Amino acid dipepetide frequency for Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.727AlaAla: 16.727 ± 0.165	1.541AlaCys: 1.541 ± 0.034	6.58AlaAsp: 6.58 ± 0.073	7.373AlaGlu: 7.373 ± 0.089	4.119AlaPhe: 4.119 ± 0.064	10.509AlaGly: 10.509 ± 0.105	2.705AlaHis: 2.705 ± 0.049	5.317AlaIle: 5.317 ± 0.064	3.663AlaLys: 3.663 ± 0.062	13.7AlaLeu: 13.7 ± 0.136	3.078AlaMet: 3.078 ± 0.054	2.664AlaAsn: 2.664 ± 0.045	5.623AlaPro: 5.623 ± 0.067	4.351AlaGln: 4.351 ± 0.061	9.817AlaArg: 9.817 ± 0.101	6.279AlaSer: 6.279 ± 0.074	5.854AlaThr: 5.854 ± 0.073	8.667AlaVal: 8.667 ± 0.091	1.753AlaTrp: 1.753 ± 0.042	2.385AlaTyr: 2.385 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.365CysAla: 1.365 ± 0.035	0.2CysCys: 0.2 ± 0.012	0.63CysAsp: 0.63 ± 0.02	0.653CysGlu: 0.653 ± 0.023	0.395CysPhe: 0.395 ± 0.019	1.187CysGly: 1.187 ± 0.031	0.317CysHis: 0.317 ± 0.016	0.483CysIle: 0.483 ± 0.019	0.283CysLys: 0.283 ± 0.014	1.029CysLeu: 1.029 ± 0.03	0.208CysMet: 0.208 ± 0.013	0.3CysAsn: 0.3 ± 0.014	0.695CysPro: 0.695 ± 0.026	0.295CysGln: 0.295 ± 0.015	1.002CysArg: 1.002 ± 0.033	0.694CysSer: 0.694 ± 0.025	0.563CysThr: 0.563 ± 0.02	0.787CysVal: 0.787 ± 0.028	0.143CysTrp: 0.143 ± 0.009	0.27CysTyr: 0.27 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.03AspAla: 7.03 ± 0.083	0.604AspCys: 0.604 ± 0.02	3.232AspAsp: 3.232 ± 0.051	3.976AspGlu: 3.976 ± 0.054	2.123AspPhe: 2.123 ± 0.04	4.634AspGly: 4.634 ± 0.066	1.208AspHis: 1.208 ± 0.026	2.501AspIle: 2.501 ± 0.046	1.628AspLys: 1.628 ± 0.036	5.403AspLeu: 5.403 ± 0.066	1.032AspMet: 1.032 ± 0.026	1.265AspAsn: 1.265 ± 0.033	3.045AspPro: 3.045 ± 0.057	1.478AspGln: 1.478 ± 0.033	4.126AspArg: 4.126 ± 0.053	2.445AspSer: 2.445 ± 0.042	2.536AspThr: 2.536 ± 0.046	4.119AspVal: 4.119 ± 0.064	0.97AspTrp: 0.97 ± 0.026	1.485AspTyr: 1.485 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.536GluAla: 7.536 ± 0.082	0.556GluCys: 0.556 ± 0.022	2.533GluAsp: 2.533 ± 0.049	3.021GluGlu: 3.021 ± 0.051	2.046GluPhe: 2.046 ± 0.04	3.966GluGly: 3.966 ± 0.05	1.592GluHis: 1.592 ± 0.04	3.278GluIle: 3.278 ± 0.056	2.127GluLys: 2.127 ± 0.045	6.593GluLeu: 6.593 ± 0.072	1.39GluMet: 1.39 ± 0.031	1.559GluAsn: 1.559 ± 0.034	2.741GluPro: 2.741 ± 0.054	2.515GluGln: 2.515 ± 0.045	5.773GluArg: 5.773 ± 0.073	2.84GluSer: 2.84 ± 0.053	2.95GluThr: 2.95 ± 0.056	4.244GluVal: 4.244 ± 0.067	0.803GluTrp: 0.803 ± 0.025	1.166GluTyr: 1.166 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.474PheAla: 4.474 ± 0.054	0.487PheCys: 0.487 ± 0.021	2.575PheAsp: 2.575 ± 0.045	2.285PheGlu: 2.285 ± 0.046	1.462PhePhe: 1.462 ± 0.039	3.5PheGly: 3.5 ± 0.058	0.822PheHis: 0.822 ± 0.028	1.597PheIle: 1.597 ± 0.041	0.929PheLys: 0.929 ± 0.032	3.198PheLeu: 3.198 ± 0.056	0.753PheMet: 0.753 ± 0.022	1.064PheAsn: 1.064 ± 0.03	1.656PhePro: 1.656 ± 0.034	0.944PheGln: 0.944 ± 0.023	2.506PheArg: 2.506 ± 0.045	2.181PheSer: 2.181 ± 0.044	1.742PheThr: 1.742 ± 0.037	2.827PheVal: 2.827 ± 0.052	0.487PheTrp: 0.487 ± 0.02	0.848PheTyr: 0.848 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	8.79GlyAla: 8.79 ± 0.098	1.067GlyCys: 1.067 ± 0.033	4.276GlyAsp: 4.276 ± 0.06	5.117GlyGlu: 5.117 ± 0.069	3.283GlyPhe: 3.283 ± 0.052	6.563GlyGly: 6.563 ± 0.083	1.956GlyHis: 1.956 ± 0.041	4.091GlyIle: 4.091 ± 0.056	3.216GlyLys: 3.216 ± 0.055	8.345GlyLeu: 8.345 ± 0.092	2.206GlyMet: 2.206 ± 0.046	2.107GlyAsn: 2.107 ± 0.039	2.874GlyPro: 2.874 ± 0.051	2.722GlyGln: 2.722 ± 0.051	6.582GlyArg: 6.582 ± 0.089	4.477GlySer: 4.477 ± 0.061	4.017GlyThr: 4.017 ± 0.066	6.247GlyVal: 6.247 ± 0.077	1.314GlyTrp: 1.314 ± 0.034	2.16GlyTyr: 2.16 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.917HisAla: 2.917 ± 0.056	0.32HisCys: 0.32 ± 0.013	1.399HisAsp: 1.399 ± 0.034	1.326HisGlu: 1.326 ± 0.034	0.981HisPhe: 0.981 ± 0.026	2.162HisGly: 2.162 ± 0.041	0.72HisHis: 0.72 ± 0.027	0.927HisIle: 0.927 ± 0.029	0.579HisLys: 0.579 ± 0.02	2.444HisLeu: 2.444 ± 0.047	0.471HisMet: 0.471 ± 0.02	0.494HisAsn: 0.494 ± 0.018	1.676HisPro: 1.676 ± 0.034	0.751HisGln: 0.751 ± 0.022	2.018HisArg: 2.018 ± 0.043	1.045HisSer: 1.045 ± 0.032	0.968HisThr: 0.968 ± 0.026	1.789HisVal: 1.789 ± 0.04	0.371HisTrp: 0.371 ± 0.018	0.682HisTyr: 0.682 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.186IleAla: 6.186 ± 0.073	0.487IleCys: 0.487 ± 0.019	3.307IleAsp: 3.307 ± 0.05	3.534IleGlu: 3.534 ± 0.045	1.398IlePhe: 1.398 ± 0.037	4.375IleGly: 4.375 ± 0.063	1.006IleHis: 1.006 ± 0.027	1.687IleIle: 1.687 ± 0.04	1.292IleLys: 1.292 ± 0.031	3.69IleLeu: 3.69 ± 0.061	0.725IleMet: 0.725 ± 0.023	1.284IleAsn: 1.284 ± 0.034	2.262IlePro: 2.262 ± 0.034	1.22IleGln: 1.22 ± 0.031	3.294IleArg: 3.294 ± 0.047	2.39IleSer: 2.39 ± 0.052	2.335IleThr: 2.335 ± 0.04	3.748IleVal: 3.748 ± 0.052	0.44IleTrp: 0.44 ± 0.018	1.004IleTyr: 1.004 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.598LysAla: 3.598 ± 0.057	0.255LysCys: 0.255 ± 0.014	1.516LysAsp: 1.516 ± 0.039	1.614LysGlu: 1.614 ± 0.047	0.913LysPhe: 0.913 ± 0.026	2.289LysGly: 2.289 ± 0.041	0.704LysHis: 0.704 ± 0.025	1.549LysIle: 1.549 ± 0.037	1.291LysLys: 1.291 ± 0.038	3.417LysLeu: 3.417 ± 0.058	0.775LysMet: 0.775 ± 0.027	0.951LysAsn: 0.951 ± 0.031	1.871LysPro: 1.871 ± 0.045	1.109LysGln: 1.109 ± 0.032	2.559LysArg: 2.559 ± 0.044	1.735LysSer: 1.735 ± 0.042	1.771LysThr: 1.771 ± 0.038	2.331LysVal: 2.331 ± 0.04	0.369LysTrp: 0.369 ± 0.016	0.713LysTyr: 0.713 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.396LeuAla: 14.396 ± 0.146	1.138LeuCys: 1.138 ± 0.028	6.219LeuAsp: 6.219 ± 0.077	5.862LeuGlu: 5.862 ± 0.079	3.65LeuPhe: 3.65 ± 0.057	8.242LeuGly: 8.242 ± 0.089	2.449LeuHis: 2.449 ± 0.044	4.447LeuIle: 4.447 ± 0.061	3.398LeuLys: 3.398 ± 0.059	10.586LeuLeu: 10.586 ± 0.121	2.285LeuMet: 2.285 ± 0.046	2.513LeuAsn: 2.513 ± 0.04	6.275LeuPro: 6.275 ± 0.081	3.356LeuGln: 3.356 ± 0.057	8.289LeuArg: 8.289 ± 0.095	5.713LeuSer: 5.713 ± 0.072	4.989LeuThr: 4.989 ± 0.06	7.623LeuVal: 7.623 ± 0.087	1.212LeuTrp: 1.212 ± 0.035	2.103LeuTyr: 2.103 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.432MetAla: 2.432 ± 0.046	0.205MetCys: 0.205 ± 0.013	1.03MetAsp: 1.03 ± 0.028	1.063MetGlu: 1.063 ± 0.03	0.69MetPhe: 0.69 ± 0.024	1.549MetGly: 1.549 ± 0.042	0.553MetHis: 0.553 ± 0.022	1.078MetIle: 1.078 ± 0.034	1.065MetLys: 1.065 ± 0.031	2.498MetLeu: 2.498 ± 0.048	0.582MetMet: 0.582 ± 0.021	0.855MetAsn: 0.855 ± 0.026	1.413MetPro: 1.413 ± 0.034	0.902MetGln: 0.902 ± 0.026	1.881MetArg: 1.881 ± 0.035	1.549MetSer: 1.549 ± 0.032	1.445MetThr: 1.445 ± 0.034	1.47MetVal: 1.47 ± 0.037	0.216MetTrp: 0.216 ± 0.012	0.367MetTyr: 0.367 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.887AsnAla: 2.887 ± 0.05	0.328AsnCys: 0.328 ± 0.016	1.306AsnAsp: 1.306 ± 0.037	1.339AsnGlu: 1.339 ± 0.037	0.928AsnPhe: 0.928 ± 0.024	2.033AsnGly: 2.033 ± 0.044	0.531AsnHis: 0.531 ± 0.021	1.211AsnIle: 1.211 ± 0.034	0.669AsnLys: 0.669 ± 0.025	2.554AsnLeu: 2.554 ± 0.049	0.525AsnMet: 0.525 ± 0.018	0.653AsnAsn: 0.653 ± 0.023	1.858AsnPro: 1.858 ± 0.038	0.758AsnGln: 0.758 ± 0.025	1.991AsnArg: 1.991 ± 0.039	1.183AsnSer: 1.183 ± 0.031	1.252AsnThr: 1.252 ± 0.033	1.893AsnVal: 1.893 ± 0.047	0.392AsnTrp: 0.392 ± 0.017	0.656AsnTyr: 0.656 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.927ProAla: 6.927 ± 0.083	0.532ProCys: 0.532 ± 0.018	3.38ProAsp: 3.38 ± 0.058	3.688ProGlu: 3.688 ± 0.05	1.838ProPhe: 1.838 ± 0.03	4.562ProGly: 4.562 ± 0.065	1.264ProHis: 1.264 ± 0.03	1.968ProIle: 1.968 ± 0.04	1.487ProLys: 1.487 ± 0.036	5.246ProLeu: 5.246 ± 0.062	1.164ProMet: 1.164 ± 0.03	1.259ProAsn: 1.259 ± 0.041	2.91ProPro: 2.91 ± 0.06	1.833ProGln: 1.833 ± 0.039	3.429ProArg: 3.429 ± 0.061	2.718ProSer: 2.718 ± 0.049	2.421ProThr: 2.421 ± 0.049	4.37ProVal: 4.37 ± 0.055	0.699ProTrp: 0.699 ± 0.029	1.209ProTyr: 1.209 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.28GlnAla: 4.28 ± 0.068	0.331GlnCys: 0.331 ± 0.017	1.447GlnAsp: 1.447 ± 0.034	1.628GlnGlu: 1.628 ± 0.04	1.236GlnPhe: 1.236 ± 0.028	2.381GlnGly: 2.381 ± 0.043	0.898GlnHis: 0.898 ± 0.027	1.608GlnIle: 1.608 ± 0.036	1.051GlnLys: 1.051 ± 0.032	3.541GlnLeu: 3.541 ± 0.056	0.807GlnMet: 0.807 ± 0.026	0.766GlnAsn: 0.766 ± 0.026	1.866GlnPro: 1.866 ± 0.042	1.569GlnGln: 1.569 ± 0.052	3.081GlnArg: 3.081 ± 0.049	1.741GlnSer: 1.741 ± 0.034	1.598GlnThr: 1.598 ± 0.034	2.574GlnVal: 2.574 ± 0.041	0.537GlnTrp: 0.537 ± 0.017	0.724GlnTyr: 0.724 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.552ArgAla: 8.552 ± 0.085	0.934ArgCys: 0.934 ± 0.029	4.288ArgAsp: 4.288 ± 0.059	4.968ArgGlu: 4.968 ± 0.059	3.299ArgPhe: 3.299 ± 0.046	5.264ArgGly: 5.264 ± 0.075	2.377ArgHis: 2.377 ± 0.046	4.119ArgIle: 4.119 ± 0.062	2.505ArgLys: 2.505 ± 0.043	9.019ArgLeu: 9.019 ± 0.112	1.977ArgMet: 1.977 ± 0.038	2.101ArgAsn: 2.101 ± 0.034	4.109ArgPro: 4.109 ± 0.065	3.025ArgGln: 3.025 ± 0.048	7.183ArgArg: 7.183 ± 0.098	4.418ArgSer: 4.418 ± 0.071	3.654ArgThr: 3.654 ± 0.052	5.526ArgVal: 5.526 ± 0.069	1.17ArgTrp: 1.17 ± 0.032	2.06ArgTyr: 2.06 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.145SerAla: 6.145 ± 0.078	0.687SerCys: 0.687 ± 0.025	2.748SerAsp: 2.748 ± 0.047	2.711SerGlu: 2.711 ± 0.046	2.018SerPhe: 2.018 ± 0.04	5.344SerGly: 5.344 ± 0.081	1.196SerHis: 1.196 ± 0.029	2.453SerIle: 2.453 ± 0.046	1.455SerLys: 1.455 ± 0.032	5.406SerLeu: 5.406 ± 0.064	1.288SerMet: 1.288 ± 0.031	1.237SerAsn: 1.237 ± 0.034	2.966SerPro: 2.966 ± 0.046	1.61SerGln: 1.61 ± 0.043	4.324SerArg: 4.324 ± 0.063	3.177SerSer: 3.177 ± 0.061	2.593SerThr: 2.593 ± 0.048	3.82SerVal: 3.82 ± 0.05	0.771SerTrp: 0.771 ± 0.025	1.221SerTyr: 1.221 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.498ThrAla: 5.498 ± 0.075	0.52ThrCys: 0.52 ± 0.02	2.456ThrAsp: 2.456 ± 0.045	2.573ThrGlu: 2.573 ± 0.053	1.722ThrPhe: 1.722 ± 0.033	4.511ThrGly: 4.511 ± 0.059	1.162ThrHis: 1.162 ± 0.03	2.19ThrIle: 2.19 ± 0.043	1.237ThrLys: 1.237 ± 0.038	5.886ThrLeu: 5.886 ± 0.074	1.058ThrMet: 1.058 ± 0.027	1.162ThrAsn: 1.162 ± 0.034	3.182ThrPro: 3.182 ± 0.062	1.518ThrGln: 1.518 ± 0.036	3.617ThrArg: 3.617 ± 0.052	2.487ThrSer: 2.487 ± 0.049	2.574ThrThr: 2.574 ± 0.056	3.93ThrVal: 3.93 ± 0.063	0.673ThrTrp: 0.673 ± 0.023	1.042ThrTyr: 1.042 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.266ValAla: 9.266 ± 0.09	0.826ValCys: 0.826 ± 0.027	4.114ValAsp: 4.114 ± 0.055	4.673ValGlu: 4.673 ± 0.06	2.798ValPhe: 2.798 ± 0.049	5.539ValGly: 5.539 ± 0.071	1.639ValHis: 1.639 ± 0.037	3.656ValIle: 3.656 ± 0.054	2.325ValLys: 2.325 ± 0.051	7.813ValLeu: 7.813 ± 0.091	1.771ValMet: 1.771 ± 0.039	1.738ValAsn: 1.738 ± 0.036	4.004ValPro: 4.004 ± 0.051	2.259ValGln: 2.259 ± 0.043	5.69ValArg: 5.69 ± 0.076	4.147ValSer: 4.147 ± 0.059	4.009ValThr: 4.009 ± 0.061	6.345ValVal: 6.345 ± 0.085	0.892ValTrp: 0.892 ± 0.025	1.399ValTyr: 1.399 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.207TrpAla: 1.207 ± 0.032	0.196TrpCys: 0.196 ± 0.01	0.604TrpAsp: 0.604 ± 0.021	0.666TrpGlu: 0.666 ± 0.021	0.533TrpPhe: 0.533 ± 0.021	0.838TrpGly: 0.838 ± 0.027	0.388TrpHis: 0.388 ± 0.018	0.712TrpIle: 0.712 ± 0.027	0.505TrpLys: 0.505 ± 0.02	1.895TrpLeu: 1.895 ± 0.049	0.366TrpMet: 0.366 ± 0.017	0.392TrpAsn: 0.392 ± 0.017	0.677TrpPro: 0.677 ± 0.024	0.68TrpGln: 0.68 ± 0.024	1.257TrpArg: 1.257 ± 0.035	0.758TrpSer: 0.758 ± 0.023	0.648TrpThr: 0.648 ± 0.025	0.957TrpVal: 0.957 ± 0.028	0.242TrpTrp: 0.242 ± 0.014	0.284TrpTyr: 0.284 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.493TyrAla: 2.493 ± 0.045	0.287TyrCys: 0.287 ± 0.015	1.2TyrAsp: 1.2 ± 0.03	1.16TyrGlu: 1.16 ± 0.029	0.906TyrPhe: 0.906 ± 0.026	1.96TyrGly: 1.96 ± 0.042	0.553TyrHis: 0.553 ± 0.02	0.791TyrIle: 0.791 ± 0.026	0.626TyrLys: 0.626 ± 0.026	2.484TyrLeu: 2.484 ± 0.044	0.38TyrMet: 0.38 ± 0.017	0.584TyrAsn: 0.584 ± 0.021	1.197TyrPro: 1.197 ± 0.031	0.771TyrGln: 0.771 ± 0.02	2.129TyrArg: 2.129 ± 0.041	1.19TyrSer: 1.19 ± 0.032	1.08TyrThr: 1.08 ± 0.029	1.636TyrVal: 1.636 ± 0.034	0.352TyrTrp: 0.352 ± 0.016	0.633TyrTyr: 0.633 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4483 proteins (1390973 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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