Amino acid dipepetide frequency for Erysipelothrix sp. HDW6C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.782AlaAla: 4.782 ± 0.109
0.521AlaCys: 0.521 ± 0.028
3.72AlaAsp: 3.72 ± 0.078
3.747AlaGlu: 3.747 ± 0.082
3.233AlaPhe: 3.233 ± 0.077
4.353AlaGly: 4.353 ± 0.103
1.511AlaHis: 1.511 ± 0.046
6.598AlaIle: 6.598 ± 0.109
4.054AlaLys: 4.054 ± 0.084
7.542AlaLeu: 7.542 ± 0.122
2.402AlaMet: 2.402 ± 0.06
3.296AlaAsn: 3.296 ± 0.082
1.897AlaPro: 1.897 ± 0.059
2.645AlaGln: 2.645 ± 0.058
2.56AlaArg: 2.56 ± 0.071
4.601AlaSer: 4.601 ± 0.082
4.428AlaThr: 4.428 ± 0.088
5.196AlaVal: 5.196 ± 0.094
0.577AlaTrp: 0.577 ± 0.034
2.741AlaTyr: 2.741 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.443CysAla: 0.443 ± 0.026
0.057CysCys: 0.057 ± 0.01
0.465CysAsp: 0.465 ± 0.025
0.365CysGlu: 0.365 ± 0.024
0.288CysPhe: 0.288 ± 0.02
0.535CysGly: 0.535 ± 0.026
0.167CysHis: 0.167 ± 0.015
0.492CysIle: 0.492 ± 0.027
0.279CysLys: 0.279 ± 0.022
0.54CysLeu: 0.54 ± 0.03
0.139CysMet: 0.139 ± 0.015
0.282CysAsn: 0.282 ± 0.022
0.238CysPro: 0.238 ± 0.023
0.176CysGln: 0.176 ± 0.016
0.229CysArg: 0.229 ± 0.019
0.407CysSer: 0.407 ± 0.024
0.361CysThr: 0.361 ± 0.02
0.54CysVal: 0.54 ± 0.032
0.042CysTrp: 0.042 ± 0.008
0.234CysTyr: 0.234 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.17AspAla: 5.17 ± 0.103
0.37AspCys: 0.37 ± 0.024
3.743AspAsp: 3.743 ± 0.08
4.345AspGlu: 4.345 ± 0.082
3.126AspPhe: 3.126 ± 0.074
4.1AspGly: 4.1 ± 0.107
1.139AspHis: 1.139 ± 0.041
5.135AspIle: 5.135 ± 0.086
3.22AspLys: 3.22 ± 0.074
5.187AspLeu: 5.187 ± 0.099
1.629AspMet: 1.629 ± 0.055
2.684AspAsn: 2.684 ± 0.065
1.867AspPro: 1.867 ± 0.056
1.775AspGln: 1.775 ± 0.054
2.351AspArg: 2.351 ± 0.072
3.23AspSer: 3.23 ± 0.072
3.656AspThr: 3.656 ± 0.084
5.233AspVal: 5.233 ± 0.103
0.47AspTrp: 0.47 ± 0.025
2.961AspTyr: 2.961 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.872GluAla: 4.872 ± 0.098
0.329GluCys: 0.329 ± 0.02
3.49GluAsp: 3.49 ± 0.077
4.074GluGlu: 4.074 ± 0.098
2.721GluPhe: 2.721 ± 0.063
3.859GluGly: 3.859 ± 0.086
1.408GluHis: 1.408 ± 0.047
5.617GluIle: 5.617 ± 0.104
4.112GluLys: 4.112 ± 0.086
5.999GluLeu: 5.999 ± 0.111
2.071GluMet: 2.071 ± 0.055
3.582GluAsn: 3.582 ± 0.078
1.823GluPro: 1.823 ± 0.047
2.095GluGln: 2.095 ± 0.055
2.997GluArg: 2.997 ± 0.073
4.19GluSer: 4.19 ± 0.087
4.418GluThr: 4.418 ± 0.093
4.859GluVal: 4.859 ± 0.09
0.449GluTrp: 0.449 ± 0.022
2.404GluTyr: 2.404 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.395PheAla: 3.395 ± 0.078
0.229PheCys: 0.229 ± 0.017
3.251PheAsp: 3.251 ± 0.069
3.197PheGlu: 3.197 ± 0.072
1.918PhePhe: 1.918 ± 0.073
3.163PheGly: 3.163 ± 0.078
0.679PheHis: 0.679 ± 0.037
3.592PheIle: 3.592 ± 0.095
2.832PheLys: 2.832 ± 0.06
3.509PheLeu: 3.509 ± 0.089
1.307PheMet: 1.307 ± 0.049
2.398PheAsn: 2.398 ± 0.061
1.317PhePro: 1.317 ± 0.04
1.197PheGln: 1.197 ± 0.039
1.417PheArg: 1.417 ± 0.052
2.898PheSer: 2.898 ± 0.07
2.973PheThr: 2.973 ± 0.07
3.52PheVal: 3.52 ± 0.066
0.312PheTrp: 0.312 ± 0.023
1.652PheTyr: 1.652 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.226GlyAla: 4.226 ± 0.086
0.526GlyCys: 0.526 ± 0.027
3.716GlyAsp: 3.716 ± 0.087
3.706GlyGlu: 3.706 ± 0.088
3.271GlyPhe: 3.271 ± 0.07
4.141GlyGly: 4.141 ± 0.11
1.283GlyHis: 1.283 ± 0.043
5.979GlyIle: 5.979 ± 0.114
3.928GlyLys: 3.928 ± 0.088
5.791GlyLeu: 5.791 ± 0.089
1.925GlyMet: 1.925 ± 0.061
3.118GlyAsn: 3.118 ± 0.097
1.384GlyPro: 1.384 ± 0.048
1.965GlyGln: 1.965 ± 0.06
2.39GlyArg: 2.39 ± 0.072
4.196GlySer: 4.196 ± 0.081
3.995GlyThr: 3.995 ± 0.098
5.112GlyVal: 5.112 ± 0.095
0.606GlyTrp: 0.606 ± 0.036
3.129GlyTyr: 3.129 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.432HisAla: 1.432 ± 0.049
0.152HisCys: 0.152 ± 0.016
1.554HisAsp: 1.554 ± 0.046
1.483HisGlu: 1.483 ± 0.05
0.904HisPhe: 0.904 ± 0.038
1.333HisGly: 1.333 ± 0.042
0.557HisHis: 0.557 ± 0.028
1.456HisIle: 1.456 ± 0.05
1.002HisLys: 1.002 ± 0.039
1.788HisLeu: 1.788 ± 0.055
0.48HisMet: 0.48 ± 0.026
0.999HisAsn: 0.999 ± 0.037
0.866HisPro: 0.866 ± 0.039
0.806HisGln: 0.806 ± 0.034
0.88HisArg: 0.88 ± 0.039
1.045HisSer: 1.045 ± 0.04
1.079HisThr: 1.079 ± 0.041
1.503HisVal: 1.503 ± 0.05
0.161HisTrp: 0.161 ± 0.016
0.958HisTyr: 0.958 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.928IleAla: 6.928 ± 0.109
0.55IleCys: 0.55 ± 0.027
5.639IleAsp: 5.639 ± 0.092
5.67IleGlu: 5.67 ± 0.1
3.128IlePhe: 3.128 ± 0.087
5.308IleGly: 5.308 ± 0.118
1.707IleHis: 1.707 ± 0.053
6.229IleIle: 6.229 ± 0.117
4.57IleLys: 4.57 ± 0.079
7.353IleLeu: 7.353 ± 0.141
2.278IleMet: 2.278 ± 0.064
4.19IleAsn: 4.19 ± 0.096
2.955IlePro: 2.955 ± 0.066
2.829IleGln: 2.829 ± 0.065
3.19IleArg: 3.19 ± 0.072
5.25IleSer: 5.25 ± 0.098
5.328IleThr: 5.328 ± 0.123
6.496IleVal: 6.496 ± 0.106
0.424IleTrp: 0.424 ± 0.025
2.604IleTyr: 2.604 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
3.894LysAla: 3.894 ± 0.094
0.244LysCys: 0.244 ± 0.02
3.86LysAsp: 3.86 ± 0.082
4.573LysGlu: 4.573 ± 0.081
1.951LysPhe: 1.951 ± 0.055
3.309LysGly: 3.309 ± 0.069
1.329LysHis: 1.329 ± 0.047
4.237LysIle: 4.237 ± 0.08
3.971LysLys: 3.971 ± 0.087
5.115LysLeu: 5.115 ± 0.08
1.849LysMet: 1.849 ± 0.058
3.136LysAsn: 3.136 ± 0.064
2.191LysPro: 2.191 ± 0.065
2.305LysGln: 2.305 ± 0.059
3.061LysArg: 3.061 ± 0.071
3.429LysSer: 3.429 ± 0.066
3.692LysThr: 3.692 ± 0.08
4.077LysVal: 4.077 ± 0.085
0.453LysTrp: 0.453 ± 0.024
2.085LysTyr: 2.085 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
6.202LeuAla: 6.202 ± 0.107
0.62LeuCys: 0.62 ± 0.033
5.819LeuAsp: 5.819 ± 0.099
6.234LeuGlu: 6.234 ± 0.109
3.942LeuPhe: 3.942 ± 0.1
5.856LeuGly: 5.856 ± 0.093
1.618LeuHis: 1.618 ± 0.053
7.268LeuIle: 7.268 ± 0.136
5.806LeuLys: 5.806 ± 0.103
7.916LeuLeu: 7.916 ± 0.164
2.781LeuMet: 2.781 ± 0.072
5.107LeuAsn: 5.107 ± 0.094
3.234LeuPro: 3.234 ± 0.078
2.92LeuGln: 2.92 ± 0.07
3.71LeuArg: 3.71 ± 0.09
6.768LeuSer: 6.768 ± 0.117
5.55LeuThr: 5.55 ± 0.099
6.727LeuVal: 6.727 ± 0.108
0.707LeuTrp: 0.707 ± 0.03
2.948LeuTyr: 2.948 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.958MetAla: 1.958 ± 0.058
0.171MetCys: 0.171 ± 0.014
1.639MetAsp: 1.639 ± 0.052
1.615MetGlu: 1.615 ± 0.05
1.204MetPhe: 1.204 ± 0.043
1.902MetGly: 1.902 ± 0.056
0.497MetHis: 0.497 ± 0.026
2.424MetIle: 2.424 ± 0.055
2.377MetLys: 2.377 ± 0.06
2.339MetLeu: 2.339 ± 0.065
1.081MetMet: 1.081 ± 0.04
1.82MetAsn: 1.82 ± 0.052
0.952MetPro: 0.952 ± 0.039
0.943MetGln: 0.943 ± 0.04
1.307MetArg: 1.307 ± 0.048
2.0MetSer: 2.0 ± 0.05
1.795MetThr: 1.795 ± 0.051
1.918MetVal: 1.918 ± 0.053
0.167MetTrp: 0.167 ± 0.015
0.837MetTyr: 0.837 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.582AsnAla: 3.582 ± 0.08
0.286AsnCys: 0.286 ± 0.023
3.207AsnAsp: 3.207 ± 0.083
3.397AsnGlu: 3.397 ± 0.077
1.985AsnPhe: 1.985 ± 0.055
3.658AsnGly: 3.658 ± 0.089
1.207AsnHis: 1.207 ± 0.046
3.998AsnIle: 3.998 ± 0.083
2.839AsnLys: 2.839 ± 0.061
4.318AsnLeu: 4.318 ± 0.099
1.207AsnMet: 1.207 ± 0.035
2.625AsnAsn: 2.625 ± 0.074
2.336AsnPro: 2.336 ± 0.066
1.966AsnGln: 1.966 ± 0.056
2.241AsnArg: 2.241 ± 0.057
2.594AsnSer: 2.594 ± 0.071
3.04AsnThr: 3.04 ± 0.102
3.777AsnVal: 3.777 ± 0.076
0.361AsnTrp: 0.361 ± 0.024
2.152AsnTyr: 2.152 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
1.851ProAla: 1.851 ± 0.058
0.166ProCys: 0.166 ± 0.016
1.587ProAsp: 1.587 ± 0.046
2.557ProGlu: 2.557 ± 0.068
1.647ProPhe: 1.647 ± 0.052
1.834ProGly: 1.834 ± 0.051
0.696ProHis: 0.696 ± 0.031
2.84ProIle: 2.84 ± 0.067
1.819ProLys: 1.819 ± 0.051
3.108ProLeu: 3.108 ± 0.073
0.883ProMet: 0.883 ± 0.042
1.689ProAsn: 1.689 ± 0.053
0.562ProPro: 0.562 ± 0.029
1.231ProGln: 1.231 ± 0.043
1.011ProArg: 1.011 ± 0.04
2.051ProSer: 2.051 ± 0.055
2.241ProThr: 2.241 ± 0.071
2.453ProVal: 2.453 ± 0.066
0.235ProTrp: 0.235 ± 0.018
1.351ProTyr: 1.351 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
2.496GlnAla: 2.496 ± 0.061
0.186GlnCys: 0.186 ± 0.017
1.881GlnAsp: 1.881 ± 0.054
2.398GlnGlu: 2.398 ± 0.064
1.612GlnPhe: 1.612 ± 0.05
2.119GlnGly: 2.119 ± 0.05
0.705GlnHis: 0.705 ± 0.028
2.584GlnIle: 2.584 ± 0.068
2.125GlnLys: 2.125 ± 0.056
3.235GlnLeu: 3.235 ± 0.065
1.019GlnMet: 1.019 ± 0.032
1.721GlnAsn: 1.721 ± 0.058
1.062GlnPro: 1.062 ± 0.038
1.333GlnGln: 1.333 ± 0.056
1.708GlnArg: 1.708 ± 0.044
2.274GlnSer: 2.274 ± 0.06
2.241GlnThr: 2.241 ± 0.067
1.982GlnVal: 1.982 ± 0.053
0.32GlnTrp: 0.32 ± 0.022
1.252GlnTyr: 1.252 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.302ArgAla: 2.302 ± 0.049
0.265ArgCys: 0.265 ± 0.018
2.524ArgAsp: 2.524 ± 0.069
2.861ArgGlu: 2.861 ± 0.072
1.97ArgPhe: 1.97 ± 0.057
2.217ArgGly: 2.217 ± 0.068
0.86ArgHis: 0.86 ± 0.039
3.733ArgIle: 3.733 ± 0.087
2.601ArgLys: 2.601 ± 0.066
3.703ArgLeu: 3.703 ± 0.088
1.255ArgMet: 1.255 ± 0.043
2.16ArgAsn: 2.16 ± 0.058
1.126ArgPro: 1.126 ± 0.044
1.418ArgGln: 1.418 ± 0.053
1.735ArgArg: 1.735 ± 0.059
2.223ArgSer: 2.223 ± 0.065
2.235ArgThr: 2.235 ± 0.053
3.114ArgVal: 3.114 ± 0.073
0.3ArgTrp: 0.3 ± 0.021
1.918ArgTyr: 1.918 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.93SerAla: 3.93 ± 0.083
0.36SerCys: 0.36 ± 0.023
3.694SerAsp: 3.694 ± 0.084
3.775SerGlu: 3.775 ± 0.084
3.241SerPhe: 3.241 ± 0.07
4.653SerGly: 4.653 ± 0.089
1.266SerHis: 1.266 ± 0.046
5.559SerIle: 5.559 ± 0.103
3.653SerLys: 3.653 ± 0.074
6.158SerLeu: 6.158 ± 0.107
1.754SerMet: 1.754 ± 0.049
3.128SerAsn: 3.128 ± 0.074
1.728SerPro: 1.728 ± 0.044
2.276SerGln: 2.276 ± 0.055
2.367SerArg: 2.367 ± 0.06
3.958SerSer: 3.958 ± 0.08
3.407SerThr: 3.407 ± 0.081
5.07SerVal: 5.07 ± 0.111
0.463SerTrp: 0.463 ± 0.023
2.519SerTyr: 2.519 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.856ThrAla: 3.856 ± 0.106
0.347ThrCys: 0.347 ± 0.024
3.319ThrAsp: 3.319 ± 0.08
3.459ThrGlu: 3.459 ± 0.088
2.87ThrPhe: 2.87 ± 0.073
4.1ThrGly: 4.1 ± 0.096
1.425ThrHis: 1.425 ± 0.043
5.578ThrIle: 5.578 ± 0.113
3.25ThrLys: 3.25 ± 0.073
6.68ThrLeu: 6.68 ± 0.099
1.704ThrMet: 1.704 ± 0.046
2.886ThrAsn: 2.886 ± 0.089
2.473ThrPro: 2.473 ± 0.071
2.373ThrGln: 2.373 ± 0.051
2.211ThrArg: 2.211 ± 0.061
3.713ThrSer: 3.713 ± 0.101
3.927ThrThr: 3.927 ± 0.141
4.976ThrVal: 4.976 ± 0.127
0.496ThrTrp: 0.496 ± 0.028
2.5ThrTyr: 2.5 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
5.907ValAla: 5.907 ± 0.101
0.578ValCys: 0.578 ± 0.028
4.982ValAsp: 4.982 ± 0.094
4.777ValGlu: 4.777 ± 0.084
3.42ValPhe: 3.42 ± 0.072
4.864ValGly: 4.864 ± 0.091
1.4ValHis: 1.4 ± 0.047
5.989ValIle: 5.989 ± 0.088
4.036ValLys: 4.036 ± 0.087
7.168ValLeu: 7.168 ± 0.109
2.126ValMet: 2.126 ± 0.062
3.624ValAsn: 3.624 ± 0.091
2.268ValPro: 2.268 ± 0.061
2.119ValGln: 2.119 ± 0.056
2.917ValArg: 2.917 ± 0.071
5.452ValSer: 5.452 ± 0.078
4.87ValThr: 4.87 ± 0.134
6.345ValVal: 6.345 ± 0.127
0.516ValTrp: 0.516 ± 0.024
2.724ValTyr: 2.724 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.38TrpAla: 0.38 ± 0.025
0.048TrpCys: 0.048 ± 0.008
0.484TrpAsp: 0.484 ± 0.028
0.458TrpGlu: 0.458 ± 0.029
0.421TrpPhe: 0.421 ± 0.025
0.507TrpGly: 0.507 ± 0.031
0.17TrpHis: 0.17 ± 0.015
0.647TrpIle: 0.647 ± 0.031
0.381TrpLys: 0.381 ± 0.02
0.722TrpLeu: 0.722 ± 0.032
0.211TrpMet: 0.211 ± 0.018
0.443TrpAsn: 0.443 ± 0.027
0.14TrpPro: 0.14 ± 0.015
0.309TrpGln: 0.309 ± 0.023
0.278TrpArg: 0.278 ± 0.02
0.492TrpSer: 0.492 ± 0.03
0.424TrpThr: 0.424 ± 0.027
0.56TrpVal: 0.56 ± 0.029
0.076TrpTrp: 0.076 ± 0.011
0.28TrpTyr: 0.28 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.798TyrAla: 2.798 ± 0.061
0.275TyrCys: 0.275 ± 0.024
2.816TyrAsp: 2.816 ± 0.108
2.679TyrGlu: 2.679 ± 0.064
1.907TyrPhe: 1.907 ± 0.062
2.574TyrGly: 2.574 ± 0.065
0.813TyrHis: 0.813 ± 0.036
2.67TyrIle: 2.67 ± 0.072
1.907TyrLys: 1.907 ± 0.055
3.563TyrLeu: 3.563 ± 0.078
0.846TyrMet: 0.846 ± 0.04
1.887TyrAsn: 1.887 ± 0.054
1.392TyrPro: 1.392 ± 0.05
1.574TyrGln: 1.574 ± 0.051
1.959TyrArg: 1.959 ± 0.062
2.189TyrSer: 2.189 ± 0.056
2.483TyrThr: 2.483 ± 0.08
2.623TyrVal: 2.623 ± 0.064
0.295TyrTrp: 0.295 ± 0.02
1.689TyrTyr: 1.689 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2192 proteins (705938 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski