Amino acid dipepetide frequency for Punica granatum (Pomegranate)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.197AlaAla: 6.197 ± 0.042	1.58AlaCys: 1.58 ± 0.025	3.044AlaAsp: 3.044 ± 0.023	4.625AlaGlu: 4.625 ± 0.037	3.285AlaPhe: 3.285 ± 0.066	4.607AlaGly: 4.607 ± 0.029	1.667AlaHis: 1.667 ± 0.025	3.396AlaIle: 3.396 ± 0.025	3.478AlaLys: 3.478 ± 0.022	6.437AlaLeu: 6.437 ± 0.036	1.68AlaMet: 1.68 ± 0.014	2.324AlaAsn: 2.324 ± 0.018	3.607AlaPro: 3.607 ± 0.025	2.399AlaGln: 2.399 ± 0.034	5.438AlaArg: 5.438 ± 0.067	7.043AlaSer: 7.043 ± 0.084	3.588AlaThr: 3.588 ± 0.023	4.804AlaVal: 4.804 ± 0.029	0.86AlaTrp: 0.86 ± 0.011	1.701AlaTyr: 1.701 ± 0.016	0.004AlaXaa: 0.004 ± 0.001
Cys	1.158CysAla: 1.158 ± 0.016	0.488CysCys: 0.488 ± 0.007	0.776CysAsp: 0.776 ± 0.01	1.085CysGlu: 1.085 ± 0.024	1.308CysPhe: 1.308 ± 0.033	1.416CysGly: 1.416 ± 0.017	0.502CysHis: 0.502 ± 0.007	0.937CysIle: 0.937 ± 0.011	1.053CysLys: 1.053 ± 0.014	2.113CysLeu: 2.113 ± 0.03	0.452CysMet: 0.452 ± 0.007	0.854CysAsn: 0.854 ± 0.019	1.19CysPro: 1.19 ± 0.017	0.611CysGln: 0.611 ± 0.008	1.4CysArg: 1.4 ± 0.022	2.156CysSer: 2.156 ± 0.042	1.118CysThr: 1.118 ± 0.023	1.011CysVal: 1.011 ± 0.016	0.297CysTrp: 0.297 ± 0.007	0.506CysTyr: 0.506 ± 0.008	0.001CysXaa: 0.001 ± 0.0
Asp	3.133AspAla: 3.133 ± 0.023	0.923AspCys: 0.923 ± 0.013	2.957AspAsp: 2.957 ± 0.022	3.466AspGlu: 3.466 ± 0.024	2.859AspPhe: 2.859 ± 0.068	3.516AspGly: 3.516 ± 0.025	1.239AspHis: 1.239 ± 0.013	2.414AspIle: 2.414 ± 0.017	2.078AspLys: 2.078 ± 0.016	4.974AspLeu: 4.974 ± 0.057	1.166AspMet: 1.166 ± 0.01	1.607AspAsn: 1.607 ± 0.014	3.133AspPro: 3.133 ± 0.048	1.881AspGln: 1.881 ± 0.043	2.708AspArg: 2.708 ± 0.018	3.926AspSer: 3.926 ± 0.031	1.804AspThr: 1.804 ± 0.013	3.015AspVal: 3.015 ± 0.022	0.718AspTrp: 0.718 ± 0.008	1.644AspTyr: 1.644 ± 0.036	0.002AspXaa: 0.002 ± 0.0
Glu	4.719GluAla: 4.719 ± 0.032	1.076GluCys: 1.076 ± 0.024	3.81GluAsp: 3.81 ± 0.05	6.17GluGlu: 6.17 ± 0.053	2.275GluPhe: 2.275 ± 0.028	4.176GluGly: 4.176 ± 0.042	1.121GluHis: 1.121 ± 0.009	3.299GluIle: 3.299 ± 0.032	3.84GluLys: 3.84 ± 0.032	5.668GluLeu: 5.668 ± 0.038	1.556GluMet: 1.556 ± 0.014	2.308GluAsn: 2.308 ± 0.016	2.486GluPro: 2.486 ± 0.02	1.869GluGln: 1.869 ± 0.016	3.527GluArg: 3.527 ± 0.026	4.523GluSer: 4.523 ± 0.039	2.686GluThr: 2.686 ± 0.021	4.04GluVal: 4.04 ± 0.028	0.756GluTrp: 0.756 ± 0.008	1.56GluTyr: 1.56 ± 0.016	0.003GluXaa: 0.003 ± 0.0
