Amino acid dipepetide frequency for Spiroplasma phage SVTS2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
3.317AlaAsp: 3.317 ± 1.335
0.553AlaGlu: 0.553 ± 0.659
2.764AlaPhe: 2.764 ± 1.434
1.658AlaGly: 1.658 ± 0.775
0.553AlaHis: 0.553 ± 0.537
1.658AlaIle: 1.658 ± 0.912
2.211AlaLys: 2.211 ± 1.035
1.658AlaLeu: 1.658 ± 0.634
1.658AlaMet: 1.658 ± 0.831
4.975AlaAsn: 4.975 ± 1.672
0.0AlaPro: 0.0 ± 0.0
0.0AlaGln: 0.0 ± 0.0
0.0AlaArg: 0.0 ± 0.0
1.106AlaSer: 1.106 ± 0.902
2.764AlaThr: 2.764 ± 1.253
1.106AlaVal: 1.106 ± 0.958
0.0AlaTrp: 0.0 ± 0.0
1.658AlaTyr: 1.658 ± 0.939
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.553CysCys: 0.553 ± 0.721
1.106CysAsp: 1.106 ± 0.958
0.0CysGlu: 0.0 ± 0.0
1.106CysPhe: 1.106 ± 0.748
1.106CysGly: 1.106 ± 0.721
0.0CysHis: 0.0 ± 0.0
2.211CysIle: 2.211 ± 1.067
2.211CysLys: 2.211 ± 1.497
1.106CysLeu: 1.106 ± 1.083
0.553CysMet: 0.553 ± 0.447
0.553CysAsn: 0.553 ± 0.719
1.106CysPro: 1.106 ± 0.923
0.0CysGln: 0.0 ± 0.0
0.553CysArg: 0.553 ± 0.42
0.553CysSer: 0.553 ± 0.634
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.553AspAla: 0.553 ± 0.659
0.553AspCys: 0.553 ± 0.719
2.764AspAsp: 2.764 ± 1.052
2.211AspGlu: 2.211 ± 0.891
2.764AspPhe: 2.764 ± 1.13
1.658AspGly: 1.658 ± 1.075
0.0AspHis: 0.0 ± 0.0
8.292AspIle: 8.292 ± 2.259
7.186AspLys: 7.186 ± 2.004
6.081AspLeu: 6.081 ± 1.089
1.106AspMet: 1.106 ± 0.523
5.528AspAsn: 5.528 ± 1.958
0.553AspPro: 0.553 ± 0.436
0.0AspGln: 0.0 ± 0.0
1.106AspArg: 1.106 ± 0.796
3.87AspSer: 3.87 ± 0.849
1.658AspThr: 1.658 ± 0.949
3.317AspVal: 3.317 ± 1.038
1.658AspTrp: 1.658 ± 1.178
2.211AspTyr: 2.211 ± 1.283
0.0AspXaa: 0.0 ± 0.0
Glu
0.0GluAla: 0.0 ± 0.0
0.553GluCys: 0.553 ± 0.721
0.553GluAsp: 0.553 ± 0.479
0.553GluGlu: 0.553 ± 0.42
2.764GluPhe: 2.764 ± 1.175
1.106GluGly: 1.106 ± 0.967
0.553GluHis: 0.553 ± 0.42
3.317GluIle: 3.317 ± 1.112
2.211GluLys: 2.211 ± 1.36
3.87GluLeu: 3.87 ± 0.869
1.106GluMet: 1.106 ± 0.608
4.975GluAsn: 4.975 ± 1.713
0.553GluPro: 0.553 ± 0.538
1.658GluGln: 1.658 ± 0.961
0.0GluArg: 0.0 ± 0.0
3.317GluSer: 3.317 ± 1.425
1.106GluThr: 1.106 ± 0.782
0.0GluVal: 0.0 ± 0.0
0.553GluTrp: 0.553 ± 0.634
3.317GluTyr: 3.317 ± 1.276
0.0GluXaa: 0.0 ± 0.0
Phe
2.211PheAla: 2.211 ± 0.901
2.211PheCys: 2.211 ± 1.156
4.975PheAsp: 4.975 ± 2.077
0.553PheGlu: 0.553 ± 0.436
7.186PhePhe: 7.186 ± 1.821
3.317PheGly: 3.317 ± 1.809
0.553PheHis: 0.553 ± 0.479
9.95PheIle: 9.95 ± 2.809
6.081PheLys: 6.081 ± 1.355
8.292PheLeu: 8.292 ± 2.368
3.317PheMet: 3.317 ± 1.247
6.081PheAsn: 6.081 ± 2.323
1.658PhePro: 1.658 ± 0.881
2.764PheGln: 2.764 ± 1.33
2.764PheArg: 2.764 ± 1.229
6.633PheSer: 6.633 ± 1.96
2.764PheThr: 2.764 ± 0.766
4.975PheVal: 4.975 ± 1.732
1.106PheTrp: 1.106 ± 0.528
3.87PheTyr: 3.87 ± 1.005
0.0PheXaa: 0.0 ± 0.0
Gly
2.211GlyAla: 2.211 ± 0.871
0.0GlyCys: 0.0 ± 0.0
0.0GlyAsp: 0.0 ± 0.0
0.553GlyGlu: 0.553 ± 0.42
5.528GlyPhe: 5.528 ± 1.838
1.106GlyGly: 1.106 ± 0.601
0.553GlyHis: 0.553 ± 0.721
4.422GlyIle: 4.422 ± 1.514
4.975GlyLys: 4.975 ± 1.095
5.528GlyLeu: 5.528 ± 1.16
1.106GlyMet: 1.106 ± 0.83
2.211GlyAsn: 2.211 ± 1.356
0.0GlyPro: 0.0 ± 0.0
1.106GlyGln: 1.106 ± 0.742
0.553GlyArg: 0.553 ± 0.436
1.658GlySer: 1.658 ± 1.02
3.317GlyThr: 3.317 ± 1.32
4.422GlyVal: 4.422 ± 1.64
1.658GlyTrp: 1.658 ± 1.308
1.106GlyTyr: 1.106 ± 0.742
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.553HisCys: 0.553 ± 0.634
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.658HisPhe: 1.658 ± 0.678
1.106HisGly: 1.106 ± 0.742
0.0HisHis: 0.0 ± 0.0
1.106HisIle: 1.106 ± 0.553
1.106HisLys: 1.106 ± 0.796
1.658HisLeu: 1.658 ± 1.012
0.553HisMet: 0.553 ± 0.659
1.106HisAsn: 1.106 ± 0.753
1.106HisPro: 1.106 ± 0.898
0.553HisGln: 0.553 ± 0.646
0.553HisArg: 0.553 ± 0.721
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.658HisTyr: 1.658 ± 0.901
0.0HisXaa: 0.0 ± 0.0
Ile
6.081IleAla: 6.081 ± 3.085
0.553IleCys: 0.553 ± 0.634
3.317IleAsp: 3.317 ± 1.989
2.211IleGlu: 2.211 ± 0.885
13.82IlePhe: 13.82 ± 3.466
5.528IleGly: 5.528 ± 1.5
1.658IleHis: 1.658 ± 1.205
11.056IleIle: 11.056 ± 2.525
12.161IleLys: 12.161 ± 1.573
11.056IleLeu: 11.056 ± 2.807
4.422IleMet: 4.422 ± 1.694
10.503IleAsn: 10.503 ± 2.327
4.422IlePro: 4.422 ± 1.578
0.553IleGln: 0.553 ± 0.479
3.87IleArg: 3.87 ± 1.67
3.87IleSer: 3.87 ± 1.564
3.87IleThr: 3.87 ± 1.386
7.739IleVal: 7.739 ± 1.372
2.211IleTrp: 2.211 ± 1.821
2.764IleTyr: 2.764 ± 0.763
0.0IleXaa: 0.0 ± 0.0
Lys
2.211LysAla: 2.211 ± 1.167
1.106LysCys: 1.106 ± 0.796
5.528LysAsp: 5.528 ± 1.835
3.317LysGlu: 3.317 ± 1.108
2.764LysPhe: 2.764 ± 1.594
2.764LysGly: 2.764 ± 1.136
1.658LysHis: 1.658 ± 0.901
12.161LysIle: 12.161 ± 2.575
7.186LysLys: 7.186 ± 2.543
11.609LysLeu: 11.609 ± 3.015
2.764LysMet: 2.764 ± 1.303
14.925LysAsn: 14.925 ± 4.54
1.658LysPro: 1.658 ± 0.927
3.317LysGln: 3.317 ± 1.507
3.87LysArg: 3.87 ± 0.949
4.422LysSer: 4.422 ± 0.913
2.764LysThr: 2.764 ± 1.605
4.422LysVal: 4.422 ± 1.789
1.658LysTrp: 1.658 ± 1.614
6.633LysTyr: 6.633 ± 1.651
0.0LysXaa: 0.0 ± 0.0
Leu
3.317LeuAla: 3.317 ± 1.325
0.553LeuCys: 0.553 ± 0.42
5.528LeuAsp: 5.528 ± 2.348
4.975LeuGlu: 4.975 ± 2.055
9.397LeuPhe: 9.397 ± 2.292
4.422LeuGly: 4.422 ± 1.791
0.0LeuHis: 0.0 ± 0.0
13.267LeuIle: 13.267 ± 3.398
8.292LeuLys: 8.292 ± 1.779
9.397LeuLeu: 9.397 ± 2.386
2.211LeuMet: 2.211 ± 1.025
3.87LeuAsn: 3.87 ± 1.692
2.211LeuPro: 2.211 ± 0.732
2.764LeuGln: 2.764 ± 1.736
3.317LeuArg: 3.317 ± 1.072
6.081LeuSer: 6.081 ± 1.144
3.317LeuThr: 3.317 ± 1.61
7.739LeuVal: 7.739 ± 2.501
0.553LeuTrp: 0.553 ± 0.479
5.528LeuTyr: 5.528 ± 1.713
0.0LeuXaa: 0.0 ± 0.0
Met
1.106MetAla: 1.106 ± 0.84
0.0MetCys: 0.0 ± 0.0
2.211MetAsp: 2.211 ± 1.115
1.106MetGlu: 1.106 ± 0.742
2.211MetPhe: 2.211 ± 1.105
1.658MetGly: 1.658 ± 0.759
0.0MetHis: 0.0 ± 0.0
3.317MetIle: 3.317 ± 1.628
2.211MetLys: 2.211 ± 0.778
3.87MetLeu: 3.87 ± 1.678
0.0MetMet: 0.0 ± 0.0
2.764MetAsn: 2.764 ± 1.065
0.0MetPro: 0.0 ± 0.0
2.211MetGln: 2.211 ± 1.018
0.553MetArg: 0.553 ± 0.436
0.0MetSer: 0.0 ± 0.0
2.211MetThr: 2.211 ± 0.952
1.106MetVal: 1.106 ± 0.872
0.553MetTrp: 0.553 ± 0.514
1.106MetTyr: 1.106 ± 0.796
0.0MetXaa: 0.0 ± 0.0
Asn
2.211AsnAla: 2.211 ± 0.961
2.764AsnCys: 2.764 ± 1.858
8.292AsnAsp: 8.292 ± 1.518
4.975AsnGlu: 4.975 ± 1.499
3.87AsnPhe: 3.87 ± 1.047
4.422AsnGly: 4.422 ± 1.31
2.764AsnHis: 2.764 ± 1.222
10.503AsnIle: 10.503 ± 1.585
6.633AsnLys: 6.633 ± 1.76
7.739AsnLeu: 7.739 ± 1.963
1.106AsnMet: 1.106 ± 0.535
8.292AsnAsn: 8.292 ± 2.257
2.211AsnPro: 2.211 ± 1.384
2.764AsnGln: 2.764 ± 0.759
0.553AsnArg: 0.553 ± 0.479
6.633AsnSer: 6.633 ± 1.927
3.87AsnThr: 3.87 ± 1.542
4.975AsnVal: 4.975 ± 1.544
2.764AsnTrp: 2.764 ± 1.376
7.739AsnTyr: 7.739 ± 1.599
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.0ProCys: 0.0 ± 0.0
1.658ProAsp: 1.658 ± 0.796
0.553ProGlu: 0.553 ± 0.42
0.0ProPhe: 0.0 ± 0.0
0.553ProGly: 0.553 ± 0.514
0.553ProHis: 0.553 ± 0.634
3.317ProIle: 3.317 ± 0.982
1.658ProLys: 1.658 ± 0.821
2.764ProLeu: 2.764 ± 1.103
0.553ProMet: 0.553 ± 0.42
1.106ProAsn: 1.106 ± 0.528
0.553ProPro: 0.553 ± 0.42
0.0ProGln: 0.0 ± 0.0
0.553ProArg: 0.553 ± 0.479
2.764ProSer: 2.764 ± 1.365
0.553ProThr: 0.553 ± 0.646
0.553ProVal: 0.553 ± 0.538
0.0ProTrp: 0.0 ± 0.0
2.211ProTyr: 2.211 ± 1.262
0.0ProXaa: 0.0 ± 0.0
Gln
0.553GlnAla: 0.553 ± 0.514
1.106GlnCys: 1.106 ± 0.742
3.317GlnAsp: 3.317 ± 1.292
0.553GlnGlu: 0.553 ± 0.538
1.658GlnPhe: 1.658 ± 0.825
2.211GlnGly: 2.211 ± 1.265
0.553GlnHis: 0.553 ± 0.646
2.764GlnIle: 2.764 ± 1.118
2.211GlnLys: 2.211 ± 1.026
1.658GlnLeu: 1.658 ± 0.743
0.0GlnMet: 0.0 ± 0.0
2.764GlnAsn: 2.764 ± 0.763
0.0GlnPro: 0.0 ± 0.0
0.553GlnGln: 0.553 ± 0.479
1.658GlnArg: 1.658 ± 1.041
2.211GlnSer: 2.211 ± 1.386
1.658GlnThr: 1.658 ± 0.69
0.553GlnVal: 0.553 ± 0.646
0.0GlnTrp: 0.0 ± 0.0
2.211GlnTyr: 2.211 ± 0.807
0.0GlnXaa: 0.0 ± 0.0
Arg
0.553ArgAla: 0.553 ± 0.479
0.553ArgCys: 0.553 ± 0.479
1.106ArgAsp: 1.106 ± 0.83
1.658ArgGlu: 1.658 ± 0.825
1.106ArgPhe: 1.106 ± 0.872
2.211ArgGly: 2.211 ± 1.193
1.106ArgHis: 1.106 ± 0.553
1.106ArgIle: 1.106 ± 0.528
4.975ArgLys: 4.975 ± 1.055
2.211ArgLeu: 2.211 ± 1.103
0.0ArgMet: 0.0 ± 0.0
1.106ArgAsn: 1.106 ± 0.958
0.0ArgPro: 0.0 ± 0.0
2.211ArgGln: 2.211 ± 1.025
1.658ArgArg: 1.658 ± 1.279
2.211ArgSer: 2.211 ± 0.928
0.553ArgThr: 0.553 ± 0.42
2.211ArgVal: 2.211 ± 0.932
1.106ArgTrp: 1.106 ± 0.848
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
2.211SerAla: 2.211 ± 0.961
1.106SerCys: 1.106 ± 0.848
0.553SerAsp: 0.553 ± 0.514
1.106SerGlu: 1.106 ± 0.753
3.87SerPhe: 3.87 ± 1.159
0.553SerGly: 0.553 ± 0.42
0.553SerHis: 0.553 ± 0.659
5.528SerIle: 5.528 ± 2.201
7.186SerLys: 7.186 ± 2.187
2.764SerLeu: 2.764 ± 0.933
2.211SerMet: 2.211 ± 1.102
9.95SerAsn: 9.95 ± 3.805
1.106SerPro: 1.106 ± 0.782
2.764SerGln: 2.764 ± 0.993
1.658SerArg: 1.658 ± 1.045
4.975SerSer: 4.975 ± 1.855
2.764SerThr: 2.764 ± 0.997
4.422SerVal: 4.422 ± 1.632
0.0SerTrp: 0.0 ± 0.0
3.87SerTyr: 3.87 ± 0.869
0.0SerXaa: 0.0 ± 0.0
Thr
1.106ThrAla: 1.106 ± 0.528
0.0ThrCys: 0.0 ± 0.0
2.764ThrAsp: 2.764 ± 0.965
2.211ThrGlu: 2.211 ± 1.347
2.764ThrPhe: 2.764 ± 1.269
2.764ThrGly: 2.764 ± 0.789
0.553ThrHis: 0.553 ± 0.537
3.87ThrIle: 3.87 ± 1.654
2.211ThrLys: 2.211 ± 1.776
1.658ThrLeu: 1.658 ± 0.524
0.553ThrMet: 0.553 ± 0.721
3.87ThrAsn: 3.87 ± 1.409
0.553ThrPro: 0.553 ± 0.538
0.553ThrGln: 0.553 ± 0.436
0.553ThrArg: 0.553 ± 0.42
1.106ThrSer: 1.106 ± 0.782
2.211ThrThr: 2.211 ± 1.442
4.975ThrVal: 4.975 ± 2.015
0.553ThrTrp: 0.553 ± 0.436
4.422ThrTyr: 4.422 ± 1.16
0.0ThrXaa: 0.0 ± 0.0
Val
1.106ValAla: 1.106 ± 0.797
0.553ValCys: 0.553 ± 0.42
1.106ValAsp: 1.106 ± 0.601
2.764ValGlu: 2.764 ± 1.448
6.081ValPhe: 6.081 ± 2.259
1.658ValGly: 1.658 ± 1.037
0.553ValHis: 0.553 ± 0.479
10.503ValIle: 10.503 ± 3.621
10.503ValLys: 10.503 ± 3.483
3.317ValLeu: 3.317 ± 1.9
1.658ValMet: 1.658 ± 1.177
4.975ValAsn: 4.975 ± 1.193
1.106ValPro: 1.106 ± 0.84
1.106ValGln: 1.106 ± 0.678
1.658ValArg: 1.658 ± 0.825
3.317ValSer: 3.317 ± 1.24
1.106ValThr: 1.106 ± 0.535
5.528ValVal: 5.528 ± 1.913
1.658ValTrp: 1.658 ± 0.942
2.211ValTyr: 2.211 ± 0.932
0.0ValXaa: 0.0 ± 0.0
Trp
1.106TrpAla: 1.106 ± 0.902
0.0TrpCys: 0.0 ± 0.0
2.211TrpAsp: 2.211 ± 1.259
0.0TrpGlu: 0.0 ± 0.0
2.764TrpPhe: 2.764 ± 1.065
0.553TrpGly: 0.553 ± 0.634
0.0TrpHis: 0.0 ± 0.0
1.106TrpIle: 1.106 ± 0.797
1.106TrpLys: 1.106 ± 0.528
1.106TrpLeu: 1.106 ± 1.533
0.553TrpMet: 0.553 ± 0.514
3.317TrpAsn: 3.317 ± 1.414
0.553TrpPro: 0.553 ± 0.42
1.106TrpGln: 1.106 ± 0.872
0.0TrpArg: 0.0 ± 0.0
0.553TrpSer: 0.553 ± 0.42
0.553TrpThr: 0.553 ± 0.721
1.106TrpVal: 1.106 ± 0.629
0.553TrpTrp: 0.553 ± 0.479
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.106TyrAla: 1.106 ± 0.553
0.0TyrCys: 0.0 ± 0.0
2.764TyrAsp: 2.764 ± 1.186
2.211TyrGlu: 2.211 ± 1.086
7.186TyrPhe: 7.186 ± 1.981
1.658TyrGly: 1.658 ± 1.099
0.553TyrHis: 0.553 ± 0.436
2.211TyrIle: 2.211 ± 0.821
4.975TyrLys: 4.975 ± 1.195
9.397TyrLeu: 9.397 ± 1.793
2.211TyrMet: 2.211 ± 0.977
2.211TyrAsn: 2.211 ± 0.972
0.553TyrPro: 0.553 ± 0.436
2.211TyrGln: 2.211 ± 1.107
2.211TyrArg: 2.211 ± 1.01
3.87TyrSer: 3.87 ± 0.894
2.211TyrThr: 2.211 ± 1.074
3.317TyrVal: 3.317 ± 1.9
1.658TyrTrp: 1.658 ± 0.524
2.764TyrTyr: 2.764 ± 1.151
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (1810 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski