Amino acid dipepetide frequency for Ornithinimicrobium pratense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.35AlaAla: 18.35 ± 0.203	0.901AlaCys: 0.901 ± 0.033	7.78AlaAsp: 7.78 ± 0.097	7.983AlaGlu: 7.983 ± 0.127	3.07AlaPhe: 3.07 ± 0.058	12.64AlaGly: 12.64 ± 0.13	2.722AlaHis: 2.722 ± 0.053	3.977AlaIle: 3.977 ± 0.07	2.006AlaLys: 2.006 ± 0.052	14.039AlaLeu: 14.039 ± 0.152	2.682AlaMet: 2.682 ± 0.055	1.792AlaAsn: 1.792 ± 0.049	6.3AlaPro: 6.3 ± 0.089	4.696AlaGln: 4.696 ± 0.077	9.725AlaArg: 9.725 ± 0.119	5.922AlaSer: 5.922 ± 0.078	7.051AlaThr: 7.051 ± 0.096	11.598AlaVal: 11.598 ± 0.122	1.956AlaTrp: 1.956 ± 0.044	2.398AlaTyr: 2.398 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.823CysAla: 0.823 ± 0.032	0.091CysCys: 0.091 ± 0.01	0.361CysAsp: 0.361 ± 0.02	0.335CysGlu: 0.335 ± 0.022	0.188CysPhe: 0.188 ± 0.012	0.775CysGly: 0.775 ± 0.03	0.162CysHis: 0.162 ± 0.011	0.168CysIle: 0.168 ± 0.012	0.082CysLys: 0.082 ± 0.009	0.579CysLeu: 0.579 ± 0.025	0.098CysMet: 0.098 ± 0.01	0.108CysAsn: 0.108 ± 0.01	0.487CysPro: 0.487 ± 0.025	0.173CysGln: 0.173 ± 0.014	0.502CysArg: 0.502 ± 0.027	0.376CysSer: 0.376 ± 0.018	0.447CysThr: 0.447 ± 0.026	0.512CysVal: 0.512 ± 0.021	0.126CysTrp: 0.126 ± 0.013	0.116CysTyr: 0.116 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.174AspAla: 7.174 ± 0.098	0.324AspCys: 0.324 ± 0.019	3.809AspAsp: 3.809 ± 0.08	4.321AspGlu: 4.321 ± 0.079	1.437AspPhe: 1.437 ± 0.04	6.087AspGly: 6.087 ± 0.086	1.527AspHis: 1.527 ± 0.038	1.884AspIle: 1.884 ± 0.047	0.915AspLys: 0.915 ± 0.033	7.252AspLeu: 7.252 ± 0.101	0.842AspMet: 0.842 ± 0.029	0.841AspAsn: 0.841 ± 0.031	4.791AspPro: 4.791 ± 0.072	2.072AspGln: 2.072 ± 0.05	4.909AspArg: 4.909 ± 0.068	2.301AspSer: 2.301 ± 0.051	2.97AspThr: 2.97 ± 0.063	5.528AspVal: 5.528 ± 0.081	0.96AspTrp: 0.96 ± 0.033	1.228AspTyr: 1.228 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.514GluAla: 7.514 ± 0.096	0.28GluCys: 0.28 ± 0.018	3.797GluAsp: 3.797 ± 0.07	4.135GluGlu: 4.135 ± 0.084	1.296GluPhe: 1.296 ± 0.035	5.214GluGly: 5.214 ± 0.075	1.852GluHis: 1.852 ± 0.043	2.153GluIle: 2.153 ± 0.053	0.955GluLys: 0.955 ± 0.032	6.818GluLeu: 6.818 ± 0.079	0.991GluMet: 0.991 ± 0.029	0.858GluAsn: 0.858 ± 0.032	3.519GluPro: 3.519 ± 0.076	3.173GluGln: 3.173 ± 0.059	5.451GluArg: 5.451 ± 0.085	2.395GluSer: 2.395 ± 0.049	2.851GluThr: 2.851 ± 0.055	5.902GluVal: 5.902 ± 0.081	0.763GluTrp: 0.763 ± 0.031	0.778GluTyr: 0.778 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.151PheAla: 3.151 ± 0.057	0.21PheCys: 0.21 ± 0.015	1.707PheAsp: 1.707 ± 0.042	1.368PheGlu: 1.368 ± 0.04	0.85PhePhe: 0.85 ± 0.037	2.767PheGly: 2.767 ± 0.067	0.526PheHis: 0.526 ± 0.027	0.827PheIle: 0.827 ± 0.033	0.38PheLys: 0.38 ± 0.019	2.499PheLeu: 2.499 ± 0.06	0.4PheMet: 0.4 ± 0.019	0.497PheAsn: 0.497 ± 0.022	1.258PhePro: 1.258 ± 0.037	0.637PheGln: 0.637 ± 0.027	1.466PheArg: 1.466 ± 0.04	1.355PheSer: 1.355 ± 0.037	1.773PheThr: 1.773 ± 0.038	2.413PheVal: 2.413 ± 0.053	0.42PheTrp: 0.42 ± 0.021	0.583PheTyr: 0.583 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.928GlyAla: 10.928 ± 0.133	0.726GlyCys: 0.726 ± 0.029	5.088GlyAsp: 5.088 ± 0.081	5.799GlyGlu: 5.799 ± 0.085	2.543GlyPhe: 2.543 ± 0.048	8.535GlyGly: 8.535 ± 0.118	2.287GlyHis: 2.287 ± 0.05	3.521GlyIle: 3.521 ± 0.072	1.745GlyLys: 1.745 ± 0.048	10.007GlyLeu: 10.007 ± 0.109	2.413GlyMet: 2.413 ± 0.054	1.428GlyAsn: 1.428 ± 0.046	5.15GlyPro: 5.15 ± 0.077	3.625GlyGln: 3.625 ± 0.061	7.595GlyArg: 7.595 ± 0.098	5.405GlySer: 5.405 ± 0.086	5.764GlyThr: 5.764 ± 0.094	8.233GlyVal: 8.233 ± 0.1	1.813GlyTrp: 1.813 ± 0.044	2.187GlyTyr: 2.187 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.605HisAla: 2.605 ± 0.06	0.144HisCys: 0.144 ± 0.012	1.552HisAsp: 1.552 ± 0.044	1.44HisGlu: 1.44 ± 0.034	0.536HisPhe: 0.536 ± 0.025	2.379HisGly: 2.379 ± 0.056	0.684HisHis: 0.684 ± 0.025	0.613HisIle: 0.613 ± 0.023	0.283HisLys: 0.283 ± 0.017	2.792HisLeu: 2.792 ± 0.055	0.303HisMet: 0.303 ± 0.017	0.35HisAsn: 0.35 ± 0.019	1.826HisPro: 1.826 ± 0.047	0.823HisGln: 0.823 ± 0.031	2.051HisArg: 2.051 ± 0.049	0.98HisSer: 0.98 ± 0.03	1.252HisThr: 1.252 ± 0.039	2.026HisVal: 2.026 ± 0.048	0.317HisTrp: 0.317 ± 0.019	0.445HisTyr: 0.445 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.474IleAla: 4.474 ± 0.074	0.294IleCys: 0.294 ± 0.019	2.377IleAsp: 2.377 ± 0.052	2.258IleGlu: 2.258 ± 0.056	0.943IlePhe: 0.943 ± 0.037	3.401IleGly: 3.401 ± 0.068	0.569IleHis: 0.569 ± 0.024	1.226IleIle: 1.226 ± 0.038	0.552IleLys: 0.552 ± 0.027	3.017IleLeu: 3.017 ± 0.06	0.512IleMet: 0.512 ± 0.025	0.737IleAsn: 0.737 ± 0.03	1.912IlePro: 1.912 ± 0.043	0.805IleGln: 0.805 ± 0.027	2.095IleArg: 2.095 ± 0.046	1.84IleSer: 1.84 ± 0.05	2.338IleThr: 2.338 ± 0.047	3.07IleVal: 3.07 ± 0.061	0.405IleTrp: 0.405 ± 0.02	0.678IleTyr: 0.678 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.966LysAla: 1.966 ± 0.054	0.054LysCys: 0.054 ± 0.007	1.049LysAsp: 1.049 ± 0.039	0.891LysGlu: 0.891 ± 0.034	0.347LysPhe: 0.347 ± 0.019	1.381LysGly: 1.381 ± 0.041	0.368LysHis: 0.368 ± 0.017	0.644LysIle: 0.644 ± 0.026	0.553LysLys: 0.553 ± 0.038	1.327LysLeu: 1.327 ± 0.04	0.323LysMet: 0.323 ± 0.017	0.334LysAsn: 0.334 ± 0.019	0.794LysPro: 0.794 ± 0.031	0.473LysGln: 0.473 ± 0.023	1.058LysArg: 1.058 ± 0.04	0.776LysSer: 0.776 ± 0.031	0.934LysThr: 0.934 ± 0.035	1.574LysVal: 1.574 ± 0.04	0.173LysTrp: 0.173 ± 0.014	0.275LysTyr: 0.275 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.573LeuAla: 15.573 ± 0.164	0.629LeuCys: 0.629 ± 0.022	6.827LeuAsp: 6.827 ± 0.089	5.628LeuGlu: 5.628 ± 0.075	2.391LeuPhe: 2.391 ± 0.056	10.31LeuGly: 10.31 ± 0.128	2.379LeuHis: 2.379 ± 0.053	3.382LeuIle: 3.382 ± 0.068	1.423LeuLys: 1.423 ± 0.048	11.714LeuLeu: 11.714 ± 0.167	1.798LeuMet: 1.798 ± 0.043	1.475LeuAsn: 1.475 ± 0.035	6.304LeuPro: 6.304 ± 0.092	3.017LeuGln: 3.017 ± 0.055	8.361LeuArg: 8.361 ± 0.102	5.457LeuSer: 5.457 ± 0.08	6.982LeuThr: 6.982 ± 0.086	10.389LeuVal: 10.389 ± 0.124	1.379LeuTrp: 1.379 ± 0.038	1.438LeuTyr: 1.438 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.435MetAla: 2.435 ± 0.049	0.12MetCys: 0.12 ± 0.011	1.017MetAsp: 1.017 ± 0.034	0.818MetGlu: 0.818 ± 0.034	0.498MetPhe: 0.498 ± 0.026	1.576MetGly: 1.576 ± 0.039	0.373MetHis: 0.373 ± 0.021	0.717MetIle: 0.717 ± 0.026	0.33MetLys: 0.33 ± 0.018	1.967MetLeu: 1.967 ± 0.044	0.349MetMet: 0.349 ± 0.02	0.418MetAsn: 0.418 ± 0.018	1.218MetPro: 1.218 ± 0.038	0.571MetGln: 0.571 ± 0.024	1.431MetArg: 1.431 ± 0.036	1.508MetSer: 1.508 ± 0.041	1.738MetThr: 1.738 ± 0.039	1.748MetVal: 1.748 ± 0.04	0.226MetTrp: 0.226 ± 0.015	0.276MetTyr: 0.276 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.902AsnAla: 1.902 ± 0.044	0.123AsnCys: 0.123 ± 0.011	0.88AsnAsp: 0.88 ± 0.028	0.754AsnGlu: 0.754 ± 0.028	0.456AsnPhe: 0.456 ± 0.022	1.38AsnGly: 1.38 ± 0.044	0.343AsnHis: 0.343 ± 0.02	0.63AsnIle: 0.63 ± 0.026	0.27AsnLys: 0.27 ± 0.017	1.694AsnLeu: 1.694 ± 0.045	0.271AsnMet: 0.271 ± 0.016	0.343AsnAsn: 0.343 ± 0.022	1.303AsnPro: 1.303 ± 0.037	0.5AsnGln: 0.5 ± 0.022	1.072AsnArg: 1.072 ± 0.032	0.708AsnSer: 0.708 ± 0.029	0.889AsnThr: 0.889 ± 0.028	1.345AsnVal: 1.345 ± 0.033	0.244AsnTrp: 0.244 ± 0.017	0.395AsnTyr: 0.395 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.298ProAla: 7.298 ± 0.093	0.278ProCys: 0.278 ± 0.017	4.382ProAsp: 4.382 ± 0.07	4.544ProGlu: 4.544 ± 0.083	1.437ProPhe: 1.437 ± 0.041	6.454ProGly: 6.454 ± 0.09	1.374ProHis: 1.374 ± 0.041	1.527ProIle: 1.527 ± 0.038	0.774ProLys: 0.774 ± 0.031	5.074ProLeu: 5.074 ± 0.082	1.159ProMet: 1.159 ± 0.033	0.772ProAsn: 0.772 ± 0.032	3.208ProPro: 3.208 ± 0.077	2.071ProGln: 2.071 ± 0.049	4.037ProArg: 4.037 ± 0.081	3.151ProSer: 3.151 ± 0.059	3.62ProThr: 3.62 ± 0.084	5.745ProVal: 5.745 ± 0.073	1.087ProTrp: 1.087 ± 0.035	1.058ProTyr: 1.058 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.484GlnAla: 4.484 ± 0.072	0.145GlnCys: 0.145 ± 0.011	2.063GlnAsp: 2.063 ± 0.044	2.307GlnGlu: 2.307 ± 0.047	0.724GlnPhe: 0.724 ± 0.029	2.916GlnGly: 2.916 ± 0.059	0.852GlnHis: 0.852 ± 0.032	1.45GlnIle: 1.45 ± 0.036	0.432GlnLys: 0.432 ± 0.02	3.608GlnLeu: 3.608 ± 0.064	0.691GlnMet: 0.691 ± 0.028	0.458GlnAsn: 0.458 ± 0.023	1.951GlnPro: 1.951 ± 0.056	1.51GlnGln: 1.51 ± 0.045	2.843GlnArg: 2.843 ± 0.056	1.331GlnSer: 1.331 ± 0.039	1.753GlnThr: 1.753 ± 0.038	3.788GlnVal: 3.788 ± 0.06	0.5GlnTrp: 0.5 ± 0.025	0.434GlnTyr: 0.434 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.362ArgAla: 9.362 ± 0.116	0.506ArgCys: 0.506 ± 0.025	4.302ArgAsp: 4.302 ± 0.07	4.89ArgGlu: 4.89 ± 0.083	1.954ArgPhe: 1.954 ± 0.048	6.101ArgGly: 6.101 ± 0.088	2.149ArgHis: 2.149 ± 0.05	2.782ArgIle: 2.782 ± 0.056	1.193ArgLys: 1.193 ± 0.04	8.153ArgLeu: 8.153 ± 0.1	1.843ArgMet: 1.843 ± 0.036	1.118ArgAsn: 1.118 ± 0.034	4.706ArgPro: 4.706 ± 0.074	2.669ArgGln: 2.669 ± 0.055	7.426ArgArg: 7.426 ± 0.107	4.261ArgSer: 4.261 ± 0.07	4.776ArgThr: 4.776 ± 0.066	6.532ArgVal: 6.532 ± 0.095	1.571ArgTrp: 1.571 ± 0.042	1.619ArgTyr: 1.619 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.245SerAla: 6.245 ± 0.087	0.336SerCys: 0.336 ± 0.02	2.636SerAsp: 2.636 ± 0.057	2.408SerGlu: 2.408 ± 0.055	1.385SerPhe: 1.385 ± 0.04	5.484SerGly: 5.484 ± 0.076	1.033SerHis: 1.033 ± 0.034	1.687SerIle: 1.687 ± 0.048	0.765SerLys: 0.765 ± 0.031	4.962SerLeu: 4.962 ± 0.074	1.247SerMet: 1.247 ± 0.035	0.849SerAsn: 0.849 ± 0.029	3.169SerPro: 3.169 ± 0.063	1.58SerGln: 1.58 ± 0.042	3.806SerArg: 3.806 ± 0.063	3.04SerSer: 3.04 ± 0.061	3.54SerThr: 3.54 ± 0.073	4.392SerVal: 4.392 ± 0.065	0.988SerTrp: 0.988 ± 0.029	1.113SerTyr: 1.113 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.169ThrAla: 7.169 ± 0.095	0.404ThrCys: 0.404 ± 0.022	3.638ThrAsp: 3.638 ± 0.055	3.168ThrGlu: 3.168 ± 0.054	1.76ThrPhe: 1.76 ± 0.045	6.313ThrGly: 6.313 ± 0.085	1.261ThrHis: 1.261 ± 0.04	2.11ThrIle: 2.11 ± 0.046	0.862ThrLys: 0.862 ± 0.036	6.131ThrLeu: 6.131 ± 0.086	1.173ThrMet: 1.173 ± 0.034	1.001ThrAsn: 1.001 ± 0.034	3.874ThrPro: 3.874 ± 0.065	1.835ThrGln: 1.835 ± 0.049	4.075ThrArg: 4.075 ± 0.068	3.372ThrSer: 3.372 ± 0.062	4.003ThrThr: 4.003 ± 0.07	5.815ThrVal: 5.815 ± 0.085	1.074ThrTrp: 1.074 ± 0.029	1.193ThrTyr: 1.193 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	11.698ValAla: 11.698 ± 0.127	0.668ValCys: 0.668 ± 0.027	5.918ValAsp: 5.918 ± 0.078	5.798ValGlu: 5.798 ± 0.089	2.23ValPhe: 2.23 ± 0.057	8.085ValGly: 8.085 ± 0.097	2.198ValHis: 2.198 ± 0.058	3.252ValIle: 3.252 ± 0.068	1.308ValLys: 1.308 ± 0.043	11.107ValLeu: 11.107 ± 0.129	1.747ValMet: 1.747 ± 0.039	1.513ValAsn: 1.513 ± 0.041	5.333ValPro: 5.333 ± 0.079	2.819ValGln: 2.819 ± 0.06	7.165ValArg: 7.165 ± 0.113	4.637ValSer: 4.637 ± 0.076	5.642ValThr: 5.642 ± 0.084	10.195ValVal: 10.195 ± 0.12	1.233ValTrp: 1.233 ± 0.034	1.378ValTyr: 1.378 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.911TrpAla: 1.911 ± 0.048	0.144TrpCys: 0.144 ± 0.013	0.808TrpAsp: 0.808 ± 0.03	0.791TrpGlu: 0.791 ± 0.033	0.505TrpPhe: 0.505 ± 0.023	1.219TrpGly: 1.219 ± 0.04	0.363TrpHis: 0.363 ± 0.019	0.495TrpIle: 0.495 ± 0.022	0.212TrpLys: 0.212 ± 0.015	1.917TrpLeu: 1.917 ± 0.049	0.318TrpMet: 0.318 ± 0.019	0.287TrpAsn: 0.287 ± 0.017	0.871TrpPro: 0.871 ± 0.031	0.614TrpGln: 0.614 ± 0.025	1.41TrpArg: 1.41 ± 0.04	1.014TrpSer: 1.014 ± 0.033	0.927TrpThr: 0.927 ± 0.03	1.45TrpVal: 1.45 ± 0.035	0.491TrpTrp: 0.491 ± 0.018	0.271TrpTyr: 0.271 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.526TyrAla: 2.526 ± 0.054	0.131TyrCys: 0.131 ± 0.012	1.184TyrAsp: 1.184 ± 0.038	1.06TyrGlu: 1.06 ± 0.038	0.535TyrPhe: 0.535 ± 0.028	1.777TyrGly: 1.777 ± 0.041	0.378TyrHis: 0.378 ± 0.019	0.456TyrIle: 0.456 ± 0.024	0.254TyrLys: 0.254 ± 0.018	2.197TyrLeu: 2.197 ± 0.051	0.175TyrMet: 0.175 ± 0.015	0.322TyrAsn: 0.322 ± 0.016	1.075TyrPro: 1.075 ± 0.036	0.581TyrGln: 0.581 ± 0.027	1.435TyrArg: 1.435 ± 0.039	0.836TyrSer: 0.836 ± 0.026	0.98TyrThr: 0.98 ± 0.036	1.669TyrVal: 1.669 ± 0.042	0.291TyrTrp: 0.291 ± 0.017	0.366TyrTyr: 0.366 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3076 proteins (1029995 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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