Amino acid dipepetide frequency for Corynebacterium freneyi DNF00450

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.971AlaAla: 18.971 ± 0.312	0.963AlaCys: 0.963 ± 0.048	9.784AlaAsp: 9.784 ± 0.153	9.138AlaGlu: 9.138 ± 0.154	3.224AlaPhe: 3.224 ± 0.077	12.29AlaGly: 12.29 ± 0.157	2.47AlaHis: 2.47 ± 0.069	5.083AlaIle: 5.083 ± 0.111	3.769AlaLys: 3.769 ± 0.105	11.258AlaLeu: 11.258 ± 0.17	3.14AlaMet: 3.14 ± 0.08	2.608AlaAsn: 2.608 ± 0.069	5.77AlaPro: 5.77 ± 0.14	3.251AlaGln: 3.251 ± 0.07	8.712AlaArg: 8.712 ± 0.144	5.662AlaSer: 5.662 ± 0.105	7.084AlaThr: 7.084 ± 0.132	10.438AlaVal: 10.438 ± 0.168	1.705AlaTrp: 1.705 ± 0.062	2.171AlaTyr: 2.171 ± 0.061	0.014AlaXaa: 0.014 ± 0.005
Cys	0.81CysAla: 0.81 ± 0.035	0.071CysCys: 0.071 ± 0.012	0.509CysAsp: 0.509 ± 0.032	0.381CysGlu: 0.381 ± 0.025	0.217CysPhe: 0.217 ± 0.019	0.918CysGly: 0.918 ± 0.042	0.169CysHis: 0.169 ± 0.015	0.276CysIle: 0.276 ± 0.021	0.093CysLys: 0.093 ± 0.012	0.583CysLeu: 0.583 ± 0.032	0.104CysMet: 0.104 ± 0.014	0.182CysAsn: 0.182 ± 0.02	0.484CysPro: 0.484 ± 0.028	0.13CysGln: 0.13 ± 0.016	0.556CysArg: 0.556 ± 0.036	0.471CysSer: 0.471 ± 0.027	0.387CysThr: 0.387 ± 0.026	0.591CysVal: 0.591 ± 0.035	0.08CysTrp: 0.08 ± 0.011	0.13CysTyr: 0.13 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.604AspAla: 9.604 ± 0.168	0.453AspCys: 0.453 ± 0.027	5.913AspAsp: 5.913 ± 0.127	5.307AspGlu: 5.307 ± 0.1	2.038AspPhe: 2.038 ± 0.059	7.37AspGly: 7.37 ± 0.135	1.519AspHis: 1.519 ± 0.05	2.923AspIle: 2.923 ± 0.072	1.552AspLys: 1.552 ± 0.06	6.215AspLeu: 6.215 ± 0.098	1.313AspMet: 1.313 ± 0.043	1.485AspAsn: 1.485 ± 0.053	4.212AspPro: 4.212 ± 0.094	1.538AspGln: 1.538 ± 0.053	4.895AspArg: 4.895 ± 0.102	3.2AspSer: 3.2 ± 0.063	2.923AspThr: 2.923 ± 0.075	6.56AspVal: 6.56 ± 0.115	0.942AspTrp: 0.942 ± 0.043	1.401AspTyr: 1.401 ± 0.052	0.002AspXaa: 0.002 ± 0.002
Glu	7.697GluAla: 7.697 ± 0.133	0.429GluCys: 0.429 ± 0.028	3.64GluAsp: 3.64 ± 0.074	4.076GluGlu: 4.076 ± 0.092	2.017GluPhe: 2.017 ± 0.051	4.923GluGly: 4.923 ± 0.102	1.487GluHis: 1.487 ± 0.047	3.015GluIle: 3.015 ± 0.073	2.202GluLys: 2.202 ± 0.064	6.967GluLeu: 6.967 ± 0.118	1.445GluMet: 1.445 ± 0.049	1.414GluAsn: 1.414 ± 0.045	3.229GluPro: 3.229 ± 0.093	2.025GluGln: 2.025 ± 0.058	4.855GluArg: 4.855 ± 0.098	3.23GluSer: 3.23 ± 0.074	3.01GluThr: 3.01 ± 0.079	5.141GluVal: 5.141 ± 0.101	1.001GluTrp: 1.001 ± 0.05	1.334GluTyr: 1.334 ± 0.048	0.003GluXaa: 0.003 ± 0.002
Phe	3.518PheAla: 3.518 ± 0.08	0.214PheCys: 0.214 ± 0.022	2.493PheAsp: 2.493 ± 0.069	1.581PheGlu: 1.581 ± 0.055	0.947PhePhe: 0.947 ± 0.046	3.356PheGly: 3.356 ± 0.082	0.636PheHis: 0.636 ± 0.032	1.387PheIle: 1.387 ± 0.053	0.582PheLys: 0.582 ± 0.032	2.607PheLeu: 2.607 ± 0.079	0.625PheMet: 0.625 ± 0.033	0.768PheAsn: 0.768 ± 0.037	1.315PhePro: 1.315 ± 0.045	0.62PheGln: 0.62 ± 0.032	1.774PheArg: 1.774 ± 0.058	1.564PheSer: 1.564 ± 0.052	2.012PheThr: 2.012 ± 0.056	2.248PheVal: 2.248 ± 0.061	0.358PheTrp: 0.358 ± 0.023	0.529PheTyr: 0.529 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.972GlyAla: 10.972 ± 0.174	0.689GlyCys: 0.689 ± 0.035	6.474GlyAsp: 6.474 ± 0.113	5.861GlyGlu: 5.861 ± 0.107	3.039GlyPhe: 3.039 ± 0.078	8.924GlyGly: 8.924 ± 0.172	2.149GlyHis: 2.149 ± 0.063	4.397GlyIle: 4.397 ± 0.087	2.899GlyLys: 2.899 ± 0.081	8.368GlyLeu: 8.368 ± 0.135	2.404GlyMet: 2.404 ± 0.075	2.101GlyAsn: 2.101 ± 0.066	4.392GlyPro: 4.392 ± 0.103	2.604GlyGln: 2.604 ± 0.082	6.691GlyArg: 6.691 ± 0.114	5.001GlySer: 5.001 ± 0.114	5.508GlyThr: 5.508 ± 0.104	7.891GlyVal: 7.891 ± 0.125	1.53GlyTrp: 1.53 ± 0.052	2.08GlyTyr: 2.08 ± 0.062	0.005GlyXaa: 0.005 ± 0.003
His	2.264HisAla: 2.264 ± 0.066	0.172HisCys: 0.172 ± 0.018	1.589HisAsp: 1.589 ± 0.05	1.184HisGlu: 1.184 ± 0.043	0.595HisPhe: 0.595 ± 0.031	2.065HisGly: 2.065 ± 0.056	0.596HisHis: 0.596 ± 0.036	0.911HisIle: 0.911 ± 0.042	0.386HisLys: 0.386 ± 0.025	2.046HisLeu: 2.046 ± 0.062	0.411HisMet: 0.411 ± 0.025	0.466HisAsn: 0.466 ± 0.028	1.554HisPro: 1.554 ± 0.051	0.532HisGln: 0.532 ± 0.028	1.697HisArg: 1.697 ± 0.058	1.04HisSer: 1.04 ± 0.045	0.913HisThr: 0.913 ± 0.043	1.814HisVal: 1.814 ± 0.062	0.28HisTrp: 0.28 ± 0.023	0.447HisTyr: 0.447 ± 0.03	0.002HisXaa: 0.002 ± 0.002
Ile	6.356IleAla: 6.356 ± 0.098	0.347IleCys: 0.347 ± 0.026	3.712IleAsp: 3.712 ± 0.079	2.957IleGlu: 2.957 ± 0.067	1.123IlePhe: 1.123 ± 0.055	4.574IleGly: 4.574 ± 0.115	0.906IleHis: 0.906 ± 0.04	2.356IleIle: 2.356 ± 0.079	0.993IleLys: 0.993 ± 0.044	3.642IleLeu: 3.642 ± 0.097	0.747IleMet: 0.747 ± 0.033	1.128IleAsn: 1.128 ± 0.047	2.374IlePro: 2.374 ± 0.072	0.894IleGln: 0.894 ± 0.038	2.761IleArg: 2.761 ± 0.067	2.171IleSer: 2.171 ± 0.066	2.694IleThr: 2.694 ± 0.063	4.203IleVal: 4.203 ± 0.088	0.376IleTrp: 0.376 ± 0.026	0.784IleTyr: 0.784 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.261LysAla: 3.261 ± 0.087	0.164LysCys: 0.164 ± 0.015	1.503LysAsp: 1.503 ± 0.056	1.461LysGlu: 1.461 ± 0.055	0.747LysPhe: 0.747 ± 0.037	2.083LysGly: 2.083 ± 0.076	0.551LysHis: 0.551 ± 0.028	1.266LysIle: 1.266 ± 0.051	1.374LysLys: 1.374 ± 0.076	2.653LysLeu: 2.653 ± 0.076	0.706LysMet: 0.706 ± 0.03	0.8LysAsn: 0.8 ± 0.036	1.527LysPro: 1.527 ± 0.06	0.8LysGln: 0.8 ± 0.038	1.884LysArg: 1.884 ± 0.057	1.507LysSer: 1.507 ± 0.055	1.561LysThr: 1.561 ± 0.054	2.211LysVal: 2.211 ± 0.062	0.394LysTrp: 0.394 ± 0.023	0.662LysTyr: 0.662 ± 0.034	0.003LysXaa: 0.003 ± 0.002
Leu	12.481LeuAla: 12.481 ± 0.155	0.638LeuCys: 0.638 ± 0.032	6.814LeuAsp: 6.814 ± 0.114	5.263LeuGlu: 5.263 ± 0.099	2.554LeuPhe: 2.554 ± 0.071	8.431LeuGly: 8.431 ± 0.13	1.845LeuHis: 1.845 ± 0.057	3.974LeuIle: 3.974 ± 0.088	2.168LeuLys: 2.168 ± 0.068	8.354LeuLeu: 8.354 ± 0.146	1.925LeuMet: 1.925 ± 0.07	1.893LeuAsn: 1.893 ± 0.056	5.284LeuPro: 5.284 ± 0.1	2.033LeuGln: 2.033 ± 0.063	6.744LeuArg: 6.744 ± 0.113	4.947LeuSer: 4.947 ± 0.089	5.527LeuThr: 5.527 ± 0.089	7.999LeuVal: 7.999 ± 0.136	1.061LeuTrp: 1.061 ± 0.042	1.48LeuTyr: 1.48 ± 0.055	0.005LeuXaa: 0.005 ± 0.004
Met	2.928MetAla: 2.928 ± 0.079	0.183MetCys: 0.183 ± 0.017	1.196MetAsp: 1.196 ± 0.038	1.043MetGlu: 1.043 ± 0.044	0.685MetPhe: 0.685 ± 0.031	1.895MetGly: 1.895 ± 0.06	0.445MetHis: 0.445 ± 0.026	1.088MetIle: 1.088 ± 0.046	0.652MetLys: 0.652 ± 0.034	2.165MetLeu: 2.165 ± 0.061	0.529MetMet: 0.529 ± 0.033	0.633MetAsn: 0.633 ± 0.033	1.372MetPro: 1.372 ± 0.046	0.543MetGln: 0.543 ± 0.028	1.577MetArg: 1.577 ± 0.052	1.617MetSer: 1.617 ± 0.055	1.786MetThr: 1.786 ± 0.049	1.8MetVal: 1.8 ± 0.053	0.289MetTrp: 0.289 ± 0.024	0.341MetTyr: 0.341 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.616AsnAla: 2.616 ± 0.061	0.175AsnCys: 0.175 ± 0.017	1.454AsnAsp: 1.454 ± 0.052	1.281AsnGlu: 1.281 ± 0.053	0.659AsnPhe: 0.659 ± 0.032	2.049AsnGly: 2.049 ± 0.07	0.509AsnHis: 0.509 ± 0.027	1.057AsnIle: 1.057 ± 0.04	0.593AsnLys: 0.593 ± 0.032	2.191AsnLeu: 2.191 ± 0.06	0.485AsnMet: 0.485 ± 0.027	0.562AsnAsn: 0.562 ± 0.032	1.847AsnPro: 1.847 ± 0.054	0.657AsnGln: 0.657 ± 0.038	1.676AsnArg: 1.676 ± 0.057	1.123AsnSer: 1.123 ± 0.049	1.183AsnThr: 1.183 ± 0.048	1.786AsnVal: 1.786 ± 0.053	0.373AsnTrp: 0.373 ± 0.026	0.556AsnTyr: 0.556 ± 0.027	0.003AsnXaa: 0.003 ± 0.003
Pro	6.655ProAla: 6.655 ± 0.133	0.307ProCys: 0.307 ± 0.024	4.243ProAsp: 4.243 ± 0.09	4.482ProGlu: 4.482 ± 0.099	1.48ProPhe: 1.48 ± 0.052	5.672ProGly: 5.672 ± 0.11	1.125ProHis: 1.125 ± 0.04	1.93ProIle: 1.93 ± 0.055	1.551ProLys: 1.551 ± 0.056	4.289ProLeu: 4.289 ± 0.082	1.209ProMet: 1.209 ± 0.04	1.323ProAsn: 1.323 ± 0.046	2.088ProPro: 2.088 ± 0.086	1.503ProGln: 1.503 ± 0.059	3.187ProArg: 3.187 ± 0.087	2.785ProSer: 2.785 ± 0.068	3.005ProThr: 3.005 ± 0.078	4.862ProVal: 4.862 ± 0.093	0.816ProTrp: 0.816 ± 0.038	1.067ProTyr: 1.067 ± 0.049	0.005ProXaa: 0.005 ± 0.003
Gln	2.962GlnAla: 2.962 ± 0.086	0.175GlnCys: 0.175 ± 0.016	1.226GlnAsp: 1.226 ± 0.044	1.411GlnGlu: 1.411 ± 0.051	0.775GlnPhe: 0.775 ± 0.04	1.903GlnGly: 1.903 ± 0.061	0.452GlnHis: 0.452 ± 0.027	1.27GlnIle: 1.27 ± 0.045	0.815GlnLys: 0.815 ± 0.038	2.763GlnLeu: 2.763 ± 0.071	0.734GlnMet: 0.734 ± 0.039	0.607GlnAsn: 0.607 ± 0.032	1.376GlnPro: 1.376 ± 0.063	0.995GlnGln: 0.995 ± 0.052	2.047GlnArg: 2.047 ± 0.061	1.305GlnSer: 1.305 ± 0.053	1.258GlnThr: 1.258 ± 0.044	2.202GlnVal: 2.202 ± 0.058	0.44GlnTrp: 0.44 ± 0.025	0.53GlnTyr: 0.53 ± 0.033	0.005GlnXaa: 0.005 ± 0.003
Arg	8.434ArgAla: 8.434 ± 0.145	0.427ArgCys: 0.427 ± 0.03	4.911ArgAsp: 4.911 ± 0.101	4.701ArgGlu: 4.701 ± 0.096	2.126ArgPhe: 2.126 ± 0.061	5.821ArgGly: 5.821 ± 0.115	1.601ArgHis: 1.601 ± 0.056	3.667ArgIle: 3.667 ± 0.085	1.964ArgLys: 1.964 ± 0.06	6.335ArgLeu: 6.335 ± 0.106	1.996ArgMet: 1.996 ± 0.056	1.726ArgAsn: 1.726 ± 0.052	3.693ArgPro: 3.693 ± 0.08	1.867ArgGln: 1.867 ± 0.066	6.837ArgArg: 6.837 ± 0.139	3.383ArgSer: 3.383 ± 0.075	3.917ArgThr: 3.917 ± 0.09	5.44ArgVal: 5.44 ± 0.098	1.057ArgTrp: 1.057 ± 0.041	1.567ArgTyr: 1.567 ± 0.052	0.003ArgXaa: 0.003 ± 0.002
Ser	6.236SerAla: 6.236 ± 0.109	0.31SerCys: 0.31 ± 0.02	3.399SerAsp: 3.399 ± 0.088	2.766SerGlu: 2.766 ± 0.063	1.533SerPhe: 1.533 ± 0.045	5.688SerGly: 5.688 ± 0.116	0.977SerHis: 0.977 ± 0.042	2.21SerIle: 2.21 ± 0.059	1.363SerLys: 1.363 ± 0.053	4.466SerLeu: 4.466 ± 0.087	1.323SerMet: 1.323 ± 0.057	1.16SerAsn: 1.16 ± 0.049	2.864SerPro: 2.864 ± 0.07	1.271SerGln: 1.271 ± 0.051	3.579SerArg: 3.579 ± 0.091	2.938SerSer: 2.938 ± 0.084	3.201SerThr: 3.201 ± 0.068	4.175SerVal: 4.175 ± 0.082	0.773SerTrp: 0.773 ± 0.037	1.021SerTyr: 1.021 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.964ThrAla: 6.964 ± 0.119	0.472ThrCys: 0.472 ± 0.034	3.515ThrAsp: 3.515 ± 0.079	2.991ThrGlu: 2.991 ± 0.067	1.737ThrPhe: 1.737 ± 0.055	5.855ThrGly: 5.855 ± 0.107	1.104ThrHis: 1.104 ± 0.048	2.689ThrIle: 2.689 ± 0.068	1.305ThrLys: 1.305 ± 0.051	5.14ThrLeu: 5.14 ± 0.097	1.31ThrMet: 1.31 ± 0.05	1.205ThrAsn: 1.205 ± 0.041	3.64ThrPro: 3.64 ± 0.073	1.21ThrGln: 1.21 ± 0.055	3.452ThrArg: 3.452 ± 0.074	3.007ThrSer: 3.007 ± 0.064	3.565ThrThr: 3.565 ± 0.102	5.664ThrVal: 5.664 ± 0.108	0.974ThrTrp: 0.974 ± 0.045	1.083ThrTyr: 1.083 ± 0.045	0.005ThrXaa: 0.005 ± 0.002
Val	10.98ValAla: 10.98 ± 0.153	0.649ValCys: 0.649 ± 0.035	6.779ValAsp: 6.779 ± 0.117	5.422ValGlu: 5.422 ± 0.1	2.395ValPhe: 2.395 ± 0.069	7.169ValGly: 7.169 ± 0.125	1.776ValHis: 1.776 ± 0.056	4.243ValIle: 4.243 ± 0.099	2.049ValLys: 2.049 ± 0.069	7.97ValLeu: 7.97 ± 0.136	1.671ValMet: 1.671 ± 0.051	1.901ValAsn: 1.901 ± 0.055	4.765ValPro: 4.765 ± 0.089	1.84ValGln: 1.84 ± 0.049	5.771ValArg: 5.771 ± 0.109	4.389ValSer: 4.389 ± 0.084	5.591ValThr: 5.591 ± 0.096	8.057ValVal: 8.057 ± 0.136	0.992ValTrp: 0.992 ± 0.041	1.336ValTyr: 1.336 ± 0.044	0.005ValXaa: 0.005 ± 0.003
Trp	1.63TrpAla: 1.63 ± 0.053	0.137TrpCys: 0.137 ± 0.014	0.751TrpAsp: 0.751 ± 0.036	0.718TrpGlu: 0.718 ± 0.031	0.553TrpPhe: 0.553 ± 0.032	1.072TrpGly: 1.072 ± 0.048	0.286TrpHis: 0.286 ± 0.022	0.657TrpIle: 0.657 ± 0.035	0.366TrpLys: 0.366 ± 0.025	1.469TrpLeu: 1.469 ± 0.059	0.355TrpMet: 0.355 ± 0.026	0.456TrpAsn: 0.456 ± 0.028	0.718TrpPro: 0.718 ± 0.037	0.373TrpGln: 0.373 ± 0.026	1.199TrpArg: 1.199 ± 0.045	0.797TrpSer: 0.797 ± 0.036	0.842TrpThr: 0.842 ± 0.032	1.07TrpVal: 1.07 ± 0.046	0.318TrpTrp: 0.318 ± 0.023	0.284TrpTyr: 0.284 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.168TyrAla: 2.168 ± 0.063	0.167TyrCys: 0.167 ± 0.015	1.456TyrAsp: 1.456 ± 0.056	1.111TyrGlu: 1.111 ± 0.046	0.691TyrPhe: 0.691 ± 0.036	1.917TyrGly: 1.917 ± 0.062	0.362TyrHis: 0.362 ± 0.028	0.697TyrIle: 0.697 ± 0.033	0.439TyrLys: 0.439 ± 0.028	1.937TyrLeu: 1.937 ± 0.066	0.329TyrMet: 0.329 ± 0.026	0.413TyrAsn: 0.413 ± 0.026	1.072TyrPro: 1.072 ± 0.045	0.564TyrGln: 0.564 ± 0.031	1.577TyrArg: 1.577 ± 0.055	1.115TyrSer: 1.115 ± 0.039	0.91TyrThr: 0.91 ± 0.04	1.586TyrVal: 1.586 ± 0.056	0.292TyrTrp: 0.292 ± 0.022	0.4TyrTyr: 0.4 ± 0.025	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.005XaaAsp: 0.005 ± 0.003	0.003XaaGlu: 0.003 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.005XaaGly: 0.005 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.003XaaLys: 0.003 ± 0.002	0.003XaaLeu: 0.003 ± 0.003	0.002XaaMet: 0.002 ± 0.002	0.003XaaAsn: 0.003 ± 0.003	0.008XaaPro: 0.008 ± 0.005	0.0XaaGln: 0.0 ± 0.0	0.006XaaArg: 0.006 ± 0.003	0.0XaaSer: 0.0 ± 0.0	0.01XaaThr: 0.01 ± 0.005	0.011XaaVal: 0.011 ± 0.005	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 1898 proteins (622226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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