Amino acid dipepetide frequency for Feline coronavirus UU30

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.116AlaAla: 4.116 ± 1.112
2.47AlaCys: 2.47 ± 0.551
2.545AlaAsp: 2.545 ± 0.5
2.62AlaGlu: 2.62 ± 0.568
3.967AlaPhe: 3.967 ± 1.36
3.143AlaGly: 3.143 ± 0.644
0.823AlaHis: 0.823 ± 0.232
5.164AlaIle: 5.164 ± 1.142
4.715AlaLys: 4.715 ± 0.983
5.015AlaLeu: 5.015 ± 0.878
1.422AlaMet: 1.422 ± 0.251
3.892AlaAsn: 3.892 ± 0.897
1.796AlaPro: 1.796 ± 0.511
1.198AlaGln: 1.198 ± 0.447
2.769AlaArg: 2.769 ± 0.841
4.266AlaSer: 4.266 ± 0.755
2.919AlaThr: 2.919 ± 0.671
5.164AlaVal: 5.164 ± 0.713
0.674AlaTrp: 0.674 ± 0.196
4.266AlaTyr: 4.266 ± 2.166
0.0AlaXaa: 0.0 ± 0.0
Cys
1.572CysAla: 1.572 ± 0.375
1.048CysCys: 1.048 ± 0.601
2.395CysAsp: 2.395 ± 0.689
0.748CysGlu: 0.748 ± 0.281
1.422CysPhe: 1.422 ± 0.359
2.844CysGly: 2.844 ± 0.844
0.449CysHis: 0.449 ± 0.219
2.021CysIle: 2.021 ± 0.649
1.572CysLys: 1.572 ± 0.537
2.245CysLeu: 2.245 ± 0.442
0.674CysMet: 0.674 ± 0.607
1.647CysAsn: 1.647 ± 0.527
1.272CysPro: 1.272 ± 0.275
0.524CysGln: 0.524 ± 0.363
0.599CysArg: 0.599 ± 0.242
1.796CysSer: 1.796 ± 0.527
2.021CysThr: 2.021 ± 0.6
2.994CysVal: 2.994 ± 0.362
0.524CysTrp: 0.524 ± 0.211
2.395CysTyr: 2.395 ± 0.645
0.0CysXaa: 0.0 ± 0.0
Asp
4.116AspAla: 4.116 ± 0.987
1.721AspCys: 1.721 ± 0.469
2.994AspAsp: 2.994 ± 0.525
2.245AspGlu: 2.245 ± 0.832
3.742AspPhe: 3.742 ± 0.635
4.116AspGly: 4.116 ± 0.633
1.347AspHis: 1.347 ± 0.594
2.32AspIle: 2.32 ± 0.464
3.143AspLys: 3.143 ± 0.748
5.763AspLeu: 5.763 ± 0.72
1.347AspMet: 1.347 ± 0.39
3.143AspAsn: 3.143 ± 0.509
1.422AspPro: 1.422 ± 0.596
0.898AspGln: 0.898 ± 0.451
1.946AspArg: 1.946 ± 0.418
3.667AspSer: 3.667 ± 0.302
2.994AspThr: 2.994 ± 0.735
6.511AspVal: 6.511 ± 1.503
0.973AspTrp: 0.973 ± 0.314
3.518AspTyr: 3.518 ± 0.682
0.0AspXaa: 0.0 ± 0.0
Glu
2.395GluAla: 2.395 ± 1.118
1.347GluCys: 1.347 ± 0.33
3.518GluAsp: 3.518 ± 0.87
2.994GluGlu: 2.994 ± 0.717
2.62GluPhe: 2.62 ± 0.803
2.769GluGly: 2.769 ± 0.699
1.497GluHis: 1.497 ± 0.599
2.17GluIle: 2.17 ± 0.938
2.62GluLys: 2.62 ± 0.421
3.892GluLeu: 3.892 ± 0.49
0.524GluMet: 0.524 ± 0.25
2.096GluAsn: 2.096 ± 0.679
1.272GluPro: 1.272 ± 0.423
2.32GluGln: 2.32 ± 0.405
2.021GluArg: 2.021 ± 0.814
3.518GluSer: 3.518 ± 0.407
2.096GluThr: 2.096 ± 0.32
3.967GluVal: 3.967 ± 1.122
0.374GluTrp: 0.374 ± 0.214
1.647GluTyr: 1.647 ± 0.331
0.0GluXaa: 0.0 ± 0.0
Phe
3.143PheAla: 3.143 ± 0.706
1.572PheCys: 1.572 ± 0.421
4.042PheAsp: 4.042 ± 0.713
3.143PheGlu: 3.143 ± 0.525
2.769PhePhe: 2.769 ± 0.678
3.443PheGly: 3.443 ± 0.388
0.15PheHis: 0.15 ± 0.118
3.218PheIle: 3.218 ± 0.723
4.266PheLys: 4.266 ± 1.066
3.518PheLeu: 3.518 ± 0.381
1.422PheMet: 1.422 ± 0.562
4.191PheAsn: 4.191 ± 1.049
0.449PhePro: 0.449 ± 0.617
1.123PheGln: 1.123 ± 1.285
0.748PheArg: 0.748 ± 0.301
3.742PheSer: 3.742 ± 1.239
3.218PheThr: 3.218 ± 0.786
7.035PheVal: 7.035 ± 1.184
0.973PheTrp: 0.973 ± 0.746
3.667PheTyr: 3.667 ± 0.792
0.0PheXaa: 0.0 ± 0.0
Gly
4.042GlyAla: 4.042 ± 0.596
1.721GlyCys: 1.721 ± 0.439
4.94GlyAsp: 4.94 ± 0.827
3.593GlyGlu: 3.593 ± 0.694
4.94GlyPhe: 4.94 ± 0.454
3.368GlyGly: 3.368 ± 0.727
0.599GlyHis: 0.599 ± 0.211
2.844GlyIle: 2.844 ± 0.277
4.79GlyLys: 4.79 ± 0.751
4.491GlyLeu: 4.491 ± 0.834
1.347GlyMet: 1.347 ± 0.573
3.143GlyAsn: 3.143 ± 0.362
1.347GlyPro: 1.347 ± 0.512
0.748GlyGln: 0.748 ± 0.491
1.422GlyArg: 1.422 ± 1.405
4.94GlySer: 4.94 ± 0.994
4.341GlyThr: 4.341 ± 0.48
5.763GlyVal: 5.763 ± 1.108
0.299GlyTrp: 0.299 ± 0.347
2.844GlyTyr: 2.844 ± 0.467
0.0GlyXaa: 0.0 ± 0.0
His
0.973HisAla: 0.973 ± 0.757
0.449HisCys: 0.449 ± 0.16
1.198HisAsp: 1.198 ± 0.603
0.748HisGlu: 0.748 ± 0.685
1.272HisPhe: 1.272 ± 0.313
0.823HisGly: 0.823 ± 0.798
0.374HisHis: 0.374 ± 0.229
1.048HisIle: 1.048 ± 0.242
1.647HisLys: 1.647 ± 0.456
1.721HisLeu: 1.721 ± 0.625
0.299HisMet: 0.299 ± 0.353
1.497HisAsn: 1.497 ± 0.509
0.524HisPro: 0.524 ± 0.206
0.299HisGln: 0.299 ± 0.209
0.225HisArg: 0.225 ± 0.093
0.599HisSer: 0.599 ± 0.318
0.973HisThr: 0.973 ± 0.806
2.021HisVal: 2.021 ± 0.587
0.15HisTrp: 0.15 ± 0.118
0.748HisTyr: 0.748 ± 0.316
0.0HisXaa: 0.0 ± 0.0
Ile
4.715IleAla: 4.715 ± 1.003
1.048IleCys: 1.048 ± 0.333
2.47IleAsp: 2.47 ± 0.76
2.395IleGlu: 2.395 ± 0.368
2.62IlePhe: 2.62 ± 0.434
3.667IleGly: 3.667 ± 0.65
0.674IleHis: 0.674 ± 0.336
2.694IleIle: 2.694 ± 2.557
3.368IleLys: 3.368 ± 1.209
5.015IleLeu: 5.015 ± 1.552
1.647IleMet: 1.647 ± 0.331
2.919IleAsn: 2.919 ± 0.622
2.245IlePro: 2.245 ± 0.441
1.347IleGln: 1.347 ± 0.348
1.647IleArg: 1.647 ± 0.505
2.694IleSer: 2.694 ± 0.674
3.817IleThr: 3.817 ± 1.498
6.586IleVal: 6.586 ± 1.105
0.449IleTrp: 0.449 ± 0.285
1.946IleTyr: 1.946 ± 0.418
0.0IleXaa: 0.0 ± 0.0
Lys
4.191LysAla: 4.191 ± 1.004
2.994LysCys: 2.994 ± 0.574
3.892LysAsp: 3.892 ± 0.759
2.694LysGlu: 2.694 ± 0.859
2.769LysPhe: 2.769 ± 0.593
2.62LysGly: 2.62 ± 0.876
1.946LysHis: 1.946 ± 0.637
4.116LysIle: 4.116 ± 0.733
2.769LysLys: 2.769 ± 0.631
6.362LysLeu: 6.362 ± 1.199
2.021LysMet: 2.021 ± 0.578
4.042LysAsn: 4.042 ± 0.785
3.742LysPro: 3.742 ± 0.779
2.769LysGln: 2.769 ± 0.53
1.721LysArg: 1.721 ± 1.014
4.341LysSer: 4.341 ± 0.448
3.967LysThr: 3.967 ± 0.93
5.239LysVal: 5.239 ± 0.732
0.449LysTrp: 0.449 ± 0.337
3.368LysTyr: 3.368 ± 0.534
0.0LysXaa: 0.0 ± 0.0
Leu
4.715LeuAla: 4.715 ± 0.72
3.143LeuCys: 3.143 ± 0.731
3.593LeuAsp: 3.593 ± 1.051
5.613LeuGlu: 5.613 ± 0.874
4.491LeuPhe: 4.491 ± 0.777
5.688LeuGly: 5.688 ± 0.757
1.497LeuHis: 1.497 ± 0.777
3.667LeuIle: 3.667 ± 1.727
6.886LeuLys: 6.886 ± 1.384
8.308LeuLeu: 8.308 ± 3.293
1.422LeuMet: 1.422 ± 0.342
5.389LeuAsn: 5.389 ± 0.715
3.742LeuPro: 3.742 ± 1.278
4.116LeuGln: 4.116 ± 0.725
2.245LeuArg: 2.245 ± 1.228
5.314LeuSer: 5.314 ± 0.378
5.164LeuThr: 5.164 ± 0.847
6.137LeuVal: 6.137 ± 1.134
1.497LeuTrp: 1.497 ± 0.545
3.293LeuTyr: 3.293 ± 0.649
0.0LeuXaa: 0.0 ± 0.0
Met
2.17MetAla: 2.17 ± 0.247
0.973MetCys: 0.973 ± 0.411
0.898MetAsp: 0.898 ± 0.303
0.15MetGlu: 0.15 ± 0.118
0.449MetPhe: 0.449 ± 0.869
1.048MetGly: 1.048 ± 0.453
0.748MetHis: 0.748 ± 0.301
1.422MetIle: 1.422 ± 0.369
0.599MetLys: 0.599 ± 0.276
3.143MetLeu: 3.143 ± 0.337
0.524MetMet: 0.524 ± 0.834
0.449MetAsn: 0.449 ± 0.271
1.272MetPro: 1.272 ± 0.319
1.048MetGln: 1.048 ± 0.783
1.048MetArg: 1.048 ± 0.453
1.572MetSer: 1.572 ± 0.472
1.422MetThr: 1.422 ± 0.596
1.946MetVal: 1.946 ± 1.316
0.075MetTrp: 0.075 ± 0.36
1.198MetTyr: 1.198 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
3.967AsnAla: 3.967 ± 0.837
1.796AsnCys: 1.796 ± 0.302
2.096AsnAsp: 2.096 ± 0.612
2.395AsnGlu: 2.395 ± 0.619
2.769AsnPhe: 2.769 ± 0.468
5.988AsnGly: 5.988 ± 1.341
0.823AsnHis: 0.823 ± 0.206
2.919AsnIle: 2.919 ± 0.62
2.694AsnLys: 2.694 ± 0.723
4.566AsnLeu: 4.566 ± 0.771
1.572AsnMet: 1.572 ± 0.412
4.566AsnAsn: 4.566 ± 0.752
1.647AsnPro: 1.647 ± 1.237
1.272AsnGln: 1.272 ± 0.847
1.647AsnArg: 1.647 ± 0.802
4.79AsnSer: 4.79 ± 0.927
3.293AsnThr: 3.293 ± 0.992
6.961AsnVal: 6.961 ± 1.303
0.524AsnTrp: 0.524 ± 0.699
1.946AsnTyr: 1.946 ± 0.659
0.0AsnXaa: 0.0 ± 0.0
Pro
2.245ProAla: 2.245 ± 0.617
0.599ProCys: 0.599 ± 0.171
2.096ProAsp: 2.096 ± 0.728
1.647ProGlu: 1.647 ± 0.383
1.871ProPhe: 1.871 ± 0.462
2.47ProGly: 2.47 ± 0.518
0.599ProHis: 0.599 ± 0.205
1.497ProIle: 1.497 ± 0.236
2.021ProLys: 2.021 ± 0.93
2.62ProLeu: 2.62 ± 0.562
0.15ProMet: 0.15 ± 0.097
1.272ProAsn: 1.272 ± 0.343
1.198ProPro: 1.198 ± 0.369
1.422ProGln: 1.422 ± 0.674
1.048ProArg: 1.048 ± 0.782
2.769ProSer: 2.769 ± 0.601
2.769ProThr: 2.769 ± 0.315
3.293ProVal: 3.293 ± 0.694
0.823ProTrp: 0.823 ± 0.248
0.898ProTyr: 0.898 ± 0.277
0.0ProXaa: 0.0 ± 0.0
Gln
2.395GlnAla: 2.395 ± 0.677
0.449GlnCys: 0.449 ± 0.214
1.347GlnAsp: 1.347 ± 0.26
1.198GlnGlu: 1.198 ± 0.35
1.572GlnPhe: 1.572 ± 0.978
1.946GlnGly: 1.946 ± 0.37
0.524GlnHis: 0.524 ± 0.772
1.422GlnIle: 1.422 ± 1.195
1.796GlnLys: 1.796 ± 0.328
3.593GlnLeu: 3.593 ± 1.091
0.524GlnMet: 0.524 ± 0.201
0.898GlnAsn: 0.898 ± 0.343
1.497GlnPro: 1.497 ± 0.421
0.973GlnGln: 0.973 ± 0.486
1.497GlnArg: 1.497 ± 1.363
1.721GlnSer: 1.721 ± 0.624
1.946GlnThr: 1.946 ± 0.675
2.395GlnVal: 2.395 ± 0.835
0.299GlnTrp: 0.299 ± 0.27
1.871GlnTyr: 1.871 ± 0.724
0.0GlnXaa: 0.0 ± 0.0
Arg
1.721ArgAla: 1.721 ± 0.656
1.123ArgCys: 1.123 ± 0.545
1.871ArgAsp: 1.871 ± 0.708
0.973ArgGlu: 0.973 ± 0.2
2.32ArgPhe: 2.32 ± 0.582
1.647ArgGly: 1.647 ± 0.975
0.374ArgHis: 0.374 ± 0.724
1.721ArgIle: 1.721 ± 0.545
2.47ArgLys: 2.47 ± 0.949
2.62ArgLeu: 2.62 ± 1.235
0.374ArgMet: 0.374 ± 0.182
2.021ArgAsn: 2.021 ± 0.59
0.748ArgPro: 0.748 ± 0.646
1.272ArgGln: 1.272 ± 0.699
1.497ArgArg: 1.497 ± 0.439
2.545ArgSer: 2.545 ± 2.958
1.946ArgThr: 1.946 ± 0.769
2.395ArgVal: 2.395 ± 0.834
0.374ArgTrp: 0.374 ± 0.25
0.748ArgTyr: 0.748 ± 0.745
0.0ArgXaa: 0.0 ± 0.0
Ser
4.865SerAla: 4.865 ± 1.001
0.898SerCys: 0.898 ± 0.371
4.566SerAsp: 4.566 ± 1.11
1.946SerGlu: 1.946 ± 0.536
3.368SerPhe: 3.368 ± 0.508
4.266SerGly: 4.266 ± 0.611
0.973SerHis: 0.973 ± 0.275
3.742SerIle: 3.742 ± 1.222
4.042SerLys: 4.042 ± 1.433
5.464SerLeu: 5.464 ± 1.366
1.721SerMet: 1.721 ± 0.367
3.368SerAsn: 3.368 ± 0.838
1.572SerPro: 1.572 ± 0.368
2.545SerGln: 2.545 ± 1.074
2.021SerArg: 2.021 ± 2.143
4.865SerSer: 4.865 ± 1.154
3.293SerThr: 3.293 ± 0.492
8.682SerVal: 8.682 ± 1.451
1.048SerTrp: 1.048 ± 1.073
3.817SerTyr: 3.817 ± 0.852
0.0SerXaa: 0.0 ± 0.0
Thr
3.742ThrAla: 3.742 ± 0.481
2.245ThrCys: 2.245 ± 0.696
3.143ThrAsp: 3.143 ± 1.035
2.32ThrGlu: 2.32 ± 0.395
3.443ThrPhe: 3.443 ± 0.909
3.593ThrGly: 3.593 ± 0.813
0.973ThrHis: 0.973 ± 0.404
4.266ThrIle: 4.266 ± 1.585
2.844ThrLys: 2.844 ± 0.689
5.464ThrLeu: 5.464 ± 0.739
1.497ThrMet: 1.497 ± 0.502
3.518ThrAsn: 3.518 ± 0.813
3.293ThrPro: 3.293 ± 0.494
2.245ThrGln: 2.245 ± 0.442
1.497ThrArg: 1.497 ± 0.367
3.967ThrSer: 3.967 ± 1.135
5.539ThrThr: 5.539 ± 0.568
6.137ThrVal: 6.137 ± 0.536
1.123ThrTrp: 1.123 ± 0.589
2.395ThrTyr: 2.395 ± 0.832
0.0ThrXaa: 0.0 ± 0.0
Val
4.341ValAla: 4.341 ± 0.654
3.218ValCys: 3.218 ± 0.832
5.464ValAsp: 5.464 ± 1.037
5.838ValGlu: 5.838 ± 1.164
5.164ValPhe: 5.164 ± 0.611
4.116ValGly: 4.116 ± 0.78
1.946ValHis: 1.946 ± 0.548
4.94ValIle: 4.94 ± 0.942
9.505ValLys: 9.505 ± 2.001
8.607ValLeu: 8.607 ± 1.719
1.796ValMet: 1.796 ± 1.387
6.586ValAsn: 6.586 ± 1.01
2.47ValPro: 2.47 ± 0.681
2.47ValGln: 2.47 ± 0.556
3.069ValArg: 3.069 ± 0.488
6.362ValSer: 6.362 ± 1.185
7.484ValThr: 7.484 ± 0.85
9.655ValVal: 9.655 ± 1.825
0.823ValTrp: 0.823 ± 0.243
3.742ValTyr: 3.742 ± 0.898
0.0ValXaa: 0.0 ± 0.0
Trp
0.299TrpAla: 0.299 ± 0.306
0.299TrpCys: 0.299 ± 0.135
1.123TrpAsp: 1.123 ± 0.366
0.374TrpGlu: 0.374 ± 0.229
1.347TrpPhe: 1.347 ± 0.324
0.15TrpGly: 0.15 ± 0.274
0.225TrpHis: 0.225 ± 0.367
0.748TrpIle: 0.748 ± 0.221
0.599TrpLys: 0.599 ± 0.214
1.272TrpLeu: 1.272 ± 1.022
0.225TrpMet: 0.225 ± 0.367
1.272TrpAsn: 1.272 ± 0.302
0.524TrpPro: 0.524 ± 0.455
0.15TrpGln: 0.15 ± 0.118
0.449TrpArg: 0.449 ± 0.16
1.123TrpSer: 1.123 ± 0.868
0.599TrpThr: 0.599 ± 0.21
0.524TrpVal: 0.524 ± 0.244
0.075TrpTrp: 0.075 ± 0.36
0.524TrpTyr: 0.524 ± 0.209
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.218TyrAla: 3.218 ± 0.594
1.647TyrCys: 1.647 ± 0.571
3.742TyrAsp: 3.742 ± 0.851
2.021TyrGlu: 2.021 ± 0.644
2.919TyrPhe: 2.919 ± 0.387
3.817TyrGly: 3.817 ± 0.639
1.048TyrHis: 1.048 ± 0.242
2.021TyrIle: 2.021 ± 0.524
3.667TyrLys: 3.667 ± 0.531
2.32TyrLeu: 2.32 ± 0.498
1.572TyrMet: 1.572 ± 0.494
2.32TyrAsn: 2.32 ± 1.014
1.272TyrPro: 1.272 ± 0.476
1.123TyrGln: 1.123 ± 0.328
1.647TyrArg: 1.647 ± 0.723
2.47TyrSer: 2.47 ± 0.698
3.443TyrThr: 3.443 ± 0.999
4.191TyrVal: 4.191 ± 1.287
0.374TyrTrp: 0.374 ± 0.242
2.919TyrTyr: 2.919 ± 0.521
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (13362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski