Amino acid dipepetide frequency for Sulfolobus sp. SCGC AB-777_L09

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.736AlaAla: 2.736 ± 0.141
0.359AlaCys: 0.359 ± 0.039
2.343AlaAsp: 2.343 ± 0.107
3.644AlaGlu: 3.644 ± 0.13
2.846AlaPhe: 2.846 ± 0.131
3.673AlaGly: 3.673 ± 0.138
0.811AlaHis: 0.811 ± 0.057
5.51AlaIle: 5.51 ± 0.169
4.269AlaLys: 4.269 ± 0.145
6.481AlaLeu: 6.481 ± 0.2
1.224AlaMet: 1.224 ± 0.078
2.098AlaAsn: 2.098 ± 0.114
1.714AlaPro: 1.714 ± 0.107
1.119AlaGln: 1.119 ± 0.065
2.288AlaArg: 2.288 ± 0.109
3.58AlaSer: 3.58 ± 0.137
2.588AlaThr: 2.588 ± 0.112
4.218AlaVal: 4.218 ± 0.165
0.553AlaTrp: 0.553 ± 0.055
2.888AlaTyr: 2.888 ± 0.11
0.0AlaXaa: 0.0 ± 0.0
Cys
0.182CysAla: 0.182 ± 0.028
0.072CysCys: 0.072 ± 0.019
0.338CysAsp: 0.338 ± 0.034
0.54CysGlu: 0.54 ± 0.056
0.211CysPhe: 0.211 ± 0.027
0.722CysGly: 0.722 ± 0.063
0.11CysHis: 0.11 ± 0.023
0.426CysIle: 0.426 ± 0.041
0.54CysLys: 0.54 ± 0.05
0.464CysLeu: 0.464 ± 0.044
0.135CysMet: 0.135 ± 0.021
0.376CysAsn: 0.376 ± 0.04
0.54CysPro: 0.54 ± 0.053
0.106CysGln: 0.106 ± 0.021
0.236CysArg: 0.236 ± 0.031
0.363CysSer: 0.363 ± 0.039
0.224CysThr: 0.224 ± 0.03
0.46CysVal: 0.46 ± 0.047
0.063CysTrp: 0.063 ± 0.016
0.321CysTyr: 0.321 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
2.402AspAla: 2.402 ± 0.103
0.355AspCys: 0.355 ± 0.041
2.044AspAsp: 2.044 ± 0.104
4.408AspGlu: 4.408 ± 0.15
2.225AspPhe: 2.225 ± 0.11
2.584AspGly: 2.584 ± 0.126
0.566AspHis: 0.566 ± 0.044
4.425AspIle: 4.425 ± 0.132
3.998AspLys: 3.998 ± 0.149
5.189AspLeu: 5.189 ± 0.173
0.988AspMet: 0.988 ± 0.069
1.875AspAsn: 1.875 ± 0.084
2.259AspPro: 2.259 ± 0.111
0.773AspGln: 0.773 ± 0.063
1.651AspArg: 1.651 ± 0.083
2.36AspSer: 2.36 ± 0.108
1.765AspThr: 1.765 ± 0.075
3.838AspVal: 3.838 ± 0.113
0.507AspTrp: 0.507 ± 0.046
2.715AspTyr: 2.715 ± 0.102
0.0AspXaa: 0.0 ± 0.0
Glu
3.694GluAla: 3.694 ± 0.146
0.532GluCys: 0.532 ± 0.049
3.331GluAsp: 3.331 ± 0.143
7.102GluGlu: 7.102 ± 0.25
3.006GluPhe: 3.006 ± 0.14
4.674GluGly: 4.674 ± 0.158
0.747GluHis: 0.747 ± 0.065
7.338GluIle: 7.338 ± 0.202
6.709GluLys: 6.709 ± 0.228
7.326GluLeu: 7.326 ± 0.219
1.49GluMet: 1.49 ± 0.08
3.424GluAsn: 3.424 ± 0.118
1.769GluPro: 1.769 ± 0.096
1.237GluGln: 1.237 ± 0.081
3.39GluArg: 3.39 ± 0.133
3.365GluSer: 3.365 ± 0.118
2.373GluThr: 2.373 ± 0.105
6.029GluVal: 6.029 ± 0.166
0.743GluTrp: 0.743 ± 0.054
2.947GluTyr: 2.947 ± 0.116
0.0GluXaa: 0.0 ± 0.0
Phe
2.36PheAla: 2.36 ± 0.127
0.291PheCys: 0.291 ± 0.036
2.217PheAsp: 2.217 ± 0.087
2.626PheGlu: 2.626 ± 0.104
2.073PhePhe: 2.073 ± 0.104
2.816PheGly: 2.816 ± 0.132
0.709PheHis: 0.709 ± 0.059
4.138PheIle: 4.138 ± 0.149
2.943PheLys: 2.943 ± 0.125
4.923PheLeu: 4.923 ± 0.183
1.157PheMet: 1.157 ± 0.074
2.55PheAsn: 2.55 ± 0.133
1.752PhePro: 1.752 ± 0.085
1.068PheGln: 1.068 ± 0.072
1.659PheArg: 1.659 ± 0.088
3.682PheSer: 3.682 ± 0.126
2.533PheThr: 2.533 ± 0.109
2.652PheVal: 2.652 ± 0.109
0.38PheTrp: 0.38 ± 0.044
2.276PheTyr: 2.276 ± 0.106
0.0PheXaa: 0.0 ± 0.0
Gly
3.302GlyAla: 3.302 ± 0.134
0.393GlyCys: 0.393 ± 0.041
3.091GlyAsp: 3.091 ± 0.107
4.598GlyGlu: 4.598 ± 0.164
3.327GlyPhe: 3.327 ± 0.114
4.594GlyGly: 4.594 ± 0.185
0.874GlyHis: 0.874 ± 0.064
6.68GlyIle: 6.68 ± 0.18
5.936GlyLys: 5.936 ± 0.194
6.405GlyLeu: 6.405 ± 0.216
1.655GlyMet: 1.655 ± 0.092
2.846GlyAsn: 2.846 ± 0.102
1.524GlyPro: 1.524 ± 0.09
1.14GlyGln: 1.14 ± 0.072
2.635GlyArg: 2.635 ± 0.114
3.935GlySer: 3.935 ± 0.147
3.146GlyThr: 3.146 ± 0.13
5.434GlyVal: 5.434 ± 0.163
0.781GlyTrp: 0.781 ± 0.06
3.737GlyTyr: 3.737 ± 0.124
0.0GlyXaa: 0.0 ± 0.0
His
0.836HisAla: 0.836 ± 0.064
0.101HisCys: 0.101 ± 0.021
0.591HisAsp: 0.591 ± 0.055
0.988HisGlu: 0.988 ± 0.063
0.646HisPhe: 0.646 ± 0.059
1.161HisGly: 1.161 ± 0.071
0.279HisHis: 0.279 ± 0.038
1.064HisIle: 1.064 ± 0.062
0.849HisLys: 0.849 ± 0.064
1.216HisLeu: 1.216 ± 0.061
0.329HisMet: 0.329 ± 0.034
0.498HisAsn: 0.498 ± 0.051
0.692HisPro: 0.692 ± 0.055
0.266HisGln: 0.266 ± 0.035
0.515HisArg: 0.515 ± 0.045
0.904HisSer: 0.904 ± 0.084
0.591HisThr: 0.591 ± 0.049
1.072HisVal: 1.072 ± 0.068
0.198HisTrp: 0.198 ± 0.028
0.633HisTyr: 0.633 ± 0.057
0.0HisXaa: 0.0 ± 0.0
Ile
5.628IleAla: 5.628 ± 0.162
0.481IleCys: 0.481 ± 0.049
4.687IleAsp: 4.687 ± 0.144
6.16IleGlu: 6.16 ± 0.194
3.61IlePhe: 3.61 ± 0.137
5.953IleGly: 5.953 ± 0.182
1.233IleHis: 1.233 ± 0.071
9.555IleIle: 9.555 ± 0.235
7.304IleLys: 7.304 ± 0.195
8.896IleLeu: 8.896 ± 0.238
1.921IleMet: 1.921 ± 0.096
4.746IleAsn: 4.746 ± 0.144
4.29IlePro: 4.29 ± 0.124
1.794IleGln: 1.794 ± 0.081
4.298IleArg: 4.298 ± 0.143
6.962IleSer: 6.962 ± 0.192
5.096IleThr: 5.096 ± 0.139
6.726IleVal: 6.726 ± 0.184
0.663IleTrp: 0.663 ± 0.068
4.096IleTyr: 4.096 ± 0.129
0.0IleXaa: 0.0 ± 0.0
Lys
4.37LysAla: 4.37 ± 0.144
0.502LysCys: 0.502 ± 0.049
4.184LysAsp: 4.184 ± 0.145
7.554LysGlu: 7.554 ± 0.206
2.905LysPhe: 2.905 ± 0.109
5.582LysGly: 5.582 ± 0.185
0.929LysHis: 0.929 ± 0.056
7.444LysIle: 7.444 ± 0.194
6.055LysLys: 6.055 ± 0.169
7.925LysLeu: 7.925 ± 0.211
1.714LysMet: 1.714 ± 0.085
3.053LysAsn: 3.053 ± 0.107
2.715LysPro: 2.715 ± 0.114
1.478LysGln: 1.478 ± 0.08
4.243LysArg: 4.243 ± 0.15
3.804LysSer: 3.804 ± 0.122
3.074LysThr: 3.074 ± 0.127
6.971LysVal: 6.971 ± 0.194
0.718LysTrp: 0.718 ± 0.059
3.754LysTyr: 3.754 ± 0.124
0.0LysXaa: 0.0 ± 0.0
Leu
6.587LeuAla: 6.587 ± 0.176
0.511LeuCys: 0.511 ± 0.049
4.906LeuAsp: 4.906 ± 0.148
6.629LeuGlu: 6.629 ± 0.176
4.222LeuPhe: 4.222 ± 0.15
6.671LeuGly: 6.671 ± 0.216
1.267LeuHis: 1.267 ± 0.071
9.416LeuIle: 9.416 ± 0.226
8.242LeuLys: 8.242 ± 0.229
10.154LeuLeu: 10.154 ± 0.259
2.208LeuMet: 2.208 ± 0.12
5.016LeuAsn: 5.016 ± 0.149
4.226LeuPro: 4.226 ± 0.144
2.39LeuGln: 2.39 ± 0.129
4.602LeuArg: 4.602 ± 0.15
8.018LeuSer: 8.018 ± 0.197
5.409LeuThr: 5.409 ± 0.156
6.929LeuVal: 6.929 ± 0.173
0.781LeuTrp: 0.781 ± 0.07
4.26LeuTyr: 4.26 ± 0.146
0.0LeuXaa: 0.0 ± 0.0
Met
1.3MetAla: 1.3 ± 0.088
0.114MetCys: 0.114 ± 0.021
1.039MetAsp: 1.039 ± 0.08
1.452MetGlu: 1.452 ± 0.082
0.849MetPhe: 0.849 ± 0.062
1.786MetGly: 1.786 ± 0.096
0.258MetHis: 0.258 ± 0.036
1.883MetIle: 1.883 ± 0.087
2.035MetLys: 2.035 ± 0.099
2.094MetLeu: 2.094 ± 0.104
0.54MetMet: 0.54 ± 0.053
0.98MetAsn: 0.98 ± 0.065
0.794MetPro: 0.794 ± 0.059
0.511MetGln: 0.511 ± 0.046
1.212MetArg: 1.212 ± 0.067
1.541MetSer: 1.541 ± 0.079
1.051MetThr: 1.051 ± 0.07
1.558MetVal: 1.558 ± 0.085
0.22MetTrp: 0.22 ± 0.037
0.684MetTyr: 0.684 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
2.504AsnAla: 2.504 ± 0.108
0.384AsnCys: 0.384 ± 0.038
2.09AsnAsp: 2.09 ± 0.106
3.344AsnGlu: 3.344 ± 0.114
2.094AsnPhe: 2.094 ± 0.099
3.749AsnGly: 3.749 ± 0.171
0.46AsnHis: 0.46 ± 0.048
3.998AsnIle: 3.998 ± 0.14
3.23AsnLys: 3.23 ± 0.129
4.484AsnLeu: 4.484 ± 0.144
0.895AsnMet: 0.895 ± 0.06
2.348AsnAsn: 2.348 ± 0.127
2.643AsnPro: 2.643 ± 0.127
0.904AsnGln: 0.904 ± 0.068
1.714AsnArg: 1.714 ± 0.084
3.036AsnSer: 3.036 ± 0.135
1.989AsnThr: 1.989 ± 0.096
3.906AsnVal: 3.906 ± 0.125
0.54AsnTrp: 0.54 ± 0.049
2.462AsnTyr: 2.462 ± 0.117
0.0AsnXaa: 0.0 ± 0.0
Pro
1.938ProAla: 1.938 ± 0.111
0.304ProCys: 0.304 ± 0.038
1.706ProAsp: 1.706 ± 0.094
2.639ProGlu: 2.639 ± 0.109
1.963ProPhe: 1.963 ± 0.102
2.115ProGly: 2.115 ± 0.113
0.806ProHis: 0.806 ± 0.063
3.403ProIle: 3.403 ± 0.122
2.825ProLys: 2.825 ± 0.1
3.939ProLeu: 3.939 ± 0.136
0.773ProMet: 0.773 ± 0.058
1.917ProAsn: 1.917 ± 0.1
2.25ProPro: 2.25 ± 0.133
1.317ProGln: 1.317 ± 0.093
1.334ProArg: 1.334 ± 0.085
3.04ProSer: 3.04 ± 0.119
2.094ProThr: 2.094 ± 0.099
2.905ProVal: 2.905 ± 0.111
0.435ProTrp: 0.435 ± 0.042
2.44ProTyr: 2.44 ± 0.119
0.0ProXaa: 0.0 ± 0.0
Gln
1.246GlnAla: 1.246 ± 0.074
0.118GlnCys: 0.118 ± 0.022
0.819GlnAsp: 0.819 ± 0.056
1.309GlnGlu: 1.309 ± 0.071
0.963GlnPhe: 0.963 ± 0.066
1.406GlnGly: 1.406 ± 0.08
0.287GlnHis: 0.287 ± 0.045
1.887GlnIle: 1.887 ± 0.106
1.444GlnLys: 1.444 ± 0.088
2.263GlnLeu: 2.263 ± 0.09
0.591GlnMet: 0.591 ± 0.051
0.963GlnAsn: 0.963 ± 0.076
0.95GlnPro: 0.95 ± 0.082
0.844GlnGln: 0.844 ± 0.08
0.946GlnArg: 0.946 ± 0.062
1.148GlnSer: 1.148 ± 0.073
1.094GlnThr: 1.094 ± 0.077
1.495GlnVal: 1.495 ± 0.084
0.241GlnTrp: 0.241 ± 0.032
1.081GlnTyr: 1.081 ± 0.079
0.0GlnXaa: 0.0 ± 0.0
Arg
2.381ArgAla: 2.381 ± 0.128
0.304ArgCys: 0.304 ± 0.042
2.174ArgAsp: 2.174 ± 0.114
3.665ArgGlu: 3.665 ± 0.148
1.596ArgPhe: 1.596 ± 0.086
3.238ArgGly: 3.238 ± 0.11
0.456ArgHis: 0.456 ± 0.04
4.003ArgIle: 4.003 ± 0.124
3.846ArgLys: 3.846 ± 0.153
4.294ArgLeu: 4.294 ± 0.148
0.785ArgMet: 0.785 ± 0.056
1.904ArgAsn: 1.904 ± 0.099
1.309ArgPro: 1.309 ± 0.084
0.929ArgGln: 0.929 ± 0.065
2.44ArgArg: 2.44 ± 0.113
2.069ArgSer: 2.069 ± 0.088
1.626ArgThr: 1.626 ± 0.079
3.614ArgVal: 3.614 ± 0.131
0.481ArgTrp: 0.481 ± 0.045
1.744ArgTyr: 1.744 ± 0.093
0.0ArgXaa: 0.0 ± 0.0
Ser
3.26SerAla: 3.26 ± 0.127
0.452SerCys: 0.452 ± 0.045
2.774SerAsp: 2.774 ± 0.118
3.825SerGlu: 3.825 ± 0.143
3.251SerPhe: 3.251 ± 0.13
3.952SerGly: 3.952 ± 0.151
0.954SerHis: 0.954 ± 0.073
5.632SerIle: 5.632 ± 0.182
4.818SerLys: 4.818 ± 0.145
7.562SerLeu: 7.562 ± 0.197
1.545SerMet: 1.545 ± 0.097
3.133SerAsn: 3.133 ± 0.134
3.027SerPro: 3.027 ± 0.101
1.697SerGln: 1.697 ± 0.085
2.377SerArg: 2.377 ± 0.094
4.961SerSer: 4.961 ± 0.176
3.374SerThr: 3.374 ± 0.133
4.602SerVal: 4.602 ± 0.153
0.815SerTrp: 0.815 ± 0.065
3.053SerTyr: 3.053 ± 0.116
0.0SerXaa: 0.0 ± 0.0
Thr
2.677ThrAla: 2.677 ± 0.107
0.283ThrCys: 0.283 ± 0.037
1.82ThrAsp: 1.82 ± 0.09
2.411ThrGlu: 2.411 ± 0.099
2.402ThrPhe: 2.402 ± 0.113
3.116ThrGly: 3.116 ± 0.124
0.798ThrHis: 0.798 ± 0.054
4.298ThrIle: 4.298 ± 0.136
2.884ThrLys: 2.884 ± 0.105
5.413ThrLeu: 5.413 ± 0.177
1.026ThrMet: 1.026 ± 0.07
2.082ThrAsn: 2.082 ± 0.097
2.567ThrPro: 2.567 ± 0.123
1.043ThrGln: 1.043 ± 0.074
1.879ThrArg: 1.879 ± 0.092
3.407ThrSer: 3.407 ± 0.139
3.01ThrThr: 3.01 ± 0.177
3.99ThrVal: 3.99 ± 0.141
0.456ThrTrp: 0.456 ± 0.039
2.212ThrTyr: 2.212 ± 0.107
0.0ThrXaa: 0.0 ± 0.0
Val
4.26ValAla: 4.26 ± 0.147
0.469ValCys: 0.469 ± 0.047
3.863ValAsp: 3.863 ± 0.145
4.847ValGlu: 4.847 ± 0.165
3.483ValPhe: 3.483 ± 0.135
4.484ValGly: 4.484 ± 0.148
0.912ValHis: 0.912 ± 0.057
8.183ValIle: 8.183 ± 0.186
7.055ValLys: 7.055 ± 0.179
7.368ValLeu: 7.368 ± 0.208
1.786ValMet: 1.786 ± 0.077
3.884ValAsn: 3.884 ± 0.127
2.926ValPro: 2.926 ± 0.12
1.258ValGln: 1.258 ± 0.066
3.2ValArg: 3.2 ± 0.11
5.024ValSer: 5.024 ± 0.123
3.96ValThr: 3.96 ± 0.137
5.894ValVal: 5.894 ± 0.189
0.646ValTrp: 0.646 ± 0.059
3.614ValTyr: 3.614 ± 0.141
0.0ValXaa: 0.0 ± 0.0
Trp
0.591TrpAla: 0.591 ± 0.049
0.038TrpCys: 0.038 ± 0.012
0.545TrpAsp: 0.545 ± 0.052
0.663TrpGlu: 0.663 ± 0.059
0.498TrpPhe: 0.498 ± 0.054
0.604TrpGly: 0.604 ± 0.06
0.203TrpHis: 0.203 ± 0.032
0.895TrpIle: 0.895 ± 0.066
0.743TrpLys: 0.743 ± 0.06
1.081TrpLeu: 1.081 ± 0.086
0.194TrpMet: 0.194 ± 0.03
0.574TrpAsn: 0.574 ± 0.056
0.241TrpPro: 0.241 ± 0.032
0.177TrpGln: 0.177 ± 0.027
0.498TrpArg: 0.498 ± 0.047
0.456TrpSer: 0.456 ± 0.053
0.405TrpThr: 0.405 ± 0.048
0.844TrpVal: 0.844 ± 0.063
0.144TrpTrp: 0.144 ± 0.025
0.515TrpTyr: 0.515 ± 0.064
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.69TyrAla: 2.69 ± 0.118
0.367TyrCys: 0.367 ± 0.042
2.364TyrAsp: 2.364 ± 0.119
2.825TyrGlu: 2.825 ± 0.099
2.635TyrPhe: 2.635 ± 0.127
3.15TyrGly: 3.15 ± 0.128
0.773TyrHis: 0.773 ± 0.059
3.922TyrIle: 3.922 ± 0.136
3.251TyrLys: 3.251 ± 0.114
4.965TyrLeu: 4.965 ± 0.152
0.937TyrMet: 0.937 ± 0.068
2.508TyrAsn: 2.508 ± 0.105
1.955TyrPro: 1.955 ± 0.099
1.043TyrGln: 1.043 ± 0.084
1.74TyrArg: 1.74 ± 0.077
3.407TyrSer: 3.407 ± 0.129
2.373TyrThr: 2.373 ± 0.091
3.982TyrVal: 3.982 ± 0.138
0.545TyrTrp: 0.545 ± 0.055
2.618TyrTyr: 2.618 ± 0.127
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 930 proteins (236844 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski