Amino acid dipepetide frequency for Nitritalea halalkaliphila LW7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.581AlaAla: 8.581 ± 0.147	0.955AlaCys: 0.955 ± 0.038	4.442AlaAsp: 4.442 ± 0.084	6.0AlaGlu: 6.0 ± 0.088	4.615AlaPhe: 4.615 ± 0.07	6.489AlaGly: 6.489 ± 0.135	1.809AlaHis: 1.809 ± 0.052	4.901AlaIle: 4.901 ± 0.084	4.185AlaLys: 4.185 ± 0.091	9.832AlaLeu: 9.832 ± 0.133	1.967AlaMet: 1.967 ± 0.05	2.934AlaAsn: 2.934 ± 0.072	3.364AlaPro: 3.364 ± 0.072	3.765AlaGln: 3.765 ± 0.076	3.938AlaArg: 3.938 ± 0.074	4.842AlaSer: 4.842 ± 0.082	3.804AlaThr: 3.804 ± 0.073	5.341AlaVal: 5.341 ± 0.093	0.923AlaTrp: 0.923 ± 0.034	3.24AlaTyr: 3.24 ± 0.072	0.005AlaXaa: 0.005 ± 0.002
Cys	0.629CysAla: 0.629 ± 0.026	0.115CysCys: 0.115 ± 0.012	0.345CysAsp: 0.345 ± 0.02	0.379CysGlu: 0.379 ± 0.025	0.464CysPhe: 0.464 ± 0.025	0.633CysGly: 0.633 ± 0.029	0.166CysHis: 0.166 ± 0.015	0.46CysIle: 0.46 ± 0.023	0.334CysLys: 0.334 ± 0.021	0.753CysLeu: 0.753 ± 0.031	0.251CysMet: 0.251 ± 0.019	0.232CysAsn: 0.232 ± 0.018	0.385CysPro: 0.385 ± 0.023	0.3CysGln: 0.3 ± 0.02	0.379CysArg: 0.379 ± 0.021	0.587CysSer: 0.587 ± 0.026	0.468CysThr: 0.468 ± 0.024	0.474CysVal: 0.474 ± 0.023	0.089CysTrp: 0.089 ± 0.01	0.248CysTyr: 0.248 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.575AspAla: 4.575 ± 0.078	0.346AspCys: 0.346 ± 0.021	1.989AspAsp: 1.989 ± 0.058	3.219AspGlu: 3.219 ± 0.067	3.42AspPhe: 3.42 ± 0.074	3.505AspGly: 3.505 ± 0.078	0.857AspHis: 0.857 ± 0.035	3.127AspIle: 3.127 ± 0.062	2.707AspLys: 2.707 ± 0.06	5.113AspLeu: 5.113 ± 0.082	1.231AspMet: 1.231 ± 0.044	1.703AspAsn: 1.703 ± 0.053	2.524AspPro: 2.524 ± 0.063	1.803AspGln: 1.803 ± 0.049	2.811AspArg: 2.811 ± 0.073	2.541AspSer: 2.541 ± 0.057	2.388AspThr: 2.388 ± 0.06	3.194AspVal: 3.194 ± 0.073	0.783AspTrp: 0.783 ± 0.03	1.987AspTyr: 1.987 ± 0.051	0.001AspXaa: 0.001 ± 0.001
Glu	6.88GluAla: 6.88 ± 0.099	0.221GluCys: 0.221 ± 0.016	3.479GluAsp: 3.479 ± 0.069	6.546GluGlu: 6.546 ± 0.109	2.468GluPhe: 2.468 ± 0.054	4.859GluGly: 4.859 ± 0.081	1.239GluHis: 1.239 ± 0.041	4.417GluIle: 4.417 ± 0.088	5.022GluLys: 5.022 ± 0.089	6.748GluLeu: 6.748 ± 0.109	1.63GluMet: 1.63 ± 0.047	3.227GluAsn: 3.227 ± 0.074	1.998GluPro: 1.998 ± 0.046	3.398GluGln: 3.398 ± 0.07	4.346GluArg: 4.346 ± 0.079	3.093GluSer: 3.093 ± 0.061	3.428GluThr: 3.428 ± 0.066	5.266GluVal: 5.266 ± 0.086	0.731GluTrp: 0.731 ± 0.03	1.484GluTyr: 1.484 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.617PheAla: 3.617 ± 0.063	0.458PheCys: 0.458 ± 0.025	2.848PheAsp: 2.848 ± 0.058	3.219PheGlu: 3.219 ± 0.06	3.206PhePhe: 3.206 ± 0.06	3.988PheGly: 3.988 ± 0.079	1.076PheHis: 1.076 ± 0.036	3.153PheIle: 3.153 ± 0.062	2.366PheLys: 2.366 ± 0.056	5.454PheLeu: 5.454 ± 0.09	1.196PheMet: 1.196 ± 0.035	2.1PheAsn: 2.1 ± 0.058	2.214PhePro: 2.214 ± 0.058	2.25PheGln: 2.25 ± 0.059	2.702PheArg: 2.702 ± 0.069	3.85PheSer: 3.85 ± 0.083	3.177PheThr: 3.177 ± 0.068	3.074PheVal: 3.074 ± 0.066	0.719PheTrp: 0.719 ± 0.034	2.123PheTyr: 2.123 ± 0.056	0.002PheXaa: 0.002 ± 0.002
Gly	5.679GlyAla: 5.679 ± 0.101	0.545GlyCys: 0.545 ± 0.027	3.455GlyAsp: 3.455 ± 0.077	4.539GlyGlu: 4.539 ± 0.083	4.125GlyPhe: 4.125 ± 0.089	5.325GlyGly: 5.325 ± 0.143	1.349GlyHis: 1.349 ± 0.046	4.909GlyIle: 4.909 ± 0.079	4.159GlyLys: 4.159 ± 0.083	7.454GlyLeu: 7.454 ± 0.112	2.006GlyMet: 2.006 ± 0.046	2.935GlyAsn: 2.935 ± 0.062	2.279GlyPro: 2.279 ± 0.061	2.888GlyGln: 2.888 ± 0.055	3.389GlyArg: 3.389 ± 0.065	4.222GlySer: 4.222 ± 0.075	3.957GlyThr: 3.957 ± 0.085	4.799GlyVal: 4.799 ± 0.096	0.84GlyTrp: 0.84 ± 0.034	2.592GlyTyr: 2.592 ± 0.057	0.005GlyXaa: 0.005 ± 0.003
His	1.864HisAla: 1.864 ± 0.056	0.225HisCys: 0.225 ± 0.017	0.845HisAsp: 0.845 ± 0.036	1.166HisGlu: 1.166 ± 0.035	1.365HisPhe: 1.365 ± 0.039	1.291HisGly: 1.291 ± 0.039	0.577HisHis: 0.577 ± 0.029	1.287HisIle: 1.287 ± 0.043	0.884HisLys: 0.884 ± 0.03	2.272HisLeu: 2.272 ± 0.055	0.446HisMet: 0.446 ± 0.022	0.568HisAsn: 0.568 ± 0.026	1.299HisPro: 1.299 ± 0.043	0.822HisGln: 0.822 ± 0.028	1.008HisArg: 1.008 ± 0.039	0.978HisSer: 0.978 ± 0.037	1.048HisThr: 1.048 ± 0.035	1.44HisVal: 1.44 ± 0.046	0.266HisTrp: 0.266 ± 0.02	0.863HisTyr: 0.863 ± 0.033	0.004HisXaa: 0.004 ± 0.002
Ile	5.164IleAla: 5.164 ± 0.086	0.498IleCys: 0.498 ± 0.024	3.346IleAsp: 3.346 ± 0.066	3.868IleGlu: 3.868 ± 0.073	2.832IlePhe: 2.832 ± 0.053	4.594IleGly: 4.594 ± 0.084	1.284IleHis: 1.284 ± 0.037	3.249IleIle: 3.249 ± 0.068	2.847IleLys: 2.847 ± 0.065	5.623IleLeu: 5.623 ± 0.1	1.116IleMet: 1.116 ± 0.039	2.42IleAsn: 2.42 ± 0.06	3.037IlePro: 3.037 ± 0.058	2.627IleGln: 2.627 ± 0.062	3.519IleArg: 3.519 ± 0.069	4.154IleSer: 4.154 ± 0.065	3.208IleThr: 3.208 ± 0.063	3.476IleVal: 3.476 ± 0.063	0.617IleTrp: 0.617 ± 0.028	1.973IleTyr: 1.973 ± 0.05	0.001IleXaa: 0.001 ± 0.001
Lys	4.351LysAla: 4.351 ± 0.085	0.266LysCys: 0.266 ± 0.018	2.583LysAsp: 2.583 ± 0.063	4.388LysGlu: 4.388 ± 0.092	1.902LysPhe: 1.902 ± 0.051	4.005LysGly: 4.005 ± 0.073	1.006LysHis: 1.006 ± 0.036	3.523LysIle: 3.523 ± 0.078	4.171LysLys: 4.171 ± 0.086	4.814LysLeu: 4.814 ± 0.077	1.389LysMet: 1.389 ± 0.042	2.374LysAsn: 2.374 ± 0.062	2.077LysPro: 2.077 ± 0.052	2.198LysGln: 2.198 ± 0.056	3.145LysArg: 3.145 ± 0.074	2.887LysSer: 2.887 ± 0.068	2.831LysThr: 2.831 ± 0.063	3.523LysVal: 3.523 ± 0.066	0.551LysTrp: 0.551 ± 0.032	1.695LysTyr: 1.695 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	9.307LeuAla: 9.307 ± 0.112	0.808LeuCys: 0.808 ± 0.031	5.313LeuAsp: 5.313 ± 0.08	7.218LeuGlu: 7.218 ± 0.116	5.363LeuPhe: 5.363 ± 0.08	7.071LeuGly: 7.071 ± 0.105	2.267LeuHis: 2.267 ± 0.063	5.919LeuIle: 5.919 ± 0.091	5.607LeuLys: 5.607 ± 0.096	12.298LeuLeu: 12.298 ± 0.18	2.354LeuMet: 2.354 ± 0.056	4.06LeuAsn: 4.06 ± 0.077	5.207LeuPro: 5.207 ± 0.072	4.547LeuGln: 4.547 ± 0.087	6.025LeuArg: 6.025 ± 0.098	7.101LeuSer: 7.101 ± 0.103	4.996LeuThr: 4.996 ± 0.083	6.112LeuVal: 6.112 ± 0.09	1.019LeuTrp: 1.019 ± 0.033	3.351LeuTyr: 3.351 ± 0.073	0.005LeuXaa: 0.005 ± 0.002
Met	1.95MetAla: 1.95 ± 0.055	0.148MetCys: 0.148 ± 0.014	1.239MetAsp: 1.239 ± 0.04	1.909MetGlu: 1.909 ± 0.049	0.748MetPhe: 0.748 ± 0.03	1.784MetGly: 1.784 ± 0.052	0.616MetHis: 0.616 ± 0.028	1.186MetIle: 1.186 ± 0.036	1.673MetLys: 1.673 ± 0.043	2.371MetLeu: 2.371 ± 0.06	0.618MetMet: 0.618 ± 0.029	0.952MetAsn: 0.952 ± 0.034	1.097MetPro: 1.097 ± 0.04	1.195MetGln: 1.195 ± 0.034	1.527MetArg: 1.527 ± 0.043	1.22MetSer: 1.22 ± 0.04	1.057MetThr: 1.057 ± 0.038	1.424MetVal: 1.424 ± 0.044	0.199MetTrp: 0.199 ± 0.015	0.655MetTyr: 0.655 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.091AsnAla: 3.091 ± 0.066	0.27AsnCys: 0.27 ± 0.017	1.69AsnAsp: 1.69 ± 0.045	2.279AsnGlu: 2.279 ± 0.054	2.258AsnPhe: 2.258 ± 0.062	2.696AsnGly: 2.696 ± 0.065	0.734AsnHis: 0.734 ± 0.031	2.367AsnIle: 2.367 ± 0.069	1.88AsnLys: 1.88 ± 0.053	3.97AsnLeu: 3.97 ± 0.084	0.967AsnMet: 0.967 ± 0.035	1.574AsnAsn: 1.574 ± 0.053	2.448AsnPro: 2.448 ± 0.055	1.568AsnGln: 1.568 ± 0.049	2.327AsnArg: 2.327 ± 0.059	2.197AsnSer: 2.197 ± 0.054	2.122AsnThr: 2.122 ± 0.051	2.449AsnVal: 2.449 ± 0.068	0.641AsnTrp: 0.641 ± 0.026	1.584AsnTyr: 1.584 ± 0.042	0.001AsnXaa: 0.001 ± 0.001
Pro	3.772ProAla: 3.772 ± 0.075	0.294ProCys: 0.294 ± 0.019	2.704ProAsp: 2.704 ± 0.065	4.128ProGlu: 4.128 ± 0.081	2.372ProPhe: 2.372 ± 0.059	2.972ProGly: 2.972 ± 0.064	0.905ProHis: 0.905 ± 0.033	2.488ProIle: 2.488 ± 0.064	2.228ProLys: 2.228 ± 0.054	4.307ProLeu: 4.307 ± 0.071	1.027ProMet: 1.027 ± 0.04	1.755ProAsn: 1.755 ± 0.044	1.21ProPro: 1.21 ± 0.043	1.513ProGln: 1.513 ± 0.042	1.755ProArg: 1.755 ± 0.045	2.436ProSer: 2.436 ± 0.05	2.004ProThr: 2.004 ± 0.047	3.106ProVal: 3.106 ± 0.061	0.448ProTrp: 0.448 ± 0.022	1.629ProTyr: 1.629 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	4.315GlnAla: 4.315 ± 0.076	0.182GlnCys: 0.182 ± 0.014	1.907GlnAsp: 1.907 ± 0.044	3.84GlnGlu: 3.84 ± 0.079	1.695GlnPhe: 1.695 ± 0.044	2.542GlnGly: 2.542 ± 0.049	0.933GlnHis: 0.933 ± 0.03	2.123GlnIle: 2.123 ± 0.054	2.05GlnLys: 2.05 ± 0.051	4.725GlnLeu: 4.725 ± 0.078	0.933GlnMet: 0.933 ± 0.038	1.603GlnAsn: 1.603 ± 0.042	1.605GlnPro: 1.605 ± 0.045	2.267GlnGln: 2.267 ± 0.072	2.392GlnArg: 2.392 ± 0.054	1.947GlnSer: 1.947 ± 0.053	1.857GlnThr: 1.857 ± 0.051	3.436GlnVal: 3.436 ± 0.064	0.392GlnTrp: 0.392 ± 0.023	1.186GlnTyr: 1.186 ± 0.037	0.002GlnXaa: 0.002 ± 0.002
Arg	4.082ArgAla: 4.082 ± 0.08	0.384ArgCys: 0.384 ± 0.022	2.442ArgAsp: 2.442 ± 0.057	4.003ArgGlu: 4.003 ± 0.078	3.159ArgPhe: 3.159 ± 0.065	3.131ArgGly: 3.131 ± 0.061	1.055ArgHis: 1.055 ± 0.03	3.445ArgIle: 3.445 ± 0.062	2.953ArgLys: 2.953 ± 0.057	5.779ArgLeu: 5.779 ± 0.089	1.563ArgMet: 1.563 ± 0.048	2.184ArgAsn: 2.184 ± 0.06	2.196ArgPro: 2.196 ± 0.053	2.442ArgGln: 2.442 ± 0.063	2.736ArgArg: 2.736 ± 0.059	2.936ArgSer: 2.936 ± 0.065	2.519ArgThr: 2.519 ± 0.061	3.753ArgVal: 3.753 ± 0.082	0.71ArgTrp: 0.71 ± 0.029	2.294ArgTyr: 2.294 ± 0.052	0.002ArgXaa: 0.002 ± 0.001
Ser	4.69SerAla: 4.69 ± 0.092	0.616SerCys: 0.616 ± 0.031	2.694SerAsp: 2.694 ± 0.068	3.471SerGlu: 3.471 ± 0.065	3.638SerPhe: 3.638 ± 0.073	4.971SerGly: 4.971 ± 0.089	1.093SerHis: 1.093 ± 0.039	3.654SerIle: 3.654 ± 0.076	2.747SerLys: 2.747 ± 0.064	6.348SerLeu: 6.348 ± 0.1	1.48SerMet: 1.48 ± 0.042	2.009SerAsn: 2.009 ± 0.063	2.804SerPro: 2.804 ± 0.066	1.869SerGln: 1.869 ± 0.054	2.902SerArg: 2.902 ± 0.07	4.028SerSer: 4.028 ± 0.078	3.116SerThr: 3.116 ± 0.063	3.463SerVal: 3.463 ± 0.072	0.82SerTrp: 0.82 ± 0.031	2.193SerTyr: 2.193 ± 0.054	0.002SerXaa: 0.002 ± 0.002
Thr	4.168ThrAla: 4.168 ± 0.071	0.432ThrCys: 0.432 ± 0.025	2.452ThrAsp: 2.452 ± 0.056	2.887ThrGlu: 2.887 ± 0.061	2.957ThrPhe: 2.957 ± 0.061	3.924ThrGly: 3.924 ± 0.075	1.101ThrHis: 1.101 ± 0.039	3.025ThrIle: 3.025 ± 0.069	2.227ThrLys: 2.227 ± 0.067	6.123ThrLeu: 6.123 ± 0.093	0.897ThrMet: 0.897 ± 0.035	1.874ThrAsn: 1.874 ± 0.051	2.439ThrPro: 2.439 ± 0.052	1.699ThrGln: 1.699 ± 0.047	2.454ThrArg: 2.454 ± 0.06	2.884ThrSer: 2.884 ± 0.07	2.328ThrThr: 2.328 ± 0.055	3.682ThrVal: 3.682 ± 0.072	0.67ThrTrp: 0.67 ± 0.033	2.044ThrTyr: 2.044 ± 0.058	0.002ThrXaa: 0.002 ± 0.001
Val	5.37ValAla: 5.37 ± 0.1	0.536ValCys: 0.536 ± 0.026	3.634ValAsp: 3.634 ± 0.072	4.456ValGlu: 4.456 ± 0.084	3.41ValPhe: 3.41 ± 0.059	4.457ValGly: 4.457 ± 0.079	1.438ValHis: 1.438 ± 0.05	3.743ValIle: 3.743 ± 0.068	3.269ValLys: 3.269 ± 0.074	7.047ValLeu: 7.047 ± 0.082	1.335ValMet: 1.335 ± 0.042	2.85ValAsn: 2.85 ± 0.068	2.84ValPro: 2.84 ± 0.055	2.73ValGln: 2.73 ± 0.053	3.585ValArg: 3.585 ± 0.07	4.099ValSer: 4.099 ± 0.074	3.207ValThr: 3.207 ± 0.079	4.226ValVal: 4.226 ± 0.088	0.712ValTrp: 0.712 ± 0.028	2.179ValTyr: 2.179 ± 0.056	0.002ValXaa: 0.002 ± 0.002
Trp	0.868TrpAla: 0.868 ± 0.04	0.13TrpCys: 0.13 ± 0.012	0.635TrpAsp: 0.635 ± 0.03	0.87TrpGlu: 0.87 ± 0.032	0.546TrpPhe: 0.546 ± 0.03	0.701TrpGly: 0.701 ± 0.031	0.243TrpHis: 0.243 ± 0.017	0.703TrpIle: 0.703 ± 0.029	0.706TrpLys: 0.706 ± 0.031	1.184TrpLeu: 1.184 ± 0.04	0.396TrpMet: 0.396 ± 0.022	0.533TrpAsn: 0.533 ± 0.029	0.449TrpPro: 0.449 ± 0.025	0.561TrpGln: 0.561 ± 0.027	0.623TrpArg: 0.623 ± 0.028	0.675TrpSer: 0.675 ± 0.028	0.623TrpThr: 0.623 ± 0.027	0.775TrpVal: 0.775 ± 0.036	0.181TrpTrp: 0.181 ± 0.015	0.363TrpTyr: 0.363 ± 0.019	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.979TyrAla: 2.979 ± 0.069	0.26TyrCys: 0.26 ± 0.019	1.782TyrAsp: 1.782 ± 0.046	2.092TyrGlu: 2.092 ± 0.052	2.247TyrPhe: 2.247 ± 0.051	2.516TyrGly: 2.516 ± 0.05	0.771TyrHis: 0.771 ± 0.036	1.768TyrIle: 1.768 ± 0.045	1.66TyrLys: 1.66 ± 0.047	3.728TyrLeu: 3.728 ± 0.077	0.761TyrMet: 0.761 ± 0.028	1.224TyrAsn: 1.224 ± 0.039	1.58TyrPro: 1.58 ± 0.04	1.489TyrGln: 1.489 ± 0.046	2.199TyrArg: 2.199 ± 0.055	1.928TyrSer: 1.928 ± 0.053	2.134TyrThr: 2.134 ± 0.053	2.108TyrVal: 2.108 ± 0.047	0.453TyrTrp: 0.453 ± 0.025	1.314TyrTyr: 1.314 ± 0.043	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.002XaaCys: 0.002 ± 0.002	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.005XaaIle: 0.005 ± 0.002	0.004XaaLys: 0.004 ± 0.002	0.004XaaLeu: 0.004 ± 0.002	0.004XaaMet: 0.004 ± 0.002	0.001XaaAsn: 0.001 ± 0.001	0.002XaaPro: 0.002 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.004XaaArg: 0.004 ± 0.002	0.004XaaSer: 0.004 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3102 proteins (823449 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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