Amino acid dipepetide frequency for Diutina rugosa (Yeast) (Candida rugosa)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.485AlaAla: 7.485 ± 0.089	0.738AlaCys: 0.738 ± 0.021	4.235AlaAsp: 4.235 ± 0.046	4.52AlaGlu: 4.52 ± 0.068	2.483AlaPhe: 2.483 ± 0.035	4.074AlaGly: 4.074 ± 0.051	1.682AlaHis: 1.682 ± 0.022	4.105AlaIle: 4.105 ± 0.048	5.054AlaLys: 5.054 ± 0.064	6.25AlaLeu: 6.25 ± 0.063	1.745AlaMet: 1.745 ± 0.026	3.453AlaAsn: 3.453 ± 0.034	4.682AlaPro: 4.682 ± 0.082	3.349AlaGln: 3.349 ± 0.052	3.478AlaArg: 3.478 ± 0.034	6.703AlaSer: 6.703 ± 0.063	5.1AlaThr: 5.1 ± 0.052	5.102AlaVal: 5.102 ± 0.055	0.738AlaTrp: 0.738 ± 0.017	2.132AlaTyr: 2.132 ± 0.029	0.002AlaXaa: 0.002 ± 0.001
Cys	0.681CysAla: 0.681 ± 0.02	0.22CysCys: 0.22 ± 0.011	0.719CysAsp: 0.719 ± 0.021	0.557CysGlu: 0.557 ± 0.015	0.525CysPhe: 0.525 ± 0.014	0.847CysGly: 0.847 ± 0.025	0.382CysHis: 0.382 ± 0.013	0.633CysIle: 0.633 ± 0.016	0.547CysLys: 0.547 ± 0.014	1.054CysLeu: 1.054 ± 0.022	0.219CysMet: 0.219 ± 0.008	0.422CysAsn: 0.422 ± 0.012	0.558CysPro: 0.558 ± 0.017	0.491CysGln: 0.491 ± 0.013	0.59CysArg: 0.59 ± 0.016	0.818CysSer: 0.818 ± 0.021	0.549CysThr: 0.549 ± 0.016	0.777CysVal: 0.777 ± 0.017	0.162CysTrp: 0.162 ± 0.007	0.405CysTyr: 0.405 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.712AspAla: 4.712 ± 0.053	0.587AspCys: 0.587 ± 0.017	6.527AspAsp: 6.527 ± 0.086	5.0AspGlu: 5.0 ± 0.062	2.468AspPhe: 2.468 ± 0.033	3.46AspGly: 3.46 ± 0.043	1.617AspHis: 1.617 ± 0.03	3.463AspIle: 3.463 ± 0.043	3.24AspLys: 3.24 ± 0.037	5.214AspLeu: 5.214 ± 0.047	1.205AspMet: 1.205 ± 0.022	2.622AspAsn: 2.622 ± 0.038	3.09AspPro: 3.09 ± 0.032	2.241AspGln: 2.241 ± 0.03	2.516AspArg: 2.516 ± 0.029	4.444AspSer: 4.444 ± 0.051	3.297AspThr: 3.297 ± 0.041	4.329AspVal: 4.329 ± 0.041	0.708AspTrp: 0.708 ± 0.017	2.319AspTyr: 2.319 ± 0.027	0.002AspXaa: 0.002 ± 0.001
Glu	4.878GluAla: 4.878 ± 0.062	0.634GluCys: 0.634 ± 0.018	3.837GluAsp: 3.837 ± 0.049	4.849GluGlu: 4.849 ± 0.066	2.562GluPhe: 2.562 ± 0.031	2.833GluGly: 2.833 ± 0.036	1.195GluHis: 1.195 ± 0.023	3.425GluIle: 3.425 ± 0.039	3.596GluLys: 3.596 ± 0.044	6.014GluLeu: 6.014 ± 0.055	1.365GluMet: 1.365 ± 0.026	2.489GluAsn: 2.489 ± 0.033	2.661GluPro: 2.661 ± 0.05	2.516GluGln: 2.516 ± 0.037	3.045GluArg: 3.045 ± 0.044	4.602GluSer: 4.602 ± 0.048	3.185GluThr: 3.185 ± 0.054	4.35GluVal: 4.35 ± 0.049	0.769GluTrp: 0.769 ± 0.017	2.132GluTyr: 2.132 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	2.931PheAla: 2.931 ± 0.032	0.514PheCys: 0.514 ± 0.015	2.983PheAsp: 2.983 ± 0.034	2.373PheGlu: 2.373 ± 0.031	1.638PhePhe: 1.638 ± 0.035	2.879PheGly: 2.879 ± 0.051	0.97PheHis: 0.97 ± 0.017	2.201PheIle: 2.201 ± 0.035	2.238PheLys: 2.238 ± 0.029	3.223PheLeu: 3.223 ± 0.043	0.861PheMet: 0.861 ± 0.019	1.953PheAsn: 1.953 ± 0.027	1.728PhePro: 1.728 ± 0.025	1.391PheGln: 1.391 ± 0.024	1.718PheArg: 1.718 ± 0.028	3.037PheSer: 3.037 ± 0.034	2.348PheThr: 2.348 ± 0.03	2.77PheVal: 2.77 ± 0.032	0.51PheTrp: 0.51 ± 0.014	1.362PheTyr: 1.362 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	4.392GlyAla: 4.392 ± 0.052	0.72GlyCys: 0.72 ± 0.017	3.811GlyAsp: 3.811 ± 0.036	3.103GlyGlu: 3.103 ± 0.041	2.519GlyPhe: 2.519 ± 0.04	4.273GlyGly: 4.273 ± 0.064	1.398GlyHis: 1.398 ± 0.026	3.014GlyIle: 3.014 ± 0.041	3.356GlyLys: 3.356 ± 0.039	4.847GlyLeu: 4.847 ± 0.048	1.132GlyMet: 1.132 ± 0.024	2.445GlyAsn: 2.445 ± 0.047	2.228GlyPro: 2.228 ± 0.031	2.095GlyGln: 2.095 ± 0.033	2.526GlyArg: 2.526 ± 0.035	4.777GlySer: 4.777 ± 0.052	3.183GlyThr: 3.183 ± 0.043	4.095GlyVal: 4.095 ± 0.041	0.784GlyTrp: 0.784 ± 0.019	2.147GlyTyr: 2.147 ± 0.031	0.001GlyXaa: 0.001 ± 0.001
His	1.447HisAla: 1.447 ± 0.024	0.31HisCys: 0.31 ± 0.012	1.527HisAsp: 1.527 ± 0.03	1.292HisGlu: 1.292 ± 0.022	0.969HisPhe: 0.969 ± 0.019	1.399HisGly: 1.399 ± 0.026	1.052HisHis: 1.052 ± 0.025	1.225HisIle: 1.225 ± 0.021	1.228HisLys: 1.228 ± 0.021	2.293HisLeu: 2.293 ± 0.034	0.499HisMet: 0.499 ± 0.015	1.024HisAsn: 1.024 ± 0.02	1.538HisPro: 1.538 ± 0.027	1.435HisGln: 1.435 ± 0.028	1.399HisArg: 1.399 ± 0.024	1.828HisSer: 1.828 ± 0.026	1.266HisThr: 1.266 ± 0.022	1.398HisVal: 1.398 ± 0.024	0.329HisTrp: 0.329 ± 0.011	0.945HisTyr: 0.945 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	3.983IleAla: 3.983 ± 0.038	0.656IleCys: 0.656 ± 0.016	3.96IleAsp: 3.96 ± 0.047	3.249IleGlu: 3.249 ± 0.038	1.871IlePhe: 1.871 ± 0.033	2.941IleGly: 2.941 ± 0.032	1.281IleHis: 1.281 ± 0.021	2.89IleIle: 2.89 ± 0.045	3.23IleLys: 3.23 ± 0.039	4.17IleLeu: 4.17 ± 0.05	1.073IleMet: 1.073 ± 0.022	2.687IleAsn: 2.687 ± 0.035	2.832IlePro: 2.832 ± 0.035	1.756IleGln: 1.756 ± 0.028	2.431IleArg: 2.431 ± 0.031	3.901IleSer: 3.901 ± 0.043	3.224IleThr: 3.224 ± 0.035	3.546IleVal: 3.546 ± 0.044	0.55IleTrp: 0.55 ± 0.017	1.702IleTyr: 1.702 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.017LysAla: 4.017 ± 0.055	0.653LysCys: 0.653 ± 0.017	3.07LysAsp: 3.07 ± 0.041	3.588LysGlu: 3.588 ± 0.048	2.499LysPhe: 2.499 ± 0.033	2.71LysGly: 2.71 ± 0.04	1.475LysHis: 1.475 ± 0.026	2.882LysIle: 2.882 ± 0.033	4.174LysLys: 4.174 ± 0.068	5.966LysLeu: 5.966 ± 0.053	1.204LysMet: 1.204 ± 0.023	2.205LysAsn: 2.205 ± 0.031	3.201LysPro: 3.201 ± 0.044	3.029LysGln: 3.029 ± 0.043	3.709LysArg: 3.709 ± 0.047	4.598LysSer: 4.598 ± 0.05	2.883LysThr: 2.883 ± 0.035	3.981LysVal: 3.981 ± 0.041	0.778LysTrp: 0.778 ± 0.017	2.117LysTyr: 2.117 ± 0.031	0.001LysXaa: 0.001 ± 0.001
Leu	7.332LeuAla: 7.332 ± 0.064	1.055LeuCys: 1.055 ± 0.02	5.36LeuAsp: 5.36 ± 0.043	5.42LeuGlu: 5.42 ± 0.051	3.36LeuPhe: 3.36 ± 0.049	4.921LeuGly: 4.921 ± 0.05	2.035LeuHis: 2.035 ± 0.026	4.461LeuIle: 4.461 ± 0.051	5.506LeuLys: 5.506 ± 0.049	7.577LeuLeu: 7.577 ± 0.076	1.95LeuMet: 1.95 ± 0.028	3.914LeuAsn: 3.914 ± 0.036	4.623LeuPro: 4.623 ± 0.049	3.67LeuGln: 3.67 ± 0.043	4.766LeuArg: 4.766 ± 0.046	7.077LeuSer: 7.077 ± 0.051	5.044LeuThr: 5.044 ± 0.052	6.414LeuVal: 6.414 ± 0.07	1.002LeuTrp: 1.002 ± 0.02	2.681LeuTyr: 2.681 ± 0.035	0.001LeuXaa: 0.001 ± 0.001
Met	2.088MetAla: 2.088 ± 0.029	0.266MetCys: 0.266 ± 0.01	1.26MetAsp: 1.26 ± 0.021	1.182MetGlu: 1.182 ± 0.023	0.882MetPhe: 0.882 ± 0.017	1.319MetGly: 1.319 ± 0.023	0.32MetHis: 0.32 ± 0.011	1.107MetIle: 1.107 ± 0.024	1.163MetLys: 1.163 ± 0.021	1.863MetLeu: 1.863 ± 0.024	0.633MetMet: 0.633 ± 0.018	0.85MetAsn: 0.85 ± 0.019	1.064MetPro: 1.064 ± 0.024	0.643MetGln: 0.643 ± 0.016	0.903MetArg: 0.903 ± 0.016	2.061MetSer: 2.061 ± 0.027	1.214MetThr: 1.214 ± 0.023	1.667MetVal: 1.667 ± 0.027	0.257MetTrp: 0.257 ± 0.011	0.631MetTyr: 0.631 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	2.788AsnAla: 2.788 ± 0.037	0.494AsnCys: 0.494 ± 0.014	2.922AsnAsp: 2.922 ± 0.038	2.426AsnGlu: 2.426 ± 0.033	1.793AsnPhe: 1.793 ± 0.029	2.691AsnGly: 2.691 ± 0.043	1.234AsnHis: 1.234 ± 0.02	2.175AsnIle: 2.175 ± 0.027	2.266AsnLys: 2.266 ± 0.033	3.848AsnLeu: 3.848 ± 0.044	0.868AsnMet: 0.868 ± 0.017	2.156AsnAsn: 2.156 ± 0.044	2.544AsnPro: 2.544 ± 0.038	2.002AsnGln: 2.002 ± 0.033	1.976AsnArg: 1.976 ± 0.028	3.15AsnSer: 3.15 ± 0.039	2.214AsnThr: 2.214 ± 0.038	2.742AsnVal: 2.742 ± 0.032	0.565AsnTrp: 0.565 ± 0.013	1.721AsnTyr: 1.721 ± 0.026	0.001AsnXaa: 0.001 ± 0.0
Pro	4.033ProAla: 4.033 ± 0.058	0.368ProCys: 0.368 ± 0.015	2.722ProAsp: 2.722 ± 0.031	3.752ProGlu: 3.752 ± 0.046	1.829ProPhe: 1.829 ± 0.024	2.699ProGly: 2.699 ± 0.042	1.348ProHis: 1.348 ± 0.027	2.483ProIle: 2.483 ± 0.03	3.181ProLys: 3.181 ± 0.043	4.157ProLeu: 4.157 ± 0.042	1.07ProMet: 1.07 ± 0.021	2.03ProAsn: 2.03 ± 0.029	4.572ProPro: 4.572 ± 0.092	3.375ProGln: 3.375 ± 0.059	2.522ProArg: 2.522 ± 0.034	5.279ProSer: 5.279 ± 0.07	3.501ProThr: 3.501 ± 0.048	3.73ProVal: 3.73 ± 0.044	0.559ProTrp: 0.559 ± 0.015	1.464ProTyr: 1.464 ± 0.027	0.003ProXaa: 0.003 ± 0.001
Gln	3.383GlnAla: 3.383 ± 0.049	0.486GlnCys: 0.486 ± 0.015	1.731GlnAsp: 1.731 ± 0.026	2.349GlnGlu: 2.349 ± 0.035	2.071GlnPhe: 2.071 ± 0.034	2.324GlnGly: 2.324 ± 0.04	1.019GlnHis: 1.019 ± 0.021	2.158GlnIle: 2.158 ± 0.034	2.241GlnLys: 2.241 ± 0.029	4.86GlnLeu: 4.86 ± 0.051	1.065GlnMet: 1.065 ± 0.02	1.487GlnAsn: 1.487 ± 0.031	2.556GlnPro: 2.556 ± 0.064	3.366GlnGln: 3.366 ± 0.107	2.556GlnArg: 2.556 ± 0.036	3.373GlnSer: 3.373 ± 0.04	2.007GlnThr: 2.007 ± 0.029	2.966GlnVal: 2.966 ± 0.036	0.694GlnTrp: 0.694 ± 0.018	1.469GlnTyr: 1.469 ± 0.025	0.001GlnXaa: 0.001 ± 0.0
Arg	3.253ArgAla: 3.253 ± 0.043	0.541ArgCys: 0.541 ± 0.015	2.891ArgAsp: 2.891 ± 0.037	2.902ArgGlu: 2.902 ± 0.042	2.089ArgPhe: 2.089 ± 0.03	2.612ArgGly: 2.612 ± 0.04	1.503ArgHis: 1.503 ± 0.028	2.481ArgIle: 2.481 ± 0.033	3.224ArgLys: 3.224 ± 0.038	4.815ArgLeu: 4.815 ± 0.05	1.032ArgMet: 1.032 ± 0.019	1.974ArgAsn: 1.974 ± 0.027	2.271ArgPro: 2.271 ± 0.035	2.769ArgGln: 2.769 ± 0.039	3.539ArgArg: 3.539 ± 0.05	3.706ArgSer: 3.706 ± 0.045	2.239ArgThr: 2.239 ± 0.031	3.34ArgVal: 3.34 ± 0.034	0.67ArgTrp: 0.67 ± 0.017	1.757ArgTyr: 1.757 ± 0.026	0.001ArgXaa: 0.001 ± 0.0
Ser	6.434SerAla: 6.434 ± 0.063	0.727SerCys: 0.727 ± 0.019	4.73SerAsp: 4.73 ± 0.055	4.405SerGlu: 4.405 ± 0.05	3.133SerPhe: 3.133 ± 0.033	4.954SerGly: 4.954 ± 0.057	1.781SerHis: 1.781 ± 0.029	4.145SerIle: 4.145 ± 0.043	4.594SerLys: 4.594 ± 0.045	6.904SerLeu: 6.904 ± 0.053	1.84SerMet: 1.84 ± 0.027	3.112SerAsn: 3.112 ± 0.041	4.83SerPro: 4.83 ± 0.075	3.511SerGln: 3.511 ± 0.041	4.001SerArg: 4.001 ± 0.039	9.066SerSer: 9.066 ± 0.131	5.212SerThr: 5.212 ± 0.058	5.867SerVal: 5.867 ± 0.054	0.942SerTrp: 0.942 ± 0.018	2.269SerTyr: 2.269 ± 0.03	0.002SerXaa: 0.002 ± 0.001
Thr	4.206ThrAla: 4.206 ± 0.046	0.573ThrCys: 0.573 ± 0.019	2.995ThrAsp: 2.995 ± 0.039	3.177ThrGlu: 3.177 ± 0.051	2.052ThrPhe: 2.052 ± 0.033	3.261ThrGly: 3.261 ± 0.047	1.327ThrHis: 1.327 ± 0.025	3.137ThrIle: 3.137 ± 0.035	3.58ThrLys: 3.58 ± 0.043	4.738ThrLeu: 4.738 ± 0.046	1.152ThrMet: 1.152 ± 0.02	2.643ThrAsn: 2.643 ± 0.034	3.915ThrPro: 3.915 ± 0.057	2.287ThrGln: 2.287 ± 0.033	2.556ThrArg: 2.556 ± 0.028	5.151ThrSer: 5.151 ± 0.055	4.542ThrThr: 4.542 ± 0.075	4.006ThrVal: 4.006 ± 0.071	0.617ThrTrp: 0.617 ± 0.016	1.663ThrTyr: 1.663 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	6.139ValAla: 6.139 ± 0.056	0.886ValCys: 0.886 ± 0.019	4.798ValAsp: 4.798 ± 0.044	4.377ValGlu: 4.377 ± 0.044	2.812ValPhe: 2.812 ± 0.038	3.858ValGly: 3.858 ± 0.048	1.441ValHis: 1.441 ± 0.024	3.669ValIle: 3.669 ± 0.038	3.966ValLys: 3.966 ± 0.038	5.945ValLeu: 5.945 ± 0.057	1.454ValMet: 1.454 ± 0.023	2.943ValAsn: 2.943 ± 0.036	3.779ValPro: 3.779 ± 0.041	2.16ValGln: 2.16 ± 0.029	2.938ValArg: 2.938 ± 0.036	5.551ValSer: 5.551 ± 0.048	4.129ValThr: 4.129 ± 0.061	6.041ValVal: 6.041 ± 0.063	0.846ValTrp: 0.846 ± 0.02	2.359ValTyr: 2.359 ± 0.031	0.001ValXaa: 0.001 ± 0.0
Trp	0.742TrpAla: 0.742 ± 0.018	0.227TrpCys: 0.227 ± 0.009	0.756TrpAsp: 0.756 ± 0.021	0.61TrpGlu: 0.61 ± 0.016	0.601TrpPhe: 0.601 ± 0.016	0.727TrpGly: 0.727 ± 0.02	0.333TrpHis: 0.333 ± 0.012	0.606TrpIle: 0.606 ± 0.017	0.693TrpLys: 0.693 ± 0.017	1.28TrpLeu: 1.28 ± 0.024	0.305TrpMet: 0.305 ± 0.011	0.568TrpAsn: 0.568 ± 0.016	0.41TrpPro: 0.41 ± 0.013	0.542TrpGln: 0.542 ± 0.016	0.732TrpArg: 0.732 ± 0.016	0.909TrpSer: 0.909 ± 0.019	0.635TrpThr: 0.635 ± 0.015	0.799TrpVal: 0.799 ± 0.018	0.271TrpTrp: 0.271 ± 0.011	0.45TrpTyr: 0.45 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.188TyrAla: 2.188 ± 0.029	0.502TyrCys: 0.502 ± 0.013	2.226TyrAsp: 2.226 ± 0.03	1.806TyrGlu: 1.806 ± 0.025	1.47TyrPhe: 1.47 ± 0.027	2.064TyrGly: 2.064 ± 0.028	1.009TyrHis: 1.009 ± 0.019	1.672TyrIle: 1.672 ± 0.026	1.661TyrLys: 1.661 ± 0.028	3.15TyrLeu: 3.15 ± 0.041	0.7TyrMet: 0.7 ± 0.015	1.6TyrAsn: 1.6 ± 0.027	1.589TyrPro: 1.589 ± 0.027	1.532TyrGln: 1.532 ± 0.026	1.707TyrArg: 1.707 ± 0.026	2.424TyrSer: 2.424 ± 0.032	1.808TyrThr: 1.808 ± 0.022	2.171TyrVal: 2.171 ± 0.03	0.445TyrTrp: 0.445 ± 0.015	1.373TyrTyr: 1.373 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.004XaaPro: 0.004 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.178XaaXaa: 0.178 ± 0.047

Statistics based on 5811 proteins (2762008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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