 0.79
3.483IleGlu: 3.483 ± 0.978
2.786IlePhe: 2.786 ± 1.037
3.831IleGly: 3.831 ± 1.282
0.697IleHis: 0.697 ± 0.324
5.225IleIle: 5.225 ± 3.435
2.438IleLys: 2.438 ± 1.233
6.966IleLeu: 6.966 ± 2.056
1.742IleMet: 1.742 ± 1.112
4.528IleAsn: 4.528 ± 2.198
2.09IlePro: 2.09 ± 0.837
3.483IleGln: 3.483 ± 1.184
2.438IleArg: 2.438 ± 1.285
5.573IleSer: 5.573 ± 0.675
3.831IleThr: 3.831 ± 0.926
3.831IleVal: 3.831 ± 2.371
0.697IleTrp: 0.697 ± 0.63
1.045IleTyr: 1.045 ± 0.547
0.0IleXaa: 0.0 ± 0.0
Lys
2.09LysAla: 2.09 ± 0.754
2.09LysCys: 2.09 ± 0.985
2.438LysAsp: 2.438 ± 0.896
1.393LysGlu: 1.393 ± 0.841
1.742LysPhe: 1.742 ± 0.489
2.438LysGly: 2.438 ± 0.982
0.348LysHis: 0.348 ± 0.418
2.09LysIle: 2.09 ± 0.582
1.393LysLys: 1.393 ± 0.569
3.483LysLeu: 3.483 ± 1.072
1.045LysMet: 1.045 ± 0.718
1.045LysAsn: 1.045 ± 0.424
2.438LysPro: 2.438 ± 1.155
1.742LysGln: 1.742 ± 1.644
1.742LysArg: 1.742 ± 1.109
3.135LysSer: 3.135 ± 0.746
1.742LysThr: 1.742 ± 0.527
5.921LysVal: 5.921 ± 0.829
0.697LysTrp: 0.697 ± 0.351
1.742LysTyr: 1.742 ± 1.33
0.0LysXaa: 0.0 ± 0.0
Leu
4.876LeuAla: 4.876 ± 1.541
2.09LeuCys: 2.09 ± 1.305
2.786LeuAsp: 2.786 ± 1.09
2.786LeuGlu: 2.786 ± 0.976
3.483LeuPhe: 3.483 ± 1.137
6.27LeuGly: 6.27 ± 0.948
0.697LeuHis: 0.697 ± 0.453
4.528LeuIle: 4.528 ± 1.849
4.18LeuLys: 4.18 ± 1.807
12.539LeuLeu: 12.539 ± 5.005
2.09LeuMet: 2.09 ± 0.896
7.315LeuAsn: 7.315 ± 0.85
5.225LeuPro: 5.225 ± 1.337
4.528LeuGln: 4.528 ± 2.075
2.438LeuArg: 2.438 ± 0.963
8.708LeuSer: 8.708 ± 1.733
4.528LeuThr: 4.528 ± 1.3
5.921LeuVal: 5.921 ± 1.481
1.045LeuTrp: 1.045 ± 0.448
5.921LeuTyr: 5.921 ± 1.913
0.0LeuXaa: 0.0 ± 0.0
Met
1.742MetAla: 1.742 ± 0.737
1.742MetCys: 1.742 ± 0.66
1.742MetAsp: 1.742 ± 0.725
0.0MetGlu: 0.0 ± 0.0
2.438MetPhe: 2.438 ± 0.718
0.348MetGly: 0.348 ± 0.222
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.697MetLys: 0.697 ± 0.658
1.045MetLeu: 1.045 ± 0.424
0.348MetMet: 0.348 ± 0.406
1.045MetAsn: 1.045 ± 0.424
0.697MetPro: 0.697 ± 0.453
0.348MetGln: 0.348 ± 0.368
0.348MetArg: 0.348 ± 0.49
1.742MetSer: 1.742 ± 0.501
0.697MetThr: 0.697 ± 0.775
0.697MetVal: 0.697 ± 0.621
0.697MetTrp: 0.697 ± 0.974
0.348MetTyr: 0.348 ± 0.487
0.0MetXaa: 0.0 ± 0.0
Asn
4.18AsnAla: 4.18 ± 1.859
2.438AsnCys: 2.438 ± 0.741
2.786AsnAsp: 2.786 ± 0.635
1.045AsnGlu: 1.045 ± 0.416
3.831AsnPhe: 3.831 ± 1.03
5.921AsnGly: 5.921 ± 1.341
1.393AsnHis: 1.393 ± 0.813
1.742AsnIle: 1.742 ± 0.501
2.438AsnLys: 2.438 ± 1.599
4.876AsnLeu: 4.876 ± 1.507
1.045AsnMet: 1.045 ± 0.416
5.225AsnAsn: 5.225 ± 1.468
3.135AsnPro: 3.135 ± 1.33
3.831AsnGln: 3.831 ± 1.444
3.483AsnArg: 3.483 ± 1.442
5.921AsnSer: 5.921 ± 1.135
4.18AsnThr: 4.18 ± 1.21
5.225AsnVal: 5.225 ± 1.238
0.348AsnTrp: 0.348 ± 0.222
3.831AsnTyr: 3.831 ± 1.589
0.0AsnXaa: 0.0 ± 0.0
Pro
2.438ProAla: 2.438 ± 0.456
1.045ProCys: 1.045 ± 0.416
2.786ProAsp: 2.786 ± 0.842
1.045ProGlu: 1.045 ± 0.571
1.742ProPhe: 1.742 ± 0.778
2.786ProGly: 2.786 ± 1.34
1.045ProHis: 1.045 ± 0.424
3.483ProIle: 3.483 ± 1.534
2.09ProLys: 2.09 ± 0.719
3.831ProLeu: 3.831 ± 1.597
0.0ProMet: 0.0 ± 0.0
3.483ProAsn: 3.483 ± 1.401
2.438ProPro: 2.438 ± 0.591
2.438ProGln: 2.438 ± 1.847
1.742ProArg: 1.742 ± 1.077
4.528ProSer: 4.528 ± 1.122
4.528ProThr: 4.528 ± 2.298
2.786ProVal: 2.786 ± 0.897
0.697ProTrp: 0.697 ± 0.444
2.09ProTyr: 2.09 ± 1.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.09GlnAla: 2.09 ± 0.97
1.393GlnCys: 1.393 ± 0.701
1.393GlnAsp: 1.393 ± 0.906
3.135GlnGlu: 3.135 ± 1.306
2.09GlnPhe: 2.09 ± 1.086
2.786GlnGly: 2.786 ± 0.65
1.045GlnHis: 1.045 ± 0.335
2.786GlnIle: 2.786 ± 0.739
2.09GlnLys: 2.09 ± 1.929
3.135GlnLeu: 3.135 ± 0.918
0.0GlnMet: 0.0 ± 0.0
3.483GlnAsn: 3.483 ± 1.231
2.09GlnPro: 2.09 ± 0.38
3.831GlnGln: 3.831 ± 1.121
1.742GlnArg: 1.742 ± 1.132
4.876GlnSer: 4.876 ± 1.352
1.393GlnThr: 1.393 ± 1.123
2.438GlnVal: 2.438 ± 0.71
0.348GlnTrp: 0.348 ± 0.222
1.393GlnTyr: 1.393 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
1.742ArgAla: 1.742 ± 1.525
0.348ArgCys: 0.348 ± 0.222
1.393ArgAsp: 1.393 ± 0.454
1.045ArgGlu: 1.045 ± 0.683
2.09ArgPhe: 2.09 ± 0.564
2.786ArgGly: 2.786 ± 1.688
0.348ArgHis: 0.348 ± 0.406
1.742ArgIle: 1.742 ± 0.748
1.393ArgLys: 1.393 ± 0.583
5.225ArgLeu: 5.225 ± 2.198
0.697ArgMet: 0.697 ± 0.738
2.786ArgAsn: 2.786 ± 0.658
0.348ArgPro: 0.348 ± 0.487
3.483ArgGln: 3.483 ± 1.333
2.09ArgArg: 2.09 ± 0.847
5.921ArgSer: 5.921 ± 1.75
1.393ArgThr: 1.393 ± 0.462
2.438ArgVal: 2.438 ± 0.973
0.697ArgTrp: 0.697 ± 0.484
1.742ArgTyr: 1.742 ± 0.664
0.0ArgXaa: 0.0 ± 0.0
Ser
4.528SerAla: 4.528 ± 1.36
1.393SerCys: 1.393 ± 0.889
3.483SerAsp: 3.483 ± 1.013
3.831SerGlu: 3.831 ± 1.359
4.528SerPhe: 4.528 ± 0.723
9.056SerGly: 9.056 ± 1.988
1.742SerHis: 1.742 ± 0.604
5.225SerIle: 5.225 ± 1.526
2.786SerLys: 2.786 ± 0.5
8.708SerLeu: 8.708 ± 2.337
0.348SerMet: 0.348 ± 0.487
3.135SerAsn: 3.135 ± 0.965
4.18SerPro: 4.18 ± 0.517
3.135SerGln: 3.135 ± 0.793
6.618SerArg: 6.618 ± 2.825
6.618SerSer: 6.618 ± 1.103
6.618SerThr: 6.618 ± 0.756
1.742SerVal: 1.742 ± 0.527
2.09SerTrp: 2.09 ± 0.801
2.438SerTyr: 2.438 ± 1.197
0.0SerXaa: 0.0 ± 0.0
Thr
7.315ThrAla: 7.315 ± 1.495
3.135ThrCys: 3.135 ± 2.0
2.786ThrAsp: 2.786 ± 0.781
1.742ThrGlu: 1.742 ± 0.744
3.831ThrPhe: 3.831 ± 1.126
6.27ThrGly: 6.27 ± 1.046
1.045ThrHis: 1.045 ± 0.874
5.921ThrIle: 5.921 ± 2.231
3.483ThrLys: 3.483 ± 0.81
4.528ThrLeu: 4.528 ± 1.08
0.697ThrMet: 0.697 ± 0.444
2.438ThrAsn: 2.438 ± 0.8
3.831ThrPro: 3.831 ± 1.122
1.393ThrGln: 1.393 ± 0.298
2.438ThrArg: 2.438 ± 0.729
6.966ThrSer: 6.966 ± 1.028
4.18ThrThr: 4.18 ± 1.34
4.528ThrVal: 4.528 ± 0.73
0.697ThrTrp: 0.697 ± 0.619
2.09ThrTyr: 2.09 ± 0.941
0.0ThrXaa: 0.0 ± 0.0
Val
4.528ValAla: 4.528 ± 1.302
2.09ValCys: 2.09 ± 0.655
3.831ValAsp: 3.831 ± 0.846
1.742ValGlu: 1.742 ± 0.845
3.135ValPhe: 3.135 ± 1.182
3.483ValGly: 3.483 ± 0.863
0.348ValHis: 0.348 ± 0.49
3.483ValIle: 3.483 ± 1.595
2.786ValLys: 2.786 ± 1.09
5.921ValLeu: 5.921 ± 0.851
1.393ValMet: 1.393 ± 0.569
7.315ValAsn: 7.315 ± 2.249
3.831ValPro: 3.831 ± 1.162
4.18ValGln: 4.18 ± 1.453
1.045ValArg: 1.045 ± 0.523
4.528ValSer: 4.528 ± 1.472
6.27ValThr: 6.27 ± 1.628
5.573ValVal: 5.573 ± 1.207
1.045ValTrp: 1.045 ± 0.547
5.225ValTyr: 5.225 ± 2.39
0.0ValXaa: 0.0 ± 0.0
Trp
0.348TrpAla: 0.348 ± 0.406
1.045TrpCys: 1.045 ± 0.798
0.0TrpAsp: 0.0 ± 0.0
0.697TrpGlu: 0.697 ± 0.453
1.393TrpPhe: 1.393 ± 0.298
0.0TrpGly: 0.0 ± 0.0
0.348TrpHis: 0.348 ± 0.222
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.045TrpLeu: 1.045 ± 0.448
0.697TrpMet: 0.697 ± 0.324
1.045TrpAsn: 1.045 ± 0.488
1.045TrpPro: 1.045 ± 0.488
0.348TrpGln: 0.348 ± 0.222
0.348TrpArg: 0.348 ± 0.418
0.697TrpSer: 0.697 ± 0.412
1.045TrpThr: 1.045 ± 0.448
1.045TrpVal: 1.045 ± 0.523
0.348TrpTrp: 0.348 ± 0.487
1.393TrpTyr: 1.393 ± 0.882
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.742TyrAla: 1.742 ± 0.615
1.393TyrCys: 1.393 ± 0.569
3.135TyrAsp: 3.135 ± 1.406
2.09TyrGlu: 2.09 ± 0.502
3.831TyrPhe: 3.831 ± 0.829
3.483TyrGly: 3.483 ± 1.096
1.045TyrHis: 1.045 ± 0.488
2.09TyrIle: 2.09 ± 0.574
1.742TyrLys: 1.742 ± 0.67
4.528TyrLeu: 4.528 ± 0.765
0.348TyrMet: 0.348 ± 0.368
3.483TyrAsn: 3.483 ± 0.745
1.393TyrPro: 1.393 ± 0.657
1.393TyrGln: 1.393 ± 0.499
2.438TyrArg: 2.438 ± 0.389
3.135TyrSer: 3.135 ± 0.433
3.483TyrThr: 3.483 ± 0.613
5.573TyrVal: 5.573 ± 1.793
0.697TyrTrp: 0.697 ± 0.351
4.876TyrTyr: 4.876 ± 1.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski