Amino acid dipepetide frequency for Winogradskyella sp. PC-19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.701AlaAla: 3.701 ± 0.096	0.513AlaCys: 0.513 ± 0.029	3.343AlaAsp: 3.343 ± 0.078	3.987AlaGlu: 3.987 ± 0.081	3.325AlaPhe: 3.325 ± 0.061	3.809AlaGly: 3.809 ± 0.086	1.034AlaHis: 1.034 ± 0.038	5.511AlaIle: 5.511 ± 0.093	4.757AlaLys: 4.757 ± 0.091	6.098AlaLeu: 6.098 ± 0.097	1.483AlaMet: 1.483 ± 0.038	3.617AlaAsn: 3.617 ± 0.078	1.737AlaPro: 1.737 ± 0.051	2.265AlaGln: 2.265 ± 0.048	1.86AlaArg: 1.86 ± 0.045	4.099AlaSer: 4.099 ± 0.066	3.629AlaThr: 3.629 ± 0.091	3.962AlaVal: 3.962 ± 0.077	0.57AlaTrp: 0.57 ± 0.024	2.366AlaTyr: 2.366 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.427CysAla: 0.427 ± 0.025	0.087CysCys: 0.087 ± 0.009	0.491CysAsp: 0.491 ± 0.031	0.478CysGlu: 0.478 ± 0.025	0.472CysPhe: 0.472 ± 0.024	0.579CysGly: 0.579 ± 0.033	0.145CysHis: 0.145 ± 0.015	0.608CysIle: 0.608 ± 0.028	0.491CysLys: 0.491 ± 0.024	0.57CysLeu: 0.57 ± 0.025	0.125CysMet: 0.125 ± 0.012	0.467CysAsn: 0.467 ± 0.022	0.356CysPro: 0.356 ± 0.027	0.209CysGln: 0.209 ± 0.016	0.165CysArg: 0.165 ± 0.012	0.552CysSer: 0.552 ± 0.031	0.401CysThr: 0.401 ± 0.028	0.433CysVal: 0.433 ± 0.024	0.054CysTrp: 0.054 ± 0.007	0.254CysTyr: 0.254 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.083AspAla: 4.083 ± 0.081	0.472AspCys: 0.472 ± 0.029	3.487AspAsp: 3.487 ± 0.078	3.83AspGlu: 3.83 ± 0.08	3.907AspPhe: 3.907 ± 0.063	3.949AspGly: 3.949 ± 0.098	0.682AspHis: 0.682 ± 0.028	5.139AspIle: 5.139 ± 0.08	4.374AspLys: 4.374 ± 0.077	5.424AspLeu: 5.424 ± 0.088	1.205AspMet: 1.205 ± 0.039	3.787AspAsn: 3.787 ± 0.079	1.441AspPro: 1.441 ± 0.046	1.276AspGln: 1.276 ± 0.037	1.75AspArg: 1.75 ± 0.043	3.451AspSer: 3.451 ± 0.078	3.158AspThr: 3.158 ± 0.073	4.064AspVal: 4.064 ± 0.086	0.772AspTrp: 0.772 ± 0.03	3.216AspTyr: 3.216 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.603GluAla: 4.603 ± 0.09	0.346GluCys: 0.346 ± 0.022	4.0GluAsp: 4.0 ± 0.066	4.621GluGlu: 4.621 ± 0.112	3.086GluPhe: 3.086 ± 0.061	3.472GluGly: 3.472 ± 0.067	1.007GluHis: 1.007 ± 0.036	5.392GluIle: 5.392 ± 0.093	5.306GluLys: 5.306 ± 0.092	5.985GluLeu: 5.985 ± 0.088	1.351GluMet: 1.351 ± 0.041	4.571GluAsn: 4.571 ± 0.07	1.497GluPro: 1.497 ± 0.045	2.111GluGln: 2.111 ± 0.048	2.61GluArg: 2.61 ± 0.059	3.433GluSer: 3.433 ± 0.063	3.927GluThr: 3.927 ± 0.074	4.256GluVal: 4.256 ± 0.069	0.571GluTrp: 0.571 ± 0.027	2.302GluTyr: 2.302 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.005PheAla: 3.005 ± 0.054	0.394PheCys: 0.394 ± 0.025	3.494PheAsp: 3.494 ± 0.076	3.582PheGlu: 3.582 ± 0.052	2.75PhePhe: 2.75 ± 0.064	3.937PheGly: 3.937 ± 0.079	0.749PheHis: 0.749 ± 0.032	4.009PheIle: 4.009 ± 0.083	4.093PheLys: 4.093 ± 0.081	4.636PheLeu: 4.636 ± 0.086	1.103PheMet: 1.103 ± 0.032	3.576PheAsn: 3.576 ± 0.074	1.646PhePro: 1.646 ± 0.039	1.561PheGln: 1.561 ± 0.038	1.626PheArg: 1.626 ± 0.044	4.203PheSer: 4.203 ± 0.076	3.329PheThr: 3.329 ± 0.082	3.163PheVal: 3.163 ± 0.063	0.551PheTrp: 0.551 ± 0.026	2.175PheTyr: 2.175 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	3.886GlyAla: 3.886 ± 0.085	0.574GlyCys: 0.574 ± 0.034	3.485GlyAsp: 3.485 ± 0.076	3.531GlyGlu: 3.531 ± 0.072	3.81GlyPhe: 3.81 ± 0.073	4.386GlyGly: 4.386 ± 0.1	1.119GlyHis: 1.119 ± 0.039	5.216GlyIle: 5.216 ± 0.084	4.811GlyLys: 4.811 ± 0.085	5.631GlyLeu: 5.631 ± 0.086	1.46GlyMet: 1.46 ± 0.045	3.89GlyAsn: 3.89 ± 0.085	1.329GlyPro: 1.329 ± 0.046	1.996GlyGln: 1.996 ± 0.052	2.074GlyArg: 2.074 ± 0.054	3.765GlySer: 3.765 ± 0.085	3.84GlyThr: 3.84 ± 0.116	4.15GlyVal: 4.15 ± 0.069	0.695GlyTrp: 0.695 ± 0.027	2.611GlyTyr: 2.611 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.839HisAla: 0.839 ± 0.03	0.166HisCys: 0.166 ± 0.015	0.817HisAsp: 0.817 ± 0.034	0.796HisGlu: 0.796 ± 0.026	1.062HisPhe: 1.062 ± 0.035	0.946HisGly: 0.946 ± 0.036	0.416HisHis: 0.416 ± 0.022	1.388HisIle: 1.388 ± 0.043	1.177HisLys: 1.177 ± 0.042	1.607HisLeu: 1.607 ± 0.048	0.31HisMet: 0.31 ± 0.02	0.989HisAsn: 0.989 ± 0.029	0.757HisPro: 0.757 ± 0.033	0.626HisGln: 0.626 ± 0.028	0.659HisArg: 0.659 ± 0.026	0.954HisSer: 0.954 ± 0.035	0.818HisThr: 0.818 ± 0.029	0.861HisVal: 0.861 ± 0.033	0.189HisTrp: 0.189 ± 0.014	0.758HisTyr: 0.758 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.437IleAla: 5.437 ± 0.095	0.666IleCys: 0.666 ± 0.028	5.374IleAsp: 5.374 ± 0.074	5.754IleGlu: 5.754 ± 0.094	3.814IlePhe: 3.814 ± 0.072	5.253IleGly: 5.253 ± 0.088	1.207IleHis: 1.207 ± 0.038	6.646IleIle: 6.646 ± 0.109	6.208IleLys: 6.208 ± 0.098	7.13IleLeu: 7.13 ± 0.11	1.396IleMet: 1.396 ± 0.045	5.277IleAsn: 5.277 ± 0.106	3.192IlePro: 3.192 ± 0.058	2.298IleGln: 2.298 ± 0.054	2.42IleArg: 2.42 ± 0.057	6.04IleSer: 6.04 ± 0.104	5.027IleThr: 5.027 ± 0.091	4.898IleVal: 4.898 ± 0.083	0.721IleTrp: 0.721 ± 0.029	2.84IleTyr: 2.84 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	5.256LysAla: 5.256 ± 0.099	0.316LysCys: 0.316 ± 0.02	4.828LysAsp: 4.828 ± 0.082	5.625LysGlu: 5.625 ± 0.111	3.024LysPhe: 3.024 ± 0.067	4.291LysGly: 4.291 ± 0.078	1.436LysHis: 1.436 ± 0.044	6.079LysIle: 6.079 ± 0.091	6.725LysLys: 6.725 ± 0.108	6.782LysLeu: 6.782 ± 0.105	1.852LysMet: 1.852 ± 0.049	5.132LysAsn: 5.132 ± 0.098	2.555LysPro: 2.555 ± 0.054	2.901LysGln: 2.901 ± 0.063	3.335LysArg: 3.335 ± 0.069	5.363LysSer: 5.363 ± 0.103	5.027LysThr: 5.027 ± 0.089	4.82LysVal: 4.82 ± 0.078	0.773LysTrp: 0.773 ± 0.032	3.119LysTyr: 3.119 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	5.419LeuAla: 5.419 ± 0.1	0.663LeuCys: 0.663 ± 0.028	5.473LeuAsp: 5.473 ± 0.087	6.006LeuGlu: 6.006 ± 0.072	4.838LeuPhe: 4.838 ± 0.085	5.517LeuGly: 5.517 ± 0.1	1.386LeuHis: 1.386 ± 0.037	6.981LeuIle: 6.981 ± 0.104	8.283LeuLys: 8.283 ± 0.118	8.456LeuLeu: 8.456 ± 0.131	1.94LeuMet: 1.94 ± 0.05	5.903LeuAsn: 5.903 ± 0.094	3.356LeuPro: 3.356 ± 0.067	3.083LeuGln: 3.083 ± 0.061	3.096LeuArg: 3.096 ± 0.062	6.634LeuSer: 6.634 ± 0.087	4.933LeuThr: 4.933 ± 0.086	5.567LeuVal: 5.567 ± 0.086	0.791LeuTrp: 0.791 ± 0.032	3.094LeuTyr: 3.094 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.505MetAla: 1.505 ± 0.039	0.144MetCys: 0.144 ± 0.013	1.027MetAsp: 1.027 ± 0.036	1.126MetGlu: 1.126 ± 0.037	0.874MetPhe: 0.874 ± 0.033	1.211MetGly: 1.211 ± 0.04	0.398MetHis: 0.398 ± 0.021	1.537MetIle: 1.537 ± 0.044	2.04MetLys: 2.04 ± 0.053	1.888MetLeu: 1.888 ± 0.05	0.527MetMet: 0.527 ± 0.029	1.23MetAsn: 1.23 ± 0.039	0.807MetPro: 0.807 ± 0.032	0.839MetGln: 0.839 ± 0.03	0.831MetArg: 0.831 ± 0.027	1.542MetSer: 1.542 ± 0.04	1.196MetThr: 1.196 ± 0.037	1.291MetVal: 1.291 ± 0.043	0.156MetTrp: 0.156 ± 0.013	0.713MetTyr: 0.713 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.978AsnAla: 3.978 ± 0.068	0.551AsnCys: 0.551 ± 0.032	3.669AsnAsp: 3.669 ± 0.079	3.639AsnGlu: 3.639 ± 0.068	3.325AsnPhe: 3.325 ± 0.076	4.248AsnGly: 4.248 ± 0.089	1.048AsnHis: 1.048 ± 0.034	5.227AsnIle: 5.227 ± 0.087	4.655AsnLys: 4.655 ± 0.078	5.59AsnLeu: 5.59 ± 0.094	1.302AsnMet: 1.302 ± 0.035	4.441AsnAsn: 4.441 ± 0.111	2.903AsnPro: 2.903 ± 0.062	2.372AsnGln: 2.372 ± 0.054	2.331AsnArg: 2.331 ± 0.06	4.27AsnSer: 4.27 ± 0.087	4.083AsnThr: 4.083 ± 0.089	3.62AsnVal: 3.62 ± 0.082	0.74AsnTrp: 0.74 ± 0.027	2.956AsnTyr: 2.956 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.648ProAla: 1.648 ± 0.05	0.213ProCys: 0.213 ± 0.015	1.97ProAsp: 1.97 ± 0.05	2.645ProGlu: 2.645 ± 0.05	1.862ProPhe: 1.862 ± 0.052	1.696ProGly: 1.696 ± 0.046	0.537ProHis: 0.537 ± 0.026	2.702ProIle: 2.702 ± 0.063	2.657ProLys: 2.657 ± 0.063	2.77ProLeu: 2.77 ± 0.054	0.708ProMet: 0.708 ± 0.031	2.415ProAsn: 2.415 ± 0.057	0.777ProPro: 0.777 ± 0.048	1.062ProGln: 1.062 ± 0.037	0.875ProArg: 0.875 ± 0.032	2.103ProSer: 2.103 ± 0.053	1.977ProThr: 1.977 ± 0.06	2.091ProVal: 2.091 ± 0.05	0.304ProTrp: 0.304 ± 0.02	1.34ProTyr: 1.34 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.841GlnAla: 1.841 ± 0.044	0.17GlnCys: 0.17 ± 0.014	1.839GlnAsp: 1.839 ± 0.046	1.908GlnGlu: 1.908 ± 0.054	1.778GlnPhe: 1.778 ± 0.047	1.666GlnGly: 1.666 ± 0.044	0.541GlnHis: 0.541 ± 0.025	2.594GlnIle: 2.594 ± 0.052	2.717GlnLys: 2.717 ± 0.065	3.47GlnLeu: 3.47 ± 0.067	0.774GlnMet: 0.774 ± 0.031	2.307GlnAsn: 2.307 ± 0.065	1.048GlnPro: 1.048 ± 0.035	1.382GlnGln: 1.382 ± 0.044	1.297GlnArg: 1.297 ± 0.038	1.939GlnSer: 1.939 ± 0.04	1.975GlnThr: 1.975 ± 0.047	1.873GlnVal: 1.873 ± 0.051	0.331GlnTrp: 0.331 ± 0.02	1.247GlnTyr: 1.247 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.068ArgAla: 2.068 ± 0.049	0.174ArgCys: 0.174 ± 0.012	1.9ArgAsp: 1.9 ± 0.053	1.976ArgGlu: 1.976 ± 0.062	1.991ArgPhe: 1.991 ± 0.046	1.922ArgGly: 1.922 ± 0.054	0.596ArgHis: 0.596 ± 0.025	2.895ArgIle: 2.895 ± 0.059	2.704ArgLys: 2.704 ± 0.058	3.427ArgLeu: 3.427 ± 0.063	0.8ArgMet: 0.8 ± 0.033	2.088ArgAsn: 2.088 ± 0.054	1.106ArgPro: 1.106 ± 0.035	1.201ArgGln: 1.201 ± 0.037	1.378ArgArg: 1.378 ± 0.049	1.783ArgSer: 1.783 ± 0.049	1.754ArgThr: 1.754 ± 0.045	2.191ArgVal: 2.191 ± 0.046	0.365ArgTrp: 0.365 ± 0.019	1.581ArgTyr: 1.581 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.719SerAla: 3.719 ± 0.066	0.625SerCys: 0.625 ± 0.027	3.898SerAsp: 3.898 ± 0.076	4.346SerGlu: 4.346 ± 0.074	3.85SerPhe: 3.85 ± 0.075	4.582SerGly: 4.582 ± 0.084	1.059SerHis: 1.059 ± 0.035	5.582SerIle: 5.582 ± 0.101	5.347SerLys: 5.347 ± 0.095	5.9SerLeu: 5.9 ± 0.095	1.229SerMet: 1.229 ± 0.039	4.266SerAsn: 4.266 ± 0.083	1.991SerPro: 1.991 ± 0.048	2.245SerGln: 2.245 ± 0.045	2.12SerArg: 2.12 ± 0.06	4.315SerSer: 4.315 ± 0.091	3.645SerThr: 3.645 ± 0.074	4.258SerVal: 4.258 ± 0.072	0.636SerTrp: 0.636 ± 0.027	2.762SerTyr: 2.762 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	3.552ThrAla: 3.552 ± 0.09	0.388ThrCys: 0.388 ± 0.03	3.584ThrAsp: 3.584 ± 0.088	3.788ThrGlu: 3.788 ± 0.079	3.239ThrPhe: 3.239 ± 0.072	3.834ThrGly: 3.834 ± 0.094	0.913ThrHis: 0.913 ± 0.029	5.204ThrIle: 5.204 ± 0.099	4.13ThrLys: 4.13 ± 0.08	5.331ThrLeu: 5.331 ± 0.081	0.976ThrMet: 0.976 ± 0.034	3.572ThrAsn: 3.572 ± 0.088	2.309ThrPro: 2.309 ± 0.069	1.861ThrGln: 1.861 ± 0.048	1.645ThrArg: 1.645 ± 0.046	4.106ThrSer: 4.106 ± 0.083	3.684ThrThr: 3.684 ± 0.102	3.827ThrVal: 3.827 ± 0.081	0.594ThrTrp: 0.594 ± 0.027	2.525ThrTyr: 2.525 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	3.929ValAla: 3.929 ± 0.077	0.501ValCys: 0.501 ± 0.023	3.787ValAsp: 3.787 ± 0.075	3.998ValGlu: 3.998 ± 0.075	3.508ValPhe: 3.508 ± 0.074	3.781ValGly: 3.781 ± 0.079	0.884ValHis: 0.884 ± 0.036	5.275ValIle: 5.275 ± 0.083	4.626ValLys: 4.626 ± 0.079	5.993ValLeu: 5.993 ± 0.08	1.31ValMet: 1.31 ± 0.04	3.822ValAsn: 3.822 ± 0.071	1.986ValPro: 1.986 ± 0.049	1.597ValGln: 1.597 ± 0.047	1.869ValArg: 1.869 ± 0.054	4.591ValSer: 4.591 ± 0.063	3.717ValThr: 3.717 ± 0.103	4.201ValVal: 4.201 ± 0.074	0.516ValTrp: 0.516 ± 0.022	2.327ValTyr: 2.327 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.518TrpAla: 0.518 ± 0.023	0.089TrpCys: 0.089 ± 0.01	0.595TrpAsp: 0.595 ± 0.026	0.632TrpGlu: 0.632 ± 0.027	0.615TrpPhe: 0.615 ± 0.028	0.567TrpGly: 0.567 ± 0.028	0.22TrpHis: 0.22 ± 0.017	0.738TrpIle: 0.738 ± 0.029	0.732TrpLys: 0.732 ± 0.031	0.993TrpLeu: 0.993 ± 0.033	0.289TrpMet: 0.289 ± 0.018	0.668TrpAsn: 0.668 ± 0.029	0.209TrpPro: 0.209 ± 0.016	0.428TrpGln: 0.428 ± 0.023	0.393TrpArg: 0.393 ± 0.023	0.632TrpSer: 0.632 ± 0.03	0.521TrpThr: 0.521 ± 0.032	0.524TrpVal: 0.524 ± 0.026	0.142TrpTrp: 0.142 ± 0.015	0.434TrpTyr: 0.434 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.249TyrAla: 2.249 ± 0.056	0.311TyrCys: 0.311 ± 0.02	2.403TyrAsp: 2.403 ± 0.055	2.181TyrGlu: 2.181 ± 0.059	2.452TyrPhe: 2.452 ± 0.055	2.613TyrGly: 2.613 ± 0.049	0.76TyrHis: 0.76 ± 0.029	2.871TyrIle: 2.871 ± 0.061	3.407TyrLys: 3.407 ± 0.083	3.738TyrLeu: 3.738 ± 0.074	0.741TyrMet: 0.741 ± 0.029	2.93TyrAsn: 2.93 ± 0.074	1.353TyrPro: 1.353 ± 0.042	1.384TyrGln: 1.384 ± 0.039	1.566TyrArg: 1.566 ± 0.049	2.6TyrSer: 2.6 ± 0.061	2.422TyrThr: 2.422 ± 0.071	2.171TyrVal: 2.171 ± 0.055	0.466TyrTrp: 0.466 ± 0.023	1.825TyrTyr: 1.825 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2717 proteins (910443 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---