Amino acid dipepetide frequency for Labedella phragmitis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.934AlaAla: 18.934 ± 0.215
0.616AlaCys: 0.616 ± 0.027
8.135AlaAsp: 8.135 ± 0.094
7.946AlaGlu: 7.946 ± 0.1
3.983AlaPhe: 3.983 ± 0.069
11.588AlaGly: 11.588 ± 0.108
2.245AlaHis: 2.245 ± 0.053
6.108AlaIle: 6.108 ± 0.092
2.248AlaLys: 2.248 ± 0.057
13.119AlaLeu: 13.119 ± 0.152
2.473AlaMet: 2.473 ± 0.048
2.231AlaAsn: 2.231 ± 0.058
6.25AlaPro: 6.25 ± 0.091
2.889AlaGln: 2.889 ± 0.049
9.037AlaArg: 9.037 ± 0.122
8.002AlaSer: 8.002 ± 0.098
7.796AlaThr: 7.796 ± 0.112
12.168AlaVal: 12.168 ± 0.14
1.74AlaTrp: 1.74 ± 0.049
2.233AlaTyr: 2.233 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.558CysAla: 0.558 ± 0.026
0.046CysCys: 0.046 ± 0.007
0.316CysAsp: 0.316 ± 0.019
0.262CysGlu: 0.262 ± 0.019
0.16CysPhe: 0.16 ± 0.012
0.516CysGly: 0.516 ± 0.025
0.101CysHis: 0.101 ± 0.01
0.196CysIle: 0.196 ± 0.014
0.046CysLys: 0.046 ± 0.006
0.387CysLeu: 0.387 ± 0.022
0.059CysMet: 0.059 ± 0.008
0.085CysAsn: 0.085 ± 0.009
0.258CysPro: 0.258 ± 0.013
0.088CysGln: 0.088 ± 0.008
0.269CysArg: 0.269 ± 0.017
0.367CysSer: 0.367 ± 0.018
0.314CysThr: 0.314 ± 0.027
0.408CysVal: 0.408 ± 0.02
0.07CysTrp: 0.07 ± 0.008
0.088CysTyr: 0.088 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
9.008AspAla: 9.008 ± 0.11
0.256AspCys: 0.256 ± 0.019
4.905AspAsp: 4.905 ± 0.093
4.67AspGlu: 4.67 ± 0.081
1.782AspPhe: 1.782 ± 0.045
6.946AspGly: 6.946 ± 0.104
1.185AspHis: 1.185 ± 0.036
2.424AspIle: 2.424 ± 0.05
0.849AspLys: 0.849 ± 0.035
6.2AspLeu: 6.2 ± 0.082
0.825AspMet: 0.825 ± 0.027
0.943AspAsn: 0.943 ± 0.042
4.266AspPro: 4.266 ± 0.077
1.324AspGln: 1.324 ± 0.039
4.755AspArg: 4.755 ± 0.079
2.927AspSer: 2.927 ± 0.058
3.115AspThr: 3.115 ± 0.053
6.517AspVal: 6.517 ± 0.087
0.971AspTrp: 0.971 ± 0.028
1.363AspTyr: 1.363 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.793GluAla: 6.793 ± 0.092
0.261GluCys: 0.261 ± 0.022
3.08GluAsp: 3.08 ± 0.058
3.282GluGlu: 3.282 ± 0.063
1.779GluPhe: 1.779 ± 0.043
3.988GluGly: 3.988 ± 0.073
1.419GluHis: 1.419 ± 0.04
2.835GluIle: 2.835 ± 0.049
1.413GluLys: 1.413 ± 0.041
6.473GluLeu: 6.473 ± 0.1
0.845GluMet: 0.845 ± 0.029
1.388GluAsn: 1.388 ± 0.039
3.169GluPro: 3.169 ± 0.071
2.089GluGln: 2.089 ± 0.05
5.707GluArg: 5.707 ± 0.1
3.574GluSer: 3.574 ± 0.055
3.402GluThr: 3.402 ± 0.065
4.352GluVal: 4.352 ± 0.066
0.919GluTrp: 0.919 ± 0.031
1.151GluTyr: 1.151 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
4.241PheAla: 4.241 ± 0.057
0.141PheCys: 0.141 ± 0.012
2.378PheAsp: 2.378 ± 0.051
1.826PheGlu: 1.826 ± 0.043
1.109PhePhe: 1.109 ± 0.041
3.418PheGly: 3.418 ± 0.056
0.517PheHis: 0.517 ± 0.023
1.201PheIle: 1.201 ± 0.04
0.389PheLys: 0.389 ± 0.021
2.925PheLeu: 2.925 ± 0.067
0.404PheMet: 0.404 ± 0.02
0.611PheAsn: 0.611 ± 0.027
1.492PhePro: 1.492 ± 0.039
0.726PheGln: 0.726 ± 0.025
1.903PheArg: 1.903 ± 0.048
2.105PheSer: 2.105 ± 0.045
2.138PheThr: 2.138 ± 0.049
3.034PheVal: 3.034 ± 0.061
0.489PheTrp: 0.489 ± 0.023
0.639PheTyr: 0.639 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.708GlyAla: 10.708 ± 0.118
0.512GlyCys: 0.512 ± 0.024
5.578GlyAsp: 5.578 ± 0.089
5.157GlyGlu: 5.157 ± 0.076
3.308GlyPhe: 3.308 ± 0.059
7.996GlyGly: 7.996 ± 0.13
1.789GlyHis: 1.789 ± 0.04
4.445GlyIle: 4.445 ± 0.078
1.877GlyLys: 1.877 ± 0.041
8.868GlyLeu: 8.868 ± 0.109
1.727GlyMet: 1.727 ± 0.046
1.722GlyAsn: 1.722 ± 0.043
3.871GlyPro: 3.871 ± 0.064
2.198GlyGln: 2.198 ± 0.051
6.686GlyArg: 6.686 ± 0.091
6.071GlySer: 6.071 ± 0.081
5.859GlyThr: 5.859 ± 0.105
8.36GlyVal: 8.36 ± 0.089
1.452GlyTrp: 1.452 ± 0.043
2.141GlyTyr: 2.141 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.221HisAla: 2.221 ± 0.051
0.097HisCys: 0.097 ± 0.01
1.352HisAsp: 1.352 ± 0.044
1.15HisGlu: 1.15 ± 0.033
0.515HisPhe: 0.515 ± 0.022
1.84HisGly: 1.84 ± 0.052
0.526HisHis: 0.526 ± 0.026
0.692HisIle: 0.692 ± 0.029
0.239HisLys: 0.239 ± 0.014
1.879HisLeu: 1.879 ± 0.049
0.292HisMet: 0.292 ± 0.017
0.32HisAsn: 0.32 ± 0.017
1.346HisPro: 1.346 ± 0.034
0.417HisGln: 0.417 ± 0.019
1.536HisArg: 1.536 ± 0.048
0.981HisSer: 0.981 ± 0.034
0.888HisThr: 0.888 ± 0.03
1.816HisVal: 1.816 ± 0.041
0.271HisTrp: 0.271 ± 0.016
0.385HisTyr: 0.385 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
7.072IleAla: 7.072 ± 0.088
0.197IleCys: 0.197 ± 0.014
3.568IleAsp: 3.568 ± 0.056
2.93IleGlu: 2.93 ± 0.057
1.102IlePhe: 1.102 ± 0.044
4.744IleGly: 4.744 ± 0.085
0.622IleHis: 0.622 ± 0.026
1.721IleIle: 1.721 ± 0.054
0.65IleLys: 0.65 ± 0.028
3.618IleLeu: 3.618 ± 0.065
0.63IleMet: 0.63 ± 0.027
0.827IleAsn: 0.827 ± 0.029
2.304IlePro: 2.304 ± 0.043
0.881IleGln: 0.881 ± 0.031
2.561IleArg: 2.561 ± 0.047
2.285IleSer: 2.285 ± 0.043
2.751IleThr: 2.751 ± 0.057
5.174IleVal: 5.174 ± 0.077
0.458IleTrp: 0.458 ± 0.022
0.705IleTyr: 0.705 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
2.105LysAla: 2.105 ± 0.067
0.066LysCys: 0.066 ± 0.007
0.966LysAsp: 0.966 ± 0.039
0.856LysGlu: 0.856 ± 0.028
0.397LysPhe: 0.397 ± 0.023
1.372LysGly: 1.372 ± 0.044
0.362LysHis: 0.362 ± 0.018
0.803LysIle: 0.803 ± 0.029
0.685LysLys: 0.685 ± 0.03
1.622LysLeu: 1.622 ± 0.046
0.289LysMet: 0.289 ± 0.018
0.52LysAsn: 0.52 ± 0.027
1.139LysPro: 1.139 ± 0.037
0.588LysGln: 0.588 ± 0.028
1.533LysArg: 1.533 ± 0.044
1.081LysSer: 1.081 ± 0.037
1.211LysThr: 1.211 ± 0.041
1.422LysVal: 1.422 ± 0.04
0.197LysTrp: 0.197 ± 0.016
0.352LysTyr: 0.352 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
13.999LeuAla: 13.999 ± 0.157
0.443LeuCys: 0.443 ± 0.02
7.156LeuAsp: 7.156 ± 0.101
5.479LeuGlu: 5.479 ± 0.095
2.898LeuPhe: 2.898 ± 0.067
9.051LeuGly: 9.051 ± 0.122
1.718LeuHis: 1.718 ± 0.04
3.853LeuIle: 3.853 ± 0.083
1.476LeuLys: 1.476 ± 0.04
9.768LeuLeu: 9.768 ± 0.137
1.465LeuMet: 1.465 ± 0.043
1.575LeuAsn: 1.575 ± 0.042
5.272LeuPro: 5.272 ± 0.068
2.146LeuGln: 2.146 ± 0.044
6.797LeuArg: 6.797 ± 0.098
6.124LeuSer: 6.124 ± 0.073
6.068LeuThr: 6.068 ± 0.091
10.113LeuVal: 10.113 ± 0.145
1.145LeuTrp: 1.145 ± 0.032
1.619LeuTyr: 1.619 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
1.947MetAla: 1.947 ± 0.041
0.075MetCys: 0.075 ± 0.01
0.775MetAsp: 0.775 ± 0.028
0.625MetGlu: 0.625 ± 0.022
0.508MetPhe: 0.508 ± 0.022
1.202MetGly: 1.202 ± 0.033
0.304MetHis: 0.304 ± 0.017
0.811MetIle: 0.811 ± 0.028
0.38MetLys: 0.38 ± 0.018
1.662MetLeu: 1.662 ± 0.038
0.273MetMet: 0.273 ± 0.016
0.419MetAsn: 0.419 ± 0.018
0.996MetPro: 0.996 ± 0.033
0.453MetGln: 0.453 ± 0.023
1.295MetArg: 1.295 ± 0.036
1.4MetSer: 1.4 ± 0.035
1.693MetThr: 1.693 ± 0.035
1.205MetVal: 1.205 ± 0.033
0.179MetTrp: 0.179 ± 0.011
0.248MetTyr: 0.248 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.523AsnAla: 2.523 ± 0.05
0.109AsnCys: 0.109 ± 0.011
1.215AsnAsp: 1.215 ± 0.04
0.965AsnGlu: 0.965 ± 0.032
0.594AsnPhe: 0.594 ± 0.028
2.036AsnGly: 2.036 ± 0.053
0.348AsnHis: 0.348 ± 0.02
0.788AsnIle: 0.788 ± 0.029
0.344AsnLys: 0.344 ± 0.02
1.719AsnLeu: 1.719 ± 0.039
0.302AsnMet: 0.302 ± 0.019
0.446AsnAsn: 0.446 ± 0.023
1.492AsnPro: 1.492 ± 0.041
0.502AsnGln: 0.502 ± 0.024
1.264AsnArg: 1.264 ± 0.032
0.969AsnSer: 0.969 ± 0.036
1.139AsnThr: 1.139 ± 0.039
1.725AsnVal: 1.725 ± 0.048
0.271AsnTrp: 0.271 ± 0.017
0.433AsnTyr: 0.433 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.562ProAla: 6.562 ± 0.081
0.163ProCys: 0.163 ± 0.013
4.06ProAsp: 4.06 ± 0.065
3.853ProGlu: 3.853 ± 0.066
1.722ProPhe: 1.722 ± 0.04
5.048ProGly: 5.048 ± 0.082
1.081ProHis: 1.081 ± 0.033
2.141ProIle: 2.141 ± 0.047
0.852ProLys: 0.852 ± 0.027
4.835ProLeu: 4.835 ± 0.07
0.787ProMet: 0.787 ± 0.025
1.077ProAsn: 1.077 ± 0.035
2.432ProPro: 2.432 ± 0.066
1.268ProGln: 1.268 ± 0.035
3.406ProArg: 3.406 ± 0.075
3.639ProSer: 3.639 ± 0.063
3.836ProThr: 3.836 ± 0.084
5.173ProVal: 5.173 ± 0.074
0.827ProTrp: 0.827 ± 0.029
1.043ProTyr: 1.043 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.741GlnAla: 2.741 ± 0.059
0.083GlnCys: 0.083 ± 0.008
1.098GlnAsp: 1.098 ± 0.035
1.19GlnGlu: 1.19 ± 0.039
0.816GlnPhe: 0.816 ± 0.03
1.704GlnGly: 1.704 ± 0.043
0.53GlnHis: 0.53 ± 0.027
1.176GlnIle: 1.176 ± 0.037
0.582GlnLys: 0.582 ± 0.026
2.575GlnLeu: 2.575 ± 0.053
0.444GlnMet: 0.444 ± 0.02
0.606GlnAsn: 0.606 ± 0.025
1.333GlnPro: 1.333 ± 0.043
0.996GlnGln: 0.996 ± 0.045
2.078GlnArg: 2.078 ± 0.045
1.526GlnSer: 1.526 ± 0.037
1.32GlnThr: 1.32 ± 0.034
1.977GlnVal: 1.977 ± 0.042
0.402GlnTrp: 0.402 ± 0.021
0.608GlnTyr: 0.608 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
8.391ArgAla: 8.391 ± 0.108
0.285ArgCys: 0.285 ± 0.017
4.29ArgAsp: 4.29 ± 0.076
4.279ArgGlu: 4.279 ± 0.077
2.638ArgPhe: 2.638 ± 0.055
5.445ArgGly: 5.445 ± 0.082
1.552ArgHis: 1.552 ± 0.043
3.648ArgIle: 3.648 ± 0.062
1.282ArgLys: 1.282 ± 0.042
7.342ArgLeu: 7.342 ± 0.105
1.529ArgMet: 1.529 ± 0.042
1.357ArgAsn: 1.357 ± 0.039
3.875ArgPro: 3.875 ± 0.077
1.748ArgGln: 1.748 ± 0.042
7.098ArgArg: 7.098 ± 0.116
5.273ArgSer: 5.273 ± 0.086
4.349ArgThr: 4.349 ± 0.071
6.344ArgVal: 6.344 ± 0.102
1.095ArgTrp: 1.095 ± 0.037
1.523ArgTyr: 1.523 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
7.921SerAla: 7.921 ± 0.095
0.257SerCys: 0.257 ± 0.015
3.742SerAsp: 3.742 ± 0.065
3.142SerGlu: 3.142 ± 0.062
2.127SerPhe: 2.127 ± 0.04
6.486SerGly: 6.486 ± 0.082
1.079SerHis: 1.079 ± 0.033
3.057SerIle: 3.057 ± 0.052
1.07SerLys: 1.07 ± 0.037
5.875SerLeu: 5.875 ± 0.078
1.177SerMet: 1.177 ± 0.034
1.138SerAsn: 1.138 ± 0.033
3.454SerPro: 3.454 ± 0.063
1.337SerGln: 1.337 ± 0.042
4.442SerArg: 4.442 ± 0.087
4.386SerSer: 4.386 ± 0.071
4.309SerThr: 4.309 ± 0.075
5.505SerVal: 5.505 ± 0.083
1.013SerTrp: 1.013 ± 0.033
1.24SerTyr: 1.24 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
8.15ThrAla: 8.15 ± 0.116
0.274ThrCys: 0.274 ± 0.019
3.96ThrAsp: 3.96 ± 0.07
3.284ThrGlu: 3.284 ± 0.058
1.963ThrPhe: 1.963 ± 0.043
6.215ThrGly: 6.215 ± 0.109
1.084ThrHis: 1.084 ± 0.035
3.239ThrIle: 3.239 ± 0.066
1.127ThrLys: 1.127 ± 0.04
5.858ThrLeu: 5.858 ± 0.077
0.933ThrMet: 0.933 ± 0.031
1.249ThrAsn: 1.249 ± 0.045
4.059ThrPro: 4.059 ± 0.069
1.247ThrGln: 1.247 ± 0.036
3.83ThrArg: 3.83 ± 0.057
3.848ThrSer: 3.848 ± 0.083
4.581ThrThr: 4.581 ± 0.085
6.524ThrVal: 6.524 ± 0.124
0.799ThrTrp: 0.799 ± 0.032
1.268ThrTyr: 1.268 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
12.153ValAla: 12.153 ± 0.15
0.501ValCys: 0.501 ± 0.022
6.501ValAsp: 6.501 ± 0.099
5.38ValGlu: 5.38 ± 0.071
3.048ValPhe: 3.048 ± 0.053
7.81ValGly: 7.81 ± 0.097
1.718ValHis: 1.718 ± 0.042
4.284ValIle: 4.284 ± 0.08
1.47ValLys: 1.47 ± 0.041
9.907ValLeu: 9.907 ± 0.129
1.463ValMet: 1.463 ± 0.038
1.799ValAsn: 1.799 ± 0.047
5.095ValPro: 5.095 ± 0.071
1.941ValGln: 1.941 ± 0.045
6.411ValArg: 6.411 ± 0.095
5.934ValSer: 5.934 ± 0.085
6.416ValThr: 6.416 ± 0.12
10.265ValVal: 10.265 ± 0.127
1.143ValTrp: 1.143 ± 0.032
1.623ValTyr: 1.623 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.462TrpAla: 1.462 ± 0.039
0.093TrpCys: 0.093 ± 0.009
0.799TrpAsp: 0.799 ± 0.027
0.619TrpGlu: 0.619 ± 0.025
0.582TrpPhe: 0.582 ± 0.024
1.007TrpGly: 1.007 ± 0.033
0.299TrpHis: 0.299 ± 0.018
0.69TrpIle: 0.69 ± 0.028
0.298TrpLys: 0.298 ± 0.018
1.52TrpLeu: 1.52 ± 0.045
0.286TrpMet: 0.286 ± 0.018
0.431TrpAsn: 0.431 ± 0.019
0.642TrpPro: 0.642 ± 0.026
0.455TrpGln: 0.455 ± 0.02
1.169TrpArg: 1.169 ± 0.033
1.067TrpSer: 1.067 ± 0.035
0.978TrpThr: 0.978 ± 0.032
1.085TrpVal: 1.085 ± 0.034
0.333TrpTrp: 0.333 ± 0.02
0.292TrpTyr: 0.292 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.252TyrAla: 2.252 ± 0.051
0.119TyrCys: 0.119 ± 0.011
1.357TyrAsp: 1.357 ± 0.045
1.024TyrGlu: 1.024 ± 0.027
0.656TyrPhe: 0.656 ± 0.027
1.914TyrGly: 1.914 ± 0.05
0.286TyrHis: 0.286 ± 0.017
0.685TyrIle: 0.685 ± 0.023
0.29TyrLys: 0.29 ± 0.017
2.013TyrLeu: 2.013 ± 0.047
0.243TyrMet: 0.243 ± 0.016
0.44TyrAsn: 0.44 ± 0.024
1.061TyrPro: 1.061 ± 0.034
0.491TyrGln: 0.491 ± 0.025
1.567TyrArg: 1.567 ± 0.041
1.198TyrSer: 1.198 ± 0.037
1.328TyrThr: 1.328 ± 0.057
1.694TyrVal: 1.694 ± 0.042
0.335TyrTrp: 0.335 ± 0.018
0.472TyrTyr: 0.472 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3187 proteins (1053170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski