Amino acid dipepetide frequency for Auraticoccus monumenti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.014AlaAla: 19.014 ± 0.186	0.909AlaCys: 0.909 ± 0.027	8.239AlaAsp: 8.239 ± 0.103	8.776AlaGlu: 8.776 ± 0.098	3.111AlaPhe: 3.111 ± 0.065	12.759AlaGly: 12.759 ± 0.108	2.295AlaHis: 2.295 ± 0.044	3.14AlaIle: 3.14 ± 0.052	1.63AlaLys: 1.63 ± 0.049	13.983AlaLeu: 13.983 ± 0.132	2.523AlaMet: 2.523 ± 0.05	1.681AlaAsn: 1.681 ± 0.041	6.766AlaPro: 6.766 ± 0.104	3.333AlaGln: 3.333 ± 0.046	9.791AlaArg: 9.791 ± 0.096	6.342AlaSer: 6.342 ± 0.081	7.488AlaThr: 7.488 ± 0.097	12.649AlaVal: 12.649 ± 0.109	1.966AlaTrp: 1.966 ± 0.039	2.029AlaTyr: 2.029 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.796CysAla: 0.796 ± 0.021	0.087CysCys: 0.087 ± 0.008	0.44CysAsp: 0.44 ± 0.024	0.376CysGlu: 0.376 ± 0.018	0.214CysPhe: 0.214 ± 0.012	0.763CysGly: 0.763 ± 0.03	0.183CysHis: 0.183 ± 0.014	0.161CysIle: 0.161 ± 0.012	0.056CysLys: 0.056 ± 0.007	0.644CysLeu: 0.644 ± 0.023	0.087CysMet: 0.087 ± 0.008	0.1CysAsn: 0.1 ± 0.009	0.433CysPro: 0.433 ± 0.02	0.174CysGln: 0.174 ± 0.013	0.574CysArg: 0.574 ± 0.021	0.412CysSer: 0.412 ± 0.018	0.479CysThr: 0.479 ± 0.024	0.564CysVal: 0.564 ± 0.018	0.121CysTrp: 0.121 ± 0.01	0.144CysTyr: 0.144 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.628AspAla: 7.628 ± 0.086	0.352AspCys: 0.352 ± 0.02	4.117AspAsp: 4.117 ± 0.078	4.099AspGlu: 4.099 ± 0.069	1.506AspPhe: 1.506 ± 0.034	6.408AspGly: 6.408 ± 0.092	1.539AspHis: 1.539 ± 0.039	1.409AspIle: 1.409 ± 0.037	0.678AspLys: 0.678 ± 0.024	7.03AspLeu: 7.03 ± 0.082	0.708AspMet: 0.708 ± 0.025	0.781AspAsn: 0.781 ± 0.034	5.254AspPro: 5.254 ± 0.083	1.98AspGln: 1.98 ± 0.039	4.888AspArg: 4.888 ± 0.062	2.342AspSer: 2.342 ± 0.042	3.004AspThr: 3.004 ± 0.057	6.362AspVal: 6.362 ± 0.07	0.986AspTrp: 0.986 ± 0.029	1.126AspTyr: 1.126 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.307GluAla: 7.307 ± 0.092	0.273GluCys: 0.273 ± 0.015	3.479GluAsp: 3.479 ± 0.06	3.739GluGlu: 3.739 ± 0.068	1.264GluPhe: 1.264 ± 0.032	4.583GluGly: 4.583 ± 0.064	1.84GluHis: 1.84 ± 0.046	1.76GluIle: 1.76 ± 0.047	0.881GluLys: 0.881 ± 0.033	7.234GluLeu: 7.234 ± 0.074	0.902GluMet: 0.902 ± 0.029	0.858GluAsn: 0.858 ± 0.025	3.63GluPro: 3.63 ± 0.061	2.765GluGln: 2.765 ± 0.05	5.453GluArg: 5.453 ± 0.071	2.358GluSer: 2.358 ± 0.041	2.802GluThr: 2.802 ± 0.045	5.974GluVal: 5.974 ± 0.072	0.788GluTrp: 0.788 ± 0.026	0.909GluTyr: 0.909 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.353PheAla: 3.353 ± 0.053	0.235PheCys: 0.235 ± 0.015	1.977PheAsp: 1.977 ± 0.043	1.392PheGlu: 1.392 ± 0.031	0.884PhePhe: 0.884 ± 0.026	2.705PheGly: 2.705 ± 0.049	0.546PheHis: 0.546 ± 0.018	0.683PheIle: 0.683 ± 0.025	0.357PheLys: 0.357 ± 0.017	2.538PheLeu: 2.538 ± 0.05	0.383PheMet: 0.383 ± 0.018	0.5PheAsn: 0.5 ± 0.022	1.243PhePro: 1.243 ± 0.031	0.665PheGln: 0.665 ± 0.021	1.597PheArg: 1.597 ± 0.04	1.58PheSer: 1.58 ± 0.036	1.918PheThr: 1.918 ± 0.04	2.406PheVal: 2.406 ± 0.046	0.455PheTrp: 0.455 ± 0.018	0.557PheTyr: 0.557 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.537GlyAla: 10.537 ± 0.109	0.751GlyCys: 0.751 ± 0.024	5.172GlyAsp: 5.172 ± 0.082	5.392GlyGlu: 5.392 ± 0.067	2.851GlyPhe: 2.851 ± 0.053	8.477GlyGly: 8.477 ± 0.103	2.062GlyHis: 2.062 ± 0.038	3.0GlyIle: 3.0 ± 0.06	1.433GlyLys: 1.433 ± 0.041	10.022GlyLeu: 10.022 ± 0.11	1.937GlyMet: 1.937 ± 0.035	1.42GlyAsn: 1.42 ± 0.042	5.253GlyPro: 5.253 ± 0.073	2.881GlyGln: 2.881 ± 0.055	8.013GlyArg: 8.013 ± 0.104	5.784GlySer: 5.784 ± 0.072	6.166GlyThr: 6.166 ± 0.081	8.408GlyVal: 8.408 ± 0.087	2.12GlyTrp: 2.12 ± 0.047	2.288GlyTyr: 2.288 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.4HisAla: 2.4 ± 0.044	0.176HisCys: 0.176 ± 0.011	1.393HisAsp: 1.393 ± 0.037	1.238HisGlu: 1.238 ± 0.035	0.504HisPhe: 0.504 ± 0.021	2.173HisGly: 2.173 ± 0.048	0.741HisHis: 0.741 ± 0.026	0.493HisIle: 0.493 ± 0.019	0.218HisLys: 0.218 ± 0.013	2.614HisLeu: 2.614 ± 0.049	0.221HisMet: 0.221 ± 0.014	0.292HisAsn: 0.292 ± 0.016	1.916HisPro: 1.916 ± 0.04	0.698HisGln: 0.698 ± 0.022	2.144HisArg: 2.144 ± 0.048	0.96HisSer: 0.96 ± 0.027	1.133HisThr: 1.133 ± 0.031	1.871HisVal: 1.871 ± 0.037	0.368HisTrp: 0.368 ± 0.016	0.403HisTyr: 0.403 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.77IleAla: 3.77 ± 0.069	0.227IleCys: 0.227 ± 0.013	2.08IleAsp: 2.08 ± 0.045	1.892IleGlu: 1.892 ± 0.04	0.708IlePhe: 0.708 ± 0.029	3.137IleGly: 3.137 ± 0.052	0.464IleHis: 0.464 ± 0.018	0.924IleIle: 0.924 ± 0.035	0.466IleLys: 0.466 ± 0.019	1.865IleLeu: 1.865 ± 0.042	0.372IleMet: 0.372 ± 0.02	0.612IleAsn: 0.612 ± 0.02	1.448IlePro: 1.448 ± 0.039	0.656IleGln: 0.656 ± 0.021	1.826IleArg: 1.826 ± 0.04	1.745IleSer: 1.745 ± 0.039	2.224IleThr: 2.224 ± 0.05	2.201IleVal: 2.201 ± 0.054	0.356IleTrp: 0.356 ± 0.018	0.516IleTyr: 0.516 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	1.66LysAla: 1.66 ± 0.046	0.062LysCys: 0.062 ± 0.007	0.735LysAsp: 0.735 ± 0.026	0.683LysGlu: 0.683 ± 0.028	0.301LysPhe: 0.301 ± 0.014	1.182LysGly: 1.182 ± 0.037	0.31LysHis: 0.31 ± 0.015	0.529LysIle: 0.529 ± 0.022	0.456LysLys: 0.456 ± 0.027	1.181LysLeu: 1.181 ± 0.033	0.276LysMet: 0.276 ± 0.017	0.292LysAsn: 0.292 ± 0.016	0.735LysPro: 0.735 ± 0.028	0.469LysGln: 0.469 ± 0.02	0.918LysArg: 0.918 ± 0.029	0.696LysSer: 0.696 ± 0.025	0.787LysThr: 0.787 ± 0.033	1.377LysVal: 1.377 ± 0.038	0.142LysTrp: 0.142 ± 0.01	0.246LysTyr: 0.246 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.505LeuAla: 15.505 ± 0.135	0.722LeuCys: 0.722 ± 0.025	7.247LeuAsp: 7.247 ± 0.08	5.639LeuGlu: 5.639 ± 0.064	2.497LeuPhe: 2.497 ± 0.051	10.185LeuGly: 10.185 ± 0.112	2.228LeuHis: 2.228 ± 0.041	2.504LeuIle: 2.504 ± 0.062	1.186LeuLys: 1.186 ± 0.035	12.086LeuLeu: 12.086 ± 0.138	1.53LeuMet: 1.53 ± 0.038	1.473LeuAsn: 1.473 ± 0.039	6.212LeuPro: 6.212 ± 0.072	3.009LeuGln: 3.009 ± 0.045	8.426LeuArg: 8.426 ± 0.096	5.691LeuSer: 5.691 ± 0.061	7.052LeuThr: 7.052 ± 0.083	11.633LeuVal: 11.633 ± 0.13	1.316LeuTrp: 1.316 ± 0.032	1.516LeuTyr: 1.516 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.227MetAla: 2.227 ± 0.04	0.099MetCys: 0.099 ± 0.009	0.801MetAsp: 0.801 ± 0.027	0.723MetGlu: 0.723 ± 0.028	0.419MetPhe: 0.419 ± 0.017	1.326MetGly: 1.326 ± 0.034	0.323MetHis: 0.323 ± 0.016	0.601MetIle: 0.601 ± 0.025	0.291MetLys: 0.291 ± 0.017	1.61MetLeu: 1.61 ± 0.041	0.321MetMet: 0.321 ± 0.018	0.349MetAsn: 0.349 ± 0.016	1.036MetPro: 1.036 ± 0.029	0.461MetGln: 0.461 ± 0.017	1.205MetArg: 1.205 ± 0.029	1.487MetSer: 1.487 ± 0.032	1.653MetThr: 1.653 ± 0.035	1.652MetVal: 1.652 ± 0.04	0.174MetTrp: 0.174 ± 0.011	0.247MetTyr: 0.247 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.834AsnAla: 1.834 ± 0.044	0.093AsnCys: 0.093 ± 0.009	0.883AsnAsp: 0.883 ± 0.031	0.754AsnGlu: 0.754 ± 0.026	0.461AsnPhe: 0.461 ± 0.019	1.413AsnGly: 1.413 ± 0.035	0.348AsnHis: 0.348 ± 0.017	0.518AsnIle: 0.518 ± 0.021	0.254AsnLys: 0.254 ± 0.015	1.58AsnLeu: 1.58 ± 0.035	0.227AsnMet: 0.227 ± 0.013	0.388AsnAsn: 0.388 ± 0.021	1.259AsnPro: 1.259 ± 0.035	0.526AsnGln: 0.526 ± 0.023	1.114AsnArg: 1.114 ± 0.031	0.732AsnSer: 0.732 ± 0.029	0.92AsnThr: 0.92 ± 0.035	1.312AsnVal: 1.312 ± 0.031	0.233AsnTrp: 0.233 ± 0.013	0.369AsnTyr: 0.369 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	8.083ProAla: 8.083 ± 0.093	0.301ProCys: 0.301 ± 0.017	4.7ProAsp: 4.7 ± 0.066	4.437ProGlu: 4.437 ± 0.063	1.435ProPhe: 1.435 ± 0.033	6.949ProGly: 6.949 ± 0.093	1.247ProHis: 1.247 ± 0.033	1.225ProIle: 1.225 ± 0.032	0.628ProLys: 0.628 ± 0.025	5.337ProLeu: 5.337 ± 0.076	0.925ProMet: 0.925 ± 0.023	0.784ProAsn: 0.784 ± 0.025	3.385ProPro: 3.385 ± 0.069	1.642ProGln: 1.642 ± 0.043	4.193ProArg: 4.193 ± 0.07	3.468ProSer: 3.468 ± 0.055	4.057ProThr: 4.057 ± 0.064	6.021ProVal: 6.021 ± 0.077	1.058ProTrp: 1.058 ± 0.026	1.061ProTyr: 1.061 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.72GlnAla: 3.72 ± 0.056	0.134GlnCys: 0.134 ± 0.011	1.429GlnAsp: 1.429 ± 0.036	1.419GlnGlu: 1.419 ± 0.033	0.707GlnPhe: 0.707 ± 0.022	2.429GlnGly: 2.429 ± 0.046	0.816GlnHis: 0.816 ± 0.023	0.973GlnIle: 0.973 ± 0.031	0.403GlnLys: 0.403 ± 0.019	3.727GlnLeu: 3.727 ± 0.057	0.547GlnMet: 0.547 ± 0.021	0.453GlnAsn: 0.453 ± 0.02	2.011GlnPro: 2.011 ± 0.045	1.609GlnGln: 1.609 ± 0.045	2.814GlnArg: 2.814 ± 0.053	1.284GlnSer: 1.284 ± 0.037	1.541GlnThr: 1.541 ± 0.035	3.283GlnVal: 3.283 ± 0.047	0.452GlnTrp: 0.452 ± 0.019	0.515GlnTyr: 0.515 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.286ArgAla: 9.286 ± 0.1	0.542ArgCys: 0.542 ± 0.02	4.217ArgAsp: 4.217 ± 0.057	4.457ArgGlu: 4.457 ± 0.068	2.264ArgPhe: 2.264 ± 0.042	6.226ArgGly: 6.226 ± 0.08	2.024ArgHis: 2.024 ± 0.043	2.558ArgIle: 2.558 ± 0.05	0.972ArgLys: 0.972 ± 0.029	9.037ArgLeu: 9.037 ± 0.099	1.801ArgMet: 1.801 ± 0.038	1.146ArgAsn: 1.146 ± 0.031	5.054ArgPro: 5.054 ± 0.081	2.432ArgGln: 2.432 ± 0.042	8.536ArgArg: 8.536 ± 0.112	4.755ArgSer: 4.755 ± 0.058	5.035ArgThr: 5.035 ± 0.069	6.86ArgVal: 6.86 ± 0.081	1.707ArgTrp: 1.707 ± 0.035	1.684ArgTyr: 1.684 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.582SerAla: 6.582 ± 0.085	0.377SerCys: 0.377 ± 0.02	2.93SerAsp: 2.93 ± 0.052	2.768SerGlu: 2.768 ± 0.045	1.545SerPhe: 1.545 ± 0.033	5.776SerGly: 5.776 ± 0.067	1.061SerHis: 1.061 ± 0.03	1.647SerIle: 1.647 ± 0.035	0.726SerLys: 0.726 ± 0.027	5.11SerLeu: 5.11 ± 0.065	1.163SerMet: 1.163 ± 0.031	0.85SerAsn: 0.85 ± 0.029	3.448SerPro: 3.448 ± 0.057	1.518SerGln: 1.518 ± 0.034	4.202SerArg: 4.202 ± 0.063	3.417SerSer: 3.417 ± 0.065	3.92SerThr: 3.92 ± 0.076	4.747SerVal: 4.747 ± 0.068	1.142SerTrp: 1.142 ± 0.029	1.163SerTyr: 1.163 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.029ThrAla: 8.029 ± 0.093	0.413ThrCys: 0.413 ± 0.026	3.898ThrAsp: 3.898 ± 0.055	3.459ThrGlu: 3.459 ± 0.055	1.835ThrPhe: 1.835 ± 0.045	6.445ThrGly: 6.445 ± 0.094	1.11ThrHis: 1.11 ± 0.031	1.902ThrIle: 1.902 ± 0.039	0.823ThrLys: 0.823 ± 0.027	6.074ThrLeu: 6.074 ± 0.09	1.043ThrMet: 1.043 ± 0.03	1.021ThrAsn: 1.021 ± 0.036	4.211ThrPro: 4.211 ± 0.062	1.533ThrGln: 1.533 ± 0.038	4.4ThrArg: 4.4 ± 0.068	3.904ThrSer: 3.904 ± 0.061	4.586ThrThr: 4.586 ± 0.087	6.236ThrVal: 6.236 ± 0.139	0.973ThrTrp: 0.973 ± 0.024	1.1ThrTyr: 1.1 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	12.765ValAla: 12.765 ± 0.121	0.734ValCys: 0.734 ± 0.024	6.375ValAsp: 6.375 ± 0.079	5.823ValGlu: 5.823 ± 0.077	2.326ValPhe: 2.326 ± 0.049	8.19ValGly: 8.19 ± 0.094	2.1ValHis: 2.1 ± 0.041	2.588ValIle: 2.588 ± 0.057	1.125ValLys: 1.125 ± 0.035	11.889ValLeu: 11.889 ± 0.135	1.539ValMet: 1.539 ± 0.029	1.54ValAsn: 1.54 ± 0.036	5.736ValPro: 5.736 ± 0.071	2.661ValGln: 2.661 ± 0.046	7.309ValArg: 7.309 ± 0.077	5.031ValSer: 5.031 ± 0.078	6.153ValThr: 6.153 ± 0.119	11.732ValVal: 11.732 ± 0.141	1.241ValTrp: 1.241 ± 0.03	1.419ValTyr: 1.419 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.722TrpAla: 1.722 ± 0.033	0.156TrpCys: 0.156 ± 0.012	0.876TrpAsp: 0.876 ± 0.028	0.764TrpGlu: 0.764 ± 0.026	0.583TrpPhe: 0.583 ± 0.018	1.121TrpGly: 1.121 ± 0.03	0.337TrpHis: 0.337 ± 0.016	0.489TrpIle: 0.489 ± 0.021	0.219TrpLys: 0.219 ± 0.013	1.973TrpLeu: 1.973 ± 0.045	0.313TrpMet: 0.313 ± 0.017	0.333TrpAsn: 0.333 ± 0.017	0.883TrpPro: 0.883 ± 0.029	0.662TrpGln: 0.662 ± 0.023	1.517TrpArg: 1.517 ± 0.039	1.161TrpSer: 1.161 ± 0.031	1.051TrpThr: 1.051 ± 0.029	1.438TrpVal: 1.438 ± 0.036	0.405TrpTrp: 0.405 ± 0.017	0.301TrpTyr: 0.301 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.205TyrAla: 2.205 ± 0.042	0.163TyrCys: 0.163 ± 0.01	1.211TyrAsp: 1.211 ± 0.028	0.973TyrGlu: 0.973 ± 0.027	0.559TyrPhe: 0.559 ± 0.021	1.72TyrGly: 1.72 ± 0.04	0.382TyrHis: 0.382 ± 0.017	0.384TyrIle: 0.384 ± 0.017	0.235TyrLys: 0.235 ± 0.014	2.118TyrLeu: 2.118 ± 0.044	0.187TyrMet: 0.187 ± 0.013	0.343TyrAsn: 0.343 ± 0.017	1.021TyrPro: 1.021 ± 0.031	0.593TyrGln: 0.593 ± 0.022	1.674TyrArg: 1.674 ± 0.034	0.946TyrSer: 0.946 ± 0.031	1.024TyrThr: 1.024 ± 0.031	1.553TyrVal: 1.553 ± 0.04	0.301TyrTrp: 0.301 ± 0.016	0.424TyrTyr: 0.424 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4049 proteins (1328520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---