Amino acid dipepetide frequency for Chitinimonas arctica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.77AlaAla: 15.77 ± 0.161
1.264AlaCys: 1.264 ± 0.034
7.048AlaAsp: 7.048 ± 0.096
7.358AlaGlu: 7.358 ± 0.105
3.647AlaPhe: 3.647 ± 0.05
10.904AlaGly: 10.904 ± 0.132
2.249AlaHis: 2.249 ± 0.046
5.627AlaIle: 5.627 ± 0.067
4.292AlaLys: 4.292 ± 0.069
13.238AlaLeu: 13.238 ± 0.146
3.297AlaMet: 3.297 ± 0.049
3.496AlaAsn: 3.496 ± 0.056
5.001AlaPro: 5.001 ± 0.071
4.844AlaGln: 4.844 ± 0.075
7.654AlaArg: 7.654 ± 0.103
6.489AlaSer: 6.489 ± 0.075
5.651AlaThr: 5.651 ± 0.07
7.82AlaVal: 7.82 ± 0.093
1.749AlaTrp: 1.749 ± 0.036
2.705AlaTyr: 2.705 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.984CysAla: 0.984 ± 0.028
0.137CysCys: 0.137 ± 0.011
0.539CysAsp: 0.539 ± 0.021
0.538CysGlu: 0.538 ± 0.022
0.336CysPhe: 0.336 ± 0.016
0.894CysGly: 0.894 ± 0.029
0.284CysHis: 0.284 ± 0.014
0.372CysIle: 0.372 ± 0.016
0.296CysLys: 0.296 ± 0.016
1.062CysLeu: 1.062 ± 0.035
0.2CysMet: 0.2 ± 0.011
0.289CysAsn: 0.289 ± 0.015
0.533CysPro: 0.533 ± 0.02
0.347CysGln: 0.347 ± 0.017
0.705CysArg: 0.705 ± 0.023
0.506CysSer: 0.506 ± 0.019
0.443CysThr: 0.443 ± 0.018
0.584CysVal: 0.584 ± 0.023
0.162CysTrp: 0.162 ± 0.012
0.252CysTyr: 0.252 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.493AspAla: 6.493 ± 0.104
0.579AspCys: 0.579 ± 0.022
3.067AspAsp: 3.067 ± 0.076
3.314AspGlu: 3.314 ± 0.053
2.331AspPhe: 2.331 ± 0.038
5.253AspGly: 5.253 ± 0.122
1.106AspHis: 1.106 ± 0.029
2.869AspIle: 2.869 ± 0.053
2.32AspLys: 2.32 ± 0.049
5.52AspLeu: 5.52 ± 0.073
1.227AspMet: 1.227 ± 0.029
1.659AspAsn: 1.659 ± 0.043
2.805AspPro: 2.805 ± 0.047
1.983AspGln: 1.983 ± 0.043
3.407AspArg: 3.407 ± 0.056
3.032AspSer: 3.032 ± 0.056
2.88AspThr: 2.88 ± 0.112
3.458AspVal: 3.458 ± 0.058
1.12AspTrp: 1.12 ± 0.029
1.718AspTyr: 1.718 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.941GluAla: 6.941 ± 0.083
0.394GluCys: 0.394 ± 0.015
2.281GluAsp: 2.281 ± 0.041
2.618GluGlu: 2.618 ± 0.054
1.831GluPhe: 1.831 ± 0.036
3.75GluGly: 3.75 ± 0.064
1.267GluHis: 1.267 ± 0.031
3.073GluIle: 3.073 ± 0.053
2.256GluLys: 2.256 ± 0.048
6.49GluLeu: 6.49 ± 0.083
1.398GluMet: 1.398 ± 0.035
1.599GluAsn: 1.599 ± 0.031
2.248GluPro: 2.248 ± 0.04
3.062GluGln: 3.062 ± 0.047
4.341GluArg: 4.341 ± 0.07
2.717GluSer: 2.717 ± 0.053
2.702GluThr: 2.702 ± 0.044
3.819GluVal: 3.819 ± 0.064
0.754GluTrp: 0.754 ± 0.022
1.336GluTyr: 1.336 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.874PheAla: 3.874 ± 0.061
0.398PheCys: 0.398 ± 0.016
2.64PheAsp: 2.64 ± 0.049
2.075PheGlu: 2.075 ± 0.04
1.29PhePhe: 1.29 ± 0.039
3.169PheGly: 3.169 ± 0.053
0.745PheHis: 0.745 ± 0.023
1.506PheIle: 1.506 ± 0.035
1.34PheLys: 1.34 ± 0.03
2.983PheLeu: 2.983 ± 0.051
0.688PheMet: 0.688 ± 0.021
1.288PheAsn: 1.288 ± 0.031
1.443PhePro: 1.443 ± 0.033
1.164PheGln: 1.164 ± 0.029
1.999PheArg: 1.999 ± 0.039
2.537PheSer: 2.537 ± 0.045
1.824PheThr: 1.824 ± 0.038
2.364PheVal: 2.364 ± 0.041
0.459PheTrp: 0.459 ± 0.016
0.959PheTyr: 0.959 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
7.633GlyAla: 7.633 ± 0.1
0.814GlyCys: 0.814 ± 0.024
4.465GlyAsp: 4.465 ± 0.111
4.965GlyGlu: 4.965 ± 0.061
3.099GlyPhe: 3.099 ± 0.041
7.017GlyGly: 7.017 ± 0.19
1.734GlyHis: 1.734 ± 0.037
3.93GlyIle: 3.93 ± 0.055
3.978GlyLys: 3.978 ± 0.062
8.648GlyLeu: 8.648 ± 0.08
2.335GlyMet: 2.335 ± 0.04
3.17GlyAsn: 3.17 ± 0.147
2.514GlyPro: 2.514 ± 0.044
3.712GlyGln: 3.712 ± 0.057
5.472GlyArg: 5.472 ± 0.08
5.144GlySer: 5.144 ± 0.117
3.866GlyThr: 3.866 ± 0.093
5.7GlyVal: 5.7 ± 0.068
1.374GlyTrp: 1.374 ± 0.033
2.395GlyTyr: 2.395 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.606HisAla: 2.606 ± 0.045
0.297HisCys: 0.297 ± 0.018
1.211HisAsp: 1.211 ± 0.032
1.1HisGlu: 1.1 ± 0.028
0.944HisPhe: 0.944 ± 0.027
2.019HisGly: 2.019 ± 0.041
0.553HisHis: 0.553 ± 0.025
1.09HisIle: 1.09 ± 0.025
0.593HisLys: 0.593 ± 0.022
2.214HisLeu: 2.214 ± 0.045
0.431HisMet: 0.431 ± 0.017
0.56HisAsn: 0.56 ± 0.019
1.301HisPro: 1.301 ± 0.031
0.73HisGln: 0.73 ± 0.026
1.318HisArg: 1.318 ± 0.034
1.102HisSer: 1.102 ± 0.029
1.003HisThr: 1.003 ± 0.027
1.183HisVal: 1.183 ± 0.029
0.385HisTrp: 0.385 ± 0.017
0.697HisTyr: 0.697 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.971IleAla: 5.971 ± 0.072
0.487IleCys: 0.487 ± 0.019
3.245IleAsp: 3.245 ± 0.047
3.182IleGlu: 3.182 ± 0.052
1.304IlePhe: 1.304 ± 0.029
4.146IleGly: 4.146 ± 0.052
0.949IleHis: 0.949 ± 0.022
1.632IleIle: 1.632 ± 0.038
1.91IleLys: 1.91 ± 0.04
3.864IleLeu: 3.864 ± 0.057
0.72IleMet: 0.72 ± 0.028
1.67IleAsn: 1.67 ± 0.04
2.057IlePro: 2.057 ± 0.036
1.545IleGln: 1.545 ± 0.034
3.01IleArg: 3.01 ± 0.049
2.968IleSer: 2.968 ± 0.044
2.436IleThr: 2.436 ± 0.055
3.35IleVal: 3.35 ± 0.047
0.574IleTrp: 0.574 ± 0.02
1.141IleTyr: 1.141 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.001LysAla: 4.001 ± 0.062
0.238LysCys: 0.238 ± 0.013
1.767LysAsp: 1.767 ± 0.045
1.676LysGlu: 1.676 ± 0.039
1.057LysPhe: 1.057 ± 0.024
2.542LysGly: 2.542 ± 0.051
0.779LysHis: 0.779 ± 0.021
1.77LysIle: 1.77 ± 0.045
1.531LysLys: 1.531 ± 0.04
4.792LysLeu: 4.792 ± 0.066
0.848LysMet: 0.848 ± 0.027
1.124LysAsn: 1.124 ± 0.03
2.335LysPro: 2.335 ± 0.051
1.989LysGln: 1.989 ± 0.042
2.541LysArg: 2.541 ± 0.044
2.052LysSer: 2.052 ± 0.042
2.113LysThr: 2.113 ± 0.047
2.495LysVal: 2.495 ± 0.047
0.422LysTrp: 0.422 ± 0.019
0.884LysTyr: 0.884 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
15.947LeuAla: 15.947 ± 0.188
1.051LeuCys: 1.051 ± 0.026
6.786LeuAsp: 6.786 ± 0.094
5.567LeuGlu: 5.567 ± 0.074
3.607LeuPhe: 3.607 ± 0.058
8.513LeuGly: 8.513 ± 0.097
2.247LeuHis: 2.247 ± 0.045
4.733LeuIle: 4.733 ± 0.076
4.21LeuLys: 4.21 ± 0.06
12.358LeuLeu: 12.358 ± 0.157
2.176LeuMet: 2.176 ± 0.045
3.341LeuAsn: 3.341 ± 0.049
6.344LeuPro: 6.344 ± 0.095
4.331LeuGln: 4.331 ± 0.062
7.482LeuArg: 7.482 ± 0.09
6.989LeuSer: 6.989 ± 0.079
5.5LeuThr: 5.5 ± 0.068
7.186LeuVal: 7.186 ± 0.082
1.141LeuTrp: 1.141 ± 0.032
2.368LeuTyr: 2.368 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.834MetAla: 2.834 ± 0.049
0.127MetCys: 0.127 ± 0.009
1.135MetAsp: 1.135 ± 0.03
1.084MetGlu: 1.084 ± 0.027
0.649MetPhe: 0.649 ± 0.023
1.624MetGly: 1.624 ± 0.039
0.502MetHis: 0.502 ± 0.021
0.878MetIle: 0.878 ± 0.028
0.965MetLys: 0.965 ± 0.025
2.728MetLeu: 2.728 ± 0.05
0.525MetMet: 0.525 ± 0.019
0.788MetAsn: 0.788 ± 0.024
1.39MetPro: 1.39 ± 0.032
1.197MetGln: 1.197 ± 0.03
1.575MetArg: 1.575 ± 0.034
1.464MetSer: 1.464 ± 0.031
1.225MetThr: 1.225 ± 0.027
1.585MetVal: 1.585 ± 0.031
0.167MetTrp: 0.167 ± 0.01
0.411MetTyr: 0.411 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.277AsnAla: 3.277 ± 0.051
0.307AsnCys: 0.307 ± 0.014
1.904AsnAsp: 1.904 ± 0.131
1.466AsnGlu: 1.466 ± 0.034
1.068AsnPhe: 1.068 ± 0.026
2.935AsnGly: 2.935 ± 0.077
0.651AsnHis: 0.651 ± 0.019
1.452AsnIle: 1.452 ± 0.036
1.115AsnLys: 1.115 ± 0.03
3.263AsnLeu: 3.263 ± 0.057
0.659AsnMet: 0.659 ± 0.022
1.03AsnAsn: 1.03 ± 0.034
1.906AsnPro: 1.906 ± 0.044
1.224AsnGln: 1.224 ± 0.035
2.074AsnArg: 2.074 ± 0.043
1.648AsnSer: 1.648 ± 0.041
1.648AsnThr: 1.648 ± 0.041
1.952AsnVal: 1.952 ± 0.048
0.56AsnTrp: 0.56 ± 0.023
0.948AsnTyr: 0.948 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
6.719ProAla: 6.719 ± 0.086
0.393ProCys: 0.393 ± 0.018
2.975ProAsp: 2.975 ± 0.052
2.838ProGlu: 2.838 ± 0.046
1.682ProPhe: 1.682 ± 0.033
3.787ProGly: 3.787 ± 0.057
1.003ProHis: 1.003 ± 0.031
2.182ProIle: 2.182 ± 0.039
1.509ProLys: 1.509 ± 0.035
5.238ProLeu: 5.238 ± 0.072
1.095ProMet: 1.095 ± 0.027
1.405ProAsn: 1.405 ± 0.034
2.536ProPro: 2.536 ± 0.053
1.828ProGln: 1.828 ± 0.041
2.637ProArg: 2.637 ± 0.045
2.724ProSer: 2.724 ± 0.041
2.506ProThr: 2.506 ± 0.061
3.66ProVal: 3.66 ± 0.057
0.67ProTrp: 0.67 ± 0.025
1.245ProTyr: 1.245 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
6.2GlnAla: 6.2 ± 0.094
0.322GlnCys: 0.322 ± 0.016
1.807GlnAsp: 1.807 ± 0.045
1.667GlnGlu: 1.667 ± 0.036
1.408GlnPhe: 1.408 ± 0.03
3.199GlnGly: 3.199 ± 0.053
0.996GlnHis: 0.996 ± 0.03
1.992GlnIle: 1.992 ± 0.039
1.272GlnLys: 1.272 ± 0.036
5.326GlnLeu: 5.326 ± 0.064
0.939GlnMet: 0.939 ± 0.026
1.022GlnAsn: 1.022 ± 0.036
2.243GlnPro: 2.243 ± 0.038
2.118GlnGln: 2.118 ± 0.04
3.056GlnArg: 3.056 ± 0.053
2.242GlnSer: 2.242 ± 0.041
2.09GlnThr: 2.09 ± 0.046
2.949GlnVal: 2.949 ± 0.054
0.594GlnTrp: 0.594 ± 0.023
0.99GlnTyr: 0.99 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
6.569ArgAla: 6.569 ± 0.088
0.612ArgCys: 0.612 ± 0.025
3.679ArgAsp: 3.679 ± 0.055
3.978ArgGlu: 3.978 ± 0.057
2.845ArgPhe: 2.845 ± 0.05
4.081ArgGly: 4.081 ± 0.051
1.803ArgHis: 1.803 ± 0.043
3.707ArgIle: 3.707 ± 0.057
2.316ArgLys: 2.316 ± 0.043
8.446ArgLeu: 8.446 ± 0.117
1.613ArgMet: 1.613 ± 0.035
2.059ArgAsn: 2.059 ± 0.04
2.969ArgPro: 2.969 ± 0.045
3.441ArgGln: 3.441 ± 0.061
4.644ArgArg: 4.644 ± 0.079
3.444ArgSer: 3.444 ± 0.057
2.903ArgThr: 2.903 ± 0.048
4.305ArgVal: 4.305 ± 0.064
1.013ArgTrp: 1.013 ± 0.029
2.17ArgTyr: 2.17 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.327SerAla: 6.327 ± 0.076
0.538SerCys: 0.538 ± 0.022
2.982SerAsp: 2.982 ± 0.055
2.904SerGlu: 2.904 ± 0.045
2.097SerPhe: 2.097 ± 0.041
5.487SerGly: 5.487 ± 0.121
1.284SerHis: 1.284 ± 0.031
2.484SerIle: 2.484 ± 0.051
1.928SerLys: 1.928 ± 0.04
6.696SerLeu: 6.696 ± 0.081
1.25SerMet: 1.25 ± 0.026
1.881SerAsn: 1.881 ± 0.043
2.736SerPro: 2.736 ± 0.045
2.334SerGln: 2.334 ± 0.04
3.793SerArg: 3.793 ± 0.045
3.243SerSer: 3.243 ± 0.067
2.89SerThr: 2.89 ± 0.056
3.779SerVal: 3.779 ± 0.054
0.873SerTrp: 0.873 ± 0.024
1.69SerTyr: 1.69 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.711ThrAla: 5.711 ± 0.074
0.378ThrCys: 0.378 ± 0.015
2.582ThrAsp: 2.582 ± 0.054
2.509ThrGlu: 2.509 ± 0.044
1.53ThrPhe: 1.53 ± 0.037
4.421ThrGly: 4.421 ± 0.08
0.971ThrHis: 0.971 ± 0.027
2.308ThrIle: 2.308 ± 0.059
1.319ThrLys: 1.319 ± 0.034
6.368ThrLeu: 6.368 ± 0.088
1.009ThrMet: 1.009 ± 0.025
1.282ThrAsn: 1.282 ± 0.04
3.172ThrPro: 3.172 ± 0.062
1.783ThrGln: 1.783 ± 0.038
3.016ThrArg: 3.016 ± 0.047
2.616ThrSer: 2.616 ± 0.052
2.687ThrThr: 2.687 ± 0.071
4.267ThrVal: 4.267 ± 0.1
0.563ThrTrp: 0.563 ± 0.024
1.152ThrTyr: 1.152 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
8.327ValAla: 8.327 ± 0.095
0.677ValCys: 0.677 ± 0.022
3.819ValAsp: 3.819 ± 0.06
4.232ValGlu: 4.232 ± 0.058
2.372ValPhe: 2.372 ± 0.047
5.197ValGly: 5.197 ± 0.07
1.268ValHis: 1.268 ± 0.029
3.077ValIle: 3.077 ± 0.052
2.543ValLys: 2.543 ± 0.048
7.51ValLeu: 7.51 ± 0.086
1.667ValMet: 1.667 ± 0.036
2.205ValAsn: 2.205 ± 0.061
3.18ValPro: 3.18 ± 0.059
2.576ValGln: 2.576 ± 0.047
4.376ValArg: 4.376 ± 0.056
4.097ValSer: 4.097 ± 0.061
3.341ValThr: 3.341 ± 0.076
5.199ValVal: 5.199 ± 0.075
0.881ValTrp: 0.881 ± 0.027
1.578ValTyr: 1.578 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.204TrpAla: 1.204 ± 0.032
0.167TrpCys: 0.167 ± 0.011
0.623TrpAsp: 0.623 ± 0.023
0.557TrpGlu: 0.557 ± 0.021
0.529TrpPhe: 0.529 ± 0.019
0.843TrpGly: 0.843 ± 0.026
0.371TrpHis: 0.371 ± 0.017
0.55TrpIle: 0.55 ± 0.021
0.445TrpLys: 0.445 ± 0.016
2.174TrpLeu: 2.174 ± 0.05
0.326TrpMet: 0.326 ± 0.013
0.465TrpAsn: 0.465 ± 0.016
0.67TrpPro: 0.67 ± 0.023
0.971TrpGln: 0.971 ± 0.028
1.326TrpArg: 1.326 ± 0.036
0.768TrpSer: 0.768 ± 0.023
0.621TrpThr: 0.621 ± 0.022
0.867TrpVal: 0.867 ± 0.023
0.263TrpTrp: 0.263 ± 0.014
0.364TrpTyr: 0.364 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.715TyrAla: 2.715 ± 0.046
0.283TyrCys: 0.283 ± 0.014
1.586TyrAsp: 1.586 ± 0.091
1.249TyrGlu: 1.249 ± 0.032
1.119TyrPhe: 1.119 ± 0.031
2.184TyrGly: 2.184 ± 0.049
0.574TyrHis: 0.574 ± 0.021
0.928TyrIle: 0.928 ± 0.028
0.816TyrLys: 0.816 ± 0.024
2.959TyrLeu: 2.959 ± 0.044
0.449TyrMet: 0.449 ± 0.017
0.755TyrAsn: 0.755 ± 0.029
1.253TyrPro: 1.253 ± 0.034
1.253TyrGln: 1.253 ± 0.033
2.17TyrArg: 2.17 ± 0.042
1.416TyrSer: 1.416 ± 0.038
1.313TyrThr: 1.313 ± 0.046
1.6TyrVal: 1.6 ± 0.035
0.381TyrTrp: 0.381 ± 0.015
0.701TyrTyr: 0.701 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4560 proteins (1522789 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski