Amino acid dipepetide frequency for Streptococcus phage Javan52

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.616AlaAla: 3.616 ± 1.267
0.077AlaCys: 0.077 ± 0.075
3.616AlaAsp: 3.616 ± 0.68
4.693AlaGlu: 4.693 ± 0.809
3.308AlaPhe: 3.308 ± 0.528
3.693AlaGly: 3.693 ± 0.924
0.769AlaHis: 0.769 ± 0.2
5.386AlaIle: 5.386 ± 0.512
6.771AlaLys: 6.771 ± 1.011
5.463AlaLeu: 5.463 ± 0.961
1.693AlaMet: 1.693 ± 0.33
3.77AlaAsn: 3.77 ± 0.705
1.77AlaPro: 1.77 ± 0.415
1.616AlaGln: 1.616 ± 0.309
2.924AlaArg: 2.924 ± 0.44
4.155AlaSer: 4.155 ± 0.641
3.77AlaThr: 3.77 ± 0.691
3.847AlaVal: 3.847 ± 0.597
0.616AlaTrp: 0.616 ± 0.247
3.001AlaTyr: 3.001 ± 0.514
0.0AlaXaa: 0.0 ± 0.0
Cys
0.231CysAla: 0.231 ± 0.128
0.0CysCys: 0.0 ± 0.0
0.308CysAsp: 0.308 ± 0.154
0.308CysGlu: 0.308 ± 0.172
0.308CysPhe: 0.308 ± 0.141
0.154CysGly: 0.154 ± 0.127
0.077CysHis: 0.077 ± 0.081
0.154CysIle: 0.154 ± 0.125
0.539CysLys: 0.539 ± 0.245
0.539CysLeu: 0.539 ± 0.248
0.231CysMet: 0.231 ± 0.16
0.154CysAsn: 0.154 ± 0.093
0.077CysPro: 0.077 ± 0.066
0.154CysGln: 0.154 ± 0.099
0.077CysArg: 0.077 ± 0.077
0.231CysSer: 0.231 ± 0.131
0.308CysThr: 0.308 ± 0.156
0.385CysVal: 0.385 ± 0.169
0.154CysTrp: 0.154 ± 0.119
0.308CysTyr: 0.308 ± 0.208
0.0CysXaa: 0.0 ± 0.0
Asp
3.078AspAla: 3.078 ± 0.526
0.231AspCys: 0.231 ± 0.149
4.463AspAsp: 4.463 ± 0.745
4.616AspGlu: 4.616 ± 0.498
3.308AspPhe: 3.308 ± 0.475
4.77AspGly: 4.77 ± 1.112
0.692AspHis: 0.692 ± 0.201
4.924AspIle: 4.924 ± 0.814
6.232AspLys: 6.232 ± 0.826
5.001AspLeu: 5.001 ± 0.593
2.693AspMet: 2.693 ± 0.446
3.001AspAsn: 3.001 ± 0.482
1.77AspPro: 1.77 ± 0.398
1.308AspGln: 1.308 ± 0.365
1.77AspArg: 1.77 ± 0.335
4.847AspSer: 4.847 ± 0.578
3.847AspThr: 3.847 ± 0.6
3.77AspVal: 3.77 ± 0.689
0.539AspTrp: 0.539 ± 0.172
4.309AspTyr: 4.309 ± 0.774
0.0AspXaa: 0.0 ± 0.0
Glu
5.232GluAla: 5.232 ± 0.973
0.154GluCys: 0.154 ± 0.135
4.847GluAsp: 4.847 ± 0.603
6.232GluGlu: 6.232 ± 0.79
2.616GluPhe: 2.616 ± 0.478
2.385GluGly: 2.385 ± 0.472
1.077GluHis: 1.077 ± 0.335
5.155GluIle: 5.155 ± 0.572
6.232GluLys: 6.232 ± 1.043
8.233GluLeu: 8.233 ± 1.212
1.462GluMet: 1.462 ± 0.373
4.847GluAsn: 4.847 ± 0.747
1.847GluPro: 1.847 ± 0.462
3.308GluGln: 3.308 ± 0.623
2.385GluArg: 2.385 ± 0.478
3.77GluSer: 3.77 ± 0.547
4.693GluThr: 4.693 ± 0.602
5.155GluVal: 5.155 ± 0.603
1.231GluTrp: 1.231 ± 0.245
3.232GluTyr: 3.232 ± 0.594
0.0GluXaa: 0.0 ± 0.0
Phe
3.078PheAla: 3.078 ± 0.548
0.308PheCys: 0.308 ± 0.153
3.539PheAsp: 3.539 ± 0.556
3.616PheGlu: 3.616 ± 0.515
1.847PhePhe: 1.847 ± 0.464
2.462PheGly: 2.462 ± 0.528
0.462PheHis: 0.462 ± 0.222
2.924PheIle: 2.924 ± 0.435
4.386PheLys: 4.386 ± 0.479
3.155PheLeu: 3.155 ± 0.597
1.308PheMet: 1.308 ± 0.366
2.77PheAsn: 2.77 ± 0.511
0.692PhePro: 0.692 ± 0.291
1.077PheGln: 1.077 ± 0.329
2.0PheArg: 2.0 ± 0.441
2.616PheSer: 2.616 ± 0.396
2.231PheThr: 2.231 ± 0.42
2.539PheVal: 2.539 ± 0.447
0.077PheTrp: 0.077 ± 0.073
2.077PheTyr: 2.077 ± 0.428
0.0PheXaa: 0.0 ± 0.0
Gly
4.078GlyAla: 4.078 ± 0.875
0.231GlyCys: 0.231 ± 0.151
3.462GlyAsp: 3.462 ± 0.62
3.155GlyGlu: 3.155 ± 0.657
3.539GlyPhe: 3.539 ± 0.625
4.232GlyGly: 4.232 ± 0.77
0.462GlyHis: 0.462 ± 0.17
4.693GlyIle: 4.693 ± 0.743
5.463GlyLys: 5.463 ± 0.604
4.77GlyLeu: 4.77 ± 0.623
1.693GlyMet: 1.693 ± 0.387
3.078GlyAsn: 3.078 ± 0.512
1.077GlyPro: 1.077 ± 0.409
1.847GlyGln: 1.847 ± 0.38
2.385GlyArg: 2.385 ± 0.411
3.155GlySer: 3.155 ± 0.638
4.078GlyThr: 4.078 ± 0.861
4.001GlyVal: 4.001 ± 0.561
1.616GlyTrp: 1.616 ± 0.27
2.539GlyTyr: 2.539 ± 0.655
0.0GlyXaa: 0.0 ± 0.0
His
0.616HisAla: 0.616 ± 0.285
0.077HisCys: 0.077 ± 0.066
0.769HisAsp: 0.769 ± 0.269
0.923HisGlu: 0.923 ± 0.243
0.539HisPhe: 0.539 ± 0.239
0.692HisGly: 0.692 ± 0.366
0.308HisHis: 0.308 ± 0.185
1.154HisIle: 1.154 ± 0.312
1.154HisLys: 1.154 ± 0.347
0.769HisLeu: 0.769 ± 0.262
0.231HisMet: 0.231 ± 0.121
1.154HisAsn: 1.154 ± 0.3
0.385HisPro: 0.385 ± 0.162
0.769HisGln: 0.769 ± 0.207
0.539HisArg: 0.539 ± 0.192
0.846HisSer: 0.846 ± 0.287
0.846HisThr: 0.846 ± 0.302
1.154HisVal: 1.154 ± 0.299
0.0HisTrp: 0.0 ± 0.0
0.923HisTyr: 0.923 ± 0.243
0.0HisXaa: 0.0 ± 0.0
Ile
4.54IleAla: 4.54 ± 0.563
0.308IleCys: 0.308 ± 0.135
5.848IleAsp: 5.848 ± 0.531
5.617IleGlu: 5.617 ± 0.821
3.385IlePhe: 3.385 ± 0.721
4.54IleGly: 4.54 ± 0.617
1.077IleHis: 1.077 ± 0.301
3.462IleIle: 3.462 ± 0.532
6.232IleLys: 6.232 ± 0.643
4.155IleLeu: 4.155 ± 0.472
1.308IleMet: 1.308 ± 0.296
4.232IleAsn: 4.232 ± 0.687
3.462IlePro: 3.462 ± 0.49
2.462IleGln: 2.462 ± 0.33
2.539IleArg: 2.539 ± 0.444
4.77IleSer: 4.77 ± 0.681
2.847IleThr: 2.847 ± 0.496
5.001IleVal: 5.001 ± 0.604
0.692IleTrp: 0.692 ± 0.217
2.616IleTyr: 2.616 ± 0.427
0.0IleXaa: 0.0 ± 0.0
Lys
6.925LysAla: 6.925 ± 1.259
0.308LysCys: 0.308 ± 0.223
6.001LysAsp: 6.001 ± 0.659
7.155LysGlu: 7.155 ± 0.989
2.847LysPhe: 2.847 ± 0.518
5.155LysGly: 5.155 ± 0.657
1.385LysHis: 1.385 ± 0.454
6.001LysIle: 6.001 ± 0.824
9.925LysLys: 9.925 ± 1.078
8.54LysLeu: 8.54 ± 0.843
2.385LysMet: 2.385 ± 0.352
5.463LysAsn: 5.463 ± 0.55
2.385LysPro: 2.385 ± 0.492
3.539LysGln: 3.539 ± 0.664
4.001LysArg: 4.001 ± 0.57
5.386LysSer: 5.386 ± 0.662
6.848LysThr: 6.848 ± 0.693
5.463LysVal: 5.463 ± 0.653
0.923LysTrp: 0.923 ± 0.337
4.54LysTyr: 4.54 ± 0.619
0.0LysXaa: 0.0 ± 0.0
Leu
5.694LeuAla: 5.694 ± 0.627
0.308LeuCys: 0.308 ± 0.162
5.848LeuAsp: 5.848 ± 0.545
7.848LeuGlu: 7.848 ± 0.895
2.924LeuPhe: 2.924 ± 0.582
4.386LeuGly: 4.386 ± 0.913
1.0LeuHis: 1.0 ± 0.291
5.386LeuIle: 5.386 ± 0.608
8.079LeuLys: 8.079 ± 1.034
6.001LeuLeu: 6.001 ± 0.766
1.924LeuMet: 1.924 ± 0.341
5.924LeuAsn: 5.924 ± 0.633
2.616LeuPro: 2.616 ± 0.394
2.693LeuGln: 2.693 ± 0.563
3.462LeuArg: 3.462 ± 0.57
5.463LeuSer: 5.463 ± 0.695
4.463LeuThr: 4.463 ± 0.688
4.078LeuVal: 4.078 ± 0.472
0.769LeuTrp: 0.769 ± 0.209
2.847LeuTyr: 2.847 ± 0.445
0.0LeuXaa: 0.0 ± 0.0
Met
2.308MetAla: 2.308 ± 0.363
0.0MetCys: 0.0 ± 0.0
1.231MetAsp: 1.231 ± 0.363
1.154MetGlu: 1.154 ± 0.324
1.154MetPhe: 1.154 ± 0.238
0.846MetGly: 0.846 ± 0.29
0.231MetHis: 0.231 ± 0.125
1.385MetIle: 1.385 ± 0.334
2.308MetLys: 2.308 ± 0.49
1.924MetLeu: 1.924 ± 0.35
0.616MetMet: 0.616 ± 0.22
1.154MetAsn: 1.154 ± 0.295
0.692MetPro: 0.692 ± 0.268
1.308MetGln: 1.308 ± 0.315
0.923MetArg: 0.923 ± 0.241
2.308MetSer: 2.308 ± 0.429
2.0MetThr: 2.0 ± 0.362
1.693MetVal: 1.693 ± 0.274
0.154MetTrp: 0.154 ± 0.105
0.616MetTyr: 0.616 ± 0.273
0.0MetXaa: 0.0 ± 0.0
Asn
4.54AsnAla: 4.54 ± 0.742
0.462AsnCys: 0.462 ± 0.177
3.539AsnAsp: 3.539 ± 0.621
4.001AsnGlu: 4.001 ± 0.526
2.847AsnPhe: 2.847 ± 0.491
4.693AsnGly: 4.693 ± 0.605
0.769AsnHis: 0.769 ± 0.219
4.155AsnIle: 4.155 ± 0.532
4.616AsnLys: 4.616 ± 0.577
4.616AsnLeu: 4.616 ± 0.642
1.231AsnMet: 1.231 ± 0.355
4.078AsnAsn: 4.078 ± 0.71
2.154AsnPro: 2.154 ± 0.367
2.154AsnGln: 2.154 ± 0.501
2.385AsnArg: 2.385 ± 0.523
3.385AsnSer: 3.385 ± 0.546
2.924AsnThr: 2.924 ± 0.61
3.616AsnVal: 3.616 ± 0.566
1.154AsnTrp: 1.154 ± 0.298
2.693AsnTyr: 2.693 ± 0.428
0.0AsnXaa: 0.0 ± 0.0
Pro
1.077ProAla: 1.077 ± 0.3
0.0ProCys: 0.0 ± 0.0
1.539ProAsp: 1.539 ± 0.429
2.462ProGlu: 2.462 ± 0.602
1.462ProPhe: 1.462 ± 0.346
1.847ProGly: 1.847 ± 0.441
0.385ProHis: 0.385 ± 0.163
1.693ProIle: 1.693 ± 0.294
3.078ProLys: 3.078 ± 0.592
2.308ProLeu: 2.308 ± 0.409
0.462ProMet: 0.462 ± 0.214
1.539ProAsn: 1.539 ± 0.383
0.692ProPro: 0.692 ± 0.266
1.693ProGln: 1.693 ± 0.385
1.385ProArg: 1.385 ± 0.371
2.77ProSer: 2.77 ± 0.458
1.847ProThr: 1.847 ± 0.365
1.231ProVal: 1.231 ± 0.302
0.0ProTrp: 0.0 ± 0.0
1.154ProTyr: 1.154 ± 0.323
0.0ProXaa: 0.0 ± 0.0
Gln
3.001GlnAla: 3.001 ± 0.642
0.308GlnCys: 0.308 ± 0.133
1.385GlnAsp: 1.385 ± 0.284
2.308GlnGlu: 2.308 ± 0.335
1.077GlnPhe: 1.077 ± 0.255
2.0GlnGly: 2.0 ± 0.612
0.539GlnHis: 0.539 ± 0.191
3.078GlnIle: 3.078 ± 0.466
4.54GlnLys: 4.54 ± 0.727
3.693GlnLeu: 3.693 ± 0.744
0.923GlnMet: 0.923 ± 0.276
2.0GlnAsn: 2.0 ± 0.402
0.846GlnPro: 0.846 ± 0.233
2.0GlnGln: 2.0 ± 0.42
1.693GlnArg: 1.693 ± 0.37
3.155GlnSer: 3.155 ± 0.563
1.924GlnThr: 1.924 ± 0.432
1.924GlnVal: 1.924 ± 0.369
0.385GlnTrp: 0.385 ± 0.145
1.077GlnTyr: 1.077 ± 0.293
0.0GlnXaa: 0.0 ± 0.0
Arg
1.539ArgAla: 1.539 ± 0.32
0.154ArgCys: 0.154 ± 0.139
2.616ArgAsp: 2.616 ± 0.429
3.385ArgGlu: 3.385 ± 0.541
1.616ArgPhe: 1.616 ± 0.312
2.308ArgGly: 2.308 ± 0.5
0.616ArgHis: 0.616 ± 0.248
3.539ArgIle: 3.539 ± 0.508
3.462ArgLys: 3.462 ± 0.587
4.078ArgLeu: 4.078 ± 0.625
1.231ArgMet: 1.231 ± 0.231
2.231ArgAsn: 2.231 ± 0.44
1.539ArgPro: 1.539 ± 0.323
1.539ArgGln: 1.539 ± 0.266
2.077ArgArg: 2.077 ± 0.423
1.539ArgSer: 1.539 ± 0.36
2.154ArgThr: 2.154 ± 0.374
2.308ArgVal: 2.308 ± 0.488
0.462ArgTrp: 0.462 ± 0.187
1.462ArgTyr: 1.462 ± 0.315
0.0ArgXaa: 0.0 ± 0.0
Ser
4.232SerAla: 4.232 ± 0.615
0.308SerCys: 0.308 ± 0.161
5.924SerAsp: 5.924 ± 0.709
3.77SerGlu: 3.77 ± 0.475
2.462SerPhe: 2.462 ± 0.496
4.463SerGly: 4.463 ± 0.659
0.923SerHis: 0.923 ± 0.247
4.078SerIle: 4.078 ± 0.566
6.078SerLys: 6.078 ± 0.722
4.001SerLeu: 4.001 ± 0.505
1.385SerMet: 1.385 ± 0.326
3.693SerAsn: 3.693 ± 0.562
1.462SerPro: 1.462 ± 0.311
2.462SerGln: 2.462 ± 0.379
2.462SerArg: 2.462 ± 0.443
5.001SerSer: 5.001 ± 0.661
3.078SerThr: 3.078 ± 0.481
4.54SerVal: 4.54 ± 0.53
0.462SerTrp: 0.462 ± 0.151
3.078SerTyr: 3.078 ± 0.555
0.0SerXaa: 0.0 ± 0.0
Thr
3.155ThrAla: 3.155 ± 0.685
0.385ThrCys: 0.385 ± 0.213
3.308ThrAsp: 3.308 ± 0.547
4.078ThrGlu: 4.078 ± 0.462
3.77ThrPhe: 3.77 ± 0.431
3.924ThrGly: 3.924 ± 0.959
1.0ThrHis: 1.0 ± 0.273
4.847ThrIle: 4.847 ± 0.786
5.617ThrLys: 5.617 ± 0.627
4.463ThrLeu: 4.463 ± 0.577
1.154ThrMet: 1.154 ± 0.313
3.385ThrAsn: 3.385 ± 0.518
1.847ThrPro: 1.847 ± 0.397
2.231ThrGln: 2.231 ± 0.336
2.231ThrArg: 2.231 ± 0.439
3.078ThrSer: 3.078 ± 0.56
3.693ThrThr: 3.693 ± 0.509
3.924ThrVal: 3.924 ± 0.737
0.539ThrTrp: 0.539 ± 0.191
3.001ThrTyr: 3.001 ± 0.505
0.0ThrXaa: 0.0 ± 0.0
Val
3.385ValAla: 3.385 ± 0.482
0.308ValCys: 0.308 ± 0.163
3.616ValAsp: 3.616 ± 0.484
4.616ValGlu: 4.616 ± 0.56
1.693ValPhe: 1.693 ± 0.403
4.309ValGly: 4.309 ± 0.584
0.616ValHis: 0.616 ± 0.264
4.386ValIle: 4.386 ± 0.682
6.232ValLys: 6.232 ± 0.764
5.001ValLeu: 5.001 ± 0.678
0.692ValMet: 0.692 ± 0.226
3.693ValAsn: 3.693 ± 0.596
1.462ValPro: 1.462 ± 0.409
2.539ValGln: 2.539 ± 0.599
2.616ValArg: 2.616 ± 0.535
4.463ValSer: 4.463 ± 0.614
5.078ValThr: 5.078 ± 0.578
4.001ValVal: 4.001 ± 0.644
0.231ValTrp: 0.231 ± 0.128
2.077ValTyr: 2.077 ± 0.471
0.0ValXaa: 0.0 ± 0.0
Trp
0.769TrpAla: 0.769 ± 0.197
0.154TrpCys: 0.154 ± 0.105
0.385TrpAsp: 0.385 ± 0.166
0.692TrpGlu: 0.692 ± 0.209
0.616TrpPhe: 0.616 ± 0.265
0.692TrpGly: 0.692 ± 0.302
0.231TrpHis: 0.231 ± 0.139
1.077TrpIle: 1.077 ± 0.23
0.616TrpLys: 0.616 ± 0.205
1.154TrpLeu: 1.154 ± 0.39
0.077TrpMet: 0.077 ± 0.084
0.769TrpAsn: 0.769 ± 0.282
0.0TrpPro: 0.0 ± 0.0
0.923TrpGln: 0.923 ± 0.253
0.385TrpArg: 0.385 ± 0.207
0.385TrpSer: 0.385 ± 0.172
0.769TrpThr: 0.769 ± 0.243
0.308TrpVal: 0.308 ± 0.141
0.154TrpTrp: 0.154 ± 0.11
0.308TrpTyr: 0.308 ± 0.135
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.462TyrAla: 3.462 ± 0.624
0.616TyrCys: 0.616 ± 0.186
2.924TyrAsp: 2.924 ± 0.418
3.462TyrGlu: 3.462 ± 0.617
1.847TyrPhe: 1.847 ± 0.342
2.0TyrGly: 2.0 ± 0.394
1.231TyrHis: 1.231 ± 0.31
1.616TyrIle: 1.616 ± 0.3
3.616TyrLys: 3.616 ± 0.625
3.924TyrLeu: 3.924 ± 0.525
1.231TyrMet: 1.231 ± 0.311
3.078TyrAsn: 3.078 ± 0.539
1.847TyrPro: 1.847 ± 0.418
2.231TyrGln: 2.231 ± 0.357
1.616TyrArg: 1.616 ± 0.397
2.539TyrSer: 2.539 ± 0.403
2.231TyrThr: 2.231 ± 0.468
2.077TyrVal: 2.077 ± 0.383
0.308TyrTrp: 0.308 ± 0.155
1.77TyrTyr: 1.77 ± 0.577
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 69 proteins (12998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski