Amino acid dipepetide frequency for Candidatus Finniella inopinata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.673AlaAla: 7.673 ± 0.154
1.063AlaCys: 1.063 ± 0.053
4.085AlaAsp: 4.085 ± 0.087
4.553AlaGlu: 4.553 ± 0.128
3.471AlaPhe: 3.471 ± 0.083
5.447AlaGly: 5.447 ± 0.109
1.736AlaHis: 1.736 ± 0.066
5.092AlaIle: 5.092 ± 0.115
4.783AlaLys: 4.783 ± 0.111
9.113AlaLeu: 9.113 ± 0.132
1.872AlaMet: 1.872 ± 0.06
2.881AlaAsn: 2.881 ± 0.078
3.196AlaPro: 3.196 ± 0.094
3.455AlaGln: 3.455 ± 0.098
3.632AlaArg: 3.632 ± 0.104
5.297AlaSer: 5.297 ± 0.12
4.37AlaThr: 4.37 ± 0.097
5.173AlaVal: 5.173 ± 0.114
0.939AlaTrp: 0.939 ± 0.043
2.472AlaTyr: 2.472 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.883CysAla: 0.883 ± 0.035
0.191CysCys: 0.191 ± 0.022
0.548CysAsp: 0.548 ± 0.035
0.558CysGlu: 0.558 ± 0.039
0.672CysPhe: 0.672 ± 0.04
0.849CysGly: 0.849 ± 0.045
0.367CysHis: 0.367 ± 0.026
0.616CysIle: 0.616 ± 0.033
0.445CysLys: 0.445 ± 0.033
1.505CysLeu: 1.505 ± 0.064
0.233CysMet: 0.233 ± 0.019
0.339CysAsn: 0.339 ± 0.028
0.528CysPro: 0.528 ± 0.033
0.654CysGln: 0.654 ± 0.045
0.498CysArg: 0.498 ± 0.033
0.76CysSer: 0.76 ± 0.043
0.504CysThr: 0.504 ± 0.031
0.795CysVal: 0.795 ± 0.041
0.171CysTrp: 0.171 ± 0.02
0.409CysTyr: 0.409 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.84AspAla: 3.84 ± 0.089
0.664AspCys: 0.664 ± 0.037
2.917AspAsp: 2.917 ± 0.099
3.022AspGlu: 3.022 ± 0.082
2.62AspPhe: 2.62 ± 0.074
3.104AspGly: 3.104 ± 0.076
1.457AspHis: 1.457 ± 0.059
3.435AspIle: 3.435 ± 0.1
2.771AspLys: 2.771 ± 0.08
5.945AspLeu: 5.945 ± 0.108
1.146AspMet: 1.146 ± 0.049
1.806AspAsn: 1.806 ± 0.066
2.442AspPro: 2.442 ± 0.069
2.699AspGln: 2.699 ± 0.076
2.618AspArg: 2.618 ± 0.08
3.084AspSer: 3.084 ± 0.089
2.504AspThr: 2.504 ± 0.066
3.341AspVal: 3.341 ± 0.08
0.831AspTrp: 0.831 ± 0.042
1.864AspTyr: 1.864 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.741GluAla: 4.741 ± 0.142
0.437GluCys: 0.437 ± 0.026
2.729GluAsp: 2.729 ± 0.072
3.646GluGlu: 3.646 ± 0.113
1.99GluPhe: 1.99 ± 0.069
3.403GluGly: 3.403 ± 0.082
1.138GluHis: 1.138 ± 0.049
3.89GluIle: 3.89 ± 0.096
4.765GluLys: 4.765 ± 0.136
4.639GluLeu: 4.639 ± 0.103
1.336GluMet: 1.336 ± 0.047
2.64GluAsn: 2.64 ± 0.08
1.922GluPro: 1.922 ± 0.072
2.765GluGln: 2.765 ± 0.077
2.998GluArg: 2.998 ± 0.089
3.291GluSer: 3.291 ± 0.094
3.391GluThr: 3.391 ± 0.081
3.25GluVal: 3.25 ± 0.093
0.71GluTrp: 0.71 ± 0.041
1.324GluTyr: 1.324 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
2.972PheAla: 2.972 ± 0.082
0.787PheCys: 0.787 ± 0.043
2.588PheAsp: 2.588 ± 0.073
2.502PheGlu: 2.502 ± 0.072
2.295PhePhe: 2.295 ± 0.078
3.273PheGly: 3.273 ± 0.08
0.957PheHis: 0.957 ± 0.043
2.765PheIle: 2.765 ± 0.073
2.554PheLys: 2.554 ± 0.074
5.002PheLeu: 5.002 ± 0.138
1.11PheMet: 1.11 ± 0.053
1.756PheAsn: 1.756 ± 0.065
1.792PhePro: 1.792 ± 0.06
1.764PheGln: 1.764 ± 0.065
1.712PheArg: 1.712 ± 0.06
3.515PheSer: 3.515 ± 0.103
2.231PheThr: 2.231 ± 0.068
2.841PheVal: 2.841 ± 0.081
0.638PheTrp: 0.638 ± 0.04
1.669PheTyr: 1.669 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.994GlyAla: 4.994 ± 0.133
0.977GlyCys: 0.977 ± 0.046
3.303GlyAsp: 3.303 ± 0.087
3.379GlyGlu: 3.379 ± 0.088
3.435GlyPhe: 3.435 ± 0.08
5.082GlyGly: 5.082 ± 0.139
1.645GlyHis: 1.645 ± 0.058
4.446GlyIle: 4.446 ± 0.095
3.959GlyLys: 3.959 ± 0.088
7.149GlyLeu: 7.149 ± 0.145
1.697GlyMet: 1.697 ± 0.06
2.596GlyAsn: 2.596 ± 0.086
2.169GlyPro: 2.169 ± 0.066
2.96GlyGln: 2.96 ± 0.075
3.277GlyArg: 3.277 ± 0.081
4.378GlySer: 4.378 ± 0.113
3.911GlyThr: 3.911 ± 0.119
4.563GlyVal: 4.563 ± 0.108
1.027GlyTrp: 1.027 ± 0.049
2.48GlyTyr: 2.48 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.683HisAla: 1.683 ± 0.068
0.319HisCys: 0.319 ± 0.028
1.24HisAsp: 1.24 ± 0.048
1.164HisGlu: 1.164 ± 0.045
1.114HisPhe: 1.114 ± 0.05
1.499HisGly: 1.499 ± 0.055
0.881HisHis: 0.881 ± 0.047
1.439HisIle: 1.439 ± 0.054
1.234HisLys: 1.234 ± 0.057
2.655HisLeu: 2.655 ± 0.087
0.514HisMet: 0.514 ± 0.034
0.983HisAsn: 0.983 ± 0.042
1.423HisPro: 1.423 ± 0.063
1.445HisGln: 1.445 ± 0.056
1.224HisArg: 1.224 ± 0.056
1.423HisSer: 1.423 ± 0.053
1.216HisThr: 1.216 ± 0.051
1.298HisVal: 1.298 ± 0.052
0.223HisTrp: 0.223 ± 0.022
0.827HisTyr: 0.827 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.149IleAla: 5.149 ± 0.113
0.702IleCys: 0.702 ± 0.041
3.722IleAsp: 3.722 ± 0.088
3.702IleGlu: 3.702 ± 0.09
2.745IlePhe: 2.745 ± 0.088
4.336IleGly: 4.336 ± 0.107
1.441IleHis: 1.441 ± 0.052
3.768IleIle: 3.768 ± 0.091
3.571IleLys: 3.571 ± 0.101
6.691IleLeu: 6.691 ± 0.134
1.302IleMet: 1.302 ± 0.056
2.803IleAsn: 2.803 ± 0.076
3.112IlePro: 3.112 ± 0.083
2.859IleGln: 2.859 ± 0.066
2.865IleArg: 2.865 ± 0.074
4.366IleSer: 4.366 ± 0.097
3.756IleThr: 3.756 ± 0.105
3.89IleVal: 3.89 ± 0.104
0.644IleTrp: 0.644 ± 0.035
2.004IleTyr: 2.004 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.373LysAla: 5.373 ± 0.116
0.383LysCys: 0.383 ± 0.028
3.421LysAsp: 3.421 ± 0.093
3.736LysGlu: 3.736 ± 0.121
1.972LysPhe: 1.972 ± 0.057
3.868LysGly: 3.868 ± 0.095
1.21LysHis: 1.21 ± 0.05
4.422LysIle: 4.422 ± 0.108
4.767LysLys: 4.767 ± 0.131
5.12LysLeu: 5.12 ± 0.121
1.34LysMet: 1.34 ± 0.058
2.998LysAsn: 2.998 ± 0.086
2.765LysPro: 2.765 ± 0.084
2.386LysGln: 2.386 ± 0.071
2.966LysArg: 2.966 ± 0.076
3.85LysSer: 3.85 ± 0.097
4.242LysThr: 4.242 ± 0.085
3.772LysVal: 3.772 ± 0.087
0.508LysTrp: 0.508 ± 0.033
1.447LysTyr: 1.447 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
8.495LeuAla: 8.495 ± 0.136
1.332LeuCys: 1.332 ± 0.055
5.235LeuAsp: 5.235 ± 0.102
6.561LeuGlu: 6.561 ± 0.139
4.464LeuPhe: 4.464 ± 0.11
7.217LeuGly: 7.217 ± 0.139
2.137LeuHis: 2.137 ± 0.063
6.322LeuIle: 6.322 ± 0.127
7.753LeuLys: 7.753 ± 0.135
10.008LeuLeu: 10.008 ± 0.212
2.514LeuMet: 2.514 ± 0.078
4.659LeuAsn: 4.659 ± 0.11
4.868LeuPro: 4.868 ± 0.103
4.348LeuGln: 4.348 ± 0.09
4.665LeuArg: 4.665 ± 0.108
8.425LeuSer: 8.425 ± 0.137
6.639LeuThr: 6.639 ± 0.133
6.393LeuVal: 6.393 ± 0.12
1.244LeuTrp: 1.244 ± 0.055
2.923LeuTyr: 2.923 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
2.291MetAla: 2.291 ± 0.073
0.167MetCys: 0.167 ± 0.017
1.055MetAsp: 1.055 ± 0.045
1.063MetGlu: 1.063 ± 0.042
0.68MetPhe: 0.68 ± 0.037
1.74MetGly: 1.74 ± 0.056
0.439MetHis: 0.439 ± 0.029
1.483MetIle: 1.483 ± 0.056
1.467MetLys: 1.467 ± 0.058
2.075MetLeu: 2.075 ± 0.059
0.738MetMet: 0.738 ± 0.045
1.037MetAsn: 1.037 ± 0.046
1.176MetPro: 1.176 ± 0.05
0.841MetGln: 0.841 ± 0.035
1.148MetArg: 1.148 ± 0.049
1.324MetSer: 1.324 ± 0.055
1.553MetThr: 1.553 ± 0.057
1.641MetVal: 1.641 ± 0.054
0.179MetTrp: 0.179 ± 0.02
0.387MetTyr: 0.387 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.206AsnAla: 3.206 ± 0.09
0.425AsnCys: 0.425 ± 0.031
2.127AsnAsp: 2.127 ± 0.062
1.663AsnGlu: 1.663 ± 0.057
1.876AsnPhe: 1.876 ± 0.071
2.582AsnGly: 2.582 ± 0.08
1.148AsnHis: 1.148 ± 0.048
2.574AsnIle: 2.574 ± 0.082
2.201AsnLys: 2.201 ± 0.08
4.719AsnLeu: 4.719 ± 0.099
0.817AsnMet: 0.817 ± 0.04
1.762AsnAsn: 1.762 ± 0.077
2.735AsnPro: 2.735 ± 0.076
2.237AsnGln: 2.237 ± 0.068
2.143AsnArg: 2.143 ± 0.069
2.52AsnSer: 2.52 ± 0.084
2.297AsnThr: 2.297 ± 0.094
2.253AsnVal: 2.253 ± 0.078
0.606AsnTrp: 0.606 ± 0.037
1.268AsnTyr: 1.268 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.497ProAla: 3.497 ± 0.08
0.49ProCys: 0.49 ± 0.028
2.687ProAsp: 2.687 ± 0.079
2.661ProGlu: 2.661 ± 0.072
2.197ProPhe: 2.197 ± 0.074
2.735ProGly: 2.735 ± 0.085
1.188ProHis: 1.188 ± 0.05
2.761ProIle: 2.761 ± 0.076
2.636ProLys: 2.636 ± 0.072
5.134ProLeu: 5.134 ± 0.105
0.849ProMet: 0.849 ± 0.044
1.75ProAsn: 1.75 ± 0.066
1.918ProPro: 1.918 ± 0.081
1.882ProGln: 1.882 ± 0.061
1.631ProArg: 1.631 ± 0.066
3.517ProSer: 3.517 ± 0.1
2.867ProThr: 2.867 ± 0.084
2.947ProVal: 2.947 ± 0.072
0.478ProTrp: 0.478 ± 0.034
1.675ProTyr: 1.675 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
4.482GlnAla: 4.482 ± 0.107
0.307GlnCys: 0.307 ± 0.023
2.241GlnAsp: 2.241 ± 0.078
2.653GlnGlu: 2.653 ± 0.093
1.585GlnPhe: 1.585 ± 0.057
3.168GlnGly: 3.168 ± 0.086
1.067GlnHis: 1.067 ± 0.049
2.833GlnIle: 2.833 ± 0.08
3.24GlnLys: 3.24 ± 0.098
4.21GlnLeu: 4.21 ± 0.097
0.903GlnMet: 0.903 ± 0.044
2.183GlnAsn: 2.183 ± 0.068
2.025GlnPro: 2.025 ± 0.082
2.512GlnGln: 2.512 ± 0.081
2.301GlnArg: 2.301 ± 0.064
3.02GlnSer: 3.02 ± 0.077
2.99GlnThr: 2.99 ± 0.082
2.556GlnVal: 2.556 ± 0.068
0.542GlnTrp: 0.542 ± 0.032
1.154GlnTyr: 1.154 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
3.19ArgAla: 3.19 ± 0.083
0.468ArgCys: 0.468 ± 0.027
2.336ArgAsp: 2.336 ± 0.069
2.552ArgGlu: 2.552 ± 0.087
2.287ArgPhe: 2.287 ± 0.067
2.695ArgGly: 2.695 ± 0.064
1.358ArgHis: 1.358 ± 0.049
2.895ArgIle: 2.895 ± 0.083
2.418ArgLys: 2.418 ± 0.075
5.654ArgLeu: 5.654 ± 0.111
1.045ArgMet: 1.045 ± 0.044
1.898ArgAsn: 1.898 ± 0.061
2.099ArgPro: 2.099 ± 0.067
2.711ArgGln: 2.711 ± 0.094
2.697ArgArg: 2.697 ± 0.09
2.775ArgSer: 2.775 ± 0.071
2.311ArgThr: 2.311 ± 0.068
3.028ArgVal: 3.028 ± 0.088
0.542ArgTrp: 0.542 ± 0.035
1.631ArgTyr: 1.631 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
5.213SerAla: 5.213 ± 0.114
0.913SerCys: 0.913 ± 0.045
3.297SerAsp: 3.297 ± 0.092
3.074SerGlu: 3.074 ± 0.07
3.575SerPhe: 3.575 ± 0.087
4.725SerGly: 4.725 ± 0.136
1.639SerHis: 1.639 ± 0.056
4.23SerIle: 4.23 ± 0.091
3.379SerLys: 3.379 ± 0.092
8.092SerLeu: 8.092 ± 0.125
1.589SerMet: 1.589 ± 0.056
2.632SerAsn: 2.632 ± 0.087
3.417SerPro: 3.417 ± 0.103
2.968SerGln: 2.968 ± 0.086
2.835SerArg: 2.835 ± 0.08
6.049SerSer: 6.049 ± 0.213
3.582SerThr: 3.582 ± 0.086
4.147SerVal: 4.147 ± 0.098
0.919SerTrp: 0.919 ± 0.043
2.37SerTyr: 2.37 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
4.551ThrAla: 4.551 ± 0.112
0.58ThrCys: 0.58 ± 0.034
2.851ThrAsp: 2.851 ± 0.068
2.649ThrGlu: 2.649 ± 0.08
2.769ThrPhe: 2.769 ± 0.086
4.005ThrGly: 4.005 ± 0.115
1.477ThrHis: 1.477 ± 0.056
3.784ThrIle: 3.784 ± 0.099
2.893ThrLys: 2.893 ± 0.074
6.992ThrLeu: 6.992 ± 0.123
0.997ThrMet: 0.997 ± 0.04
2.309ThrAsn: 2.309 ± 0.071
3.411ThrPro: 3.411 ± 0.078
2.466ThrGln: 2.466 ± 0.078
2.233ThrArg: 2.233 ± 0.068
3.959ThrSer: 3.959 ± 0.1
3.852ThrThr: 3.852 ± 0.133
3.818ThrVal: 3.818 ± 0.094
0.648ThrTrp: 0.648 ± 0.034
1.924ThrTyr: 1.924 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.942ValAla: 4.942 ± 0.106
0.803ValCys: 0.803 ± 0.044
3.403ValAsp: 3.403 ± 0.09
3.762ValGlu: 3.762 ± 0.096
2.837ValPhe: 2.837 ± 0.084
4.4ValGly: 4.4 ± 0.096
1.298ValHis: 1.298 ± 0.052
4.3ValIle: 4.3 ± 0.101
3.439ValLys: 3.439 ± 0.093
6.595ValLeu: 6.595 ± 0.129
1.615ValMet: 1.615 ± 0.05
2.398ValAsn: 2.398 ± 0.072
2.715ValPro: 2.715 ± 0.075
2.352ValGln: 2.352 ± 0.066
2.743ValArg: 2.743 ± 0.077
4.382ValSer: 4.382 ± 0.098
3.772ValThr: 3.772 ± 0.09
4.745ValVal: 4.745 ± 0.122
0.706ValTrp: 0.706 ± 0.034
1.9ValTyr: 1.9 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.791TrpAla: 0.791 ± 0.04
0.175TrpCys: 0.175 ± 0.019
0.548TrpAsp: 0.548 ± 0.033
0.496TrpGlu: 0.496 ± 0.031
0.586TrpPhe: 0.586 ± 0.041
0.809TrpGly: 0.809 ± 0.035
0.381TrpHis: 0.381 ± 0.026
0.708TrpIle: 0.708 ± 0.046
0.592TrpLys: 0.592 ± 0.033
1.523TrpLeu: 1.523 ± 0.064
0.283TrpMet: 0.283 ± 0.022
0.439TrpAsn: 0.439 ± 0.03
0.498TrpPro: 0.498 ± 0.035
0.809TrpGln: 0.809 ± 0.045
0.762TrpArg: 0.762 ± 0.044
0.766TrpSer: 0.766 ± 0.036
0.602TrpThr: 0.602 ± 0.036
0.855TrpVal: 0.855 ± 0.051
0.185TrpTrp: 0.185 ± 0.02
0.341TrpTyr: 0.341 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.338TyrAla: 2.338 ± 0.063
0.343TyrCys: 0.343 ± 0.023
1.776TyrAsp: 1.776 ± 0.063
1.605TyrGlu: 1.605 ± 0.067
1.557TyrPhe: 1.557 ± 0.066
2.49TyrGly: 2.49 ± 0.074
0.843TyrHis: 0.843 ± 0.043
1.665TyrIle: 1.665 ± 0.064
1.681TyrLys: 1.681 ± 0.065
3.381TyrLeu: 3.381 ± 0.092
0.582TyrMet: 0.582 ± 0.034
1.29TyrAsn: 1.29 ± 0.054
1.286TyrPro: 1.286 ± 0.052
1.856TyrGln: 1.856 ± 0.063
1.641TyrArg: 1.641 ± 0.066
1.946TyrSer: 1.946 ± 0.062
1.577TyrThr: 1.577 ± 0.057
1.802TyrVal: 1.802 ± 0.049
0.409TyrTrp: 0.409 ± 0.03
1.083TyrTyr: 1.083 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1538 proteins (501607 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski