Amino acid dipepetide frequency for Erysipelatoclostridium sp. An173

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.559AlaAla: 3.559 ± 0.092	0.874AlaCys: 0.874 ± 0.03	2.702AlaAsp: 2.702 ± 0.054	2.191AlaGlu: 2.191 ± 0.063	2.578AlaPhe: 2.578 ± 0.055	3.958AlaGly: 3.958 ± 0.085	0.897AlaHis: 0.897 ± 0.035	5.91AlaIle: 5.91 ± 0.091	5.073AlaLys: 5.073 ± 0.086	5.948AlaLeu: 5.948 ± 0.102	1.861AlaMet: 1.861 ± 0.05	3.397AlaAsn: 3.397 ± 0.075	1.524AlaPro: 1.524 ± 0.049	1.537AlaGln: 1.537 ± 0.052	2.064AlaArg: 2.064 ± 0.051	3.656AlaSer: 3.656 ± 0.077	3.36AlaThr: 3.36 ± 0.071	3.897AlaVal: 3.897 ± 0.087	0.405AlaTrp: 0.405 ± 0.021	2.536AlaTyr: 2.536 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.638CysAla: 0.638 ± 0.028	0.252CysCys: 0.252 ± 0.019	0.786CysAsp: 0.786 ± 0.03	0.578CysGlu: 0.578 ± 0.029	0.707CysPhe: 0.707 ± 0.028	1.125CysGly: 1.125 ± 0.041	0.343CysHis: 0.343 ± 0.024	1.16CysIle: 1.16 ± 0.04	1.024CysLys: 1.024 ± 0.037	1.387CysLeu: 1.387 ± 0.039	0.314CysMet: 0.314 ± 0.019	0.751CysAsn: 0.751 ± 0.032	0.545CysPro: 0.545 ± 0.032	0.527CysGln: 0.527 ± 0.027	0.418CysArg: 0.418 ± 0.024	0.808CysSer: 0.808 ± 0.031	0.577CysThr: 0.577 ± 0.032	0.79CysVal: 0.79 ± 0.032	0.09CysTrp: 0.09 ± 0.01	0.625CysTyr: 0.625 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	3.006AspAla: 3.006 ± 0.06	0.807AspCys: 0.807 ± 0.032	4.161AspAsp: 4.161 ± 0.082	5.09AspGlu: 5.09 ± 0.088	3.213AspPhe: 3.213 ± 0.076	3.982AspGly: 3.982 ± 0.089	1.189AspHis: 1.189 ± 0.038	5.519AspIle: 5.519 ± 0.094	4.458AspLys: 4.458 ± 0.072	5.75AspLeu: 5.75 ± 0.086	1.554AspMet: 1.554 ± 0.043	3.609AspAsn: 3.609 ± 0.078	1.634AspPro: 1.634 ± 0.045	2.146AspGln: 2.146 ± 0.053	1.934AspArg: 1.934 ± 0.055	3.365AspSer: 3.365 ± 0.084	2.769AspThr: 2.769 ± 0.059	3.949AspVal: 3.949 ± 0.077	0.482AspTrp: 0.482 ± 0.023	3.789AspTyr: 3.789 ± 0.078	0.0AspXaa: 0.0 ± 0.0
Glu	4.2GluAla: 4.2 ± 0.082	0.702GluCys: 0.702 ± 0.031	3.779GluAsp: 3.779 ± 0.073	4.696GluGlu: 4.696 ± 0.082	2.638GluPhe: 2.638 ± 0.057	3.173GluGly: 3.173 ± 0.065	1.162GluHis: 1.162 ± 0.036	6.31GluIle: 6.31 ± 0.092	5.658GluLys: 5.658 ± 0.101	6.385GluLeu: 6.385 ± 0.088	2.109GluMet: 2.109 ± 0.049	4.86GluAsn: 4.86 ± 0.081	1.482GluPro: 1.482 ± 0.047	2.238GluGln: 2.238 ± 0.052	2.201GluArg: 2.201 ± 0.059	2.92GluSer: 2.92 ± 0.062	3.259GluThr: 3.259 ± 0.06	4.404GluVal: 4.404 ± 0.084	0.4GluTrp: 0.4 ± 0.023	3.22GluTyr: 3.22 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	2.422PheAla: 2.422 ± 0.053	0.606PheCys: 0.606 ± 0.027	3.235PheAsp: 3.235 ± 0.068	2.86PheGlu: 2.86 ± 0.056	1.848PhePhe: 1.848 ± 0.061	2.708PheGly: 2.708 ± 0.065	0.669PheHis: 0.669 ± 0.033	4.179PheIle: 4.179 ± 0.087	3.603PheLys: 3.603 ± 0.063	3.595PheLeu: 3.595 ± 0.076	1.085PheMet: 1.085 ± 0.036	2.917PheAsn: 2.917 ± 0.068	1.112PhePro: 1.112 ± 0.035	1.047PheGln: 1.047 ± 0.034	1.132PheArg: 1.132 ± 0.034	2.938PheSer: 2.938 ± 0.062	2.252PheThr: 2.252 ± 0.056	3.037PheVal: 3.037 ± 0.063	0.289PheTrp: 0.289 ± 0.021	2.026PheTyr: 2.026 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	3.685GlyAla: 3.685 ± 0.083	0.953GlyCys: 0.953 ± 0.041	3.187GlyAsp: 3.187 ± 0.073	3.134GlyGlu: 3.134 ± 0.07	2.865GlyPhe: 2.865 ± 0.056	3.687GlyGly: 3.687 ± 0.088	1.2GlyHis: 1.2 ± 0.036	5.871GlyIle: 5.871 ± 0.097	4.881GlyLys: 4.881 ± 0.086	5.227GlyLeu: 5.227 ± 0.079	1.692GlyMet: 1.692 ± 0.044	3.263GlyAsn: 3.263 ± 0.068	1.125GlyPro: 1.125 ± 0.044	1.801GlyGln: 1.801 ± 0.052	1.986GlyArg: 1.986 ± 0.057	3.421GlySer: 3.421 ± 0.074	3.357GlyThr: 3.357 ± 0.074	3.985GlyVal: 3.985 ± 0.078	0.518GlyTrp: 0.518 ± 0.027	3.246GlyTyr: 3.246 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.831HisAla: 0.831 ± 0.033	0.339HisCys: 0.339 ± 0.023	1.278HisAsp: 1.278 ± 0.039	1.157HisGlu: 1.157 ± 0.04	0.818HisPhe: 0.818 ± 0.035	1.245HisGly: 1.245 ± 0.044	0.555HisHis: 0.555 ± 0.039	1.438HisIle: 1.438 ± 0.045	0.969HisLys: 0.969 ± 0.035	1.727HisLeu: 1.727 ± 0.054	0.374HisMet: 0.374 ± 0.019	0.919HisAsn: 0.919 ± 0.034	0.765HisPro: 0.765 ± 0.03	0.824HisGln: 0.824 ± 0.033	0.677HisArg: 0.677 ± 0.031	1.022HisSer: 1.022 ± 0.035	0.754HisThr: 0.754 ± 0.032	1.009HisVal: 1.009 ± 0.034	0.133HisTrp: 0.133 ± 0.012	0.952HisTyr: 0.952 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	5.815IleAla: 5.815 ± 0.105	1.343IleCys: 1.343 ± 0.044	6.525IleAsp: 6.525 ± 0.092	6.487IleGlu: 6.487 ± 0.095	3.871IlePhe: 3.871 ± 0.081	5.248IleGly: 5.248 ± 0.082	1.376IleHis: 1.376 ± 0.043	8.908IleIle: 8.908 ± 0.155	7.447IleLys: 7.447 ± 0.109	7.961IleLeu: 7.961 ± 0.125	2.162IleMet: 2.162 ± 0.049	6.007IleAsn: 6.007 ± 0.103	2.994IlePro: 2.994 ± 0.072	2.395IleGln: 2.395 ± 0.058	2.664IleArg: 2.664 ± 0.064	5.969IleSer: 5.969 ± 0.094	4.841IleThr: 4.841 ± 0.087	6.328IleVal: 6.328 ± 0.094	0.522IleTrp: 0.522 ± 0.029	3.963IleTyr: 3.963 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	4.643LysAla: 4.643 ± 0.078	0.802LysCys: 0.802 ± 0.036	5.034LysAsp: 5.034 ± 0.082	7.31LysGlu: 7.31 ± 0.113	2.4LysPhe: 2.4 ± 0.053	3.598LysGly: 3.598 ± 0.071	1.396LysHis: 1.396 ± 0.044	7.34LysIle: 7.34 ± 0.106	7.343LysLys: 7.343 ± 0.115	6.502LysLeu: 6.502 ± 0.088	2.572LysMet: 2.572 ± 0.061	4.974LysAsn: 4.974 ± 0.094	1.998LysPro: 1.998 ± 0.055	3.361LysGln: 3.361 ± 0.065	3.184LysArg: 3.184 ± 0.061	3.557LysSer: 3.557 ± 0.059	4.199LysThr: 4.199 ± 0.079	4.721LysVal: 4.721 ± 0.081	0.59LysTrp: 0.59 ± 0.03	4.13LysTyr: 4.13 ± 0.076	0.0LysXaa: 0.0 ± 0.0
Leu	6.012LeuAla: 6.012 ± 0.09	1.214LeuCys: 1.214 ± 0.041	5.889LeuAsp: 5.889 ± 0.095	6.229LeuGlu: 6.229 ± 0.097	4.083LeuPhe: 4.083 ± 0.085	5.334LeuGly: 5.334 ± 0.092	1.318LeuHis: 1.318 ± 0.04	8.461LeuIle: 8.461 ± 0.121	8.189LeuLys: 8.189 ± 0.121	8.802LeuLeu: 8.802 ± 0.156	2.475LeuMet: 2.475 ± 0.061	5.663LeuAsn: 5.663 ± 0.083	2.983LeuPro: 2.983 ± 0.06	2.965LeuGln: 2.965 ± 0.06	2.736LeuArg: 2.736 ± 0.068	6.122LeuSer: 6.122 ± 0.098	4.95LeuThr: 4.95 ± 0.079	5.992LeuVal: 5.992 ± 0.079	0.537LeuTrp: 0.537 ± 0.024	3.736LeuTyr: 3.736 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.904MetAla: 1.904 ± 0.061	0.289MetCys: 0.289 ± 0.017	1.479MetAsp: 1.479 ± 0.042	1.751MetGlu: 1.751 ± 0.055	1.074MetPhe: 1.074 ± 0.034	1.435MetGly: 1.435 ± 0.044	0.388MetHis: 0.388 ± 0.022	2.729MetIle: 2.729 ± 0.066	2.512MetLys: 2.512 ± 0.057	2.381MetLeu: 2.381 ± 0.057	0.846MetMet: 0.846 ± 0.035	1.514MetAsn: 1.514 ± 0.042	0.912MetPro: 0.912 ± 0.035	0.942MetGln: 0.942 ± 0.032	0.808MetArg: 0.808 ± 0.032	1.614MetSer: 1.614 ± 0.046	1.316MetThr: 1.316 ± 0.044	1.728MetVal: 1.728 ± 0.048	0.161MetTrp: 0.161 ± 0.013	0.93MetTyr: 0.93 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.985AsnAla: 2.985 ± 0.067	0.875AsnCys: 0.875 ± 0.036	4.167AsnAsp: 4.167 ± 0.081	4.274AsnGlu: 4.274 ± 0.073	2.349AsnPhe: 2.349 ± 0.055	3.84AsnGly: 3.84 ± 0.072	1.289AsnHis: 1.289 ± 0.041	5.421AsnIle: 5.421 ± 0.087	4.703AsnLys: 4.703 ± 0.088	5.172AsnLeu: 5.172 ± 0.09	1.349AsnMet: 1.349 ± 0.037	4.338AsnAsn: 4.338 ± 0.095	2.076AsnPro: 2.076 ± 0.051	2.915AsnGln: 2.915 ± 0.072	2.087AsnArg: 2.087 ± 0.052	3.358AsnSer: 3.358 ± 0.071	2.735AsnThr: 2.735 ± 0.056	3.641AsnVal: 3.641 ± 0.067	0.447AsnTrp: 0.447 ± 0.021	3.299AsnTyr: 3.299 ± 0.074	0.0AsnXaa: 0.0 ± 0.0
Pro	1.592ProAla: 1.592 ± 0.05	0.361ProCys: 0.361 ± 0.019	1.881ProAsp: 1.881 ± 0.048	2.216ProGlu: 2.216 ± 0.058	1.406ProPhe: 1.406 ± 0.044	1.717ProGly: 1.717 ± 0.046	0.487ProHis: 0.487 ± 0.026	2.44ProIle: 2.44 ± 0.062	1.871ProLys: 1.871 ± 0.052	2.67ProLeu: 2.67 ± 0.063	0.717ProMet: 0.717 ± 0.03	1.524ProAsn: 1.524 ± 0.043	0.49ProPro: 0.49 ± 0.024	0.94ProGln: 0.94 ± 0.031	0.848ProArg: 0.848 ± 0.035	1.61ProSer: 1.61 ± 0.045	1.499ProThr: 1.499 ± 0.045	2.235ProVal: 2.235 ± 0.056	0.242ProTrp: 0.242 ± 0.02	1.406ProTyr: 1.406 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.127GlnAla: 2.127 ± 0.059	0.37GlnCys: 0.37 ± 0.02	1.974GlnAsp: 1.974 ± 0.049	2.68GlnGlu: 2.68 ± 0.069	1.327GlnPhe: 1.327 ± 0.042	1.851GlnGly: 1.851 ± 0.052	0.54GlnHis: 0.54 ± 0.029	3.289GlnIle: 3.289 ± 0.067	2.708GlnLys: 2.708 ± 0.061	3.497GlnLeu: 3.497 ± 0.069	0.961GlnMet: 0.961 ± 0.035	2.024GlnAsn: 2.024 ± 0.054	0.859GlnPro: 0.859 ± 0.033	1.289GlnGln: 1.289 ± 0.043	1.273GlnArg: 1.273 ± 0.04	1.769GlnSer: 1.769 ± 0.049	1.657GlnThr: 1.657 ± 0.047	2.137GlnVal: 2.137 ± 0.057	0.289GlnTrp: 0.289 ± 0.02	1.598GlnTyr: 1.598 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.633ArgAla: 1.633 ± 0.044	0.477ArgCys: 0.477 ± 0.025	1.846ArgAsp: 1.846 ± 0.053	2.041ArgGlu: 2.041 ± 0.051	1.638ArgPhe: 1.638 ± 0.048	1.661ArgGly: 1.661 ± 0.051	0.687ArgHis: 0.687 ± 0.032	3.058ArgIle: 3.058 ± 0.066	2.806ArgLys: 2.806 ± 0.056	3.283ArgLeu: 3.283 ± 0.063	0.949ArgMet: 0.949 ± 0.032	1.932ArgAsn: 1.932 ± 0.054	0.918ArgPro: 0.918 ± 0.04	1.261ArgGln: 1.261 ± 0.038	1.348ArgArg: 1.348 ± 0.046	1.663ArgSer: 1.663 ± 0.04	1.435ArgThr: 1.435 ± 0.046	2.197ArgVal: 2.197 ± 0.053	0.263ArgTrp: 0.263 ± 0.019	1.964ArgTyr: 1.964 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	3.121SerAla: 3.121 ± 0.072	0.711SerCys: 0.711 ± 0.031	3.631SerAsp: 3.631 ± 0.083	3.152SerGlu: 3.152 ± 0.073	2.957SerPhe: 2.957 ± 0.063	4.007SerGly: 4.007 ± 0.077	1.079SerHis: 1.079 ± 0.04	5.101SerIle: 5.101 ± 0.092	4.755SerLys: 4.755 ± 0.085	6.127SerLeu: 6.127 ± 0.102	1.552SerMet: 1.552 ± 0.044	3.611SerAsn: 3.611 ± 0.085	1.35SerPro: 1.35 ± 0.044	1.945SerGln: 1.945 ± 0.05	2.037SerArg: 2.037 ± 0.052	3.907SerSer: 3.907 ± 0.077	2.697SerThr: 2.697 ± 0.061	3.448SerVal: 3.448 ± 0.065	0.483SerTrp: 0.483 ± 0.026	2.896SerTyr: 2.896 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	2.899ThrAla: 2.899 ± 0.07	0.624ThrCys: 0.624 ± 0.031	2.66ThrAsp: 2.66 ± 0.068	2.308ThrGlu: 2.308 ± 0.056	2.229ThrPhe: 2.229 ± 0.049	3.586ThrGly: 3.586 ± 0.079	0.785ThrHis: 0.785 ± 0.033	5.177ThrIle: 5.177 ± 0.076	3.758ThrLys: 3.758 ± 0.07	4.889ThrLeu: 4.889 ± 0.084	1.347ThrMet: 1.347 ± 0.039	3.071ThrAsn: 3.071 ± 0.078	1.786ThrPro: 1.786 ± 0.05	1.15ThrGln: 1.15 ± 0.037	1.588ThrArg: 1.588 ± 0.05	3.195ThrSer: 3.195 ± 0.062	3.177ThrThr: 3.177 ± 0.093	3.816ThrVal: 3.816 ± 0.067	0.339ThrTrp: 0.339 ± 0.022	2.491ThrTyr: 2.491 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	4.13ValAla: 4.13 ± 0.078	1.007ValCys: 1.007 ± 0.033	4.372ValAsp: 4.372 ± 0.084	4.475ValGlu: 4.475 ± 0.078	2.831ValPhe: 2.831 ± 0.067	3.627ValGly: 3.627 ± 0.062	1.008ValHis: 1.008 ± 0.035	6.187ValIle: 6.187 ± 0.091	4.691ValLys: 4.691 ± 0.076	6.335ValLeu: 6.335 ± 0.097	1.63ValMet: 1.63 ± 0.046	3.713ValAsn: 3.713 ± 0.08	1.855ValPro: 1.855 ± 0.046	1.502ValGln: 1.502 ± 0.041	1.882ValArg: 1.882 ± 0.05	4.415ValSer: 4.415 ± 0.074	3.544ValThr: 3.544 ± 0.069	4.626ValVal: 4.626 ± 0.09	0.387ValTrp: 0.387 ± 0.022	2.895ValTyr: 2.895 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.368TrpAla: 0.368 ± 0.021	0.124TrpCys: 0.124 ± 0.011	0.384TrpAsp: 0.384 ± 0.024	0.315TrpGlu: 0.315 ± 0.02	0.338TrpPhe: 0.338 ± 0.021	0.473TrpGly: 0.473 ± 0.026	0.155TrpHis: 0.155 ± 0.014	0.618TrpIle: 0.618 ± 0.032	0.435TrpLys: 0.435 ± 0.024	0.811TrpLeu: 0.811 ± 0.033	0.208TrpMet: 0.208 ± 0.017	0.39TrpAsn: 0.39 ± 0.02	0.163TrpPro: 0.163 ± 0.014	0.409TrpGln: 0.409 ± 0.023	0.25TrpArg: 0.25 ± 0.018	0.409TrpSer: 0.409 ± 0.02	0.295TrpThr: 0.295 ± 0.017	0.387TrpVal: 0.387 ± 0.021	0.096TrpTrp: 0.096 ± 0.011	0.405TrpTyr: 0.405 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.047	0.715TyrCys: 0.715 ± 0.028	3.437TyrAsp: 3.437 ± 0.065	2.852TyrGlu: 2.852 ± 0.061	2.391TyrPhe: 2.391 ± 0.054	2.829TyrGly: 2.829 ± 0.058	1.264TyrHis: 1.264 ± 0.043	3.712TyrIle: 3.712 ± 0.073	2.769TyrLys: 2.769 ± 0.061	5.239TyrLeu: 5.239 ± 0.099	0.957TyrMet: 0.957 ± 0.032	2.841TyrAsn: 2.841 ± 0.07	1.579TyrPro: 1.579 ± 0.049	3.024TyrGln: 3.024 ± 0.073	1.941TyrArg: 1.941 ± 0.049	2.848TyrSer: 2.848 ± 0.062	2.205TyrThr: 2.205 ± 0.063	2.784TyrVal: 2.784 ± 0.064	0.361TyrTrp: 0.361 ± 0.02	2.671TyrTyr: 2.671 ± 0.069	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2792 proteins (844320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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