Amino acid dipepetide frequency for Arsenicitalea aurantiaca

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.701AlaAla: 16.701 ± 0.2	0.878AlaCys: 0.878 ± 0.029	7.21AlaAsp: 7.21 ± 0.087	9.025AlaGlu: 9.025 ± 0.124	4.65AlaPhe: 4.65 ± 0.08	11.437AlaGly: 11.437 ± 0.12	2.375AlaHis: 2.375 ± 0.053	7.494AlaIle: 7.494 ± 0.095	2.596AlaLys: 2.596 ± 0.051	15.229AlaLeu: 15.229 ± 0.141	3.716AlaMet: 3.716 ± 0.064	2.863AlaAsn: 2.863 ± 0.051	6.244AlaPro: 6.244 ± 0.12	3.97AlaGln: 3.97 ± 0.058	9.963AlaArg: 9.963 ± 0.114	6.309AlaSer: 6.309 ± 0.083	5.803AlaThr: 5.803 ± 0.075	8.538AlaVal: 8.538 ± 0.093	1.351AlaTrp: 1.351 ± 0.037	2.554AlaTyr: 2.554 ± 0.05	0.002AlaXaa: 0.002 ± 0.001
Cys	0.84CysAla: 0.84 ± 0.03	0.085CysCys: 0.085 ± 0.009	0.436CysAsp: 0.436 ± 0.019	0.357CysGlu: 0.357 ± 0.021	0.238CysPhe: 0.238 ± 0.015	0.754CysGly: 0.754 ± 0.03	0.203CysHis: 0.203 ± 0.013	0.331CysIle: 0.331 ± 0.02	0.116CysLys: 0.116 ± 0.01	0.699CysLeu: 0.699 ± 0.021	0.14CysMet: 0.14 ± 0.011	0.172CysAsn: 0.172 ± 0.013	0.393CysPro: 0.393 ± 0.02	0.167CysGln: 0.167 ± 0.012	0.512CysArg: 0.512 ± 0.022	0.368CysSer: 0.368 ± 0.02	0.38CysThr: 0.38 ± 0.019	0.489CysVal: 0.489 ± 0.022	0.087CysTrp: 0.087 ± 0.009	0.177CysTyr: 0.177 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.219AspAla: 7.219 ± 0.088	0.392AspCys: 0.392 ± 0.021	2.746AspAsp: 2.746 ± 0.058	3.412AspGlu: 3.412 ± 0.069	2.241AspPhe: 2.241 ± 0.044	5.169AspGly: 5.169 ± 0.067	1.132AspHis: 1.132 ± 0.031	3.133AspIle: 3.133 ± 0.054	1.209AspLys: 1.209 ± 0.034	5.878AspLeu: 5.878 ± 0.091	1.31AspMet: 1.31 ± 0.034	1.178AspAsn: 1.178 ± 0.035	3.721AspPro: 3.721 ± 0.056	1.552AspGln: 1.552 ± 0.038	4.376AspArg: 4.376 ± 0.07	1.755AspSer: 1.755 ± 0.041	2.505AspThr: 2.505 ± 0.057	3.84AspVal: 3.84 ± 0.059	0.96AspTrp: 0.96 ± 0.029	1.425AspTyr: 1.425 ± 0.037	0.001AspXaa: 0.001 ± 0.001
Glu	9.181GluAla: 9.181 ± 0.121	0.282GluCys: 0.282 ± 0.018	3.237GluAsp: 3.237 ± 0.055	3.504GluGlu: 3.504 ± 0.065	1.755GluPhe: 1.755 ± 0.042	5.209GluGly: 5.209 ± 0.072	1.209GluHis: 1.209 ± 0.032	4.015GluIle: 4.015 ± 0.059	1.839GluLys: 1.839 ± 0.053	5.361GluLeu: 5.361 ± 0.086	1.575GluMet: 1.575 ± 0.036	1.494GluAsn: 1.494 ± 0.042	3.177GluPro: 3.177 ± 0.069	1.878GluGln: 1.878 ± 0.045	5.255GluArg: 5.255 ± 0.081	2.282GluSer: 2.282 ± 0.048	4.211GluThr: 4.211 ± 0.065	3.771GluVal: 3.771 ± 0.067	0.65GluTrp: 0.65 ± 0.025	0.912GluTyr: 0.912 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.924PheAla: 4.924 ± 0.072	0.348PheCys: 0.348 ± 0.019	2.471PheAsp: 2.471 ± 0.046	2.345PheGlu: 2.345 ± 0.05	1.431PhePhe: 1.431 ± 0.039	3.989PheGly: 3.989 ± 0.063	0.737PheHis: 0.737 ± 0.028	1.863PheIle: 1.863 ± 0.043	0.741PheLys: 0.741 ± 0.026	3.424PheLeu: 3.424 ± 0.073	0.838PheMet: 0.838 ± 0.029	1.052PheAsn: 1.052 ± 0.033	1.594PhePro: 1.594 ± 0.039	0.889PheGln: 0.889 ± 0.03	2.132PheArg: 2.132 ± 0.047	2.405PheSer: 2.405 ± 0.046	2.059PheThr: 2.059 ± 0.051	3.008PheVal: 3.008 ± 0.059	0.586PheTrp: 0.586 ± 0.025	0.855PheTyr: 0.855 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.194GlyAla: 10.194 ± 0.113	0.659GlyCys: 0.659 ± 0.022	4.27GlyAsp: 4.27 ± 0.082	5.408GlyGlu: 5.408 ± 0.075	3.851GlyPhe: 3.851 ± 0.06	7.634GlyGly: 7.634 ± 0.114	1.933GlyHis: 1.933 ± 0.042	5.066GlyIle: 5.066 ± 0.075	2.456GlyLys: 2.456 ± 0.056	9.915GlyLeu: 9.915 ± 0.126	2.408GlyMet: 2.408 ± 0.051	2.25GlyAsn: 2.25 ± 0.053	3.849GlyPro: 3.849 ± 0.062	3.004GlyGln: 3.004 ± 0.06	6.876GlyArg: 6.876 ± 0.078	4.628GlySer: 4.628 ± 0.076	5.052GlyThr: 5.052 ± 0.081	6.554GlyVal: 6.554 ± 0.077	1.422GlyTrp: 1.422 ± 0.037	2.244GlyTyr: 2.244 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.364HisAla: 2.364 ± 0.047	0.185HisCys: 0.185 ± 0.012	1.115HisAsp: 1.115 ± 0.038	1.128HisGlu: 1.128 ± 0.032	0.871HisPhe: 0.871 ± 0.028	1.881HisGly: 1.881 ± 0.046	0.584HisHis: 0.584 ± 0.033	0.943HisIle: 0.943 ± 0.028	0.438HisLys: 0.438 ± 0.021	2.079HisLeu: 2.079 ± 0.052	0.485HisMet: 0.485 ± 0.022	0.447HisAsn: 0.447 ± 0.019	1.278HisPro: 1.278 ± 0.034	0.545HisGln: 0.545 ± 0.021	1.413HisArg: 1.413 ± 0.035	0.777HisSer: 0.777 ± 0.029	0.884HisThr: 0.884 ± 0.026	1.485HisVal: 1.485 ± 0.037	0.32HisTrp: 0.32 ± 0.017	0.538HisTyr: 0.538 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	8.535IleAla: 8.535 ± 0.108	0.479IleCys: 0.479 ± 0.018	3.594IleAsp: 3.594 ± 0.056	3.789IleGlu: 3.789 ± 0.06	1.865IlePhe: 1.865 ± 0.052	5.632IleGly: 5.632 ± 0.08	0.928IleHis: 0.928 ± 0.034	2.633IleIle: 2.633 ± 0.057	1.153IleLys: 1.153 ± 0.038	4.98IleLeu: 4.98 ± 0.076	1.023IleMet: 1.023 ± 0.03	1.377IleAsn: 1.377 ± 0.039	2.345IlePro: 2.345 ± 0.047	1.061IleGln: 1.061 ± 0.031	3.209IleArg: 3.209 ± 0.061	2.852IleSer: 2.852 ± 0.058	2.789IleThr: 2.789 ± 0.056	4.836IleVal: 4.836 ± 0.071	0.595IleTrp: 0.595 ± 0.024	1.066IleTyr: 1.066 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.337LysAla: 3.337 ± 0.06	0.107LysCys: 0.107 ± 0.01	1.118LysAsp: 1.118 ± 0.036	0.955LysGlu: 0.955 ± 0.032	0.672LysPhe: 0.672 ± 0.026	2.034LysGly: 2.034 ± 0.049	0.429LysHis: 0.429 ± 0.02	1.2LysIle: 1.2 ± 0.041	0.766LysLys: 0.766 ± 0.034	2.369LysLeu: 2.369 ± 0.054	0.537LysMet: 0.537 ± 0.027	0.511LysAsn: 0.511 ± 0.025	1.473LysPro: 1.473 ± 0.043	0.586LysGln: 0.586 ± 0.021	1.851LysArg: 1.851 ± 0.052	1.469LysSer: 1.469 ± 0.037	1.466LysThr: 1.466 ± 0.041	1.753LysVal: 1.753 ± 0.044	0.253LysTrp: 0.253 ± 0.015	0.442LysTyr: 0.442 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.649LeuAla: 14.649 ± 0.129	0.841LeuCys: 0.841 ± 0.028	6.118LeuAsp: 6.118 ± 0.078	6.337LeuGlu: 6.337 ± 0.08	3.844LeuPhe: 3.844 ± 0.07	9.594LeuGly: 9.594 ± 0.118	1.783LeuHis: 1.783 ± 0.042	5.257LeuIle: 5.257 ± 0.084	2.663LeuLys: 2.663 ± 0.061	10.001LeuLeu: 10.001 ± 0.134	2.368LeuMet: 2.368 ± 0.051	2.458LeuAsn: 2.458 ± 0.053	5.684LeuPro: 5.684 ± 0.091	2.472LeuGln: 2.472 ± 0.052	7.072LeuArg: 7.072 ± 0.085	6.589LeuSer: 6.589 ± 0.077	5.377LeuThr: 5.377 ± 0.069	8.528LeuVal: 8.528 ± 0.113	1.152LeuTrp: 1.152 ± 0.037	2.2LeuTyr: 2.2 ± 0.047	0.002LeuXaa: 0.002 ± 0.001
Met	3.388MetAla: 3.388 ± 0.063	0.113MetCys: 0.113 ± 0.009	1.077MetAsp: 1.077 ± 0.03	1.029MetGlu: 1.029 ± 0.03	0.711MetPhe: 0.711 ± 0.025	2.025MetGly: 2.025 ± 0.045	0.394MetHis: 0.394 ± 0.017	1.402MetIle: 1.402 ± 0.037	0.807MetLys: 0.807 ± 0.03	2.67MetLeu: 2.67 ± 0.057	0.659MetMet: 0.659 ± 0.024	0.67MetAsn: 0.67 ± 0.026	1.541MetPro: 1.541 ± 0.037	0.789MetGln: 0.789 ± 0.028	1.876MetArg: 1.876 ± 0.043	1.62MetSer: 1.62 ± 0.04	1.83MetThr: 1.83 ± 0.036	1.843MetVal: 1.843 ± 0.041	0.198MetTrp: 0.198 ± 0.014	0.251MetTyr: 0.251 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.134AsnAla: 3.134 ± 0.06	0.194AsnCys: 0.194 ± 0.015	1.207AsnAsp: 1.207 ± 0.043	1.199AsnGlu: 1.199 ± 0.039	0.981AsnPhe: 0.981 ± 0.032	2.305AsnGly: 2.305 ± 0.049	0.417AsnHis: 0.417 ± 0.019	1.28AsnIle: 1.28 ± 0.033	0.481AsnLys: 0.481 ± 0.022	2.462AsnLeu: 2.462 ± 0.052	0.545AsnMet: 0.545 ± 0.021	0.617AsnAsn: 0.617 ± 0.032	1.789AsnPro: 1.789 ± 0.043	0.718AsnGln: 0.718 ± 0.028	1.792AsnArg: 1.792 ± 0.044	1.151AsnSer: 1.151 ± 0.035	1.169AsnThr: 1.169 ± 0.031	1.888AsnVal: 1.888 ± 0.046	0.415AsnTrp: 0.415 ± 0.022	0.645AsnTyr: 0.645 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.696ProAla: 6.696 ± 0.1	0.249ProCys: 0.249 ± 0.015	3.748ProAsp: 3.748 ± 0.064	4.322ProGlu: 4.322 ± 0.079	2.099ProPhe: 2.099 ± 0.042	4.778ProGly: 4.778 ± 0.075	1.149ProHis: 1.149 ± 0.034	2.574ProIle: 2.574 ± 0.05	1.129ProLys: 1.129 ± 0.038	4.963ProLeu: 4.963 ± 0.076	1.282ProMet: 1.282 ± 0.036	1.267ProAsn: 1.267 ± 0.035	2.396ProPro: 2.396 ± 0.06	1.644ProGln: 1.644 ± 0.038	3.335ProArg: 3.335 ± 0.06	2.705ProSer: 2.705 ± 0.055	2.473ProThr: 2.473 ± 0.052	4.42ProVal: 4.42 ± 0.07	0.634ProTrp: 0.634 ± 0.024	1.208ProTyr: 1.208 ± 0.034	0.001ProXaa: 0.001 ± 0.001
Gln	3.588GlnAla: 3.588 ± 0.058	0.185GlnCys: 0.185 ± 0.013	1.317GlnAsp: 1.317 ± 0.035	1.297GlnGlu: 1.297 ± 0.032	1.09GlnPhe: 1.09 ± 0.03	2.235GlnGly: 2.235 ± 0.044	0.528GlnHis: 0.528 ± 0.021	1.821GlnIle: 1.821 ± 0.041	0.782GlnLys: 0.782 ± 0.03	2.773GlnLeu: 2.773 ± 0.048	0.973GlnMet: 0.973 ± 0.026	0.767GlnAsn: 0.767 ± 0.023	1.559GlnPro: 1.559 ± 0.039	1.081GlnGln: 1.081 ± 0.039	2.371GlnArg: 2.371 ± 0.052	1.745GlnSer: 1.745 ± 0.042	1.638GlnThr: 1.638 ± 0.037	2.136GlnVal: 2.136 ± 0.047	0.377GlnTrp: 0.377 ± 0.02	0.58GlnTyr: 0.58 ± 0.025	0.001GlnXaa: 0.001 ± 0.001
Arg	8.882ArgAla: 8.882 ± 0.1	0.451ArgCys: 0.451 ± 0.02	4.003ArgAsp: 4.003 ± 0.064	4.423ArgGlu: 4.423 ± 0.067	3.099ArgPhe: 3.099 ± 0.055	4.964ArgGly: 4.964 ± 0.078	1.805ArgHis: 1.805 ± 0.052	4.23ArgIle: 4.23 ± 0.062	1.823ArgLys: 1.823 ± 0.048	8.421ArgLeu: 8.421 ± 0.109	1.977ArgMet: 1.977 ± 0.041	1.856ArgAsn: 1.856 ± 0.04	3.95ArgPro: 3.95 ± 0.068	2.668ArgGln: 2.668 ± 0.057	5.968ArgArg: 5.968 ± 0.084	3.68ArgSer: 3.68 ± 0.05	3.661ArgThr: 3.661 ± 0.07	4.922ArgVal: 4.922 ± 0.07	0.936ArgTrp: 0.936 ± 0.028	1.684ArgTyr: 1.684 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.434SerAla: 6.434 ± 0.086	0.325SerCys: 0.325 ± 0.016	2.726SerAsp: 2.726 ± 0.06	2.843SerGlu: 2.843 ± 0.049	2.123SerPhe: 2.123 ± 0.05	5.664SerGly: 5.664 ± 0.081	0.995SerHis: 0.995 ± 0.028	2.776SerIle: 2.776 ± 0.054	1.023SerLys: 1.023 ± 0.032	5.401SerLeu: 5.401 ± 0.077	1.261SerMet: 1.261 ± 0.037	1.298SerAsn: 1.298 ± 0.034	2.738SerPro: 2.738 ± 0.059	1.433SerGln: 1.433 ± 0.033	3.704SerArg: 3.704 ± 0.054	2.597SerSer: 2.597 ± 0.05	2.583SerThr: 2.583 ± 0.054	4.073SerVal: 4.073 ± 0.053	0.691SerTrp: 0.691 ± 0.026	1.189SerTyr: 1.189 ± 0.03	0.002SerXaa: 0.002 ± 0.001
Thr	6.129ThrAla: 6.129 ± 0.076	0.337ThrCys: 0.337 ± 0.016	2.817ThrAsp: 2.817 ± 0.054	2.93ThrGlu: 2.93 ± 0.05	1.844ThrPhe: 1.844 ± 0.038	5.477ThrGly: 5.477 ± 0.075	1.063ThrHis: 1.063 ± 0.03	3.162ThrIle: 3.162 ± 0.061	0.991ThrLys: 0.991 ± 0.031	6.524ThrLeu: 6.524 ± 0.093	1.13ThrMet: 1.13 ± 0.033	1.274ThrAsn: 1.274 ± 0.036	3.491ThrPro: 3.491 ± 0.053	1.34ThrGln: 1.34 ± 0.039	3.603ThrArg: 3.603 ± 0.059	2.639ThrSer: 2.639 ± 0.057	2.786ThrThr: 2.786 ± 0.053	4.012ThrVal: 4.012 ± 0.064	0.528ThrTrp: 0.528 ± 0.026	1.116ThrTyr: 1.116 ± 0.033	0.002ThrXaa: 0.002 ± 0.001
Val	9.035ValAla: 9.035 ± 0.099	0.508ValCys: 0.508 ± 0.021	4.085ValAsp: 4.085 ± 0.063	4.639ValGlu: 4.639 ± 0.073	2.887ValPhe: 2.887 ± 0.056	5.883ValGly: 5.883 ± 0.09	1.342ValHis: 1.342 ± 0.036	4.081ValIle: 4.081 ± 0.065	1.567ValLys: 1.567 ± 0.043	8.13ValLeu: 8.13 ± 0.099	1.913ValMet: 1.913 ± 0.049	1.897ValAsn: 1.897 ± 0.049	4.091ValPro: 4.091 ± 0.068	1.88ValGln: 1.88 ± 0.044	5.061ValArg: 5.061 ± 0.074	4.482ValSer: 4.482 ± 0.053	4.736ValThr: 4.736 ± 0.063	5.811ValVal: 5.811 ± 0.088	0.869ValTrp: 0.869 ± 0.031	1.49ValTyr: 1.49 ± 0.033	0.002ValXaa: 0.002 ± 0.001
Trp	1.211TrpAla: 1.211 ± 0.033	0.129TrpCys: 0.129 ± 0.011	0.6TrpAsp: 0.6 ± 0.025	0.564TrpGlu: 0.564 ± 0.028	0.519TrpPhe: 0.519 ± 0.022	0.944TrpGly: 0.944 ± 0.032	0.307TrpHis: 0.307 ± 0.017	0.649TrpIle: 0.649 ± 0.024	0.308TrpLys: 0.308 ± 0.016	1.479TrpLeu: 1.479 ± 0.037	0.321TrpMet: 0.321 ± 0.017	0.379TrpAsn: 0.379 ± 0.018	0.677TrpPro: 0.677 ± 0.025	0.535TrpGln: 0.535 ± 0.022	1.16TrpArg: 1.16 ± 0.034	0.742TrpSer: 0.742 ± 0.026	0.726TrpThr: 0.726 ± 0.027	0.834TrpVal: 0.834 ± 0.026	0.203TrpTrp: 0.203 ± 0.013	0.279TrpTyr: 0.279 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.468TyrAla: 2.468 ± 0.047	0.199TyrCys: 0.199 ± 0.013	1.256TyrAsp: 1.256 ± 0.037	1.287TyrGlu: 1.287 ± 0.034	0.92TyrPhe: 0.92 ± 0.031	2.065TyrGly: 2.065 ± 0.049	0.447TyrHis: 0.447 ± 0.022	0.83TyrIle: 0.83 ± 0.027	0.44TyrLys: 0.44 ± 0.019	2.231TyrLeu: 2.231 ± 0.047	0.431TyrMet: 0.431 ± 0.02	0.564TyrAsn: 0.564 ± 0.023	1.081TyrPro: 1.081 ± 0.028	0.634TyrGln: 0.634 ± 0.026	1.873TyrArg: 1.873 ± 0.048	1.08TyrSer: 1.08 ± 0.027	1.067TyrThr: 1.067 ± 0.033	1.648TyrVal: 1.648 ± 0.041	0.337TyrTrp: 0.337 ± 0.018	0.51TyrTyr: 0.51 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3476 proteins (1110746 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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