Amino acid dipepetide frequency for Sulfitobacter sabulilitoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.72AlaAla: 17.72 ± 0.173	1.2AlaCys: 1.2 ± 0.035	7.653AlaAsp: 7.653 ± 0.085	7.195AlaGlu: 7.195 ± 0.095	4.228AlaPhe: 4.228 ± 0.066	10.893AlaGly: 10.893 ± 0.146	2.548AlaHis: 2.548 ± 0.056	5.806AlaIle: 5.806 ± 0.066	3.449AlaLys: 3.449 ± 0.07	13.991AlaLeu: 13.991 ± 0.127	4.042AlaMet: 4.042 ± 0.064	2.562AlaAsn: 2.562 ± 0.048	6.4AlaPro: 6.4 ± 0.09	5.215AlaGln: 5.215 ± 0.083	9.956AlaArg: 9.956 ± 0.119	5.573AlaSer: 5.573 ± 0.076	6.473AlaThr: 6.473 ± 0.087	8.669AlaVal: 8.669 ± 0.091	1.439AlaTrp: 1.439 ± 0.039	2.496AlaTyr: 2.496 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.201CysAla: 1.201 ± 0.033	0.104CysCys: 0.104 ± 0.008	0.673CysAsp: 0.673 ± 0.02	0.376CysGlu: 0.376 ± 0.019	0.335CysPhe: 0.335 ± 0.017	0.945CysGly: 0.945 ± 0.035	0.273CysHis: 0.273 ± 0.016	0.426CysIle: 0.426 ± 0.018	0.197CysLys: 0.197 ± 0.013	0.829CysLeu: 0.829 ± 0.026	0.178CysMet: 0.178 ± 0.011	0.214CysAsn: 0.214 ± 0.012	0.504CysPro: 0.504 ± 0.019	0.228CysGln: 0.228 ± 0.015	0.526CysArg: 0.526 ± 0.021	0.411CysSer: 0.411 ± 0.02	0.432CysThr: 0.432 ± 0.022	0.67CysVal: 0.67 ± 0.023	0.115CysTrp: 0.115 ± 0.009	0.226CysTyr: 0.226 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	8.651AspAla: 8.651 ± 0.097	0.52AspCys: 0.52 ± 0.022	3.954AspAsp: 3.954 ± 0.073	3.119AspGlu: 3.119 ± 0.056	2.215AspPhe: 2.215 ± 0.037	5.757AspGly: 5.757 ± 0.087	1.588AspHis: 1.588 ± 0.044	3.385AspIle: 3.385 ± 0.057	1.64AspLys: 1.64 ± 0.04	7.04AspLeu: 7.04 ± 0.084	1.866AspMet: 1.866 ± 0.036	1.296AspAsn: 1.296 ± 0.035	3.896AspPro: 3.896 ± 0.051	2.006AspGln: 2.006 ± 0.046	4.845AspArg: 4.845 ± 0.072	2.175AspSer: 2.175 ± 0.05	3.657AspThr: 3.657 ± 0.07	4.768AspVal: 4.768 ± 0.071	1.209AspTrp: 1.209 ± 0.033	1.586AspTyr: 1.586 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.164GluAla: 7.164 ± 0.099	0.331GluCys: 0.331 ± 0.019	3.2GluAsp: 3.2 ± 0.054	2.72GluGlu: 2.72 ± 0.07	1.677GluPhe: 1.677 ± 0.041	4.172GluGly: 4.172 ± 0.063	1.039GluHis: 1.039 ± 0.029	3.17GluIle: 3.17 ± 0.053	1.732GluLys: 1.732 ± 0.042	4.435GluLeu: 4.435 ± 0.075	1.737GluMet: 1.737 ± 0.039	1.512GluAsn: 1.512 ± 0.038	2.196GluPro: 2.196 ± 0.053	1.831GluGln: 1.831 ± 0.047	3.789GluArg: 3.789 ± 0.066	1.625GluSer: 1.625 ± 0.04	3.5GluThr: 3.5 ± 0.049	4.045GluVal: 4.045 ± 0.058	0.636GluTrp: 0.636 ± 0.02	1.008GluTyr: 1.008 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.543PheAla: 4.543 ± 0.067	0.458PheCys: 0.458 ± 0.022	3.083PheAsp: 3.083 ± 0.049	2.084PheGlu: 2.084 ± 0.045	1.328PhePhe: 1.328 ± 0.042	3.648PheGly: 3.648 ± 0.067	0.729PheHis: 0.729 ± 0.03	1.546PheIle: 1.546 ± 0.041	0.945PheLys: 0.945 ± 0.032	3.119PheLeu: 3.119 ± 0.057	0.857PheMet: 0.857 ± 0.026	0.993PheAsn: 0.993 ± 0.028	1.402PhePro: 1.402 ± 0.037	1.002PheGln: 1.002 ± 0.033	2.009PheArg: 2.009 ± 0.043	2.037PheSer: 2.037 ± 0.048	2.054PheThr: 2.054 ± 0.044	2.755PheVal: 2.755 ± 0.054	0.544PheTrp: 0.544 ± 0.022	0.87PheTyr: 0.87 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.563GlyAla: 10.563 ± 0.127	0.823GlyCys: 0.823 ± 0.028	5.373GlyAsp: 5.373 ± 0.088	4.055GlyGlu: 4.055 ± 0.062	3.742GlyPhe: 3.742 ± 0.06	7.803GlyGly: 7.803 ± 0.164	2.054GlyHis: 2.054 ± 0.046	4.34GlyIle: 4.34 ± 0.063	2.888GlyLys: 2.888 ± 0.058	9.224GlyLeu: 9.224 ± 0.105	2.603GlyMet: 2.603 ± 0.051	2.165GlyAsn: 2.165 ± 0.099	3.908GlyPro: 3.908 ± 0.062	3.251GlyGln: 3.251 ± 0.058	5.9GlyArg: 5.9 ± 0.077	4.201GlySer: 4.201 ± 0.083	4.919GlyThr: 4.919 ± 0.08	6.57GlyVal: 6.57 ± 0.076	1.491GlyTrp: 1.491 ± 0.039	2.299GlyTyr: 2.299 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.537HisAla: 2.537 ± 0.052	0.225HisCys: 0.225 ± 0.012	1.486HisAsp: 1.486 ± 0.039	0.959HisGlu: 0.959 ± 0.029	0.784HisPhe: 0.784 ± 0.026	1.962HisGly: 1.962 ± 0.047	0.61HisHis: 0.61 ± 0.025	0.992HisIle: 0.992 ± 0.029	0.499HisLys: 0.499 ± 0.02	2.221HisLeu: 2.221 ± 0.052	0.559HisMet: 0.559 ± 0.02	0.443HisAsn: 0.443 ± 0.022	1.442HisPro: 1.442 ± 0.036	0.575HisGln: 0.575 ± 0.022	1.463HisArg: 1.463 ± 0.037	0.944HisSer: 0.944 ± 0.027	0.902HisThr: 0.902 ± 0.03	1.633HisVal: 1.633 ± 0.036	0.342HisTrp: 0.342 ± 0.018	0.571HisTyr: 0.571 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.167IleAla: 7.167 ± 0.088	0.595IleCys: 0.595 ± 0.021	3.797IleAsp: 3.797 ± 0.062	3.351IleGlu: 3.351 ± 0.058	1.608IlePhe: 1.608 ± 0.043	4.754IleGly: 4.754 ± 0.071	0.902IleHis: 0.902 ± 0.027	2.122IleIle: 2.122 ± 0.047	1.482IleLys: 1.482 ± 0.037	4.439IleLeu: 4.439 ± 0.071	1.058IleMet: 1.058 ± 0.031	1.425IleAsn: 1.425 ± 0.034	2.244IlePro: 2.244 ± 0.049	1.087IleGln: 1.087 ± 0.034	3.069IleArg: 3.069 ± 0.05	2.795IleSer: 2.795 ± 0.054	3.003IleThr: 3.003 ± 0.043	3.902IleVal: 3.902 ± 0.059	0.752IleTrp: 0.752 ± 0.024	1.163IleTyr: 1.163 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.547LysAla: 3.547 ± 0.062	0.178LysCys: 0.178 ± 0.011	1.604LysAsp: 1.604 ± 0.042	1.167LysGlu: 1.167 ± 0.037	0.875LysPhe: 0.875 ± 0.027	2.488LysGly: 2.488 ± 0.048	0.549LysHis: 0.549 ± 0.023	1.558LysIle: 1.558 ± 0.04	1.065LysLys: 1.065 ± 0.035	2.623LysLeu: 2.623 ± 0.047	0.838LysMet: 0.838 ± 0.028	0.673LysAsn: 0.673 ± 0.027	1.678LysPro: 1.678 ± 0.047	0.795LysGln: 0.795 ± 0.029	2.128LysArg: 2.128 ± 0.047	1.785LysSer: 1.785 ± 0.045	1.968LysThr: 1.968 ± 0.042	2.04LysVal: 2.04 ± 0.044	0.349LysTrp: 0.349 ± 0.018	0.615LysTyr: 0.615 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.805LeuAla: 12.805 ± 0.135	0.965LeuCys: 0.965 ± 0.032	6.222LeuAsp: 6.222 ± 0.084	4.871LeuGlu: 4.871 ± 0.065	3.295LeuPhe: 3.295 ± 0.058	8.528LeuGly: 8.528 ± 0.108	1.966LeuHis: 1.966 ± 0.044	5.202LeuIle: 5.202 ± 0.075	2.816LeuLys: 2.816 ± 0.052	8.681LeuLeu: 8.681 ± 0.106	2.714LeuMet: 2.714 ± 0.051	2.547LeuAsn: 2.547 ± 0.049	5.57LeuPro: 5.57 ± 0.081	2.646LeuGln: 2.646 ± 0.045	7.589LeuArg: 7.589 ± 0.108	6.47LeuSer: 6.47 ± 0.085	6.06LeuThr: 6.06 ± 0.075	6.901LeuVal: 6.901 ± 0.084	1.278LeuTrp: 1.278 ± 0.04	1.904LeuTyr: 1.904 ± 0.042	0.001LeuXaa: 0.001 ± 0.001
Met	3.593MetAla: 3.593 ± 0.054	0.212MetCys: 0.212 ± 0.013	1.5MetAsp: 1.5 ± 0.034	1.233MetGlu: 1.233 ± 0.032	0.833MetPhe: 0.833 ± 0.031	2.371MetGly: 2.371 ± 0.043	0.5MetHis: 0.5 ± 0.026	1.638MetIle: 1.638 ± 0.036	0.97MetLys: 0.97 ± 0.029	2.682MetLeu: 2.682 ± 0.053	0.837MetMet: 0.837 ± 0.025	0.807MetAsn: 0.807 ± 0.027	1.551MetPro: 1.551 ± 0.036	1.09MetGln: 1.09 ± 0.028	1.957MetArg: 1.957 ± 0.044	1.737MetSer: 1.737 ± 0.038	2.397MetThr: 2.397 ± 0.039	1.866MetVal: 1.866 ± 0.038	0.266MetTrp: 0.266 ± 0.016	0.387MetTyr: 0.387 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.044AsnAla: 3.044 ± 0.056	0.23AsnCys: 0.23 ± 0.014	1.586AsnAsp: 1.586 ± 0.084	1.029AsnGlu: 1.029 ± 0.033	0.885AsnPhe: 0.885 ± 0.03	2.268AsnGly: 2.268 ± 0.057	0.466AsnHis: 0.466 ± 0.019	1.28AsnIle: 1.28 ± 0.038	0.61AsnLys: 0.61 ± 0.023	2.391AsnLeu: 2.391 ± 0.05	0.694AsnMet: 0.694 ± 0.027	0.644AsnAsn: 0.644 ± 0.027	1.679AsnPro: 1.679 ± 0.037	0.679AsnGln: 0.679 ± 0.024	1.737AsnArg: 1.737 ± 0.039	1.082AsnSer: 1.082 ± 0.036	1.338AsnThr: 1.338 ± 0.038	1.729AsnVal: 1.729 ± 0.044	0.404AsnTrp: 0.404 ± 0.02	0.601AsnTyr: 0.601 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.073ProAla: 6.073 ± 0.091	0.354ProCys: 0.354 ± 0.017	4.33ProAsp: 4.33 ± 0.059	3.497ProGlu: 3.497 ± 0.059	1.989ProPhe: 1.989 ± 0.041	4.759ProGly: 4.759 ± 0.066	1.124ProHis: 1.124 ± 0.035	2.188ProIle: 2.188 ± 0.048	1.56ProLys: 1.56 ± 0.047	4.685ProLeu: 4.685 ± 0.063	1.368ProMet: 1.368 ± 0.036	1.244ProAsn: 1.244 ± 0.035	2.424ProPro: 2.424 ± 0.051	1.956ProGln: 1.956 ± 0.048	3.297ProArg: 3.297 ± 0.051	2.404ProSer: 2.404 ± 0.044	2.44ProThr: 2.44 ± 0.05	4.326ProVal: 4.326 ± 0.066	0.643ProTrp: 0.643 ± 0.023	1.128ProTyr: 1.128 ± 0.036	0.001ProXaa: 0.001 ± 0.001
Gln	4.445GlnAla: 4.445 ± 0.076	0.217GlnCys: 0.217 ± 0.012	1.999GlnAsp: 1.999 ± 0.036	1.442GlnGlu: 1.442 ± 0.039	1.085GlnPhe: 1.085 ± 0.031	2.947GlnGly: 2.947 ± 0.047	0.599GlnHis: 0.599 ± 0.023	1.994GlnIle: 1.994 ± 0.045	0.964GlnLys: 0.964 ± 0.028	2.66GlnLeu: 2.66 ± 0.052	1.181GlnMet: 1.181 ± 0.035	0.829GlnAsn: 0.829 ± 0.028	1.643GlnPro: 1.643 ± 0.036	1.084GlnGln: 1.084 ± 0.039	2.209GlnArg: 2.209 ± 0.047	1.935GlnSer: 1.935 ± 0.05	2.007GlnThr: 2.007 ± 0.05	2.527GlnVal: 2.527 ± 0.043	0.392GlnTrp: 0.392 ± 0.018	0.598GlnTyr: 0.598 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.005ArgAla: 9.005 ± 0.101	0.491ArgCys: 0.491 ± 0.02	5.159ArgAsp: 5.159 ± 0.071	3.505ArgGlu: 3.505 ± 0.064	2.686ArgPhe: 2.686 ± 0.055	4.934ArgGly: 4.934 ± 0.067	1.658ArgHis: 1.658 ± 0.037	4.05ArgIle: 4.05 ± 0.066	2.118ArgLys: 2.118 ± 0.043	7.388ArgLeu: 7.388 ± 0.105	2.088ArgMet: 2.088 ± 0.046	1.673ArgAsn: 1.673 ± 0.037	3.439ArgPro: 3.439 ± 0.055	2.397ArgGln: 2.397 ± 0.049	5.407ArgArg: 5.407 ± 0.085	3.404ArgSer: 3.404 ± 0.062	3.283ArgThr: 3.283 ± 0.055	4.942ArgVal: 4.942 ± 0.066	0.959ArgTrp: 0.959 ± 0.031	1.61ArgTyr: 1.61 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.738SerAla: 5.738 ± 0.078	0.413SerCys: 0.413 ± 0.02	3.385SerAsp: 3.385 ± 0.047	2.459SerGlu: 2.459 ± 0.054	2.184SerPhe: 2.184 ± 0.053	5.353SerGly: 5.353 ± 0.082	1.098SerHis: 1.098 ± 0.031	2.384SerIle: 2.384 ± 0.046	1.356SerLys: 1.356 ± 0.039	4.869SerLeu: 4.869 ± 0.071	1.329SerMet: 1.329 ± 0.038	1.306SerAsn: 1.306 ± 0.042	2.516SerPro: 2.516 ± 0.048	1.59SerGln: 1.59 ± 0.036	3.256SerArg: 3.256 ± 0.064	2.443SerSer: 2.443 ± 0.058	2.436SerThr: 2.436 ± 0.057	3.831SerVal: 3.831 ± 0.065	0.597SerTrp: 0.597 ± 0.023	1.227SerTyr: 1.227 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.687ThrAla: 6.687 ± 0.087	0.512ThrCys: 0.512 ± 0.025	3.476ThrAsp: 3.476 ± 0.052	2.768ThrGlu: 2.768 ± 0.053	1.915ThrPhe: 1.915 ± 0.038	5.805ThrGly: 5.805 ± 0.076	1.195ThrHis: 1.195 ± 0.032	2.684ThrIle: 2.684 ± 0.059	1.379ThrLys: 1.379 ± 0.036	6.301ThrLeu: 6.301 ± 0.096	1.318ThrMet: 1.318 ± 0.035	1.235ThrAsn: 1.235 ± 0.037	3.713ThrPro: 3.713 ± 0.053	1.864ThrGln: 1.864 ± 0.037	3.819ThrArg: 3.819 ± 0.06	2.654ThrSer: 2.654 ± 0.062	2.968ThrThr: 2.968 ± 0.06	4.413ThrVal: 4.413 ± 0.076	0.727ThrTrp: 0.727 ± 0.026	1.251ThrTyr: 1.251 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.049ValAla: 9.049 ± 0.092	0.659ValCys: 0.659 ± 0.025	4.237ValAsp: 4.237 ± 0.058	4.062ValGlu: 4.062 ± 0.064	2.868ValPhe: 2.868 ± 0.057	5.56ValGly: 5.56 ± 0.075	1.393ValHis: 1.393 ± 0.035	4.282ValIle: 4.282 ± 0.057	1.93ValLys: 1.93 ± 0.046	7.692ValLeu: 7.692 ± 0.099	2.263ValMet: 2.263 ± 0.045	1.906ValAsn: 1.906 ± 0.05	3.825ValPro: 3.825 ± 0.059	2.241ValGln: 2.241 ± 0.047	4.52ValArg: 4.52 ± 0.078	4.147ValSer: 4.147 ± 0.056	4.905ValThr: 4.905 ± 0.067	5.737ValVal: 5.737 ± 0.093	0.974ValTrp: 0.974 ± 0.034	1.529ValTyr: 1.529 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.457TrpAla: 1.457 ± 0.039	0.143TrpCys: 0.143 ± 0.012	0.792TrpAsp: 0.792 ± 0.025	0.553TrpGlu: 0.553 ± 0.025	0.577TrpPhe: 0.577 ± 0.022	1.021TrpGly: 1.021 ± 0.035	0.353TrpHis: 0.353 ± 0.019	0.732TrpIle: 0.732 ± 0.024	0.376TrpLys: 0.376 ± 0.02	1.495TrpLeu: 1.495 ± 0.042	0.417TrpMet: 0.417 ± 0.019	0.385TrpAsn: 0.385 ± 0.019	0.685TrpPro: 0.685 ± 0.026	0.582TrpGln: 0.582 ± 0.024	1.128TrpArg: 1.128 ± 0.036	0.791TrpSer: 0.791 ± 0.024	0.795TrpThr: 0.795 ± 0.025	0.909TrpVal: 0.909 ± 0.03	0.224TrpTrp: 0.224 ± 0.012	0.265TrpTyr: 0.265 ± 0.018	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.52TyrAla: 2.52 ± 0.046	0.234TyrCys: 0.234 ± 0.015	1.662TyrAsp: 1.662 ± 0.033	1.077TyrGlu: 1.077 ± 0.029	0.898TyrPhe: 0.898 ± 0.03	2.204TyrGly: 2.204 ± 0.051	0.504TyrHis: 0.504 ± 0.02	0.94TyrIle: 0.94 ± 0.028	0.545TyrLys: 0.545 ± 0.024	2.266TyrLeu: 2.266 ± 0.046	0.475TyrMet: 0.475 ± 0.023	0.518TyrAsn: 0.518 ± 0.019	1.073TyrPro: 1.073 ± 0.028	0.638TyrGln: 0.638 ± 0.026	1.589TyrArg: 1.589 ± 0.032	1.159TyrSer: 1.159 ± 0.03	1.146TyrThr: 1.146 ± 0.034	1.547TyrVal: 1.547 ± 0.041	0.338TyrTrp: 0.338 ± 0.017	0.546TyrTyr: 0.546 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3675 proteins (1186263 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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