Amino acid dipepetide frequency for Culex pipiens associated Tunisia virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.852AlaAla: 0.852 ± 0.466
0.0AlaCys: 0.0 ± 0.0
1.42AlaAsp: 1.42 ± 0.777
0.568AlaGlu: 0.568 ± 0.311
0.852AlaPhe: 0.852 ± 0.54
1.42AlaGly: 1.42 ± 0.357
0.568AlaHis: 0.568 ± 0.311
1.988AlaIle: 1.988 ± 0.686
1.136AlaLys: 1.136 ± 0.65
1.42AlaLeu: 1.42 ± 0.553
0.0AlaMet: 0.0 ± 0.0
0.852AlaAsn: 0.852 ± 0.466
0.0AlaPro: 0.0 ± 0.0
0.852AlaGln: 0.852 ± 0.54
0.0AlaArg: 0.0 ± 0.0
2.556AlaSer: 2.556 ± 1.066
0.0AlaThr: 0.0 ± 0.0
1.704AlaVal: 1.704 ± 0.44
0.0AlaTrp: 0.0 ± 0.0
1.988AlaTyr: 1.988 ± 1.088
0.0AlaXaa: 0.0 ± 0.0
Cys
1.136CysAla: 1.136 ± 0.622
0.0CysCys: 0.0 ± 0.0
1.988CysAsp: 1.988 ± 0.447
1.704CysGlu: 1.704 ± 0.621
0.568CysPhe: 0.568 ± 0.311
0.852CysGly: 0.852 ± 0.22
0.284CysHis: 0.284 ± 0.687
1.704CysIle: 1.704 ± 0.933
1.988CysLys: 1.988 ± 0.447
0.284CysLeu: 0.284 ± 0.155
0.0CysMet: 0.0 ± 0.0
1.704CysAsn: 1.704 ± 0.44
1.42CysPro: 1.42 ± 0.548
0.0CysGln: 0.0 ± 0.0
0.284CysArg: 0.284 ± 0.155
1.704CysSer: 1.704 ± 1.027
0.568CysThr: 0.568 ± 0.311
0.852CysVal: 0.852 ± 0.466
0.0CysTrp: 0.0 ± 0.0
0.568CysTyr: 0.568 ± 1.048
0.0CysXaa: 0.0 ± 0.0
Asp
1.136AspAla: 1.136 ± 0.524
1.136AspCys: 1.136 ± 0.524
4.828AspAsp: 4.828 ± 1.098
5.68AspGlu: 5.68 ± 1.422
4.26AspPhe: 4.26 ± 0.663
2.84AspGly: 2.84 ± 1.082
1.704AspHis: 1.704 ± 0.49
6.248AspIle: 6.248 ± 1.103
5.964AspLys: 5.964 ± 1.555
6.248AspLeu: 6.248 ± 1.1
1.988AspMet: 1.988 ± 1.0
5.396AspAsn: 5.396 ± 1.057
2.556AspPro: 2.556 ± 1.399
2.84AspGln: 2.84 ± 0.91
2.272AspArg: 2.272 ± 1.085
5.964AspSer: 5.964 ± 1.316
2.272AspThr: 2.272 ± 0.696
5.112AspVal: 5.112 ± 1.138
0.284AspTrp: 0.284 ± 0.155
2.556AspTyr: 2.556 ± 1.901
0.0AspXaa: 0.0 ± 0.0
Glu
1.136GluAla: 1.136 ± 0.253
0.568GluCys: 0.568 ± 0.598
3.124GluAsp: 3.124 ± 0.949
3.408GluGlu: 3.408 ± 1.012
3.976GluPhe: 3.976 ± 0.54
2.556GluGly: 2.556 ± 0.931
0.852GluHis: 0.852 ± 0.466
7.1GluIle: 7.1 ± 1.573
6.816GluLys: 6.816 ± 1.246
5.112GluLeu: 5.112 ± 0.431
0.568GluMet: 0.568 ± 0.311
6.532GluAsn: 6.532 ± 1.036
1.704GluPro: 1.704 ± 0.49
1.704GluGln: 1.704 ± 0.44
3.408GluArg: 3.408 ± 0.879
3.692GluSer: 3.692 ± 0.689
2.556GluThr: 2.556 ± 1.399
3.124GluVal: 3.124 ± 0.843
0.284GluTrp: 0.284 ± 0.155
4.26GluTyr: 4.26 ± 0.544
0.0GluXaa: 0.0 ± 0.0
Phe
1.136PheAla: 1.136 ± 0.524
0.568PheCys: 0.568 ± 0.311
5.396PheAsp: 5.396 ± 0.895
5.68PheGlu: 5.68 ± 0.858
2.84PhePhe: 2.84 ± 1.774
1.136PheGly: 1.136 ± 0.959
0.852PheHis: 0.852 ± 0.68
4.544PheIle: 4.544 ± 1.393
3.408PheLys: 3.408 ± 0.619
5.68PheLeu: 5.68 ± 0.721
0.852PheMet: 0.852 ± 0.22
3.976PheAsn: 3.976 ± 1.265
1.136PhePro: 1.136 ± 1.304
1.42PheGln: 1.42 ± 0.962
2.272PheArg: 2.272 ± 1.019
7.668PheSer: 7.668 ± 3.112
2.556PheThr: 2.556 ± 0.599
4.544PheVal: 4.544 ± 0.975
0.284PheTrp: 0.284 ± 0.155
3.124PheTyr: 3.124 ± 0.689
0.0PheXaa: 0.0 ± 0.0
Gly
0.852GlyAla: 0.852 ± 0.22
1.704GlyCys: 1.704 ± 0.49
2.84GlyAsp: 2.84 ± 0.714
2.272GlyGlu: 2.272 ± 0.78
2.272GlyPhe: 2.272 ± 1.139
2.556GlyGly: 2.556 ± 0.931
0.568GlyHis: 0.568 ± 0.311
1.704GlyIle: 1.704 ± 0.49
3.408GlyLys: 3.408 ± 1.388
4.544GlyLeu: 4.544 ± 1.461
0.852GlyMet: 0.852 ± 0.466
3.124GlyAsn: 3.124 ± 1.235
0.284GlyPro: 0.284 ± 0.155
0.0GlyGln: 0.0 ± 0.0
1.42GlyArg: 1.42 ± 1.129
2.272GlySer: 2.272 ± 1.139
0.852GlyThr: 0.852 ± 0.68
3.976GlyVal: 3.976 ± 1.171
0.568GlyTrp: 0.568 ± 1.501
2.272GlyTyr: 2.272 ± 0.78
0.0GlyXaa: 0.0 ± 0.0
His
0.568HisAla: 0.568 ± 0.311
0.284HisCys: 0.284 ± 0.155
0.284HisAsp: 0.284 ± 0.155
1.136HisGlu: 1.136 ± 0.65
1.42HisPhe: 1.42 ± 0.357
0.852HisGly: 0.852 ± 0.22
1.136HisHis: 1.136 ± 1.196
1.42HisIle: 1.42 ± 1.67
1.704HisLys: 1.704 ± 0.49
2.272HisLeu: 2.272 ± 0.505
0.284HisMet: 0.284 ± 0.155
1.136HisAsn: 1.136 ± 0.253
0.284HisPro: 0.284 ± 0.155
0.0HisGln: 0.0 ± 0.0
1.42HisArg: 1.42 ± 0.357
2.272HisSer: 2.272 ± 0.83
2.556HisThr: 2.556 ± 0.718
1.42HisVal: 1.42 ± 0.357
0.568HisTrp: 0.568 ± 0.598
1.704HisTyr: 1.704 ± 0.933
0.0HisXaa: 0.0 ± 0.0
Ile
1.136IleAla: 1.136 ± 0.622
1.42IleCys: 1.42 ± 0.95
7.1IleAsp: 7.1 ± 1.659
5.112IleGlu: 5.112 ± 2.034
5.396IlePhe: 5.396 ± 1.057
3.408IleGly: 3.408 ± 0.979
3.124IleHis: 3.124 ± 1.235
6.816IleIle: 6.816 ± 1.456
8.52IleLys: 8.52 ± 2.448
10.508IleLeu: 10.508 ± 0.805
0.852IleMet: 0.852 ± 1.216
5.396IleAsn: 5.396 ± 2.718
4.26IlePro: 4.26 ± 1.56
1.704IleGln: 1.704 ± 0.475
3.124IleArg: 3.124 ± 0.761
7.1IleSer: 7.1 ± 2.259
4.26IleThr: 4.26 ± 0.941
1.988IleVal: 1.988 ± 1.126
0.284IleTrp: 0.284 ± 0.155
5.112IleTyr: 5.112 ± 1.282
0.0IleXaa: 0.0 ± 0.0
Lys
1.988LysAla: 1.988 ± 0.716
1.42LysCys: 1.42 ± 0.777
6.248LysAsp: 6.248 ± 1.445
5.112LysGlu: 5.112 ± 1.861
7.384LysPhe: 7.384 ± 1.009
3.124LysGly: 3.124 ± 1.139
1.136LysHis: 1.136 ± 0.622
9.656LysIle: 9.656 ± 1.726
5.964LysLys: 5.964 ± 1.647
9.94LysLeu: 9.94 ± 2.199
1.988LysMet: 1.988 ± 0.563
7.1LysAsn: 7.1 ± 0.889
4.26LysPro: 4.26 ± 1.072
2.84LysGln: 2.84 ± 0.47
3.408LysArg: 3.408 ± 0.979
5.396LysSer: 5.396 ± 1.046
6.248LysThr: 6.248 ± 0.625
3.408LysVal: 3.408 ± 0.862
0.852LysTrp: 0.852 ± 0.466
5.964LysTyr: 5.964 ± 1.777
0.0LysXaa: 0.0 ± 0.0
Leu
1.988LeuAla: 1.988 ± 0.447
1.988LeuCys: 1.988 ± 1.006
8.236LeuAsp: 8.236 ± 2.613
5.964LeuGlu: 5.964 ± 1.159
3.124LeuPhe: 3.124 ± 0.761
3.408LeuGly: 3.408 ± 1.388
2.556LeuHis: 2.556 ± 1.562
7.1LeuIle: 7.1 ± 2.082
10.792LeuLys: 10.792 ± 1.784
6.816LeuLeu: 6.816 ± 0.641
3.692LeuMet: 3.692 ± 1.331
5.112LeuAsn: 5.112 ± 1.99
3.124LeuPro: 3.124 ± 0.692
2.84LeuGln: 2.84 ± 1.089
2.556LeuArg: 2.556 ± 0.718
8.236LeuSer: 8.236 ± 1.83
5.112LeuThr: 5.112 ± 2.286
4.828LeuVal: 4.828 ± 1.097
0.284LeuTrp: 0.284 ± 0.155
5.112LeuTyr: 5.112 ± 1.319
0.0LeuXaa: 0.0 ± 0.0
Met
0.852MetAla: 0.852 ± 0.54
0.284MetCys: 0.284 ± 0.155
1.704MetAsp: 1.704 ± 0.44
0.852MetGlu: 0.852 ± 0.466
1.42MetPhe: 1.42 ± 0.777
0.0MetGly: 0.0 ± 0.0
0.284MetHis: 0.284 ± 0.155
1.704MetIle: 1.704 ± 0.966
1.988MetLys: 1.988 ± 1.088
1.136MetLeu: 1.136 ± 0.622
0.284MetMet: 0.284 ± 0.155
1.704MetAsn: 1.704 ± 0.475
0.284MetPro: 0.284 ± 0.155
0.284MetGln: 0.284 ± 0.155
1.42MetArg: 1.42 ± 1.129
2.556MetSer: 2.556 ± 1.046
0.852MetThr: 0.852 ± 0.54
1.704MetVal: 1.704 ± 0.838
0.0MetTrp: 0.0 ± 0.0
1.136MetTyr: 1.136 ± 0.959
0.0MetXaa: 0.0 ± 0.0
Asn
0.852AsnAla: 0.852 ± 0.466
1.988AsnCys: 1.988 ± 1.245
2.556AsnAsp: 2.556 ± 0.79
3.976AsnGlu: 3.976 ± 0.752
5.68AsnPhe: 5.68 ± 1.393
1.988AsnGly: 1.988 ± 0.633
1.42AsnHis: 1.42 ± 0.484
5.68AsnIle: 5.68 ± 0.644
6.532AsnLys: 6.532 ± 1.889
7.668AsnLeu: 7.668 ± 1.533
2.84AsnMet: 2.84 ± 1.181
3.408AsnAsn: 3.408 ± 0.979
1.988AsnPro: 1.988 ± 0.764
2.272AsnGln: 2.272 ± 1.642
2.556AsnArg: 2.556 ± 1.823
6.248AsnSer: 6.248 ± 1.469
3.124AsnThr: 3.124 ± 1.147
5.112AsnVal: 5.112 ± 0.776
0.284AsnTrp: 0.284 ± 0.155
1.704AsnTyr: 1.704 ± 0.49
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.0ProCys: 0.0 ± 0.0
2.556ProAsp: 2.556 ± 0.506
4.26ProGlu: 4.26 ± 0.779
1.42ProPhe: 1.42 ± 0.553
2.272ProGly: 2.272 ± 0.78
0.568ProHis: 0.568 ± 0.285
1.136ProIle: 1.136 ± 0.622
2.272ProLys: 2.272 ± 0.505
3.124ProLeu: 3.124 ± 1.347
0.284ProMet: 0.284 ± 0.155
2.272ProAsn: 2.272 ± 1.139
0.852ProPro: 0.852 ± 0.68
1.136ProGln: 1.136 ± 0.253
0.852ProArg: 0.852 ± 1.102
3.692ProSer: 3.692 ± 0.583
2.272ProThr: 2.272 ± 1.129
2.272ProVal: 2.272 ± 1.068
0.0ProTrp: 0.0 ± 0.0
1.704ProTyr: 1.704 ± 0.933
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
2.272GlnAsp: 2.272 ± 0.776
1.136GlnGlu: 1.136 ± 0.622
1.988GlnPhe: 1.988 ± 0.764
1.42GlnGly: 1.42 ± 0.357
0.284GlnHis: 0.284 ± 0.155
2.272GlnIle: 2.272 ± 0.582
1.42GlnLys: 1.42 ± 0.357
3.692GlnLeu: 3.692 ± 1.946
0.568GlnMet: 0.568 ± 0.285
1.704GlnAsn: 1.704 ± 0.44
0.568GlnPro: 0.568 ± 0.311
1.136GlnGln: 1.136 ± 0.253
1.136GlnArg: 1.136 ± 0.524
3.124GlnSer: 3.124 ± 2.167
1.42GlnThr: 1.42 ± 0.553
0.852GlnVal: 0.852 ± 0.22
0.284GlnTrp: 0.284 ± 0.155
0.852GlnTyr: 0.852 ± 0.77
0.0GlnXaa: 0.0 ± 0.0
Arg
0.568ArgAla: 0.568 ± 0.285
1.704ArgCys: 1.704 ± 0.49
1.704ArgAsp: 1.704 ± 1.258
2.84ArgGlu: 2.84 ± 0.868
2.556ArgPhe: 2.556 ± 1.835
1.136ArgGly: 1.136 ± 0.622
1.704ArgHis: 1.704 ± 0.933
4.26ArgIle: 4.26 ± 0.658
3.408ArgLys: 3.408 ± 0.979
2.84ArgLeu: 2.84 ± 1.089
0.568ArgMet: 0.568 ± 1.048
3.124ArgAsn: 3.124 ± 1.971
0.568ArgPro: 0.568 ± 0.311
0.852ArgGln: 0.852 ± 1.551
2.556ArgArg: 2.556 ± 0.659
2.272ArgSer: 2.272 ± 0.83
2.556ArgThr: 2.556 ± 0.506
2.556ArgVal: 2.556 ± 2.302
0.0ArgTrp: 0.0 ± 0.0
1.42ArgTyr: 1.42 ± 0.777
0.0ArgXaa: 0.0 ± 0.0
Ser
2.556SerAla: 2.556 ± 0.541
1.704SerCys: 1.704 ± 0.806
5.964SerAsp: 5.964 ± 1.543
3.976SerGlu: 3.976 ± 0.762
3.976SerPhe: 3.976 ± 2.605
4.26SerGly: 4.26 ± 0.941
1.704SerHis: 1.704 ± 0.621
8.52SerIle: 8.52 ± 1.878
9.372SerLys: 9.372 ± 2.104
6.248SerLeu: 6.248 ± 1.34
2.556SerMet: 2.556 ± 0.705
5.112SerAsn: 5.112 ± 0.431
2.84SerPro: 2.84 ± 0.714
2.84SerGln: 2.84 ± 0.969
3.408SerArg: 3.408 ± 4.397
6.816SerSer: 6.816 ± 5.427
5.964SerThr: 5.964 ± 1.083
2.84SerVal: 2.84 ± 2.588
0.852SerTrp: 0.852 ± 0.466
3.976SerTyr: 3.976 ± 0.953
0.0SerXaa: 0.0 ± 0.0
Thr
0.284ThrAla: 0.284 ± 0.403
1.136ThrCys: 1.136 ± 0.253
3.408ThrAsp: 3.408 ± 0.991
2.556ThrGlu: 2.556 ± 0.955
1.704ThrPhe: 1.704 ± 0.44
1.42ThrGly: 1.42 ± 0.357
0.852ThrHis: 0.852 ± 0.77
4.26ThrIle: 4.26 ± 1.072
4.828ThrLys: 4.828 ± 1.45
4.828ThrLeu: 4.828 ± 2.172
1.136ThrMet: 1.136 ± 0.65
3.692ThrAsn: 3.692 ± 0.847
3.124ThrPro: 3.124 ± 0.752
1.42ThrGln: 1.42 ± 0.484
2.84ThrArg: 2.84 ± 0.47
5.112ThrSer: 5.112 ± 1.649
3.124ThrThr: 3.124 ± 1.227
3.408ThrVal: 3.408 ± 0.979
0.568ThrTrp: 0.568 ± 1.501
2.84ThrTyr: 2.84 ± 2.004
0.0ThrXaa: 0.0 ± 0.0
Val
1.136ValAla: 1.136 ± 0.524
0.568ValCys: 0.568 ± 0.285
3.976ValAsp: 3.976 ± 1.729
2.84ValGlu: 2.84 ± 0.714
3.976ValPhe: 3.976 ± 0.752
1.704ValGly: 1.704 ± 1.216
1.988ValHis: 1.988 ± 1.088
4.26ValIle: 4.26 ± 0.941
6.248ValLys: 6.248 ± 1.792
5.964ValLeu: 5.964 ± 1.28
0.0ValMet: 0.0 ± 0.0
3.408ValAsn: 3.408 ± 1.388
1.704ValPro: 1.704 ± 1.963
1.42ValGln: 1.42 ± 0.484
2.272ValArg: 2.272 ± 0.78
3.976ValSer: 3.976 ± 1.206
3.692ValThr: 3.692 ± 1.344
2.272ValVal: 2.272 ± 0.696
0.852ValTrp: 0.852 ± 0.466
2.556ValTyr: 2.556 ± 0.541
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.568TrpCys: 0.568 ± 0.311
0.852TrpAsp: 0.852 ± 0.466
0.284TrpGlu: 0.284 ± 0.155
0.284TrpPhe: 0.284 ± 0.155
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.852TrpIle: 0.852 ± 1.398
0.284TrpLys: 0.284 ± 1.123
0.284TrpLeu: 0.284 ± 0.155
0.284TrpMet: 0.284 ± 0.155
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.568TrpArg: 0.568 ± 0.311
1.136TrpSer: 1.136 ± 0.524
0.568TrpThr: 0.568 ± 0.598
0.284TrpVal: 0.284 ± 0.155
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.568TyrCys: 0.568 ± 0.311
4.828TyrAsp: 4.828 ± 1.711
3.124TyrGlu: 3.124 ± 0.843
3.976TyrPhe: 3.976 ± 0.54
1.988TyrGly: 1.988 ± 1.111
1.136TyrHis: 1.136 ± 1.286
5.396TyrIle: 5.396 ± 1.95
7.384TyrLys: 7.384 ± 2.043
4.26TyrLeu: 4.26 ± 1.099
0.568TyrMet: 0.568 ± 0.311
3.124TyrAsn: 3.124 ± 1.74
1.988TyrPro: 1.988 ± 0.633
0.568TyrGln: 0.568 ± 0.311
1.42TyrArg: 1.42 ± 0.777
3.976TyrSer: 3.976 ± 2.299
1.988TyrThr: 1.988 ± 1.006
2.556TyrVal: 2.556 ± 0.599
0.0TyrTrp: 0.0 ± 0.0
2.84TyrTyr: 2.84 ± 1.082
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3522 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski