Amino acid dipepetide frequency for Mycolicibacterium brumae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.736AlaAla: 21.736 ± 0.256	0.924AlaCys: 0.924 ± 0.028	9.403AlaAsp: 9.403 ± 0.098	8.774AlaGlu: 8.774 ± 0.101	3.375AlaPhe: 3.375 ± 0.055	12.477AlaGly: 12.477 ± 0.133	2.564AlaHis: 2.564 ± 0.052	5.198AlaIle: 5.198 ± 0.065	3.191AlaLys: 3.191 ± 0.065	13.73AlaLeu: 13.73 ± 0.125	2.885AlaMet: 2.885 ± 0.055	2.684AlaAsn: 2.684 ± 0.049	7.126AlaPro: 7.126 ± 0.111	4.042AlaGln: 4.042 ± 0.056	9.04AlaArg: 9.04 ± 0.096	5.601AlaSer: 5.601 ± 0.065	7.148AlaThr: 7.148 ± 0.088	11.874AlaVal: 11.874 ± 0.122	1.632AlaTrp: 1.632 ± 0.042	2.31AlaTyr: 2.31 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.15CysAla: 1.15 ± 0.033	0.11CysCys: 0.11 ± 0.009	0.547CysAsp: 0.547 ± 0.023	0.426CysGlu: 0.426 ± 0.023	0.221CysPhe: 0.221 ± 0.014	0.996CysGly: 0.996 ± 0.029	0.18CysHis: 0.18 ± 0.013	0.183CysIle: 0.183 ± 0.013	0.121CysLys: 0.121 ± 0.01	0.649CysLeu: 0.649 ± 0.024	0.127CysMet: 0.127 ± 0.011	0.148CysAsn: 0.148 ± 0.012	0.532CysPro: 0.532 ± 0.026	0.242CysGln: 0.242 ± 0.015	0.573CysArg: 0.573 ± 0.025	0.458CysSer: 0.458 ± 0.02	0.361CysThr: 0.361 ± 0.017	0.657CysVal: 0.657 ± 0.022	0.135CysTrp: 0.135 ± 0.012	0.195CysTyr: 0.195 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.251AspAla: 8.251 ± 0.102	0.487AspCys: 0.487 ± 0.02	4.442AspAsp: 4.442 ± 0.07	4.047AspGlu: 4.047 ± 0.064	1.789AspPhe: 1.789 ± 0.039	6.65AspGly: 6.65 ± 0.093	1.284AspHis: 1.284 ± 0.037	2.553AspIle: 2.553 ± 0.056	1.302AspLys: 1.302 ± 0.041	6.202AspLeu: 6.202 ± 0.075	0.926AspMet: 0.926 ± 0.029	1.341AspAsn: 1.341 ± 0.039	4.861AspPro: 4.861 ± 0.073	1.791AspGln: 1.791 ± 0.042	4.547AspArg: 4.547 ± 0.066	2.845AspSer: 2.845 ± 0.049	3.349AspThr: 3.349 ± 0.051	4.945AspVal: 4.945 ± 0.066	1.02AspTrp: 1.02 ± 0.033	1.461AspTyr: 1.461 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.249GluAla: 6.249 ± 0.078	0.377GluCys: 0.377 ± 0.018	2.642GluAsp: 2.642 ± 0.058	2.555GluGlu: 2.555 ± 0.056	1.955GluPhe: 1.955 ± 0.04	3.225GluGly: 3.225 ± 0.06	1.488GluHis: 1.488 ± 0.033	2.595GluIle: 2.595 ± 0.058	1.335GluLys: 1.335 ± 0.042	7.17GluLeu: 7.17 ± 0.094	1.073GluMet: 1.073 ± 0.03	1.17GluAsn: 1.17 ± 0.033	3.283GluPro: 3.283 ± 0.065	2.305GluGln: 2.305 ± 0.044	4.209GluArg: 4.209 ± 0.067	2.786GluSer: 2.786 ± 0.048	2.788GluThr: 2.788 ± 0.051	4.545GluVal: 4.545 ± 0.066	0.66GluTrp: 0.66 ± 0.025	1.105GluTyr: 1.105 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.117PheAla: 4.117 ± 0.06	0.304PheCys: 0.304 ± 0.017	2.371PheAsp: 2.371 ± 0.041	1.488PheGlu: 1.488 ± 0.04	1.006PhePhe: 1.006 ± 0.029	3.475PheGly: 3.475 ± 0.059	0.61PheHis: 0.61 ± 0.023	1.087PheIle: 1.087 ± 0.033	0.475PheLys: 0.475 ± 0.022	2.577PheLeu: 2.577 ± 0.048	0.452PheMet: 0.452 ± 0.023	0.773PheAsn: 0.773 ± 0.028	1.397PhePro: 1.397 ± 0.036	0.668PheGln: 0.668 ± 0.024	1.603PheArg: 1.603 ± 0.037	1.576PheSer: 1.576 ± 0.036	2.043PheThr: 2.043 ± 0.044	2.376PheVal: 2.376 ± 0.041	0.454PheTrp: 0.454 ± 0.017	0.627PheTyr: 0.627 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.175GlyAla: 11.175 ± 0.11	0.838GlyCys: 0.838 ± 0.037	5.292GlyAsp: 5.292 ± 0.078	4.742GlyGlu: 4.742 ± 0.063	3.055GlyPhe: 3.055 ± 0.05	7.706GlyGly: 7.706 ± 0.119	1.993GlyHis: 1.993 ± 0.044	3.799GlyIle: 3.799 ± 0.054	2.368GlyLys: 2.368 ± 0.051	8.845GlyLeu: 8.845 ± 0.105	2.178GlyMet: 2.178 ± 0.048	1.896GlyAsn: 1.896 ± 0.043	4.783GlyPro: 4.783 ± 0.074	2.784GlyGln: 2.784 ± 0.051	6.425GlyArg: 6.425 ± 0.081	5.085GlySer: 5.085 ± 0.074	4.479GlyThr: 4.479 ± 0.063	8.082GlyVal: 8.082 ± 0.082	1.624GlyTrp: 1.624 ± 0.038	2.496GlyTyr: 2.496 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.249HisAla: 2.249 ± 0.044	0.19HisCys: 0.19 ± 0.013	1.263HisAsp: 1.263 ± 0.029	0.941HisGlu: 0.941 ± 0.033	0.624HisPhe: 0.624 ± 0.021	1.946HisGly: 1.946 ± 0.042	0.585HisHis: 0.585 ± 0.027	0.762HisIle: 0.762 ± 0.026	0.384HisLys: 0.384 ± 0.02	2.0HisLeu: 2.0 ± 0.045	0.283HisMet: 0.283 ± 0.015	0.471HisAsn: 0.471 ± 0.022	1.66HisPro: 1.66 ± 0.045	0.609HisGln: 0.609 ± 0.02	1.824HisArg: 1.824 ± 0.042	1.006HisSer: 1.006 ± 0.031	1.207HisThr: 1.207 ± 0.034	1.438HisVal: 1.438 ± 0.04	0.36HisTrp: 0.36 ± 0.018	0.495HisTyr: 0.495 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.406IleAla: 6.406 ± 0.083	0.391IleCys: 0.391 ± 0.017	3.32IleAsp: 3.32 ± 0.062	2.519IleGlu: 2.519 ± 0.055	1.056IlePhe: 1.056 ± 0.035	4.499IleGly: 4.499 ± 0.068	0.684IleHis: 0.684 ± 0.026	1.473IleIle: 1.473 ± 0.044	0.857IleLys: 0.857 ± 0.029	3.045IleLeu: 3.045 ± 0.05	0.593IleMet: 0.593 ± 0.024	1.076IleAsn: 1.076 ± 0.029	2.373IlePro: 2.373 ± 0.046	0.856IleGln: 0.856 ± 0.029	2.692IleArg: 2.692 ± 0.049	2.173IleSer: 2.173 ± 0.041	2.841IleThr: 2.841 ± 0.045	3.534IleVal: 3.534 ± 0.053	0.465IleTrp: 0.465 ± 0.02	0.796IleTyr: 0.796 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.743LysAla: 2.743 ± 0.071	0.127LysCys: 0.127 ± 0.01	1.083LysAsp: 1.083 ± 0.036	0.934LysGlu: 0.934 ± 0.033	0.597LysPhe: 0.597 ± 0.022	1.536LysGly: 1.536 ± 0.038	0.495LysHis: 0.495 ± 0.021	1.035LysIle: 1.035 ± 0.034	0.74LysLys: 0.74 ± 0.037	2.363LysLeu: 2.363 ± 0.05	0.505LysMet: 0.505 ± 0.023	0.559LysAsn: 0.559 ± 0.024	1.475LysPro: 1.475 ± 0.038	0.684LysGln: 0.684 ± 0.025	1.595LysArg: 1.595 ± 0.039	1.241LysSer: 1.241 ± 0.039	1.409LysThr: 1.409 ± 0.044	1.954LysVal: 1.954 ± 0.05	0.294LysTrp: 0.294 ± 0.016	0.473LysTyr: 0.473 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.051LeuAla: 15.051 ± 0.113	0.782LeuCys: 0.782 ± 0.024	6.582LeuAsp: 6.582 ± 0.091	4.474LeuGlu: 4.474 ± 0.069	2.609LeuPhe: 2.609 ± 0.049	9.012LeuGly: 9.012 ± 0.096	1.816LeuHis: 1.816 ± 0.039	4.352LeuIle: 4.352 ± 0.072	1.809LeuLys: 1.809 ± 0.042	10.057LeuLeu: 10.057 ± 0.117	1.792LeuMet: 1.792 ± 0.04	2.141LeuAsn: 2.141 ± 0.045	5.994LeuPro: 5.994 ± 0.065	2.26LeuGln: 2.26 ± 0.047	8.026LeuArg: 8.026 ± 0.115	5.701LeuSer: 5.701 ± 0.074	6.678LeuThr: 6.678 ± 0.082	8.261LeuVal: 8.261 ± 0.102	1.267LeuTrp: 1.267 ± 0.039	1.606LeuTyr: 1.606 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.725MetAla: 2.725 ± 0.05	0.175MetCys: 0.175 ± 0.012	0.942MetAsp: 0.942 ± 0.03	0.736MetGlu: 0.736 ± 0.028	0.642MetPhe: 0.642 ± 0.029	1.478MetGly: 1.478 ± 0.039	0.366MetHis: 0.366 ± 0.017	0.886MetIle: 0.886 ± 0.026	0.429MetLys: 0.429 ± 0.02	2.076MetLeu: 2.076 ± 0.048	0.393MetMet: 0.393 ± 0.019	0.498MetAsn: 0.498 ± 0.022	1.236MetPro: 1.236 ± 0.035	0.46MetGln: 0.46 ± 0.021	1.47MetArg: 1.47 ± 0.044	1.546MetSer: 1.546 ± 0.04	1.748MetThr: 1.748 ± 0.033	1.618MetVal: 1.618 ± 0.037	0.267MetTrp: 0.267 ± 0.018	0.329MetTyr: 0.329 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.772AsnAla: 2.772 ± 0.052	0.188AsnCys: 0.188 ± 0.014	1.222AsnAsp: 1.222 ± 0.031	0.965AsnGlu: 0.965 ± 0.028	0.65AsnPhe: 0.65 ± 0.028	1.988AsnGly: 1.988 ± 0.049	0.479AsnHis: 0.479 ± 0.025	0.94AsnIle: 0.94 ± 0.026	0.499AsnLys: 0.499 ± 0.022	2.146AsnLeu: 2.146 ± 0.04	0.433AsnMet: 0.433 ± 0.018	0.564AsnAsn: 0.564 ± 0.024	1.924AsnPro: 1.924 ± 0.043	0.652AsnGln: 0.652 ± 0.025	1.655AsnArg: 1.655 ± 0.036	1.15AsnSer: 1.15 ± 0.035	1.385AsnThr: 1.385 ± 0.034	1.745AsnVal: 1.745 ± 0.039	0.412AsnTrp: 0.412 ± 0.016	0.569AsnTyr: 0.569 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	8.177ProAla: 8.177 ± 0.115	0.307ProCys: 0.307 ± 0.017	4.657ProAsp: 4.657 ± 0.07	4.106ProGlu: 4.106 ± 0.068	1.561ProPhe: 1.561 ± 0.039	5.953ProGly: 5.953 ± 0.084	1.1ProHis: 1.1 ± 0.032	2.178ProIle: 2.178 ± 0.042	1.341ProLys: 1.341 ± 0.038	4.798ProLeu: 4.798 ± 0.071	1.205ProMet: 1.205 ± 0.026	1.381ProAsn: 1.381 ± 0.036	3.356ProPro: 3.356 ± 0.082	1.784ProGln: 1.784 ± 0.046	3.468ProArg: 3.468 ± 0.06	3.112ProSer: 3.112 ± 0.056	3.565ProThr: 3.565 ± 0.062	5.137ProVal: 5.137 ± 0.087	0.858ProTrp: 0.858 ± 0.028	1.112ProTyr: 1.112 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.475GlnAla: 3.475 ± 0.061	0.184GlnCys: 0.184 ± 0.013	1.179GlnAsp: 1.179 ± 0.029	1.077GlnGlu: 1.077 ± 0.026	0.893GlnPhe: 0.893 ± 0.028	1.863GlnGly: 1.863 ± 0.043	0.662GlnHis: 0.662 ± 0.025	1.536GlnIle: 1.536 ± 0.04	0.63GlnLys: 0.63 ± 0.026	3.483GlnLeu: 3.483 ± 0.061	0.684GlnMet: 0.684 ± 0.024	0.651GlnAsn: 0.651 ± 0.026	1.732GlnPro: 1.732 ± 0.054	1.307GlnGln: 1.307 ± 0.037	2.727GlnArg: 2.727 ± 0.053	1.356GlnSer: 1.356 ± 0.039	1.636GlnThr: 1.636 ± 0.04	2.577GlnVal: 2.577 ± 0.052	0.533GlnTrp: 0.533 ± 0.025	0.567GlnTyr: 0.567 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.9ArgAla: 8.9 ± 0.106	0.621ArgCys: 0.621 ± 0.026	4.424ArgAsp: 4.424 ± 0.066	3.807ArgGlu: 3.807 ± 0.061	2.337ArgPhe: 2.337 ± 0.047	5.419ArgGly: 5.419 ± 0.078	1.647ArgHis: 1.647 ± 0.041	3.457ArgIle: 3.457 ± 0.06	1.624ArgLys: 1.624 ± 0.038	7.373ArgLeu: 7.373 ± 0.09	1.8ArgMet: 1.8 ± 0.034	1.734ArgAsn: 1.734 ± 0.035	4.099ArgPro: 4.099 ± 0.06	2.257ArgGln: 2.257 ± 0.045	6.98ArgArg: 6.98 ± 0.091	3.877ArgSer: 3.877 ± 0.068	3.93ArgThr: 3.93 ± 0.048	5.68ArgVal: 5.68 ± 0.072	1.345ArgTrp: 1.345 ± 0.033	1.799ArgTyr: 1.799 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.992SerAla: 6.992 ± 0.078	0.425SerCys: 0.425 ± 0.025	3.056SerAsp: 3.056 ± 0.062	2.659SerGlu: 2.659 ± 0.046	1.611SerPhe: 1.611 ± 0.041	5.618SerGly: 5.618 ± 0.073	1.016SerHis: 1.016 ± 0.026	1.989SerIle: 1.989 ± 0.041	1.152SerLys: 1.152 ± 0.036	4.633SerLeu: 4.633 ± 0.058	1.319SerMet: 1.319 ± 0.032	1.082SerAsn: 1.082 ± 0.034	2.981SerPro: 2.981 ± 0.053	1.403SerGln: 1.403 ± 0.034	3.633SerArg: 3.633 ± 0.05	2.962SerSer: 2.962 ± 0.056	3.171SerThr: 3.171 ± 0.053	4.417SerVal: 4.417 ± 0.062	0.941SerTrp: 0.941 ± 0.029	1.216SerTyr: 1.216 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.015ThrAla: 8.015 ± 0.094	0.405ThrCys: 0.405 ± 0.022	3.586ThrAsp: 3.586 ± 0.058	3.179ThrGlu: 3.179 ± 0.05	1.666ThrPhe: 1.666 ± 0.037	5.826ThrGly: 5.826 ± 0.076	1.12ThrHis: 1.12 ± 0.03	2.342ThrIle: 2.342 ± 0.048	1.192ThrLys: 1.192 ± 0.032	5.731ThrLeu: 5.731 ± 0.067	1.183ThrMet: 1.183 ± 0.035	1.191ThrAsn: 1.191 ± 0.032	3.937ThrPro: 3.937 ± 0.067	1.436ThrGln: 1.436 ± 0.041	3.62ThrArg: 3.62 ± 0.057	3.017ThrSer: 3.017 ± 0.058	3.494ThrThr: 3.494 ± 0.099	5.897ThrVal: 5.897 ± 0.081	0.753ThrTrp: 0.753 ± 0.024	1.19ThrTyr: 1.19 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.546ValAla: 11.546 ± 0.117	0.797ValCys: 0.797 ± 0.028	5.856ValAsp: 5.856 ± 0.077	4.484ValGlu: 4.484 ± 0.058	2.628ValPhe: 2.628 ± 0.047	7.035ValGly: 7.035 ± 0.083	1.443ValHis: 1.443 ± 0.036	4.004ValIle: 4.004 ± 0.071	1.735ValLys: 1.735 ± 0.042	9.236ValLeu: 9.236 ± 0.106	1.562ValMet: 1.562 ± 0.04	2.07ValAsn: 2.07 ± 0.048	4.331ValPro: 4.331 ± 0.068	1.914ValGln: 1.914 ± 0.045	5.898ValArg: 5.898 ± 0.077	4.727ValSer: 4.727 ± 0.066	5.545ValThr: 5.545 ± 0.068	8.105ValVal: 8.105 ± 0.091	1.051ValTrp: 1.051 ± 0.03	1.609ValTyr: 1.609 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.614TrpAla: 1.614 ± 0.038	0.163TrpCys: 0.163 ± 0.012	0.831TrpAsp: 0.831 ± 0.028	0.631TrpGlu: 0.631 ± 0.028	0.509TrpPhe: 0.509 ± 0.023	0.986TrpGly: 0.986 ± 0.031	0.328TrpHis: 0.328 ± 0.017	0.623TrpIle: 0.623 ± 0.023	0.29TrpLys: 0.29 ± 0.017	1.74TrpLeu: 1.74 ± 0.041	0.334TrpMet: 0.334 ± 0.017	0.382TrpAsn: 0.382 ± 0.017	0.822TrpPro: 0.822 ± 0.022	0.588TrpGln: 0.588 ± 0.021	1.274TrpArg: 1.274 ± 0.033	0.914TrpSer: 0.914 ± 0.026	0.855TrpThr: 0.855 ± 0.032	1.205TrpVal: 1.205 ± 0.034	0.347TrpTrp: 0.347 ± 0.017	0.306TrpTyr: 0.306 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.371TyrAla: 2.371 ± 0.049	0.216TyrCys: 0.216 ± 0.013	1.395TyrAsp: 1.395 ± 0.035	0.968TyrGlu: 0.968 ± 0.032	0.695TyrPhe: 0.695 ± 0.021	1.958TyrGly: 1.958 ± 0.043	0.439TyrHis: 0.439 ± 0.018	0.658TyrIle: 0.658 ± 0.026	0.369TyrLys: 0.369 ± 0.016	2.418TyrLeu: 2.418 ± 0.051	0.29TyrMet: 0.29 ± 0.018	0.527TyrAsn: 0.527 ± 0.023	1.252TyrPro: 1.252 ± 0.034	0.709TyrGln: 0.709 ± 0.025	1.852TyrArg: 1.852 ± 0.044	1.143TyrSer: 1.143 ± 0.033	1.147TyrThr: 1.147 ± 0.034	1.528TyrVal: 1.528 ± 0.035	0.324TyrTrp: 0.324 ± 0.019	0.47TyrTyr: 0.47 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3575 proteins (1151525 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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