Amino acid dipepetide frequency for Loktanella salsilacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.966AlaAla: 17.966 ± 0.172	1.195AlaCys: 1.195 ± 0.033	8.013AlaAsp: 8.013 ± 0.093	6.578AlaGlu: 6.578 ± 0.076	4.446AlaPhe: 4.446 ± 0.064	10.763AlaGly: 10.763 ± 0.112	2.281AlaHis: 2.281 ± 0.047	6.578AlaIle: 6.578 ± 0.084	3.908AlaLys: 3.908 ± 0.061	13.869AlaLeu: 13.869 ± 0.152	4.022AlaMet: 4.022 ± 0.064	3.095AlaAsn: 3.095 ± 0.054	6.149AlaPro: 6.149 ± 0.092	5.443AlaGln: 5.443 ± 0.071	7.761AlaArg: 7.761 ± 0.099	5.783AlaSer: 5.783 ± 0.067	6.832AlaThr: 6.832 ± 0.091	8.773AlaVal: 8.773 ± 0.109	1.388AlaTrp: 1.388 ± 0.036	2.537AlaTyr: 2.537 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.165CysAla: 1.165 ± 0.034	0.09CysCys: 0.09 ± 0.008	0.671CysAsp: 0.671 ± 0.023	0.401CysGlu: 0.401 ± 0.018	0.312CysPhe: 0.312 ± 0.018	0.961CysGly: 0.961 ± 0.027	0.266CysHis: 0.266 ± 0.015	0.456CysIle: 0.456 ± 0.022	0.206CysLys: 0.206 ± 0.015	0.807CysLeu: 0.807 ± 0.028	0.195CysMet: 0.195 ± 0.014	0.244CysAsn: 0.244 ± 0.014	0.47CysPro: 0.47 ± 0.022	0.247CysGln: 0.247 ± 0.012	0.516CysArg: 0.516 ± 0.025	0.407CysSer: 0.407 ± 0.02	0.485CysThr: 0.485 ± 0.024	0.605CysVal: 0.605 ± 0.024	0.092CysTrp: 0.092 ± 0.008	0.205CysTyr: 0.205 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.583AspAla: 8.583 ± 0.098	0.534AspCys: 0.534 ± 0.021	4.158AspAsp: 4.158 ± 0.085	2.936AspGlu: 2.936 ± 0.06	2.396AspPhe: 2.396 ± 0.047	6.065AspGly: 6.065 ± 0.093	1.479AspHis: 1.479 ± 0.037	3.477AspIle: 3.477 ± 0.058	1.719AspLys: 1.719 ± 0.039	6.801AspLeu: 6.801 ± 0.075	1.946AspMet: 1.946 ± 0.041	1.522AspAsn: 1.522 ± 0.045	3.654AspPro: 3.654 ± 0.055	2.145AspGln: 2.145 ± 0.04	4.351AspArg: 4.351 ± 0.058	2.333AspSer: 2.333 ± 0.049	3.799AspThr: 3.799 ± 0.082	4.941AspVal: 4.941 ± 0.08	1.195AspTrp: 1.195 ± 0.035	1.593AspTyr: 1.593 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.381GluAla: 6.381 ± 0.088	0.288GluCys: 0.288 ± 0.015	2.807GluAsp: 2.807 ± 0.059	2.525GluGlu: 2.525 ± 0.058	1.494GluPhe: 1.494 ± 0.031	3.772GluGly: 3.772 ± 0.062	0.963GluHis: 0.963 ± 0.03	2.88GluIle: 2.88 ± 0.058	1.824GluLys: 1.824 ± 0.044	4.246GluLeu: 4.246 ± 0.066	1.518GluMet: 1.518 ± 0.038	1.56GluAsn: 1.56 ± 0.036	1.982GluPro: 1.982 ± 0.049	1.654GluGln: 1.654 ± 0.041	3.202GluArg: 3.202 ± 0.049	2.0GluSer: 2.0 ± 0.047	2.962GluThr: 2.962 ± 0.051	3.771GluVal: 3.771 ± 0.06	0.573GluTrp: 0.573 ± 0.022	0.943GluTyr: 0.943 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.815PheAla: 4.815 ± 0.064	0.417PheCys: 0.417 ± 0.018	2.996PheAsp: 2.996 ± 0.051	1.921PheGlu: 1.921 ± 0.042	1.347PhePhe: 1.347 ± 0.035	3.665PheGly: 3.665 ± 0.069	0.736PheHis: 0.736 ± 0.028	1.798PheIle: 1.798 ± 0.043	0.986PheLys: 0.986 ± 0.029	3.176PheLeu: 3.176 ± 0.057	0.963PheMet: 0.963 ± 0.025	1.07PheAsn: 1.07 ± 0.03	1.485PhePro: 1.485 ± 0.032	1.073PheGln: 1.073 ± 0.032	1.956PheArg: 1.956 ± 0.041	1.989PheSer: 1.989 ± 0.044	2.217PheThr: 2.217 ± 0.05	2.693PheVal: 2.693 ± 0.048	0.571PheTrp: 0.571 ± 0.025	0.917PheTyr: 0.917 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.598GlyAla: 9.598 ± 0.104	0.804GlyCys: 0.804 ± 0.025	5.188GlyAsp: 5.188 ± 0.095	3.822GlyGlu: 3.822 ± 0.058	3.58GlyPhe: 3.58 ± 0.068	7.284GlyGly: 7.284 ± 0.131	1.854GlyHis: 1.854 ± 0.038	4.655GlyIle: 4.655 ± 0.067	2.967GlyLys: 2.967 ± 0.055	8.934GlyLeu: 8.934 ± 0.09	2.556GlyMet: 2.556 ± 0.055	2.4GlyAsn: 2.4 ± 0.086	3.704GlyPro: 3.704 ± 0.059	3.468GlyGln: 3.468 ± 0.058	5.278GlyArg: 5.278 ± 0.077	4.154GlySer: 4.154 ± 0.068	5.39GlyThr: 5.39 ± 0.074	6.336GlyVal: 6.336 ± 0.083	1.449GlyTrp: 1.449 ± 0.037	2.281GlyTyr: 2.281 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.346HisAla: 2.346 ± 0.05	0.234HisCys: 0.234 ± 0.015	1.398HisAsp: 1.398 ± 0.036	0.857HisGlu: 0.857 ± 0.027	0.814HisPhe: 0.814 ± 0.028	1.834HisGly: 1.834 ± 0.042	0.533HisHis: 0.533 ± 0.023	1.028HisIle: 1.028 ± 0.03	0.517HisLys: 0.517 ± 0.018	2.035HisLeu: 2.035 ± 0.042	0.586HisMet: 0.586 ± 0.025	0.513HisAsn: 0.513 ± 0.022	1.326HisPro: 1.326 ± 0.038	0.558HisGln: 0.558 ± 0.023	1.229HisArg: 1.229 ± 0.031	0.892HisSer: 0.892 ± 0.028	0.957HisThr: 0.957 ± 0.032	1.454HisVal: 1.454 ± 0.037	0.359HisTrp: 0.359 ± 0.017	0.522HisTyr: 0.522 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	8.008IleAla: 8.008 ± 0.087	0.641IleCys: 0.641 ± 0.025	3.89IleAsp: 3.89 ± 0.053	3.041IleGlu: 3.041 ± 0.058	1.897IlePhe: 1.897 ± 0.045	5.014IleGly: 5.014 ± 0.07	0.937IleHis: 0.937 ± 0.029	2.701IleIle: 2.701 ± 0.05	1.59IleLys: 1.59 ± 0.038	4.682IleLeu: 4.682 ± 0.069	1.306IleMet: 1.306 ± 0.037	1.545IleAsn: 1.545 ± 0.037	2.473IlePro: 2.473 ± 0.051	1.268IleGln: 1.268 ± 0.035	2.906IleArg: 2.906 ± 0.048	2.935IleSer: 2.935 ± 0.054	3.387IleThr: 3.387 ± 0.067	4.253IleVal: 4.253 ± 0.061	0.752IleTrp: 0.752 ± 0.023	1.282IleTyr: 1.282 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.707LysAla: 3.707 ± 0.06	0.152LysCys: 0.152 ± 0.011	1.833LysAsp: 1.833 ± 0.047	1.268LysGlu: 1.268 ± 0.039	0.945LysPhe: 0.945 ± 0.029	2.57LysGly: 2.57 ± 0.05	0.612LysHis: 0.612 ± 0.023	1.672LysIle: 1.672 ± 0.041	1.079LysLys: 1.079 ± 0.033	2.944LysLeu: 2.944 ± 0.053	0.883LysMet: 0.883 ± 0.027	0.811LysAsn: 0.811 ± 0.028	1.665LysPro: 1.665 ± 0.036	0.892LysGln: 0.892 ± 0.035	2.037LysArg: 2.037 ± 0.046	1.927LysSer: 1.927 ± 0.041	2.023LysThr: 2.023 ± 0.04	2.263LysVal: 2.263 ± 0.05	0.37LysTrp: 0.37 ± 0.017	0.613LysTyr: 0.613 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.591LeuAla: 12.591 ± 0.137	0.95LeuCys: 0.95 ± 0.026	6.144LeuAsp: 6.144 ± 0.073	4.196LeuGlu: 4.196 ± 0.063	3.37LeuPhe: 3.37 ± 0.057	8.096LeuGly: 8.096 ± 0.092	1.902LeuHis: 1.902 ± 0.046	5.657LeuIle: 5.657 ± 0.076	2.986LeuLys: 2.986 ± 0.046	8.958LeuLeu: 8.958 ± 0.12	2.786LeuMet: 2.786 ± 0.046	2.883LeuAsn: 2.883 ± 0.055	5.47LeuPro: 5.47 ± 0.082	3.135LeuGln: 3.135 ± 0.053	6.805LeuArg: 6.805 ± 0.087	6.461LeuSer: 6.461 ± 0.076	6.917LeuThr: 6.917 ± 0.09	6.491LeuVal: 6.491 ± 0.089	1.223LeuTrp: 1.223 ± 0.032	1.914LeuTyr: 1.914 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.584MetAla: 3.584 ± 0.059	0.201MetCys: 0.201 ± 0.016	1.591MetAsp: 1.591 ± 0.034	1.157MetGlu: 1.157 ± 0.038	0.876MetPhe: 0.876 ± 0.029	2.374MetGly: 2.374 ± 0.046	0.506MetHis: 0.506 ± 0.02	1.794MetIle: 1.794 ± 0.04	1.069MetLys: 1.069 ± 0.029	2.649MetLeu: 2.649 ± 0.053	0.894MetMet: 0.894 ± 0.03	0.931MetAsn: 0.931 ± 0.025	1.66MetPro: 1.66 ± 0.042	1.148MetGln: 1.148 ± 0.031	1.836MetArg: 1.836 ± 0.044	1.718MetSer: 1.718 ± 0.037	2.546MetThr: 2.546 ± 0.046	1.868MetVal: 1.868 ± 0.045	0.271MetTrp: 0.271 ± 0.014	0.358MetTyr: 0.358 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.604AsnAla: 3.604 ± 0.056	0.268AsnCys: 0.268 ± 0.016	1.813AsnAsp: 1.813 ± 0.078	1.116AsnGlu: 1.116 ± 0.03	1.044AsnPhe: 1.044 ± 0.032	2.542AsnGly: 2.542 ± 0.053	0.504AsnHis: 0.504 ± 0.02	1.495AsnIle: 1.495 ± 0.037	0.701AsnLys: 0.701 ± 0.021	2.636AsnLeu: 2.636 ± 0.047	0.757AsnMet: 0.757 ± 0.028	0.761AsnAsn: 0.761 ± 0.026	1.819AsnPro: 1.819 ± 0.041	0.773AsnGln: 0.773 ± 0.024	1.747AsnArg: 1.747 ± 0.038	1.183AsnSer: 1.183 ± 0.035	1.569AsnThr: 1.569 ± 0.057	2.024AsnVal: 2.024 ± 0.042	0.452AsnTrp: 0.452 ± 0.021	0.7AsnTyr: 0.7 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.333ProAla: 6.333 ± 0.089	0.358ProCys: 0.358 ± 0.019	4.176ProAsp: 4.176 ± 0.058	3.012ProGlu: 3.012 ± 0.062	1.88ProPhe: 1.88 ± 0.038	4.198ProGly: 4.198 ± 0.058	1.033ProHis: 1.033 ± 0.035	2.419ProIle: 2.419 ± 0.043	1.528ProLys: 1.528 ± 0.036	4.733ProLeu: 4.733 ± 0.072	1.41ProMet: 1.41 ± 0.037	1.322ProAsn: 1.322 ± 0.031	2.176ProPro: 2.176 ± 0.05	1.972ProGln: 1.972 ± 0.039	2.658ProArg: 2.658 ± 0.05	2.507ProSer: 2.507 ± 0.05	2.574ProThr: 2.574 ± 0.047	4.167ProVal: 4.167 ± 0.065	0.658ProTrp: 0.658 ± 0.022	1.125ProTyr: 1.125 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.54GlnAla: 4.54 ± 0.069	0.218GlnCys: 0.218 ± 0.015	2.154GlnAsp: 2.154 ± 0.043	1.376GlnGlu: 1.376 ± 0.038	1.185GlnPhe: 1.185 ± 0.036	2.765GlnGly: 2.765 ± 0.049	0.647GlnHis: 0.647 ± 0.023	2.444GlnIle: 2.444 ± 0.049	1.017GlnLys: 1.017 ± 0.026	3.112GlnLeu: 3.112 ± 0.053	1.195GlnMet: 1.195 ± 0.033	1.028GlnAsn: 1.028 ± 0.03	1.742GlnPro: 1.742 ± 0.036	1.273GlnGln: 1.273 ± 0.033	2.288GlnArg: 2.288 ± 0.05	2.034GlnSer: 2.034 ± 0.044	2.358GlnThr: 2.358 ± 0.05	2.617GlnVal: 2.617 ± 0.048	0.406GlnTrp: 0.406 ± 0.018	0.579GlnTyr: 0.579 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.411ArgAla: 7.411 ± 0.085	0.464ArgCys: 0.464 ± 0.02	4.327ArgAsp: 4.327 ± 0.062	2.786ArgGlu: 2.786 ± 0.05	2.38ArgPhe: 2.38 ± 0.043	4.459ArgGly: 4.459 ± 0.065	1.442ArgHis: 1.442 ± 0.033	3.72ArgIle: 3.72 ± 0.057	2.034ArgLys: 2.034 ± 0.049	6.561ArgLeu: 6.561 ± 0.093	1.92ArgMet: 1.92 ± 0.038	1.719ArgAsn: 1.719 ± 0.037	2.925ArgPro: 2.925 ± 0.057	2.267ArgGln: 2.267 ± 0.051	4.376ArgArg: 4.376 ± 0.069	3.188ArgSer: 3.188 ± 0.055	3.297ArgThr: 3.297 ± 0.055	4.384ArgVal: 4.384 ± 0.069	0.898ArgTrp: 0.898 ± 0.03	1.502ArgTyr: 1.502 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.029SerAla: 6.029 ± 0.068	0.434SerCys: 0.434 ± 0.021	3.568SerAsp: 3.568 ± 0.058	2.428SerGlu: 2.428 ± 0.045	2.239SerPhe: 2.239 ± 0.049	5.141SerGly: 5.141 ± 0.075	1.086SerHis: 1.086 ± 0.028	2.529SerIle: 2.529 ± 0.048	1.518SerLys: 1.518 ± 0.041	4.936SerLeu: 4.936 ± 0.066	1.311SerMet: 1.311 ± 0.03	1.471SerAsn: 1.471 ± 0.039	2.43SerPro: 2.43 ± 0.042	1.696SerGln: 1.696 ± 0.036	3.094SerArg: 3.094 ± 0.06	2.526SerSer: 2.526 ± 0.055	2.649SerThr: 2.649 ± 0.047	3.887SerVal: 3.887 ± 0.061	0.678SerTrp: 0.678 ± 0.025	1.34SerTyr: 1.34 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.554ThrAla: 7.554 ± 0.102	0.56ThrCys: 0.56 ± 0.023	4.008ThrAsp: 4.008 ± 0.074	2.752ThrGlu: 2.752 ± 0.049	2.316ThrPhe: 2.316 ± 0.051	5.713ThrGly: 5.713 ± 0.081	1.127ThrHis: 1.127 ± 0.034	3.127ThrIle: 3.127 ± 0.062	1.546ThrLys: 1.546 ± 0.043	6.775ThrLeu: 6.775 ± 0.093	1.456ThrMet: 1.456 ± 0.032	1.473ThrAsn: 1.473 ± 0.038	3.7ThrPro: 3.7 ± 0.053	2.137ThrGln: 2.137 ± 0.049	3.451ThrArg: 3.451 ± 0.058	2.97ThrSer: 2.97 ± 0.053	3.301ThrThr: 3.301 ± 0.068	4.685ThrVal: 4.685 ± 0.08	0.736ThrTrp: 0.736 ± 0.025	1.449ThrTyr: 1.449 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.122ValAla: 9.122 ± 0.097	0.629ValCys: 0.629 ± 0.025	4.351ValAsp: 4.351 ± 0.064	3.617ValGlu: 3.617 ± 0.07	2.8ValPhe: 2.8 ± 0.052	5.381ValGly: 5.381 ± 0.073	1.277ValHis: 1.277 ± 0.029	4.338ValIle: 4.338 ± 0.061	2.092ValLys: 2.092 ± 0.042	7.335ValLeu: 7.335 ± 0.088	2.405ValMet: 2.405 ± 0.049	2.101ValAsn: 2.101 ± 0.04	3.626ValPro: 3.626 ± 0.052	2.474ValGln: 2.474 ± 0.043	4.099ValArg: 4.099 ± 0.067	4.127ValSer: 4.127 ± 0.063	5.407ValThr: 5.407 ± 0.097	5.501ValVal: 5.501 ± 0.082	1.038ValTrp: 1.038 ± 0.034	1.471ValTyr: 1.471 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.336TrpAla: 1.336 ± 0.032	0.147TrpCys: 0.147 ± 0.012	0.848TrpAsp: 0.848 ± 0.029	0.539TrpGlu: 0.539 ± 0.02	0.563TrpPhe: 0.563 ± 0.022	0.98TrpGly: 0.98 ± 0.028	0.332TrpHis: 0.332 ± 0.016	0.714TrpIle: 0.714 ± 0.027	0.405TrpLys: 0.405 ± 0.021	1.574TrpLeu: 1.574 ± 0.04	0.409TrpMet: 0.409 ± 0.02	0.419TrpAsn: 0.419 ± 0.018	0.722TrpPro: 0.722 ± 0.025	0.639TrpGln: 0.639 ± 0.022	0.995TrpArg: 0.995 ± 0.03	0.779TrpSer: 0.779 ± 0.024	0.894TrpThr: 0.894 ± 0.024	0.911TrpVal: 0.911 ± 0.03	0.214TrpTrp: 0.214 ± 0.015	0.242TrpTyr: 0.242 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.708TyrAla: 2.708 ± 0.049	0.214TyrCys: 0.214 ± 0.015	1.693TyrAsp: 1.693 ± 0.042	1.019TyrGlu: 1.019 ± 0.029	0.909TyrPhe: 0.909 ± 0.029	2.124TyrGly: 2.124 ± 0.052	0.474TyrHis: 0.474 ± 0.021	1.025TyrIle: 1.025 ± 0.029	0.573TyrLys: 0.573 ± 0.02	2.173TyrLeu: 2.173 ± 0.043	0.508TyrMet: 0.508 ± 0.022	0.641TyrAsn: 0.641 ± 0.026	1.065TyrPro: 1.065 ± 0.034	0.716TyrGln: 0.716 ± 0.023	1.476TyrArg: 1.476 ± 0.034	1.075TyrSer: 1.075 ± 0.031	1.271TyrThr: 1.271 ± 0.033	1.571TyrVal: 1.571 ± 0.033	0.339TyrTrp: 0.339 ± 0.019	0.584TyrTyr: 0.584 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3957 proteins (1233139 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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