Amino acid dipepetide frequency for Sanguibacter antarcticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.447AlaAla: 19.447 ± 0.239
0.853AlaCys: 0.853 ± 0.03
8.249AlaAsp: 8.249 ± 0.1
7.285AlaGlu: 7.285 ± 0.095
3.463AlaPhe: 3.463 ± 0.058
12.3AlaGly: 12.3 ± 0.127
2.755AlaHis: 2.755 ± 0.057
4.654AlaIle: 4.654 ± 0.077
2.083AlaLys: 2.083 ± 0.064
14.492AlaLeu: 14.492 ± 0.15
2.46AlaMet: 2.46 ± 0.055
2.09AlaAsn: 2.09 ± 0.047
7.019AlaPro: 7.019 ± 0.103
4.151AlaGln: 4.151 ± 0.077
9.921AlaArg: 9.921 ± 0.129
7.771AlaSer: 7.771 ± 0.105
8.191AlaThr: 8.191 ± 0.104
12.337AlaVal: 12.337 ± 0.135
1.819AlaTrp: 1.819 ± 0.041
2.277AlaTyr: 2.277 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.819CysAla: 0.819 ± 0.025
0.059CysCys: 0.059 ± 0.008
0.358CysAsp: 0.358 ± 0.018
0.319CysGlu: 0.319 ± 0.016
0.179CysPhe: 0.179 ± 0.014
0.69CysGly: 0.69 ± 0.024
0.145CysHis: 0.145 ± 0.012
0.206CysIle: 0.206 ± 0.015
0.084CysLys: 0.084 ± 0.009
0.529CysLeu: 0.529 ± 0.022
0.08CysMet: 0.08 ± 0.008
0.122CysAsn: 0.122 ± 0.013
0.373CysPro: 0.373 ± 0.019
0.146CysGln: 0.146 ± 0.012
0.401CysArg: 0.401 ± 0.019
0.462CysSer: 0.462 ± 0.023
0.49CysThr: 0.49 ± 0.021
0.567CysVal: 0.567 ± 0.024
0.082CysTrp: 0.082 ± 0.009
0.135CysTyr: 0.135 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
9.055AspAla: 9.055 ± 0.102
0.307AspCys: 0.307 ± 0.018
4.757AspAsp: 4.757 ± 0.071
4.488AspGlu: 4.488 ± 0.076
1.463AspPhe: 1.463 ± 0.041
6.636AspGly: 6.636 ± 0.098
1.321AspHis: 1.321 ± 0.037
2.057AspIle: 2.057 ± 0.041
0.887AspLys: 0.887 ± 0.035
7.273AspLeu: 7.273 ± 0.092
0.816AspMet: 0.816 ± 0.029
0.838AspAsn: 0.838 ± 0.032
4.188AspPro: 4.188 ± 0.071
1.633AspGln: 1.633 ± 0.04
4.118AspArg: 4.118 ± 0.064
2.836AspSer: 2.836 ± 0.051
3.088AspThr: 3.088 ± 0.057
6.551AspVal: 6.551 ± 0.081
0.825AspTrp: 0.825 ± 0.028
1.144AspTyr: 1.144 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.638GluAla: 6.638 ± 0.101
0.315GluCys: 0.315 ± 0.019
2.829GluAsp: 2.829 ± 0.066
2.683GluGlu: 2.683 ± 0.055
1.218GluPhe: 1.218 ± 0.04
3.724GluGly: 3.724 ± 0.075
1.798GluHis: 1.798 ± 0.046
2.853GluIle: 2.853 ± 0.061
1.159GluLys: 1.159 ± 0.04
5.96GluLeu: 5.96 ± 0.1
1.032GluMet: 1.032 ± 0.037
1.132GluAsn: 1.132 ± 0.037
3.267GluPro: 3.267 ± 0.066
2.072GluGln: 2.072 ± 0.045
4.721GluArg: 4.721 ± 0.083
2.967GluSer: 2.967 ± 0.048
3.398GluThr: 3.398 ± 0.058
4.887GluVal: 4.887 ± 0.076
0.677GluTrp: 0.677 ± 0.028
0.968GluTyr: 0.968 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.581PheAla: 3.581 ± 0.061
0.221PheCys: 0.221 ± 0.016
2.0PheAsp: 2.0 ± 0.043
1.463PheGlu: 1.463 ± 0.039
0.903PhePhe: 0.903 ± 0.033
2.761PheGly: 2.761 ± 0.051
0.531PheHis: 0.531 ± 0.023
0.886PheIle: 0.886 ± 0.029
0.443PheLys: 0.443 ± 0.021
2.526PheLeu: 2.526 ± 0.051
0.422PheMet: 0.422 ± 0.023
0.559PheAsn: 0.559 ± 0.025
1.203PhePro: 1.203 ± 0.041
0.641PheGln: 0.641 ± 0.025
1.505PheArg: 1.505 ± 0.04
1.672PheSer: 1.672 ± 0.039
1.945PheThr: 1.945 ± 0.044
2.746PheVal: 2.746 ± 0.058
0.415PheTrp: 0.415 ± 0.023
0.567PheTyr: 0.567 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
11.319GlyAla: 11.319 ± 0.151
0.661GlyCys: 0.661 ± 0.029
5.016GlyAsp: 5.016 ± 0.067
4.501GlyGlu: 4.501 ± 0.067
2.806GlyPhe: 2.806 ± 0.056
7.431GlyGly: 7.431 ± 0.105
1.945GlyHis: 1.945 ± 0.047
3.957GlyIle: 3.957 ± 0.065
1.856GlyLys: 1.856 ± 0.05
9.173GlyLeu: 9.173 ± 0.102
1.953GlyMet: 1.953 ± 0.042
1.445GlyAsn: 1.445 ± 0.043
4.321GlyPro: 4.321 ± 0.065
2.483GlyGln: 2.483 ± 0.053
6.398GlyArg: 6.398 ± 0.087
5.707GlySer: 5.707 ± 0.082
6.504GlyThr: 6.504 ± 0.102
7.917GlyVal: 7.917 ± 0.098
1.647GlyTrp: 1.647 ± 0.04
2.108GlyTyr: 2.108 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.601HisAla: 2.601 ± 0.052
0.134HisCys: 0.134 ± 0.012
1.557HisAsp: 1.557 ± 0.042
1.285HisGlu: 1.285 ± 0.041
0.488HisPhe: 0.488 ± 0.02
2.123HisGly: 2.123 ± 0.048
0.604HisHis: 0.604 ± 0.028
0.615HisIle: 0.615 ± 0.026
0.289HisLys: 0.289 ± 0.018
2.258HisLeu: 2.258 ± 0.054
0.305HisMet: 0.305 ± 0.017
0.33HisAsn: 0.33 ± 0.02
1.484HisPro: 1.484 ± 0.038
0.589HisGln: 0.589 ± 0.025
1.646HisArg: 1.646 ± 0.043
0.995HisSer: 0.995 ± 0.029
1.204HisThr: 1.204 ± 0.042
2.083HisVal: 2.083 ± 0.043
0.247HisTrp: 0.247 ± 0.017
0.377HisTyr: 0.377 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.29IleAla: 5.29 ± 0.078
0.217IleCys: 0.217 ± 0.016
3.087IleAsp: 3.087 ± 0.052
2.432IleGlu: 2.432 ± 0.048
0.938IlePhe: 0.938 ± 0.034
3.731IleGly: 3.731 ± 0.064
0.617IleHis: 0.617 ± 0.027
1.411IleIle: 1.411 ± 0.043
0.727IleLys: 0.727 ± 0.03
3.19IleLeu: 3.19 ± 0.062
0.597IleMet: 0.597 ± 0.027
0.778IleAsn: 0.778 ± 0.034
1.842IlePro: 1.842 ± 0.047
0.771IleGln: 0.771 ± 0.029
2.041IleArg: 2.041 ± 0.042
2.029IleSer: 2.029 ± 0.048
2.705IleThr: 2.705 ± 0.052
3.917IleVal: 3.917 ± 0.072
0.366IleTrp: 0.366 ± 0.017
0.631IleTyr: 0.631 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
2.015LysAla: 2.015 ± 0.058
0.081LysCys: 0.081 ± 0.01
1.038LysAsp: 1.038 ± 0.032
0.82LysGlu: 0.82 ± 0.028
0.433LysPhe: 0.433 ± 0.017
1.303LysGly: 1.303 ± 0.037
0.442LysHis: 0.442 ± 0.023
0.895LysIle: 0.895 ± 0.031
0.578LysLys: 0.578 ± 0.029
1.403LysLeu: 1.403 ± 0.041
0.315LysMet: 0.315 ± 0.018
0.477LysAsn: 0.477 ± 0.02
0.933LysPro: 0.933 ± 0.033
0.522LysGln: 0.522 ± 0.025
1.202LysArg: 1.202 ± 0.036
1.046LysSer: 1.046 ± 0.03
1.13LysThr: 1.13 ± 0.033
1.624LysVal: 1.624 ± 0.044
0.151LysTrp: 0.151 ± 0.015
0.401LysTyr: 0.401 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.137LeuAla: 15.137 ± 0.164
0.657LeuCys: 0.657 ± 0.025
7.428LeuAsp: 7.428 ± 0.096
5.16LeuGlu: 5.16 ± 0.083
2.43LeuPhe: 2.43 ± 0.05
9.268LeuGly: 9.268 ± 0.101
1.933LeuHis: 1.933 ± 0.045
2.772LeuIle: 2.772 ± 0.073
1.488LeuLys: 1.488 ± 0.045
10.216LeuLeu: 10.216 ± 0.127
1.604LeuMet: 1.604 ± 0.046
1.5LeuAsn: 1.5 ± 0.043
5.472LeuPro: 5.472 ± 0.087
2.254LeuGln: 2.254 ± 0.045
7.406LeuArg: 7.406 ± 0.097
5.924LeuSer: 5.924 ± 0.076
6.843LeuThr: 6.843 ± 0.083
11.59LeuVal: 11.59 ± 0.158
1.184LeuTrp: 1.184 ± 0.036
1.564LeuTyr: 1.564 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.05MetAla: 2.05 ± 0.047
0.111MetCys: 0.111 ± 0.01
0.906MetAsp: 0.906 ± 0.033
0.639MetGlu: 0.639 ± 0.028
0.506MetPhe: 0.506 ± 0.025
1.238MetGly: 1.238 ± 0.037
0.359MetHis: 0.359 ± 0.019
0.79MetIle: 0.79 ± 0.032
0.422MetLys: 0.422 ± 0.02
1.894MetLeu: 1.894 ± 0.045
0.287MetMet: 0.287 ± 0.018
0.487MetAsn: 0.487 ± 0.021
1.013MetPro: 1.013 ± 0.033
0.437MetGln: 0.437 ± 0.02
1.305MetArg: 1.305 ± 0.036
1.452MetSer: 1.452 ± 0.036
1.813MetThr: 1.813 ± 0.038
1.514MetVal: 1.514 ± 0.041
0.19MetTrp: 0.19 ± 0.014
0.276MetTyr: 0.276 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.082AsnAla: 2.082 ± 0.048
0.108AsnCys: 0.108 ± 0.01
1.1AsnAsp: 1.1 ± 0.031
0.825AsnGlu: 0.825 ± 0.028
0.47AsnPhe: 0.47 ± 0.021
1.635AsnGly: 1.635 ± 0.041
0.414AsnHis: 0.414 ± 0.02
0.771AsnIle: 0.771 ± 0.03
0.308AsnLys: 0.308 ± 0.018
1.811AsnLeu: 1.811 ± 0.043
0.312AsnMet: 0.312 ± 0.019
0.418AsnAsn: 0.418 ± 0.022
1.243AsnPro: 1.243 ± 0.036
0.476AsnGln: 0.476 ± 0.024
1.085AsnArg: 1.085 ± 0.036
0.831AsnSer: 0.831 ± 0.031
1.029AsnThr: 1.029 ± 0.036
1.568AsnVal: 1.568 ± 0.041
0.205AsnTrp: 0.205 ± 0.014
0.4AsnTyr: 0.4 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.509ProAla: 7.509 ± 0.119
0.236ProCys: 0.236 ± 0.014
4.236ProAsp: 4.236 ± 0.073
3.666ProGlu: 3.666 ± 0.06
1.466ProPhe: 1.466 ± 0.035
5.476ProGly: 5.476 ± 0.08
1.154ProHis: 1.154 ± 0.032
1.565ProIle: 1.565 ± 0.04
0.775ProLys: 0.775 ± 0.032
4.75ProLeu: 4.75 ± 0.07
0.859ProMet: 0.859 ± 0.03
0.805ProAsn: 0.805 ± 0.027
2.539ProPro: 2.539 ± 0.066
1.527ProGln: 1.527 ± 0.038
3.517ProArg: 3.517 ± 0.074
3.646ProSer: 3.646 ± 0.063
3.839ProThr: 3.839 ± 0.073
5.592ProVal: 5.592 ± 0.07
0.891ProTrp: 0.891 ± 0.031
0.936ProTyr: 0.936 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.616GlnAla: 3.616 ± 0.062
0.159GlnCys: 0.159 ± 0.014
1.419GlnAsp: 1.419 ± 0.038
1.292GlnGlu: 1.292 ± 0.037
0.649GlnPhe: 0.649 ± 0.026
2.138GlnGly: 2.138 ± 0.045
0.662GlnHis: 0.662 ± 0.024
1.31GlnIle: 1.31 ± 0.042
0.499GlnLys: 0.499 ± 0.019
2.768GlnLeu: 2.768 ± 0.047
0.579GlnMet: 0.579 ± 0.023
0.526GlnAsn: 0.526 ± 0.025
1.507GlnPro: 1.507 ± 0.042
1.005GlnGln: 1.005 ± 0.035
2.223GlnArg: 2.223 ± 0.054
1.513GlnSer: 1.513 ± 0.043
1.679GlnThr: 1.679 ± 0.043
2.899GlnVal: 2.899 ± 0.056
0.403GlnTrp: 0.403 ± 0.022
0.544GlnTyr: 0.544 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
9.282ArgAla: 9.282 ± 0.121
0.401ArgCys: 0.401 ± 0.02
4.092ArgAsp: 4.092 ± 0.071
3.952ArgGlu: 3.952 ± 0.072
1.995ArgPhe: 1.995 ± 0.047
5.313ArgGly: 5.313 ± 0.073
1.456ArgHis: 1.456 ± 0.041
2.948ArgIle: 2.948 ± 0.057
1.199ArgLys: 1.199 ± 0.033
7.219ArgLeu: 7.219 ± 0.097
1.505ArgMet: 1.505 ± 0.037
1.108ArgAsn: 1.108 ± 0.034
3.922ArgPro: 3.922 ± 0.077
1.945ArgGln: 1.945 ± 0.049
6.423ArgArg: 6.423 ± 0.124
5.048ArgSer: 5.048 ± 0.07
5.249ArgThr: 5.249 ± 0.079
5.723ArgVal: 5.723 ± 0.073
1.254ArgTrp: 1.254 ± 0.039
1.463ArgTyr: 1.463 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
7.872SerAla: 7.872 ± 0.097
0.362SerCys: 0.362 ± 0.018
3.474SerAsp: 3.474 ± 0.065
2.998SerGlu: 2.998 ± 0.051
1.737SerPhe: 1.737 ± 0.041
6.136SerGly: 6.136 ± 0.087
1.068SerHis: 1.068 ± 0.032
2.35SerIle: 2.35 ± 0.055
0.934SerLys: 0.934 ± 0.034
5.586SerLeu: 5.586 ± 0.087
1.313SerMet: 1.313 ± 0.036
0.991SerAsn: 0.991 ± 0.033
3.319SerPro: 3.319 ± 0.06
1.549SerGln: 1.549 ± 0.038
4.084SerArg: 4.084 ± 0.068
4.164SerSer: 4.164 ± 0.074
4.725SerThr: 4.725 ± 0.074
5.408SerVal: 5.408 ± 0.085
0.981SerTrp: 0.981 ± 0.037
1.19SerTyr: 1.19 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
8.393ThrAla: 8.393 ± 0.115
0.388ThrCys: 0.388 ± 0.018
4.259ThrAsp: 4.259 ± 0.071
3.282ThrGlu: 3.282 ± 0.056
2.148ThrPhe: 2.148 ± 0.047
6.358ThrGly: 6.358 ± 0.084
1.292ThrHis: 1.292 ± 0.038
2.873ThrIle: 2.873 ± 0.056
1.093ThrLys: 1.093 ± 0.041
6.388ThrLeu: 6.388 ± 0.089
1.136ThrMet: 1.136 ± 0.033
1.156ThrAsn: 1.156 ± 0.033
4.165ThrPro: 4.165 ± 0.076
1.734ThrGln: 1.734 ± 0.042
3.783ThrArg: 3.783 ± 0.058
4.601ThrSer: 4.601 ± 0.064
5.447ThrThr: 5.447 ± 0.095
7.009ThrVal: 7.009 ± 0.111
1.017ThrTrp: 1.017 ± 0.032
1.37ThrTyr: 1.37 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
12.997ValAla: 12.997 ± 0.137
0.718ValCys: 0.718 ± 0.031
6.42ValAsp: 6.42 ± 0.088
5.48ValGlu: 5.48 ± 0.069
2.572ValPhe: 2.572 ± 0.058
8.109ValGly: 8.109 ± 0.111
2.095ValHis: 2.095 ± 0.045
3.273ValIle: 3.273 ± 0.052
1.401ValLys: 1.401 ± 0.04
10.795ValLeu: 10.795 ± 0.125
1.569ValMet: 1.569 ± 0.041
1.605ValAsn: 1.605 ± 0.038
5.551ValPro: 5.551 ± 0.084
2.454ValGln: 2.454 ± 0.048
7.199ValArg: 7.199 ± 0.097
5.445ValSer: 5.445 ± 0.081
6.391ValThr: 6.391 ± 0.092
11.672ValVal: 11.672 ± 0.151
1.223ValTrp: 1.223 ± 0.038
1.623ValTyr: 1.623 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.595TrpAla: 1.595 ± 0.04
0.134TrpCys: 0.134 ± 0.012
0.807TrpAsp: 0.807 ± 0.032
0.667TrpGlu: 0.667 ± 0.029
0.517TrpPhe: 0.517 ± 0.02
0.994TrpGly: 0.994 ± 0.032
0.317TrpHis: 0.317 ± 0.017
0.58TrpIle: 0.58 ± 0.024
0.261TrpLys: 0.261 ± 0.016
1.578TrpLeu: 1.578 ± 0.042
0.308TrpMet: 0.308 ± 0.018
0.36TrpAsn: 0.36 ± 0.021
0.671TrpPro: 0.671 ± 0.03
0.427TrpGln: 0.427 ± 0.02
1.107TrpArg: 1.107 ± 0.033
1.023TrpSer: 1.023 ± 0.031
1.03TrpThr: 1.03 ± 0.033
1.192TrpVal: 1.192 ± 0.038
0.343TrpTrp: 0.343 ± 0.02
0.282TrpTyr: 0.282 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.317TyrAla: 2.317 ± 0.05
0.129TyrCys: 0.129 ± 0.011
1.246TyrAsp: 1.246 ± 0.037
1.062TyrGlu: 1.062 ± 0.03
0.612TyrPhe: 0.612 ± 0.025
1.784TyrGly: 1.784 ± 0.047
0.305TyrHis: 0.305 ± 0.019
0.55TyrIle: 0.55 ± 0.028
0.323TyrLys: 0.323 ± 0.018
2.026TyrLeu: 2.026 ± 0.049
0.234TyrMet: 0.234 ± 0.014
0.365TyrAsn: 0.365 ± 0.023
0.95TyrPro: 0.95 ± 0.032
0.574TyrGln: 0.574 ± 0.025
1.413TyrArg: 1.413 ± 0.042
1.109TyrSer: 1.109 ± 0.033
1.193TyrThr: 1.193 ± 0.037
1.796TyrVal: 1.796 ± 0.037
0.268TyrTrp: 0.268 ± 0.018
0.42TyrTyr: 0.42 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3108 proteins (1047096 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski