Amino acid dipepetide frequency for Oharaeibacter diazotrophicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	27.148AlaAla: 27.148 ± 0.313	1.079AlaCys: 1.079 ± 0.032	9.397AlaAsp: 9.397 ± 0.106	9.04AlaGlu: 9.04 ± 0.099	5.058AlaPhe: 5.058 ± 0.063	14.333AlaGly: 14.333 ± 0.133	2.237AlaHis: 2.237 ± 0.04	6.334AlaIle: 6.334 ± 0.076	3.363AlaLys: 3.363 ± 0.063	15.294AlaLeu: 15.294 ± 0.149	3.474AlaMet: 3.474 ± 0.053	2.355AlaAsn: 2.355 ± 0.037	7.51AlaPro: 7.51 ± 0.11	2.458AlaGln: 2.458 ± 0.045	11.41AlaArg: 11.41 ± 0.124	5.887AlaSer: 5.887 ± 0.079	7.5AlaThr: 7.5 ± 0.093	13.271AlaVal: 13.271 ± 0.131	1.615AlaTrp: 1.615 ± 0.035	2.632AlaTyr: 2.632 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.869CysAla: 0.869 ± 0.026	0.083CysCys: 0.083 ± 0.008	0.461CysAsp: 0.461 ± 0.018	0.353CysGlu: 0.353 ± 0.015	0.295CysPhe: 0.295 ± 0.014	0.895CysGly: 0.895 ± 0.028	0.209CysHis: 0.209 ± 0.012	0.249CysIle: 0.249 ± 0.014	0.138CysLys: 0.138 ± 0.011	0.663CysLeu: 0.663 ± 0.024	0.125CysMet: 0.125 ± 0.01	0.177CysAsn: 0.177 ± 0.013	0.417CysPro: 0.417 ± 0.019	0.138CysGln: 0.138 ± 0.01	0.661CysArg: 0.661 ± 0.023	0.345CysSer: 0.345 ± 0.016	0.392CysThr: 0.392 ± 0.016	0.555CysVal: 0.555 ± 0.019	0.108CysTrp: 0.108 ± 0.009	0.166CysTyr: 0.166 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.37AspAla: 8.37 ± 0.093	0.452AspCys: 0.452 ± 0.018	3.807AspAsp: 3.807 ± 0.059	3.422AspGlu: 3.422 ± 0.057	2.118AspPhe: 2.118 ± 0.041	6.711AspGly: 6.711 ± 0.076	1.33AspHis: 1.33 ± 0.034	2.084AspIle: 2.084 ± 0.047	1.376AspLys: 1.376 ± 0.041	6.76AspLeu: 6.76 ± 0.091	1.054AspMet: 1.054 ± 0.025	0.94AspAsn: 0.94 ± 0.026	4.35AspPro: 4.35 ± 0.056	1.23AspGln: 1.23 ± 0.033	5.351AspArg: 5.351 ± 0.071	1.627AspSer: 1.627 ± 0.035	2.59AspThr: 2.59 ± 0.04	5.55AspVal: 5.55 ± 0.061	0.917AspTrp: 0.917 ± 0.025	1.283AspTyr: 1.283 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.507GluAla: 8.507 ± 0.1	0.286GluCys: 0.286 ± 0.015	2.638GluAsp: 2.638 ± 0.046	2.76GluGlu: 2.76 ± 0.048	1.413GluPhe: 1.413 ± 0.033	4.237GluGly: 4.237 ± 0.06	1.0GluHis: 1.0 ± 0.028	3.382GluIle: 3.382 ± 0.053	1.688GluLys: 1.688 ± 0.046	4.468GluLeu: 4.468 ± 0.063	1.287GluMet: 1.287 ± 0.033	1.134GluAsn: 1.134 ± 0.031	3.013GluPro: 3.013 ± 0.055	1.319GluGln: 1.319 ± 0.033	5.35GluArg: 5.35 ± 0.077	1.808GluSer: 1.808 ± 0.043	3.581GluThr: 3.581 ± 0.069	4.094GluVal: 4.094 ± 0.051	0.559GluTrp: 0.559 ± 0.02	0.802GluTyr: 0.802 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	5.279PheAla: 5.279 ± 0.069	0.334PheCys: 0.334 ± 0.016	2.695PheAsp: 2.695 ± 0.039	1.997PheGlu: 1.997 ± 0.035	1.14PhePhe: 1.14 ± 0.033	3.587PheGly: 3.587 ± 0.059	0.696PheHis: 0.696 ± 0.022	0.829PheIle: 0.829 ± 0.024	0.788PheLys: 0.788 ± 0.026	3.247PheLeu: 3.247 ± 0.054	0.642PheMet: 0.642 ± 0.021	0.72PheAsn: 0.72 ± 0.027	1.578PhePro: 1.578 ± 0.038	0.846PheGln: 0.846 ± 0.024	2.479PheArg: 2.479 ± 0.037	1.75PheSer: 1.75 ± 0.035	1.75PheThr: 1.75 ± 0.04	3.405PheVal: 3.405 ± 0.055	0.457PheTrp: 0.457 ± 0.02	0.758PheTyr: 0.758 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.873GlyAla: 11.873 ± 0.105	0.803GlyCys: 0.803 ± 0.028	5.06GlyAsp: 5.06 ± 0.065	4.934GlyGlu: 4.934 ± 0.064	3.75GlyPhe: 3.75 ± 0.053	8.621GlyGly: 8.621 ± 0.137	1.903GlyHis: 1.903 ± 0.045	3.946GlyIle: 3.946 ± 0.059	2.504GlyLys: 2.504 ± 0.049	9.766GlyLeu: 9.766 ± 0.098	1.933GlyMet: 1.933 ± 0.039	1.713GlyAsn: 1.713 ± 0.051	4.43GlyPro: 4.43 ± 0.06	1.973GlyGln: 1.973 ± 0.037	8.626GlyArg: 8.626 ± 0.076	4.379GlySer: 4.379 ± 0.074	5.258GlyThr: 5.258 ± 0.071	7.218GlyVal: 7.218 ± 0.075	1.445GlyTrp: 1.445 ± 0.039	2.125GlyTyr: 2.125 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.437HisAla: 2.437 ± 0.045	0.183HisCys: 0.183 ± 0.01	1.286HisAsp: 1.286 ± 0.033	0.906HisGlu: 0.906 ± 0.026	0.712HisPhe: 0.712 ± 0.021	2.056HisGly: 2.056 ± 0.04	0.543HisHis: 0.543 ± 0.026	0.469HisIle: 0.469 ± 0.018	0.299HisLys: 0.299 ± 0.015	1.97HisLeu: 1.97 ± 0.043	0.376HisMet: 0.376 ± 0.017	0.306HisAsn: 0.306 ± 0.015	1.337HisPro: 1.337 ± 0.033	0.363HisGln: 0.363 ± 0.016	1.497HisArg: 1.497 ± 0.034	0.593HisSer: 0.593 ± 0.02	0.75HisThr: 0.75 ± 0.021	1.789HisVal: 1.789 ± 0.036	0.265HisTrp: 0.265 ± 0.013	0.436HisTyr: 0.436 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	7.002IleAla: 7.002 ± 0.071	0.357IleCys: 0.357 ± 0.017	3.111IleAsp: 3.111 ± 0.052	2.784IleGlu: 2.784 ± 0.049	1.184IlePhe: 1.184 ± 0.029	4.548IleGly: 4.548 ± 0.058	0.729IleHis: 0.729 ± 0.025	0.96IleIle: 0.96 ± 0.03	0.861IleLys: 0.861 ± 0.032	3.762IleLeu: 3.762 ± 0.054	0.613IleMet: 0.613 ± 0.02	0.789IleAsn: 0.789 ± 0.025	1.972IlePro: 1.972 ± 0.037	0.899IleGln: 0.899 ± 0.027	3.288IleArg: 3.288 ± 0.047	1.853IleSer: 1.853 ± 0.038	1.909IleThr: 1.909 ± 0.056	4.111IleVal: 4.111 ± 0.058	0.441IleTrp: 0.441 ± 0.015	0.772IleTyr: 0.772 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.675LysAla: 3.675 ± 0.069	0.127LysCys: 0.127 ± 0.01	1.283LysAsp: 1.283 ± 0.035	1.038LysGlu: 1.038 ± 0.037	0.656LysPhe: 0.656 ± 0.025	2.194LysGly: 2.194 ± 0.048	0.37LysHis: 0.37 ± 0.017	1.277LysIle: 1.277 ± 0.03	0.81LysLys: 0.81 ± 0.032	2.529LysLeu: 2.529 ± 0.055	0.526LysMet: 0.526 ± 0.019	0.569LysAsn: 0.569 ± 0.022	1.732LysPro: 1.732 ± 0.043	0.555LysGln: 0.555 ± 0.024	1.834LysArg: 1.834 ± 0.04	1.227LysSer: 1.227 ± 0.032	1.487LysThr: 1.487 ± 0.04	2.245LysVal: 2.245 ± 0.052	0.264LysTrp: 0.264 ± 0.014	0.471LysTyr: 0.471 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	17.229LeuAla: 17.229 ± 0.146	0.717LeuCys: 0.717 ± 0.025	6.55LeuAsp: 6.55 ± 0.073	4.687LeuGlu: 4.687 ± 0.061	3.385LeuPhe: 3.385 ± 0.052	8.783LeuGly: 8.783 ± 0.101	1.677LeuHis: 1.677 ± 0.033	3.809LeuIle: 3.809 ± 0.056	2.947LeuLys: 2.947 ± 0.06	8.313LeuLeu: 8.313 ± 0.108	1.838LeuMet: 1.838 ± 0.034	1.724LeuAsn: 1.724 ± 0.032	5.718LeuPro: 5.718 ± 0.061	1.905LeuGln: 1.905 ± 0.043	6.505LeuArg: 6.505 ± 0.081	5.42LeuSer: 5.42 ± 0.08	5.142LeuThr: 5.142 ± 0.112	9.378LeuVal: 9.378 ± 0.106	1.107LeuTrp: 1.107 ± 0.026	1.825LeuTyr: 1.825 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.913MetAla: 2.913 ± 0.048	0.12MetCys: 0.12 ± 0.008	1.001MetAsp: 1.001 ± 0.028	0.871MetGlu: 0.871 ± 0.025	0.549MetPhe: 0.549 ± 0.021	1.45MetGly: 1.45 ± 0.037	0.334MetHis: 0.334 ± 0.016	1.049MetIle: 1.049 ± 0.03	0.673MetLys: 0.673 ± 0.02	1.971MetLeu: 1.971 ± 0.037	0.477MetMet: 0.477 ± 0.019	0.574MetAsn: 0.574 ± 0.02	1.306MetPro: 1.306 ± 0.027	0.496MetGln: 0.496 ± 0.018	1.685MetArg: 1.685 ± 0.035	1.345MetSer: 1.345 ± 0.028	1.858MetThr: 1.858 ± 0.038	1.642MetVal: 1.642 ± 0.035	0.175MetTrp: 0.175 ± 0.01	0.224MetTyr: 0.224 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.498AsnAla: 2.498 ± 0.048	0.183AsnCys: 0.183 ± 0.012	1.046AsnAsp: 1.046 ± 0.035	0.831AsnGlu: 0.831 ± 0.024	0.696AsnPhe: 0.696 ± 0.023	1.849AsnGly: 1.849 ± 0.04	0.376AsnHis: 0.376 ± 0.017	0.724AsnIle: 0.724 ± 0.023	0.436AsnLys: 0.436 ± 0.019	1.98AsnLeu: 1.98 ± 0.039	0.404AsnMet: 0.404 ± 0.018	0.396AsnAsn: 0.396 ± 0.021	1.442AsnPro: 1.442 ± 0.031	0.495AsnGln: 0.495 ± 0.02	1.499AsnArg: 1.499 ± 0.033	0.698AsnSer: 0.698 ± 0.026	0.944AsnThr: 0.944 ± 0.035	1.725AsnVal: 1.725 ± 0.05	0.294AsnTrp: 0.294 ± 0.015	0.481AsnTyr: 0.481 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.942ProAla: 8.942 ± 0.131	0.294ProCys: 0.294 ± 0.015	4.175ProAsp: 4.175 ± 0.061	3.525ProGlu: 3.525 ± 0.061	2.042ProPhe: 2.042 ± 0.04	5.144ProGly: 5.144 ± 0.07	1.011ProHis: 1.011 ± 0.029	2.211ProIle: 2.211 ± 0.039	1.54ProLys: 1.54 ± 0.036	4.789ProLeu: 4.789 ± 0.069	1.175ProMet: 1.175 ± 0.026	1.12ProAsn: 1.12 ± 0.026	3.157ProPro: 3.157 ± 0.07	1.123ProGln: 1.123 ± 0.03	3.557ProArg: 3.557 ± 0.06	2.567ProSer: 2.567 ± 0.043	3.002ProThr: 3.002 ± 0.042	5.005ProVal: 5.005 ± 0.058	0.728ProTrp: 0.728 ± 0.023	1.112ProTyr: 1.112 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	2.734GlnAla: 2.734 ± 0.045	0.106GlnCys: 0.106 ± 0.009	0.981GlnAsp: 0.981 ± 0.026	0.921GlnGlu: 0.921 ± 0.029	0.713GlnPhe: 0.713 ± 0.027	1.726GlnGly: 1.726 ± 0.037	0.369GlnHis: 0.369 ± 0.014	1.308GlnIle: 1.308 ± 0.055	0.651GlnLys: 0.651 ± 0.025	1.953GlnLeu: 1.953 ± 0.055	0.525GlnMet: 0.525 ± 0.019	0.497GlnAsn: 0.497 ± 0.019	1.231GlnPro: 1.231 ± 0.026	0.639GlnGln: 0.639 ± 0.024	1.752GlnArg: 1.752 ± 0.042	1.114GlnSer: 1.114 ± 0.033	1.262GlnThr: 1.262 ± 0.033	1.809GlnVal: 1.809 ± 0.061	0.249GlnTrp: 0.249 ± 0.013	0.414GlnTyr: 0.414 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.401ArgAla: 10.401 ± 0.117	0.481ArgCys: 0.481 ± 0.023	4.614ArgAsp: 4.614 ± 0.071	4.056ArgGlu: 4.056 ± 0.062	3.202ArgPhe: 3.202 ± 0.054	5.735ArgGly: 5.735 ± 0.063	1.847ArgHis: 1.847 ± 0.037	4.162ArgIle: 4.162 ± 0.054	1.681ArgLys: 1.681 ± 0.038	9.347ArgLeu: 9.347 ± 0.099	1.794ArgMet: 1.794 ± 0.043	1.482ArgAsn: 1.482 ± 0.032	4.857ArgPro: 4.857 ± 0.065	1.904ArgGln: 1.904 ± 0.038	7.956ArgArg: 7.956 ± 0.109	3.483ArgSer: 3.483 ± 0.061	4.092ArgThr: 4.092 ± 0.06	5.824ArgVal: 5.824 ± 0.066	1.067ArgTrp: 1.067 ± 0.027	1.515ArgTyr: 1.515 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.997SerAla: 5.997 ± 0.078	0.323SerCys: 0.323 ± 0.017	2.509SerAsp: 2.509 ± 0.052	2.005SerGlu: 2.005 ± 0.046	1.927SerPhe: 1.927 ± 0.04	4.814SerGly: 4.814 ± 0.072	0.811SerHis: 0.811 ± 0.024	2.044SerIle: 2.044 ± 0.04	1.053SerLys: 1.053 ± 0.028	4.304SerLeu: 4.304 ± 0.068	0.981SerMet: 0.981 ± 0.023	0.923SerAsn: 0.923 ± 0.028	2.571SerPro: 2.571 ± 0.046	0.951SerGln: 0.951 ± 0.029	3.15SerArg: 3.15 ± 0.052	2.194SerSer: 2.194 ± 0.056	2.521SerThr: 2.521 ± 0.06	3.635SerVal: 3.635 ± 0.054	0.637SerTrp: 0.637 ± 0.022	1.033SerTyr: 1.033 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	7.878ThrAla: 7.878 ± 0.104	0.383ThrCys: 0.383 ± 0.016	3.054ThrAsp: 3.054 ± 0.042	2.357ThrGlu: 2.357 ± 0.045	1.84ThrPhe: 1.84 ± 0.033	5.436ThrGly: 5.436 ± 0.075	0.876ThrHis: 0.876 ± 0.027	2.617ThrIle: 2.617 ± 0.06	1.094ThrLys: 1.094 ± 0.03	5.793ThrLeu: 5.793 ± 0.108	1.104ThrMet: 1.104 ± 0.03	1.024ThrAsn: 1.024 ± 0.032	3.224ThrPro: 3.224 ± 0.045	1.078ThrGln: 1.078 ± 0.103	3.697ThrArg: 3.697 ± 0.058	2.457ThrSer: 2.457 ± 0.049	3.239ThrThr: 3.239 ± 0.114	5.453ThrVal: 5.453 ± 0.07	0.668ThrTrp: 0.668 ± 0.027	1.09ThrTyr: 1.09 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	13.71ValAla: 13.71 ± 0.141	0.641ValCys: 0.641 ± 0.023	5.601ValAsp: 5.601 ± 0.072	5.3ValGlu: 5.3 ± 0.066	3.064ValPhe: 3.064 ± 0.046	7.279ValGly: 7.279 ± 0.083	1.592ValHis: 1.592 ± 0.033	3.392ValIle: 3.392 ± 0.055	2.128ValLys: 2.128 ± 0.048	8.449ValLeu: 8.449 ± 0.088	1.77ValMet: 1.77 ± 0.037	1.742ValAsn: 1.742 ± 0.036	4.766ValPro: 4.766 ± 0.063	1.695ValGln: 1.695 ± 0.035	6.311ValArg: 6.311 ± 0.078	4.038ValSer: 4.038 ± 0.06	5.234ValThr: 5.234 ± 0.082	8.862ValVal: 8.862 ± 0.086	0.976ValTrp: 0.976 ± 0.027	1.622ValTyr: 1.622 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.288TrpAla: 1.288 ± 0.033	0.151TrpCys: 0.151 ± 0.01	0.586TrpAsp: 0.586 ± 0.02	0.456TrpGlu: 0.456 ± 0.017	0.511TrpPhe: 0.511 ± 0.02	0.857TrpGly: 0.857 ± 0.027	0.284TrpHis: 0.284 ± 0.014	0.599TrpIle: 0.599 ± 0.022	0.377TrpLys: 0.377 ± 0.015	1.399TrpLeu: 1.399 ± 0.035	0.296TrpMet: 0.296 ± 0.013	0.388TrpAsn: 0.388 ± 0.017	0.685TrpPro: 0.685 ± 0.024	0.376TrpGln: 0.376 ± 0.016	1.226TrpArg: 1.226 ± 0.031	0.751TrpSer: 0.751 ± 0.025	0.904TrpThr: 0.904 ± 0.027	0.798TrpVal: 0.798 ± 0.024	0.248TrpTrp: 0.248 ± 0.012	0.32TrpTyr: 0.32 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.643TyrAla: 2.643 ± 0.039	0.195TyrCys: 0.195 ± 0.011	1.47TyrAsp: 1.47 ± 0.04	1.08TyrGlu: 1.08 ± 0.028	0.721TyrPhe: 0.721 ± 0.02	2.004TyrGly: 2.004 ± 0.04	0.381TyrHis: 0.381 ± 0.015	0.501TyrIle: 0.501 ± 0.019	0.463TyrLys: 0.463 ± 0.018	1.903TyrLeu: 1.903 ± 0.039	0.319TyrMet: 0.319 ± 0.016	0.419TyrAsn: 0.419 ± 0.017	0.923TyrPro: 0.923 ± 0.023	0.511TyrGln: 0.511 ± 0.02	1.667TyrArg: 1.667 ± 0.039	0.846TyrSer: 0.846 ± 0.027	0.948TyrThr: 0.948 ± 0.026	1.804TyrVal: 1.804 ± 0.037	0.28TyrTrp: 0.28 ± 0.015	0.493TyrTyr: 0.493 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4501 proteins (1466482 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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