Amino acid dipepetide frequency for Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.203AlaAla: 10.203 ± 0.061	1.149AlaCys: 1.149 ± 0.017	4.457AlaAsp: 4.457 ± 0.027	5.295AlaGlu: 5.295 ± 0.041	3.203AlaPhe: 3.203 ± 0.027	6.201AlaGly: 6.201 ± 0.036	2.019AlaHis: 2.019 ± 0.021	4.326AlaIle: 4.326 ± 0.032	3.562AlaLys: 3.562 ± 0.034	8.35AlaLeu: 8.35 ± 0.041	1.993AlaMet: 1.993 ± 0.021	2.853AlaAsn: 2.853 ± 0.022	4.814AlaPro: 4.814 ± 0.037	3.661AlaGln: 3.661 ± 0.028	5.314AlaArg: 5.314 ± 0.034	7.455AlaSer: 7.455 ± 0.048	5.73AlaThr: 5.73 ± 0.041	5.819AlaVal: 5.819 ± 0.039	1.276AlaTrp: 1.276 ± 0.019	2.301AlaTyr: 2.301 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.032CysAla: 1.032 ± 0.014	0.243CysCys: 0.243 ± 0.009	0.694CysAsp: 0.694 ± 0.013	0.619CysGlu: 0.619 ± 0.011	0.541CysPhe: 0.541 ± 0.011	0.94CysGly: 0.94 ± 0.017	0.343CysHis: 0.343 ± 0.008	0.703CysIle: 0.703 ± 0.011	0.439CysLys: 0.439 ± 0.008	1.374CysLeu: 1.374 ± 0.018	0.278CysMet: 0.278 ± 0.006	0.408CysAsn: 0.408 ± 0.009	0.661CysPro: 0.661 ± 0.014	0.469CysGln: 0.469 ± 0.01	0.807CysArg: 0.807 ± 0.014	0.935CysSer: 0.935 ± 0.016	0.745CysThr: 0.745 ± 0.015	0.852CysVal: 0.852 ± 0.015	0.205CysTrp: 0.205 ± 0.006	0.369CysTyr: 0.369 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.778AspAla: 4.778 ± 0.034	0.644AspCys: 0.644 ± 0.011	3.914AspAsp: 3.914 ± 0.039	4.245AspGlu: 4.245 ± 0.036	2.1AspPhe: 2.1 ± 0.021	3.869AspGly: 3.869 ± 0.031	1.354AspHis: 1.354 ± 0.018	2.798AspIle: 2.798 ± 0.026	1.982AspLys: 1.982 ± 0.021	5.289AspLeu: 5.289 ± 0.034	1.14AspMet: 1.14 ± 0.015	1.718AspAsn: 1.718 ± 0.019	3.415AspPro: 3.415 ± 0.026	1.939AspGln: 1.939 ± 0.021	3.206AspArg: 3.206 ± 0.036	3.959AspSer: 3.959 ± 0.03	2.922AspThr: 2.922 ± 0.025	3.489AspVal: 3.489 ± 0.028	0.906AspTrp: 0.906 ± 0.013	1.661AspTyr: 1.661 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.455GluAla: 5.455 ± 0.038	0.622GluCys: 0.622 ± 0.012	4.004GluAsp: 4.004 ± 0.036	5.481GluGlu: 5.481 ± 0.053	1.909GluPhe: 1.909 ± 0.017	3.814GluGly: 3.814 ± 0.035	1.412GluHis: 1.412 ± 0.019	2.992GluIle: 2.992 ± 0.027	3.214GluLys: 3.214 ± 0.032	5.207GluLeu: 5.207 ± 0.037	1.426GluMet: 1.426 ± 0.018	2.064GluAsn: 2.064 ± 0.021	2.773GluPro: 2.773 ± 0.037	2.563GluGln: 2.563 ± 0.027	3.887GluArg: 3.887 ± 0.03	4.186GluSer: 4.186 ± 0.037	3.54GluThr: 3.54 ± 0.029	3.658GluVal: 3.658 ± 0.026	0.884GluTrp: 0.884 ± 0.013	1.667GluTyr: 1.667 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.162PheAla: 3.162 ± 0.027	0.582PheCys: 0.582 ± 0.011	2.227PheAsp: 2.227 ± 0.02	2.052PheGlu: 2.052 ± 0.017	1.615PhePhe: 1.615 ± 0.021	2.752PheGly: 2.752 ± 0.031	0.98PheHis: 0.98 ± 0.016	1.738PheIle: 1.738 ± 0.021	1.268PheLys: 1.268 ± 0.018	3.632PheLeu: 3.632 ± 0.029	0.749PheMet: 0.749 ± 0.013	1.286PheAsn: 1.286 ± 0.016	1.973PhePro: 1.973 ± 0.021	1.445PheGln: 1.445 ± 0.017	2.025PheArg: 2.025 ± 0.021	2.902PheSer: 2.902 ± 0.025	2.192PheThr: 2.192 ± 0.021	2.435PheVal: 2.435 ± 0.023	0.674PheTrp: 0.674 ± 0.011	1.134PheTyr: 1.134 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.591GlyAla: 5.591 ± 0.039	0.926GlyCys: 0.926 ± 0.015	3.576GlyAsp: 3.576 ± 0.027	3.686GlyGlu: 3.686 ± 0.03	2.843GlyPhe: 2.843 ± 0.027	5.879GlyGly: 5.879 ± 0.056	1.698GlyHis: 1.698 ± 0.019	3.352GlyIle: 3.352 ± 0.025	3.013GlyLys: 3.013 ± 0.029	6.39GlyLeu: 6.39 ± 0.039	1.551GlyMet: 1.551 ± 0.022	2.311GlyAsn: 2.311 ± 0.022	3.331GlyPro: 3.331 ± 0.026	2.555GlyGln: 2.555 ± 0.025	4.187GlyArg: 4.187 ± 0.033	5.666GlySer: 5.666 ± 0.043	3.961GlyThr: 3.961 ± 0.028	4.647GlyVal: 4.647 ± 0.034	1.218GlyTrp: 1.218 ± 0.017	2.188GlyTyr: 2.188 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	2.059HisAla: 2.059 ± 0.021	0.341HisCys: 0.341 ± 0.009	1.369HisAsp: 1.369 ± 0.017	1.399HisGlu: 1.399 ± 0.016	0.935HisPhe: 0.935 ± 0.013	1.785HisGly: 1.785 ± 0.018	1.039HisHis: 1.039 ± 0.019	1.199HisIle: 1.199 ± 0.014	0.806HisLys: 0.806 ± 0.015	2.487HisLeu: 2.487 ± 0.02	0.487HisMet: 0.487 ± 0.009	0.854HisAsn: 0.854 ± 0.015	1.834HisPro: 1.834 ± 0.022	1.07HisGln: 1.07 ± 0.016	1.701HisArg: 1.701 ± 0.021	1.867HisSer: 1.867 ± 0.024	1.357HisThr: 1.357 ± 0.016	1.457HisVal: 1.457 ± 0.016	0.386HisTrp: 0.386 ± 0.007	0.747HisTyr: 0.747 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.217IleAla: 4.217 ± 0.031	0.749IleCys: 0.749 ± 0.013	2.722IleAsp: 2.722 ± 0.025	2.662IleGlu: 2.662 ± 0.026	1.955IlePhe: 1.955 ± 0.021	3.087IleGly: 3.087 ± 0.028	1.259IleHis: 1.259 ± 0.016	2.387IleIle: 2.387 ± 0.025	1.853IleLys: 1.853 ± 0.022	4.633IleLeu: 4.633 ± 0.038	0.923IleMet: 0.923 ± 0.014	1.664IleAsn: 1.664 ± 0.019	3.1IlePro: 3.1 ± 0.023	1.897IleGln: 1.897 ± 0.02	2.793IleArg: 2.793 ± 0.023	3.617IleSer: 3.617 ± 0.028	2.806IleThr: 2.806 ± 0.027	3.124IleVal: 3.124 ± 0.027	0.699IleTrp: 0.699 ± 0.013	1.455IleTyr: 1.455 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.766LysAla: 3.766 ± 0.036	0.446LysCys: 0.446 ± 0.01	2.295LysAsp: 2.295 ± 0.026	2.904LysGlu: 2.904 ± 0.032	1.228LysPhe: 1.228 ± 0.014	2.607LysGly: 2.607 ± 0.026	1.009LysHis: 1.009 ± 0.015	1.948LysIle: 1.948 ± 0.022	2.649LysLys: 2.649 ± 0.038	3.65LysLeu: 3.65 ± 0.029	0.849LysMet: 0.849 ± 0.013	1.459LysAsn: 1.459 ± 0.017	2.423LysPro: 2.423 ± 0.028	1.7LysGln: 1.7 ± 0.019	3.027LysArg: 3.027 ± 0.031	2.994LysSer: 2.994 ± 0.027	2.443LysThr: 2.443 ± 0.026	2.571LysVal: 2.571 ± 0.021	0.581LysTrp: 0.581 ± 0.01	1.217LysTyr: 1.217 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.456LeuAla: 8.456 ± 0.046	1.296LeuCys: 1.296 ± 0.018	5.267LeuAsp: 5.267 ± 0.037	5.601LeuGlu: 5.601 ± 0.038	3.408LeuPhe: 3.408 ± 0.028	6.216LeuGly: 6.216 ± 0.038	2.44LeuHis: 2.44 ± 0.022	4.042LeuIle: 4.042 ± 0.031	3.762LeuLys: 3.762 ± 0.03	9.025LeuLeu: 9.025 ± 0.059	1.829LeuMet: 1.829 ± 0.017	3.159LeuAsn: 3.159 ± 0.026	5.68LeuPro: 5.68 ± 0.034	4.077LeuGln: 4.077 ± 0.038	6.176LeuArg: 6.176 ± 0.041	7.462LeuSer: 7.462 ± 0.045	5.24LeuThr: 5.24 ± 0.038	5.851LeuVal: 5.851 ± 0.041	1.286LeuTrp: 1.286 ± 0.018	2.558LeuTyr: 2.558 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.117MetAla: 2.117 ± 0.019	0.24MetCys: 0.24 ± 0.008	1.155MetAsp: 1.155 ± 0.016	1.218MetGlu: 1.218 ± 0.016	0.713MetPhe: 0.713 ± 0.012	1.443MetGly: 1.443 ± 0.018	0.486MetHis: 0.486 ± 0.011	0.985MetIle: 0.985 ± 0.012	0.869MetLys: 0.869 ± 0.012	1.879MetLeu: 1.879 ± 0.016	0.548MetMet: 0.548 ± 0.01	0.751MetAsn: 0.751 ± 0.012	1.165MetPro: 1.165 ± 0.018	0.884MetGln: 0.884 ± 0.016	1.26MetArg: 1.26 ± 0.017	1.774MetSer: 1.774 ± 0.017	1.299MetThr: 1.299 ± 0.015	1.363MetVal: 1.363 ± 0.016	0.256MetTrp: 0.256 ± 0.006	0.514MetTyr: 0.514 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.007AsnAla: 3.007 ± 0.025	0.431AsnCys: 0.431 ± 0.01	1.754AsnAsp: 1.754 ± 0.016	1.861AsnGlu: 1.861 ± 0.019	1.248AsnPhe: 1.248 ± 0.017	2.638AsnGly: 2.638 ± 0.025	0.857AsnHis: 0.857 ± 0.012	1.808AsnIle: 1.808 ± 0.022	1.302AsnLys: 1.302 ± 0.016	3.208AsnLeu: 3.208 ± 0.024	0.74AsnMet: 0.74 ± 0.011	1.395AsnAsn: 1.395 ± 0.023	2.426AsnPro: 2.426 ± 0.022	1.256AsnGln: 1.256 ± 0.017	1.873AsnArg: 1.873 ± 0.019	2.496AsnSer: 2.496 ± 0.026	2.076AsnThr: 2.076 ± 0.021	2.228AsnVal: 2.228 ± 0.018	0.536AsnTrp: 0.536 ± 0.01	1.056AsnTyr: 1.056 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.601ProAla: 5.601 ± 0.043	0.565ProCys: 0.565 ± 0.011	3.198ProAsp: 3.198 ± 0.023	3.846ProGlu: 3.846 ± 0.035	2.049ProPhe: 2.049 ± 0.022	3.934ProGly: 3.934 ± 0.032	1.421ProHis: 1.421 ± 0.018	2.433ProIle: 2.433 ± 0.022	2.276ProLys: 2.276 ± 0.026	4.923ProLeu: 4.923 ± 0.032	1.027ProMet: 1.027 ± 0.015	2.026ProAsn: 2.026 ± 0.024	4.945ProPro: 4.945 ± 0.066	2.488ProGln: 2.488 ± 0.028	3.515ProArg: 3.515 ± 0.031	5.941ProSer: 5.941 ± 0.048	4.144ProThr: 4.144 ± 0.031	3.696ProVal: 3.696 ± 0.033	0.792ProTrp: 0.792 ± 0.011	1.552ProTyr: 1.552 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.659GlnAla: 3.659 ± 0.03	0.462GlnCys: 0.462 ± 0.011	2.026GlnAsp: 2.026 ± 0.021	2.428GlnGlu: 2.428 ± 0.024	1.31GlnPhe: 1.31 ± 0.017	2.477GlnGly: 2.477 ± 0.023	1.149GlnHis: 1.149 ± 0.015	1.92GlnIle: 1.92 ± 0.02	1.8GlnLys: 1.8 ± 0.018	3.684GlnLeu: 3.684 ± 0.031	0.89GlnMet: 0.89 ± 0.014	1.432GlnAsn: 1.432 ± 0.017	2.65GlnPro: 2.65 ± 0.028	2.772GlnGln: 2.772 ± 0.058	2.778GlnArg: 2.778 ± 0.024	3.134GlnSer: 3.134 ± 0.025	2.468GlnThr: 2.468 ± 0.024	2.3GlnVal: 2.3 ± 0.019	0.602GlnTrp: 0.602 ± 0.011	1.188GlnTyr: 1.188 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.074ArgAla: 5.074 ± 0.031	0.757ArgCys: 0.757 ± 0.012	3.379ArgAsp: 3.379 ± 0.032	3.912ArgGlu: 3.912 ± 0.033	2.267ArgPhe: 2.267 ± 0.022	3.813ArgGly: 3.813 ± 0.034	1.655ArgHis: 1.655 ± 0.02	2.869ArgIle: 2.869 ± 0.023	3.181ArgLys: 3.181 ± 0.03	5.891ArgLeu: 5.891 ± 0.041	1.317ArgMet: 1.317 ± 0.016	2.141ArgAsn: 2.141 ± 0.021	3.554ArgPro: 3.554 ± 0.033	2.676ArgGln: 2.676 ± 0.023	5.244ArgArg: 5.244 ± 0.047	4.835ArgSer: 4.835 ± 0.041	3.438ArgThr: 3.438 ± 0.027	3.679ArgVal: 3.679 ± 0.024	1.027ArgTrp: 1.027 ± 0.018	1.771ArgTyr: 1.771 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.901SerAla: 6.901 ± 0.038	0.896SerCys: 0.896 ± 0.012	4.082SerAsp: 4.082 ± 0.038	4.029SerGlu: 4.029 ± 0.034	2.989SerPhe: 2.989 ± 0.025	5.447SerGly: 5.447 ± 0.038	1.995SerHis: 1.995 ± 0.024	3.8SerIle: 3.8 ± 0.029	3.176SerLys: 3.176 ± 0.031	7.417SerLeu: 7.417 ± 0.044	1.643SerMet: 1.643 ± 0.019	2.76SerAsn: 2.76 ± 0.028	5.454SerPro: 5.454 ± 0.05	3.232SerGln: 3.232 ± 0.026	4.945SerArg: 4.945 ± 0.044	8.951SerSer: 8.951 ± 0.076	5.663SerThr: 5.663 ± 0.044	4.647SerVal: 4.647 ± 0.03	1.151SerTrp: 1.151 ± 0.015	2.104SerTyr: 2.104 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.731ThrAla: 5.731 ± 0.037	0.778ThrCys: 0.778 ± 0.012	2.916ThrAsp: 2.916 ± 0.026	3.138ThrGlu: 3.138 ± 0.027	2.248ThrPhe: 2.248 ± 0.023	4.338ThrGly: 4.338 ± 0.029	1.38ThrHis: 1.38 ± 0.015	3.109ThrIle: 3.109 ± 0.027	2.297ThrLys: 2.297 ± 0.021	5.562ThrLeu: 5.562 ± 0.038	1.161ThrMet: 1.161 ± 0.013	2.029ThrAsn: 2.029 ± 0.022	4.339ThrPro: 4.339 ± 0.039	2.203ThrGln: 2.203 ± 0.019	3.268ThrArg: 3.268 ± 0.029	5.271ThrSer: 5.271 ± 0.039	5.009ThrThr: 5.009 ± 0.052	4.051ThrVal: 4.051 ± 0.033	0.888ThrTrp: 0.888 ± 0.013	1.714ThrTyr: 1.714 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.626ValAla: 5.626 ± 0.035	0.907ValCys: 0.907 ± 0.013	3.762ValAsp: 3.762 ± 0.033	3.941ValGlu: 3.941 ± 0.029	2.509ValPhe: 2.509 ± 0.025	4.228ValGly: 4.228 ± 0.034	1.495ValHis: 1.495 ± 0.017	3.0ValIle: 3.0 ± 0.026	2.581ValLys: 2.581 ± 0.024	5.912ValLeu: 5.912 ± 0.043	1.355ValMet: 1.355 ± 0.017	2.159ValAsn: 2.159 ± 0.023	3.628ValPro: 3.628 ± 0.028	2.508ValGln: 2.508 ± 0.023	3.71ValArg: 3.71 ± 0.028	4.69ValSer: 4.69 ± 0.029	3.696ValThr: 3.696 ± 0.027	4.625ValVal: 4.625 ± 0.04	0.924ValTrp: 0.924 ± 0.014	1.873ValTyr: 1.873 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.213TrpAla: 1.213 ± 0.017	0.194TrpCys: 0.194 ± 0.006	0.895TrpAsp: 0.895 ± 0.015	0.895TrpGlu: 0.895 ± 0.013	0.559TrpPhe: 0.559 ± 0.01	0.962TrpGly: 0.962 ± 0.015	0.376TrpHis: 0.376 ± 0.008	0.756TrpIle: 0.756 ± 0.011	0.75TrpLys: 0.75 ± 0.012	1.432TrpLeu: 1.432 ± 0.019	0.379TrpMet: 0.379 ± 0.009	0.631TrpAsn: 0.631 ± 0.01	0.635TrpPro: 0.635 ± 0.011	0.595TrpGln: 0.595 ± 0.01	1.002TrpArg: 1.002 ± 0.015	1.094TrpSer: 1.094 ± 0.014	0.992TrpThr: 0.992 ± 0.015	0.954TrpVal: 0.954 ± 0.014	0.297TrpTrp: 0.297 ± 0.008	0.449TrpTyr: 0.449 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.335TyrAla: 2.335 ± 0.022	0.428TyrCys: 0.428 ± 0.01	1.635TyrAsp: 1.635 ± 0.018	1.546TyrGlu: 1.546 ± 0.017	1.195TyrPhe: 1.195 ± 0.015	2.138TyrGly: 2.138 ± 0.024	0.814TyrHis: 0.814 ± 0.013	1.436TyrIle: 1.436 ± 0.019	0.986TyrLys: 0.986 ± 0.014	2.886TyrLeu: 2.886 ± 0.026	0.633TyrMet: 0.633 ± 0.011	1.097TyrAsn: 1.097 ± 0.016	1.57TyrPro: 1.57 ± 0.016	1.139TyrGln: 1.139 ± 0.019	1.762TyrArg: 1.762 ± 0.019	2.055TyrSer: 2.055 ± 0.021	1.71TyrThr: 1.71 ± 0.022	1.682TyrVal: 1.682 ± 0.019	0.471TyrTrp: 0.471 ± 0.011	0.994TyrTyr: 0.994 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10842 proteins (5397569 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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