Amino acid dipepetide frequency for Roseivirga misakiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.789AlaAla: 4.789 ± 0.093	0.563AlaCys: 0.563 ± 0.022	3.988AlaAsp: 3.988 ± 0.098	4.26AlaGlu: 4.26 ± 0.081	3.67AlaPhe: 3.67 ± 0.058	4.631AlaGly: 4.631 ± 0.075	1.058AlaHis: 1.058 ± 0.032	5.514AlaIle: 5.514 ± 0.073	4.4AlaLys: 4.4 ± 0.066	7.081AlaLeu: 7.081 ± 0.098	1.714AlaMet: 1.714 ± 0.047	3.576AlaAsn: 3.576 ± 0.099	2.116AlaPro: 2.116 ± 0.051	2.653AlaGln: 2.653 ± 0.041	2.456AlaArg: 2.456 ± 0.047	4.624AlaSer: 4.624 ± 0.154	3.898AlaThr: 3.898 ± 0.245	4.247AlaVal: 4.247 ± 0.06	0.677AlaTrp: 0.677 ± 0.024	2.642AlaTyr: 2.642 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.41CysAla: 0.41 ± 0.02	0.075CysCys: 0.075 ± 0.007	0.364CysAsp: 0.364 ± 0.019	0.363CysGlu: 0.363 ± 0.018	0.342CysPhe: 0.342 ± 0.02	0.518CysGly: 0.518 ± 0.022	0.155CysHis: 0.155 ± 0.012	0.474CysIle: 0.474 ± 0.022	0.266CysLys: 0.266 ± 0.014	0.62CysLeu: 0.62 ± 0.022	0.124CysMet: 0.124 ± 0.011	0.265CysAsn: 0.265 ± 0.017	0.254CysPro: 0.254 ± 0.017	0.216CysGln: 0.216 ± 0.014	0.19CysArg: 0.19 ± 0.012	0.397CysSer: 0.397 ± 0.018	0.296CysThr: 0.296 ± 0.017	0.298CysVal: 0.298 ± 0.015	0.072CysTrp: 0.072 ± 0.007	0.211CysTyr: 0.211 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.701AspAla: 3.701 ± 0.098	0.321AspCys: 0.321 ± 0.017	3.32AspAsp: 3.32 ± 0.088	4.002AspGlu: 4.002 ± 0.054	3.755AspPhe: 3.755 ± 0.064	4.367AspGly: 4.367 ± 0.13	1.102AspHis: 1.102 ± 0.03	4.349AspIle: 4.349 ± 0.067	3.672AspLys: 3.672 ± 0.068	5.969AspLeu: 5.969 ± 0.085	1.263AspMet: 1.263 ± 0.031	3.086AspAsn: 3.086 ± 0.105	2.249AspPro: 2.249 ± 0.06	2.451AspGln: 2.451 ± 0.086	2.628AspArg: 2.628 ± 0.041	3.282AspSer: 3.282 ± 0.06	2.481AspThr: 2.481 ± 0.056	3.555AspVal: 3.555 ± 0.072	0.806AspTrp: 0.806 ± 0.024	2.729AspTyr: 2.729 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.746GluAla: 4.746 ± 0.076	0.25GluCys: 0.25 ± 0.015	3.541GluAsp: 3.541 ± 0.063	5.072GluGlu: 5.072 ± 0.096	3.075GluPhe: 3.075 ± 0.043	4.143GluGly: 4.143 ± 0.055	1.039GluHis: 1.039 ± 0.028	5.15GluIle: 5.15 ± 0.068	4.99GluLys: 4.99 ± 0.094	6.407GluLeu: 6.407 ± 0.088	1.699GluMet: 1.699 ± 0.048	3.925GluAsn: 3.925 ± 0.062	1.8GluPro: 1.8 ± 0.043	2.268GluGln: 2.268 ± 0.048	2.823GluArg: 2.823 ± 0.053	4.084GluSer: 4.084 ± 0.061	3.405GluThr: 3.405 ± 0.056	4.862GluVal: 4.862 ± 0.055	0.71GluTrp: 0.71 ± 0.023	2.195GluTyr: 2.195 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.104PheAla: 3.104 ± 0.053	0.33PheCys: 0.33 ± 0.016	3.609PheAsp: 3.609 ± 0.063	3.642PheGlu: 3.642 ± 0.059	2.711PhePhe: 2.711 ± 0.057	3.712PheGly: 3.712 ± 0.061	0.842PheHis: 0.842 ± 0.027	3.632PheIle: 3.632 ± 0.069	3.315PheLys: 3.315 ± 0.061	4.761PheLeu: 4.761 ± 0.091	1.144PheMet: 1.144 ± 0.032	3.037PheAsn: 3.037 ± 0.054	1.649PhePro: 1.649 ± 0.036	1.911PheGln: 1.911 ± 0.039	1.95PheArg: 1.95 ± 0.048	3.902PheSer: 3.902 ± 0.063	3.16PheThr: 3.16 ± 0.105	3.089PheVal: 3.089 ± 0.046	0.606PheTrp: 0.606 ± 0.024	2.003PheTyr: 2.003 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.605GlyAla: 4.605 ± 0.065	0.507GlyCys: 0.507 ± 0.028	3.932GlyAsp: 3.932 ± 0.101	4.142GlyGlu: 4.142 ± 0.059	3.87GlyPhe: 3.87 ± 0.063	5.03GlyGly: 5.03 ± 0.097	1.147GlyHis: 1.147 ± 0.033	5.391GlyIle: 5.391 ± 0.075	4.546GlyLys: 4.546 ± 0.073	6.827GlyLeu: 6.827 ± 0.081	1.636GlyMet: 1.636 ± 0.044	3.554GlyAsn: 3.554 ± 0.074	1.711GlyPro: 1.711 ± 0.055	2.543GlyGln: 2.543 ± 0.042	2.776GlyArg: 2.776 ± 0.055	4.393GlySer: 4.393 ± 0.082	4.241GlyThr: 4.241 ± 0.148	4.734GlyVal: 4.734 ± 0.064	0.792GlyTrp: 0.792 ± 0.027	2.753GlyTyr: 2.753 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.969HisAla: 0.969 ± 0.03	0.132HisCys: 0.132 ± 0.011	0.847HisAsp: 0.847 ± 0.028	1.026HisGlu: 1.026 ± 0.033	1.061HisPhe: 1.061 ± 0.029	1.069HisGly: 1.069 ± 0.03	0.426HisHis: 0.426 ± 0.019	1.177HisIle: 1.177 ± 0.036	0.953HisLys: 0.953 ± 0.029	1.759HisLeu: 1.759 ± 0.043	0.375HisMet: 0.375 ± 0.016	0.746HisAsn: 0.746 ± 0.022	0.822HisPro: 0.822 ± 0.03	0.667HisGln: 0.667 ± 0.025	0.7HisArg: 0.7 ± 0.022	1.001HisSer: 1.001 ± 0.03	0.861HisThr: 0.861 ± 0.028	0.953HisVal: 0.953 ± 0.03	0.236HisTrp: 0.236 ± 0.013	0.762HisTyr: 0.762 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.511IleAla: 5.511 ± 0.068	0.506IleCys: 0.506 ± 0.022	4.92IleAsp: 4.92 ± 0.069	5.046IleGlu: 5.046 ± 0.072	3.285IlePhe: 3.285 ± 0.062	5.459IleGly: 5.459 ± 0.069	1.26IleHis: 1.26 ± 0.033	4.978IleIle: 4.978 ± 0.083	4.602IleLys: 4.602 ± 0.075	6.352IleLeu: 6.352 ± 0.101	1.38IleMet: 1.38 ± 0.038	4.092IleAsn: 4.092 ± 0.056	2.952IlePro: 2.952 ± 0.047	2.548IleGln: 2.548 ± 0.043	2.93IleArg: 2.93 ± 0.046	5.649IleSer: 5.649 ± 0.072	4.293IleThr: 4.293 ± 0.12	4.571IleVal: 4.571 ± 0.064	0.753IleTrp: 0.753 ± 0.034	2.536IleTyr: 2.536 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.887LysAla: 4.887 ± 0.08	0.252LysCys: 0.252 ± 0.015	3.781LysAsp: 3.781 ± 0.062	5.141LysGlu: 5.141 ± 0.105	2.553LysPhe: 2.553 ± 0.052	4.256LysGly: 4.256 ± 0.078	1.11LysHis: 1.11 ± 0.035	4.415LysIle: 4.415 ± 0.078	5.017LysLys: 5.017 ± 0.102	5.853LysLeu: 5.853 ± 0.098	1.641LysMet: 1.641 ± 0.04	3.53LysAsn: 3.53 ± 0.066	2.39LysPro: 2.39 ± 0.056	2.17LysGln: 2.17 ± 0.047	3.094LysArg: 3.094 ± 0.068	4.511LysSer: 4.511 ± 0.073	3.692LysThr: 3.692 ± 0.06	4.658LysVal: 4.658 ± 0.068	0.723LysTrp: 0.723 ± 0.026	2.398LysTyr: 2.398 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	6.783LeuAla: 6.783 ± 0.078	0.571LeuCys: 0.571 ± 0.021	5.495LeuAsp: 5.495 ± 0.078	6.136LeuGlu: 6.136 ± 0.082	4.669LeuPhe: 4.669 ± 0.085	6.385LeuGly: 6.385 ± 0.097	1.361LeuHis: 1.361 ± 0.039	7.238LeuIle: 7.238 ± 0.12	7.031LeuLys: 7.031 ± 0.109	9.061LeuLeu: 9.061 ± 0.141	2.196LeuMet: 2.196 ± 0.058	5.454LeuAsn: 5.454 ± 0.074	3.712LeuPro: 3.712 ± 0.064	2.775LeuGln: 2.775 ± 0.047	3.74LeuArg: 3.74 ± 0.062	7.607LeuSer: 7.607 ± 0.092	5.672LeuThr: 5.672 ± 0.088	6.178LeuVal: 6.178 ± 0.077	0.914LeuTrp: 0.914 ± 0.028	2.926LeuTyr: 2.926 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.906MetAla: 1.906 ± 0.046	0.096MetCys: 0.096 ± 0.008	1.244MetAsp: 1.244 ± 0.029	1.404MetGlu: 1.404 ± 0.039	0.849MetPhe: 0.849 ± 0.027	1.535MetGly: 1.535 ± 0.039	0.391MetHis: 0.391 ± 0.019	1.675MetIle: 1.675 ± 0.039	1.915MetLys: 1.915 ± 0.05	2.031MetLeu: 2.031 ± 0.053	0.59MetMet: 0.59 ± 0.026	1.265MetAsn: 1.265 ± 0.033	0.908MetPro: 0.908 ± 0.029	0.753MetGln: 0.753 ± 0.024	1.033MetArg: 1.033 ± 0.03	1.664MetSer: 1.664 ± 0.036	1.303MetThr: 1.303 ± 0.032	1.511MetVal: 1.511 ± 0.038	0.166MetTrp: 0.166 ± 0.012	0.56MetTyr: 0.56 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.639AsnAla: 3.639 ± 0.109	0.28AsnCys: 0.28 ± 0.016	3.294AsnAsp: 3.294 ± 0.079	3.453AsnGlu: 3.453 ± 0.052	2.73AsnPhe: 2.73 ± 0.05	4.173AsnGly: 4.173 ± 0.1	0.901AsnHis: 0.901 ± 0.025	3.693AsnIle: 3.693 ± 0.054	3.096AsnLys: 3.096 ± 0.062	5.078AsnLeu: 5.078 ± 0.069	1.211AsnMet: 1.211 ± 0.029	2.93AsnAsn: 2.93 ± 0.123	2.654AsnPro: 2.654 ± 0.048	2.21AsnGln: 2.21 ± 0.042	2.426AsnArg: 2.426 ± 0.048	3.57AsnSer: 3.57 ± 0.084	3.134AsnThr: 3.134 ± 0.144	3.232AsnVal: 3.232 ± 0.101	0.711AsnTrp: 0.711 ± 0.023	2.256AsnTyr: 2.256 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.283ProAla: 2.283 ± 0.045	0.178ProCys: 0.178 ± 0.011	2.384ProAsp: 2.384 ± 0.079	2.923ProGlu: 2.923 ± 0.051	1.933ProPhe: 1.933 ± 0.044	2.224ProGly: 2.224 ± 0.044	0.557ProHis: 0.557 ± 0.022	2.664ProIle: 2.664 ± 0.045	2.364ProLys: 2.364 ± 0.052	3.002ProLeu: 3.002 ± 0.057	0.767ProMet: 0.767 ± 0.025	2.178ProAsn: 2.178 ± 0.06	0.914ProPro: 0.914 ± 0.031	1.086ProGln: 1.086 ± 0.026	1.124ProArg: 1.124 ± 0.03	2.465ProSer: 2.465 ± 0.075	2.031ProThr: 2.031 ± 0.044	2.389ProVal: 2.389 ± 0.046	0.403ProTrp: 0.403 ± 0.019	1.311ProTyr: 1.311 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.356GlnAla: 2.356 ± 0.045	0.138GlnCys: 0.138 ± 0.011	1.729GlnAsp: 1.729 ± 0.04	2.473GlnGlu: 2.473 ± 0.045	1.95GlnPhe: 1.95 ± 0.042	2.074GlnGly: 2.074 ± 0.041	0.587GlnHis: 0.587 ± 0.021	2.614GlnIle: 2.614 ± 0.04	2.463GlnLys: 2.463 ± 0.052	3.457GlnLeu: 3.457 ± 0.054	0.986GlnMet: 0.986 ± 0.029	1.9GlnAsn: 1.9 ± 0.043	1.134GlnPro: 1.134 ± 0.029	1.265GlnGln: 1.265 ± 0.031	1.565GlnArg: 1.565 ± 0.04	2.298GlnSer: 2.298 ± 0.048	1.905GlnThr: 1.905 ± 0.039	2.481GlnVal: 2.481 ± 0.042	0.421GlnTrp: 0.421 ± 0.017	1.275GlnTyr: 1.275 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.487ArgAla: 2.487 ± 0.047	0.174ArgCys: 0.174 ± 0.012	2.082ArgAsp: 2.082 ± 0.046	2.453ArgGlu: 2.453 ± 0.058	2.303ArgPhe: 2.303 ± 0.045	2.405ArgGly: 2.405 ± 0.05	0.672ArgHis: 0.672 ± 0.022	3.188ArgIle: 3.188 ± 0.055	3.094ArgLys: 3.094 ± 0.058	4.151ArgLeu: 4.151 ± 0.071	1.114ArgMet: 1.114 ± 0.031	2.323ArgAsn: 2.323 ± 0.046	1.396ArgPro: 1.396 ± 0.032	1.411ArgGln: 1.411 ± 0.036	1.819ArgArg: 1.819 ± 0.042	2.659ArgSer: 2.659 ± 0.047	2.067ArgThr: 2.067 ± 0.044	2.763ArgVal: 2.763 ± 0.049	0.453ArgTrp: 0.453 ± 0.017	1.687ArgTyr: 1.687 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.627SerAla: 4.627 ± 0.124	0.486SerCys: 0.486 ± 0.023	3.964SerAsp: 3.964 ± 0.076	4.233SerGlu: 4.233 ± 0.07	4.05SerPhe: 4.05 ± 0.069	5.269SerGly: 5.269 ± 0.115	1.029SerHis: 1.029 ± 0.027	5.324SerIle: 5.324 ± 0.073	4.213SerLys: 4.213 ± 0.064	6.819SerLeu: 6.819 ± 0.072	1.418SerMet: 1.418 ± 0.036	3.515SerAsn: 3.515 ± 0.071	2.338SerPro: 2.338 ± 0.044	2.309SerGln: 2.309 ± 0.047	2.637SerArg: 2.637 ± 0.055	4.538SerSer: 4.538 ± 0.102	3.971SerThr: 3.971 ± 0.093	4.356SerVal: 4.356 ± 0.082	0.74SerTrp: 0.74 ± 0.028	2.661SerTyr: 2.661 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.156ThrAla: 4.156 ± 0.204	0.282ThrCys: 0.282 ± 0.017	3.526ThrAsp: 3.526 ± 0.101	3.264ThrGlu: 3.264 ± 0.049	3.083ThrPhe: 3.083 ± 0.08	4.268ThrGly: 4.268 ± 0.144	0.894ThrHis: 0.894 ± 0.024	4.369ThrIle: 4.369 ± 0.098	3.074ThrLys: 3.074 ± 0.053	5.432ThrLeu: 5.432 ± 0.103	0.995ThrMet: 0.995 ± 0.029	2.981ThrAsn: 2.981 ± 0.119	2.286ThrPro: 2.286 ± 0.063	1.727ThrGln: 1.727 ± 0.038	1.948ThrArg: 1.948 ± 0.04	3.769ThrSer: 3.769 ± 0.097	3.164ThrThr: 3.164 ± 0.091	3.917ThrVal: 3.917 ± 0.205	0.677ThrTrp: 0.677 ± 0.026	2.312ThrTyr: 2.312 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.459ValAla: 4.459 ± 0.07	0.432ValCys: 0.432 ± 0.018	4.006ValAsp: 4.006 ± 0.086	4.074ValGlu: 4.074 ± 0.064	3.41ValPhe: 3.41 ± 0.058	4.3ValGly: 4.3 ± 0.074	1.007ValHis: 1.007 ± 0.027	4.876ValIle: 4.876 ± 0.072	4.183ValLys: 4.183 ± 0.071	6.365ValLeu: 6.365 ± 0.077	1.459ValMet: 1.459 ± 0.038	3.63ValAsn: 3.63 ± 0.069	2.173ValPro: 2.173 ± 0.042	2.004ValGln: 2.004 ± 0.037	2.531ValArg: 2.531 ± 0.043	4.867ValSer: 4.867 ± 0.078	3.851ValThr: 3.851 ± 0.192	4.489ValVal: 4.489 ± 0.065	0.689ValTrp: 0.689 ± 0.026	2.288ValTyr: 2.288 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.667TrpAla: 0.667 ± 0.023	0.08TrpCys: 0.08 ± 0.008	0.681TrpAsp: 0.681 ± 0.026	0.698TrpGlu: 0.698 ± 0.026	0.588TrpPhe: 0.588 ± 0.022	0.755TrpGly: 0.755 ± 0.026	0.211TrpHis: 0.211 ± 0.013	0.719TrpIle: 0.719 ± 0.024	0.725TrpLys: 0.725 ± 0.03	1.177TrpLeu: 1.177 ± 0.033	0.311TrpMet: 0.311 ± 0.017	0.62TrpAsn: 0.62 ± 0.023	0.296TrpPro: 0.296 ± 0.015	0.455TrpGln: 0.455 ± 0.018	0.535TrpArg: 0.535 ± 0.023	0.744TrpSer: 0.744 ± 0.025	0.62TrpThr: 0.62 ± 0.035	0.753TrpVal: 0.753 ± 0.028	0.154TrpTrp: 0.154 ± 0.013	0.4TrpTyr: 0.4 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.473TyrAla: 2.473 ± 0.045	0.255TyrCys: 0.255 ± 0.016	2.381TyrAsp: 2.381 ± 0.049	2.383TyrGlu: 2.383 ± 0.047	2.222TyrPhe: 2.222 ± 0.05	2.555TyrGly: 2.555 ± 0.05	0.794TyrHis: 0.794 ± 0.025	2.182TyrIle: 2.182 ± 0.045	2.154TyrLys: 2.154 ± 0.053	3.702TyrLeu: 3.702 ± 0.067	0.776TyrMet: 0.776 ± 0.031	2.065TyrAsn: 2.065 ± 0.047	1.428TyrPro: 1.428 ± 0.035	1.65TyrGln: 1.65 ± 0.037	1.795TyrArg: 1.795 ± 0.04	2.474TyrSer: 2.474 ± 0.049	2.079TyrThr: 2.079 ± 0.063	2.054TyrVal: 2.054 ± 0.042	0.484TyrTrp: 0.484 ± 0.021	1.643TyrTyr: 1.643 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3764 proteins (1367009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---