Phe	2.921PheAla: 2.921 ± 0.045	1.046PheCys: 1.046 ± 0.03	2.001PheAsp: 2.001 ± 0.017	2.029PheGlu: 2.029 ± 0.017	1.697PhePhe: 1.697 ± 0.016	3.434PheGly: 3.434 ± 0.048	1.355PheHis: 1.355 ± 0.041	1.808PheIle: 1.808 ± 0.015	1.661PheLys: 1.661 ± 0.015	4.437PheLeu: 4.437 ± 0.047	0.962PheMet: 0.962 ± 0.013	1.373PheAsn: 1.373 ± 0.013	2.357PhePro: 2.357 ± 0.023	1.411PheGln: 1.411 ± 0.015	2.729PheArg: 2.729 ± 0.042	3.909PheSer: 3.909 ± 0.034	2.702PheThr: 2.702 ± 0.069	2.556PheVal: 2.556 ± 0.025	0.559PheTrp: 0.559 ± 0.008	1.209PheTyr: 1.209 ± 0.03	0.002PheXaa: 0.002 ± 0.0
Gly	4.303GlyAla: 4.303 ± 0.026	1.395GlyCys: 1.395 ± 0.015	3.639GlyAsp: 3.639 ± 0.058	4.169GlyGlu: 4.169 ± 0.043	3.112GlyPhe: 3.112 ± 0.042	5.694GlyGly: 5.694 ± 0.06	1.906GlyHis: 1.906 ± 0.031	3.401GlyIle: 3.401 ± 0.038	3.853GlyLys: 3.853 ± 0.033	7.923GlyLeu: 7.923 ± 0.099	1.484GlyMet: 1.484 ± 0.014	2.637GlyAsn: 2.637 ± 0.021	4.385GlyPro: 4.385 ± 0.086	2.203GlyGln: 2.203 ± 0.022	4.663GlyArg: 4.663 ± 0.042	6.804GlySer: 6.804 ± 0.049	3.755GlyThr: 3.755 ± 0.042	4.102GlyVal: 4.102 ± 0.036	0.975GlyTrp: 0.975 ± 0.012	2.068GlyTyr: 2.068 ± 0.037	0.005GlyXaa: 0.005 ± 0.001
His	1.513HisAla: 1.513 ± 0.018	0.581HisCys: 0.581 ± 0.011	0.971HisAsp: 0.971 ± 0.01	1.344HisGlu: 1.344 ± 0.015	1.148HisPhe: 1.148 ± 0.018	2.136HisGly: 2.136 ± 0.039	0.871HisHis: 0.871 ± 0.011	1.17HisIle: 1.17 ± 0.012	0.93HisLys: 0.93 ± 0.01	2.585HisLeu: 2.585 ± 0.023	0.525HisMet: 0.525 ± 0.008	0.726HisAsn: 0.726 ± 0.008	1.895HisPro: 1.895 ± 0.04	0.901HisGln: 0.901 ± 0.011	1.858HisArg: 1.858 ± 0.025	1.945HisSer: 1.945 ± 0.018	1.082HisThr: 1.082 ± 0.03	1.456HisVal: 1.456 ± 0.015	0.321HisTrp: 0.321 ± 0.006	0.666HisTyr: 0.666 ± 0.007	0.001HisXaa: 0.001 ± 0.0
Ile	3.289IleAla: 3.289 ± 0.023	0.955IleCys: 0.955 ± 0.011	2.695IleAsp: 2.695 ± 0.039	2.964IleGlu: 2.964 ± 0.02	1.873IlePhe: 1.873 ± 0.015	3.25IleGly: 3.25 ± 0.024	1.181IleHis: 1.181 ± 0.015	2.245IleIle: 2.245 ± 0.019	2.387IleLys: 2.387 ± 0.026	4.484IleLeu: 4.484 ± 0.032	0.986IleMet: 0.986 ± 0.01	1.781IleAsn: 1.781 ± 0.017	3.062IlePro: 3.062 ± 0.036	1.589IleGln: 1.589 ± 0.013	2.812IleArg: 2.812 ± 0.02	4.197IleSer: 4.197 ± 0.026	2.232IleThr: 2.232 ± 0.017	2.814IleVal: 2.814 ± 0.019	0.605IleTrp: 0.605 ± 0.007	1.441IleTyr: 1.441 ± 0.025	0.003IleXaa: 0.003 ± 0.0
Lys	3.623LysAla: 3.623 ± 0.03	0.94LysCys: 0.94 ± 0.017	2.524LysAsp: 2.524 ± 0.017	3.817LysGlu: 3.817 ± 0.03	1.972LysPhe: 1.972 ± 0.025	3.635LysGly: 3.635 ± 0.04	1.141LysHis: 1.141 ± 0.016	2.55LysIle: 2.55 ± 0.019	3.743LysLys: 3.743 ± 0.028	5.048LysLeu: 5.048 ± 0.031	1.314LysMet: 1.314 ± 0.011	1.957LysAsn: 1.957 ± 0.015	2.458LysPro: 2.458 ± 0.025	1.798LysGln: 1.798 ± 0.017	3.194LysArg: 3.194 ± 0.027	3.87LysSer: 3.87 ± 0.031	2.226LysThr: 2.226 ± 0.015	3.845LysVal: 3.845 ± 0.042	0.742LysTrp: 0.742 ± 0.007	1.277LysTyr: 1.277 ± 0.012	0.003LysXaa: 0.003 ± 0.0
Leu	7.079LeuAla: 7.079 ± 0.069	1.846LeuCys: 1.846 ± 0.02	4.663LeuAsp: 4.663 ± 0.032	5.545LeuGlu: 5.545 ± 0.035	3.728LeuPhe: 3.728 ± 0.035	7.319LeuGly: 7.319 ± 0.14	2.692LeuHis: 2.692 ± 0.028	4.123LeuIle: 4.123 ± 0.022	5.299LeuLys: 5.299 ± 0.034	11.347LeuLeu: 11.347 ± 0.116	2.008LeuMet: 2.008 ± 0.014	3.231LeuAsn: 3.231 ± 0.021	5.656LeuPro: 5.656 ± 0.036	4.019LeuGln: 4.019 ± 0.029	7.415LeuArg: 7.415 ± 0.083	8.354LeuSer: 8.354 ± 0.045	4.787LeuThr: 4.787 ± 0.06	6.061LeuVal: 6.061 ± 0.035	1.176LeuTrp: 1.176 ± 0.015	2.188LeuTyr: 2.188 ± 0.019	0.005LeuXaa: 0.005 ± 0.001
Met	2.108MetAla: 2.108 ± 0.018	0.315MetCys: 0.315 ± 0.005	1.281MetAsp: 1.281 ± 0.013	1.863MetGlu: 1.863 ± 0.017	0.697MetPhe: 0.697 ± 0.008	1.969MetGly: 1.969 ± 0.045	0.531MetHis: 0.531 ± 0.006	1.123MetIle: 1.123 ± 0.01	1.408MetLys: 1.408 ± 0.013	1.943MetLeu: 1.943 ± 0.016	0.613MetMet: 0.613 ± 0.008	0.899MetAsn: 0.899 ± 0.01	1.048MetPro: 1.048 ± 0.011	0.789MetGln: 0.789 ± 0.01	1.483MetArg: 1.483 ± 0.02	1.593MetSer: 1.593 ± 0.012	1.056MetThr: 1.056 ± 0.011	1.488MetVal: 1.488 ± 0.013	0.3MetTrp: 0.3 ± 0.007	0.547MetTyr: 0.547 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	2.728AsnAla: 2.728 ± 0.03	0.706AsnCys: 0.706 ± 0.008	1.572AsnAsp: 1.572 ± 0.018	1.891AsnGlu: 1.891 ± 0.017	1.643AsnPhe: 1.643 ± 0.018	2.652AsnGly: 2.652 ± 0.019	0.849AsnHis: 0.849 ± 0.01	1.792AsnIle: 1.792 ± 0.015	1.685AsnLys: 1.685 ± 0.014	4.014AsnLeu: 4.014 ± 0.034	0.895AsnMet: 0.895 ± 0.009	1.557AsnAsn: 1.557 ± 0.017	2.289AsnPro: 2.289 ± 0.02	1.278AsnGln: 1.278 ± 0.012	1.984AsnArg: 1.984 ± 0.015	3.119AsnSer: 3.119 ± 0.021	1.494AsnThr: 1.494 ± 0.013	2.21AsnVal: 2.21 ± 0.017	0.49AsnTrp: 0.49 ± 0.007	1.067AsnTyr: 1.067 ± 0.011	0.002AsnXaa: 0.002 ± 0.0
Pro	4.076ProAla: 4.076 ± 0.035	1.291ProCys: 1.291 ± 0.04	3.292ProAsp: 3.292 ± 0.048	3.192ProGlu: 3.192 ± 0.021	2.455ProPhe: 2.455 ± 0.045	3.744ProGly: 3.744 ± 0.035	1.471ProHis: 1.471 ± 0.025	2.459ProIle: 2.459 ± 0.018	2.799ProLys: 2.799 ± 0.032	4.971ProLeu: 4.971 ± 0.043	1.095ProMet: 1.095 ± 0.01	2.243ProAsn: 2.243 ± 0.018	4.745ProPro: 4.745 ± 0.047	1.805ProGln: 1.805 ± 0.018	3.691ProArg: 3.691 ± 0.041	6.479ProSer: 6.479 ± 0.072	3.744ProThr: 3.744 ± 0.065	3.775ProVal: 3.775 ± 0.036	0.854ProTrp: 0.854 ± 0.017	1.441ProTyr: 1.441 ± 0.018	0.005ProXaa: 0.005 ± 0.001
Gln	2.421GlnAla: 2.421 ± 0.019	0.54GlnCys: 0.54 ± 0.009	1.456GlnAsp: 1.456 ± 0.015	2.24GlnGlu: 2.24 ± 0.02	1.217GlnPhe: 1.217 ± 0.011	2.352GlnGly: 2.352 ± 0.033	0.787GlnHis: 0.787 ± 0.009	1.615GlnIle: 1.615 ± 0.014	1.8GlnLys: 1.8 ± 0.014	3.19GlnLeu: 3.19 ± 0.022	0.894GlnMet: 0.894 ± 0.008	1.258GlnAsn: 1.258 ± 0.012	1.874GlnPro: 1.874 ± 0.022	1.648GlnGln: 1.648 ± 0.019	2.506GlnArg: 2.506 ± 0.041	2.638GlnSer: 2.638 ± 0.029	1.469GlnThr: 1.469 ± 0.011	2.257GlnVal: 2.257 ± 0.021	0.462GlnTrp: 0.462 ± 0.006	0.827GlnTyr: 0.827 ± 0.01	0.002GlnXaa: 0.002 ± 0.0
Arg	5.133ArgAla: 5.133 ± 0.059	1.186ArgCys: 1.186 ± 0.012	3.17ArgAsp: 3.17 ± 0.036	3.779ArgGlu: 3.779 ± 0.028	2.319ArgPhe: 2.319 ± 0.018	4.554ArgGly: 4.554 ± 0.046	1.492ArgHis: 1.492 ± 0.014	2.945ArgIle: 2.945 ± 0.025	3.936ArgLys: 3.936 ± 0.033	6.613ArgLeu: 6.613 ± 0.073	1.626ArgMet: 1.626 ± 0.017	2.181ArgAsn: 2.181 ± 0.019	4.497ArgPro: 4.497 ± 0.078	1.987ArgGln: 1.987 ± 0.016	5.237ArgArg: 5.237 ± 0.043	5.306ArgSer: 5.306 ± 0.036	3.297ArgThr: 3.297 ± 0.039	5.055ArgVal: 5.055 ± 0.06	1.001ArgTrp: 1.001 ± 0.013	1.345ArgTyr: 1.345 ± 0.01	0.005ArgXaa: 0.005 ± 0.001
Ser	6.249SerAla: 6.249 ± 0.055	2.244SerCys: 2.244 ± 0.055	3.907SerAsp: 3.907 ± 0.036	4.29SerGlu: 4.29 ± 0.025	3.576SerPhe: 3.576 ± 0.024	6.786SerGly: 6.786 ± 0.051	2.099SerHis: 2.099 ± 0.02	4.136SerIle: 4.136 ± 0.033	4.272SerLys: 4.272 ± 0.033	8.601SerLeu: 8.601 ± 0.067	2.02SerMet: 2.02 ± 0.019	3.208SerAsn: 3.208 ± 0.021	6.057SerPro: 6.057 ± 0.072	2.666SerGln: 2.666 ± 0.022	5.8SerArg: 5.8 ± 0.039	10.685SerSer: 10.685 ± 0.059	4.984SerThr: 4.984 ± 0.039	4.815SerVal: 4.815 ± 0.027	1.177SerTrp: 1.177 ± 0.011	1.989SerTyr: 1.989 ± 0.015	0.005SerXaa: 0.005 ± 0.001
Thr	3.908ThrAla: 3.908 ± 0.049	0.929ThrCys: 0.929 ± 0.011	2.113ThrAsp: 2.113 ± 0.02	2.85ThrGlu: 2.85 ± 0.047	2.513ThrPhe: 2.513 ± 0.055	3.814ThrGly: 3.814 ± 0.039	1.057ThrHis: 1.057 ± 0.018	2.426ThrIle: 2.426 ± 0.016	2.113ThrLys: 2.113 ± 0.015	4.745ThrLeu: 4.745 ± 0.033	1.419ThrMet: 1.419 ± 0.048	1.603ThrAsn: 1.603 ± 0.014	2.993ThrPro: 2.993 ± 0.029	1.31ThrGln: 1.31 ± 0.012	3.205ThrArg: 3.205 ± 0.037	4.874ThrSer: 4.874 ± 0.047	2.982ThrThr: 2.982 ± 0.044	3.205ThrVal: 3.205 ± 0.023	0.651ThrTrp: 0.651 ± 0.007	1.222ThrTyr: 1.222 ± 0.013	0.004ThrXaa: 0.004 ± 0.001
Val	4.551ValAla: 4.551 ± 0.029	1.278ValCys: 1.278 ± 0.021	3.356ValAsp: 3.356 ± 0.023	4.013ValGlu: 4.013 ± 0.031	2.374ValPhe: 2.374 ± 0.021	4.501ValGly: 4.501 ± 0.046	1.712ValHis: 1.712 ± 0.02	3.093ValIle: 3.093 ± 0.027	3.19ValLys: 3.19 ± 0.021	5.787ValLeu: 5.787 ± 0.036	1.436ValMet: 1.436 ± 0.014	2.579ValAsn: 2.579 ± 0.03	4.1ValPro: 4.1 ± 0.05	2.053ValGln: 2.053 ± 0.017	4.424ValArg: 4.424 ± 0.054	5.024ValSer: 5.024 ± 0.039	3.049ValThr: 3.049 ± 0.027	4.349ValVal: 4.349 ± 0.029	0.737ValTrp: 0.737 ± 0.01	1.894ValTyr: 1.894 ± 0.023	0.003ValXaa: 0.003 ± 0.001
Trp	0.979TrpAla: 0.979 ± 0.013	0.249TrpCys: 0.249 ± 0.007	0.697TrpAsp: 0.697 ± 0.011	0.767TrpGlu: 0.767 ± 0.009	0.474TrpPhe: 0.474 ± 0.006	0.858TrpGly: 0.858 ± 0.013	0.32TrpHis: 0.32 ± 0.005	0.67TrpIle: 0.67 ± 0.007	0.899TrpLys: 0.899 ± 0.014	1.312TrpLeu: 1.312 ± 0.015	0.31TrpMet: 0.31 ± 0.005	0.59TrpAsn: 0.59 ± 0.007	0.561TrpPro: 0.561 ± 0.006	0.409TrpGln: 0.409 ± 0.005	1.001TrpArg: 1.001 ± 0.011	1.023TrpSer: 1.023 ± 0.011	0.74TrpThr: 0.74 ± 0.011	0.887TrpVal: 0.887 ± 0.01	0.259TrpTrp: 0.259 ± 0.005	0.296TrpTyr: 0.296 ± 0.005	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.671TyrAla: 1.671 ± 0.016	0.861TyrCys: 0.861 ± 0.023	1.238TyrAsp: 1.238 ± 0.013	1.368TyrGlu: 1.368 ± 0.012	1.63TyrPhe: 1.63 ± 0.045	2.058TyrGly: 2.058 ± 0.036	0.632TyrHis: 0.632 ± 0.007	1.241TyrIle: 1.241 ± 0.013	1.252TyrLys: 1.252 ± 0.01	2.342TyrLeu: 2.342 ± 0.017	0.612TyrMet: 0.612 ± 0.009	1.0TyrAsn: 1.0 ± 0.01	1.229TyrPro: 1.229 ± 0.014	0.826TyrGln: 0.826 ± 0.009	1.582TyrArg: 1.582 ± 0.016	2.093TyrSer: 2.093 ± 0.015	1.138TyrThr: 1.138 ± 0.011	1.754TyrVal: 1.754 ± 0.039	0.362TyrTrp: 0.362 ± 0.005	0.888TyrTyr: 0.888 ± 0.012	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.003XaaGlu: 0.003 ± 0.0	0.003XaaPhe: 0.003 ± 0.0	0.005XaaGly: 0.005 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.006XaaLeu: 0.006 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.003XaaPro: 0.003 ± 0.0	0.002XaaGln: 0.002 ± 0.0	0.005XaaArg: 0.005 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.0	0.004XaaVal: 0.004 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 50426 proteins (14680046 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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