Amino acid dipepetide frequency for Manitoba virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.553AlaAla: 1.553 ± 0.743
0.887AlaCys: 0.887 ± 0.311
2.662AlaAsp: 2.662 ± 0.67
1.109AlaGlu: 1.109 ± 0.531
0.887AlaPhe: 0.887 ± 0.706
1.775AlaGly: 1.775 ± 0.845
1.109AlaHis: 1.109 ± 0.423
4.437AlaIle: 4.437 ± 1.38
2.218AlaLys: 2.218 ± 0.433
3.549AlaLeu: 3.549 ± 1.136
0.665AlaMet: 0.665 ± 0.367
1.996AlaAsn: 1.996 ± 0.444
1.553AlaPro: 1.553 ± 0.568
1.996AlaGln: 1.996 ± 0.682
1.775AlaArg: 1.775 ± 0.908
2.662AlaSer: 2.662 ± 1.279
2.44AlaThr: 2.44 ± 0.822
1.553AlaVal: 1.553 ± 0.454
0.222AlaTrp: 0.222 ± 0.298
1.996AlaTyr: 1.996 ± 1.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.665CysAla: 0.665 ± 0.258
0.222CysCys: 0.222 ± 0.131
0.222CysAsp: 0.222 ± 0.131
0.444CysGlu: 0.444 ± 0.211
0.222CysPhe: 0.222 ± 0.131
1.109CysGly: 1.109 ± 0.457
0.665CysHis: 0.665 ± 0.301
1.553CysIle: 1.553 ± 0.703
1.553CysLys: 1.553 ± 0.467
0.665CysLeu: 0.665 ± 0.418
0.222CysMet: 0.222 ± 0.286
1.331CysAsn: 1.331 ± 0.55
0.887CysPro: 0.887 ± 0.514
1.331CysGln: 1.331 ± 0.379
0.665CysArg: 0.665 ± 0.269
1.553CysSer: 1.553 ± 0.306
0.665CysThr: 0.665 ± 0.324
0.665CysVal: 0.665 ± 0.305
0.222CysTrp: 0.222 ± 0.131
1.331CysTyr: 1.331 ± 0.452
0.0CysXaa: 0.0 ± 0.0
Asp
1.109AspAla: 1.109 ± 0.86
0.665AspCys: 0.665 ± 0.38
4.658AspAsp: 4.658 ± 1.363
2.884AspGlu: 2.884 ± 0.664
3.549AspPhe: 3.549 ± 0.771
2.662AspGly: 2.662 ± 0.617
1.553AspHis: 1.553 ± 0.724
3.327AspIle: 3.327 ± 1.114
4.215AspLys: 4.215 ± 1.338
7.986AspLeu: 7.986 ± 1.304
2.218AspMet: 2.218 ± 0.751
2.884AspAsn: 2.884 ± 0.713
2.662AspPro: 2.662 ± 0.716
3.106AspGln: 3.106 ± 0.839
1.553AspArg: 1.553 ± 0.433
1.331AspSer: 1.331 ± 0.427
1.109AspThr: 1.109 ± 0.349
2.884AspVal: 2.884 ± 0.728
1.996AspTrp: 1.996 ± 0.396
3.771AspTyr: 3.771 ± 0.632
0.0AspXaa: 0.0 ± 0.0
Glu
1.109GluAla: 1.109 ± 0.628
1.331GluCys: 1.331 ± 0.472
2.884GluAsp: 2.884 ± 0.734
4.88GluGlu: 4.88 ± 1.363
2.44GluPhe: 2.44 ± 1.024
2.44GluGly: 2.44 ± 0.622
1.109GluHis: 1.109 ± 0.466
3.771GluIle: 3.771 ± 1.288
4.658GluLys: 4.658 ± 0.895
6.433GluLeu: 6.433 ± 0.909
1.996GluMet: 1.996 ± 0.968
3.106GluAsn: 3.106 ± 1.055
1.996GluPro: 1.996 ± 0.48
2.218GluGln: 2.218 ± 0.633
1.331GluArg: 1.331 ± 0.61
4.215GluSer: 4.215 ± 0.812
3.771GluThr: 3.771 ± 1.048
2.662GluVal: 2.662 ± 0.754
1.775GluTrp: 1.775 ± 0.401
3.771GluTyr: 3.771 ± 1.145
0.0GluXaa: 0.0 ± 0.0
Phe
1.553PheAla: 1.553 ± 0.577
1.331PheCys: 1.331 ± 0.796
2.884PheAsp: 2.884 ± 0.94
2.662PheGlu: 2.662 ± 1.302
1.996PhePhe: 1.996 ± 0.355
2.44PheGly: 2.44 ± 0.94
0.887PheHis: 0.887 ± 0.28
2.662PheIle: 2.662 ± 1.468
4.215PheLys: 4.215 ± 1.126
3.993PheLeu: 3.993 ± 0.903
0.887PheMet: 0.887 ± 0.342
2.662PheAsn: 2.662 ± 0.662
2.44PhePro: 2.44 ± 0.34
2.218PheGln: 2.218 ± 0.895
2.44PheArg: 2.44 ± 0.555
3.771PheSer: 3.771 ± 0.912
1.109PheThr: 1.109 ± 0.53
3.327PheVal: 3.327 ± 1.182
0.665PheTrp: 0.665 ± 0.393
1.775PheTyr: 1.775 ± 0.455
0.0PheXaa: 0.0 ± 0.0
Gly
0.444GlyAla: 0.444 ± 0.277
0.665GlyCys: 0.665 ± 0.314
3.549GlyAsp: 3.549 ± 0.846
3.106GlyGlu: 3.106 ± 0.905
2.662GlyPhe: 2.662 ± 0.862
2.662GlyGly: 2.662 ± 0.437
0.665GlyHis: 0.665 ± 0.269
4.658GlyIle: 4.658 ± 0.729
4.437GlyLys: 4.437 ± 1.018
7.098GlyLeu: 7.098 ± 2.165
0.665GlyMet: 0.665 ± 0.354
2.218GlyAsn: 2.218 ± 0.395
0.887GlyPro: 0.887 ± 0.524
1.775GlyGln: 1.775 ± 0.642
1.553GlyArg: 1.553 ± 0.821
4.88GlySer: 4.88 ± 0.993
3.327GlyThr: 3.327 ± 0.857
2.44GlyVal: 2.44 ± 1.127
1.331GlyTrp: 1.331 ± 0.502
1.109GlyTyr: 1.109 ± 0.466
0.0GlyXaa: 0.0 ± 0.0
His
0.887HisAla: 0.887 ± 0.261
0.0HisCys: 0.0 ± 0.0
2.884HisAsp: 2.884 ± 1.287
0.887HisGlu: 0.887 ± 0.348
0.665HisPhe: 0.665 ± 0.349
1.109HisGly: 1.109 ± 0.508
1.109HisHis: 1.109 ± 0.744
3.327HisIle: 3.327 ± 0.706
1.331HisLys: 1.331 ± 0.634
2.884HisLeu: 2.884 ± 0.628
0.665HisMet: 0.665 ± 0.393
1.775HisAsn: 1.775 ± 0.584
2.218HisPro: 2.218 ± 0.466
0.665HisGln: 0.665 ± 0.345
1.553HisArg: 1.553 ± 0.745
1.331HisSer: 1.331 ± 0.278
0.0HisThr: 0.0 ± 0.0
0.887HisVal: 0.887 ± 0.408
0.665HisTrp: 0.665 ± 0.269
0.887HisTyr: 0.887 ± 0.367
0.0HisXaa: 0.0 ± 0.0
Ile
1.996IleAla: 1.996 ± 0.556
1.775IleCys: 1.775 ± 0.436
4.437IleAsp: 4.437 ± 0.617
5.768IleGlu: 5.768 ± 1.229
2.884IlePhe: 2.884 ± 0.714
5.324IleGly: 5.324 ± 1.053
1.996IleHis: 1.996 ± 0.721
9.317IleIle: 9.317 ± 1.904
6.655IleLys: 6.655 ± 1.829
7.098IleLeu: 7.098 ± 1.571
1.775IleMet: 1.775 ± 0.956
5.546IleAsn: 5.546 ± 1.21
2.884IlePro: 2.884 ± 0.73
2.218IleGln: 2.218 ± 0.797
5.324IleArg: 5.324 ± 1.121
7.764IleSer: 7.764 ± 2.129
3.549IleThr: 3.549 ± 1.224
3.993IleVal: 3.993 ± 1.054
1.109IleTrp: 1.109 ± 0.453
3.327IleTyr: 3.327 ± 0.723
0.0IleXaa: 0.0 ± 0.0
Lys
1.775LysAla: 1.775 ± 0.662
0.444LysCys: 0.444 ± 0.452
2.218LysAsp: 2.218 ± 0.622
4.88LysGlu: 4.88 ± 1.088
1.109LysPhe: 1.109 ± 0.663
4.658LysGly: 4.658 ± 0.765
1.109LysHis: 1.109 ± 0.598
7.098LysIle: 7.098 ± 1.148
5.546LysLys: 5.546 ± 0.959
7.542LysLeu: 7.542 ± 0.998
2.884LysMet: 2.884 ± 0.867
6.211LysAsn: 6.211 ± 1.19
1.996LysPro: 1.996 ± 0.528
1.109LysGln: 1.109 ± 0.613
3.993LysArg: 3.993 ± 1.083
5.102LysSer: 5.102 ± 1.066
2.884LysThr: 2.884 ± 1.174
5.102LysVal: 5.102 ± 0.752
2.218LysTrp: 2.218 ± 0.607
3.549LysTyr: 3.549 ± 0.734
0.0LysXaa: 0.0 ± 0.0
Leu
3.771LeuAla: 3.771 ± 0.769
0.665LeuCys: 0.665 ± 0.269
6.877LeuAsp: 6.877 ± 0.649
6.655LeuGlu: 6.655 ± 0.851
5.989LeuPhe: 5.989 ± 0.949
3.549LeuGly: 3.549 ± 1.148
3.327LeuHis: 3.327 ± 0.89
9.095LeuIle: 9.095 ± 1.692
7.32LeuLys: 7.32 ± 0.869
8.208LeuLeu: 8.208 ± 1.369
1.553LeuMet: 1.553 ± 0.496
6.211LeuAsn: 6.211 ± 1.547
4.437LeuPro: 4.437 ± 0.629
3.771LeuGln: 3.771 ± 1.017
5.546LeuArg: 5.546 ± 1.314
7.542LeuSer: 7.542 ± 1.65
5.324LeuThr: 5.324 ± 0.785
4.88LeuVal: 4.88 ± 0.832
1.553LeuTrp: 1.553 ± 0.753
4.658LeuTyr: 4.658 ± 0.68
0.0LeuXaa: 0.0 ± 0.0
Met
0.444MetAla: 0.444 ± 0.262
0.665MetCys: 0.665 ± 0.269
1.775MetAsp: 1.775 ± 0.622
1.775MetGlu: 1.775 ± 0.645
2.662MetPhe: 2.662 ± 0.691
0.887MetGly: 0.887 ± 0.408
0.0MetHis: 0.0 ± 0.0
3.549MetIle: 3.549 ± 0.707
1.331MetLys: 1.331 ± 0.733
3.549MetLeu: 3.549 ± 0.676
1.996MetMet: 1.996 ± 0.572
1.331MetAsn: 1.331 ± 0.372
0.222MetPro: 0.222 ± 0.361
0.0MetGln: 0.0 ± 0.0
1.109MetArg: 1.109 ± 0.55
1.553MetSer: 1.553 ± 0.58
0.222MetThr: 0.222 ± 0.37
1.553MetVal: 1.553 ± 0.577
0.887MetTrp: 0.887 ± 0.491
0.444MetTyr: 0.444 ± 0.256
0.0MetXaa: 0.0 ± 0.0
Asn
2.44AsnAla: 2.44 ± 0.925
0.887AsnCys: 0.887 ± 0.289
3.327AsnAsp: 3.327 ± 0.491
1.996AsnGlu: 1.996 ± 0.615
1.775AsnPhe: 1.775 ± 0.681
1.996AsnGly: 1.996 ± 0.686
3.106AsnHis: 3.106 ± 0.676
4.437AsnIle: 4.437 ± 0.989
3.106AsnLys: 3.106 ± 1.154
7.986AsnLeu: 7.986 ± 1.892
1.996AsnMet: 1.996 ± 0.717
3.993AsnAsn: 3.993 ± 1.265
2.662AsnPro: 2.662 ± 0.469
2.884AsnGln: 2.884 ± 0.724
1.996AsnArg: 1.996 ± 0.589
4.658AsnSer: 4.658 ± 1.24
3.549AsnThr: 3.549 ± 0.758
4.88AsnVal: 4.88 ± 1.51
1.331AsnTrp: 1.331 ± 0.531
3.771AsnTyr: 3.771 ± 1.429
0.0AsnXaa: 0.0 ± 0.0
Pro
1.331ProAla: 1.331 ± 0.528
0.222ProCys: 0.222 ± 0.131
3.106ProAsp: 3.106 ± 0.63
2.218ProGlu: 2.218 ± 0.782
1.331ProPhe: 1.331 ± 0.508
1.331ProGly: 1.331 ± 0.479
0.444ProHis: 0.444 ± 0.262
3.993ProIle: 3.993 ± 0.96
3.549ProLys: 3.549 ± 0.626
4.215ProLeu: 4.215 ± 0.865
1.331ProMet: 1.331 ± 0.688
3.327ProAsn: 3.327 ± 0.917
2.44ProPro: 2.44 ± 0.813
0.887ProGln: 0.887 ± 0.498
0.887ProArg: 0.887 ± 0.367
3.771ProSer: 3.771 ± 0.616
2.884ProThr: 2.884 ± 0.661
1.775ProVal: 1.775 ± 0.733
0.444ProTrp: 0.444 ± 0.262
1.775ProTyr: 1.775 ± 0.638
0.0ProXaa: 0.0 ± 0.0
Gln
1.109GlnAla: 1.109 ± 0.243
0.665GlnCys: 0.665 ± 0.329
1.775GlnAsp: 1.775 ± 1.218
1.775GlnGlu: 1.775 ± 0.546
1.996GlnPhe: 1.996 ± 0.778
1.331GlnGly: 1.331 ± 0.601
0.665GlnHis: 0.665 ± 0.515
2.44GlnIle: 2.44 ± 0.557
3.106GlnLys: 3.106 ± 0.975
2.44GlnLeu: 2.44 ± 0.71
0.0GlnMet: 0.0 ± 0.0
1.996GlnAsn: 1.996 ± 0.865
0.665GlnPro: 0.665 ± 0.384
1.109GlnGln: 1.109 ± 0.496
1.553GlnArg: 1.553 ± 0.537
4.658GlnSer: 4.658 ± 0.924
1.775GlnThr: 1.775 ± 0.852
1.996GlnVal: 1.996 ± 0.771
0.665GlnTrp: 0.665 ± 0.431
1.775GlnTyr: 1.775 ± 0.753
0.0GlnXaa: 0.0 ± 0.0
Arg
2.44ArgAla: 2.44 ± 0.988
0.665ArgCys: 0.665 ± 0.329
1.553ArgAsp: 1.553 ± 0.348
3.549ArgGlu: 3.549 ± 1.114
3.106ArgPhe: 3.106 ± 1.17
2.884ArgGly: 2.884 ± 0.802
1.331ArgHis: 1.331 ± 0.482
2.44ArgIle: 2.44 ± 0.699
2.884ArgLys: 2.884 ± 1.115
2.218ArgLeu: 2.218 ± 0.976
1.331ArgMet: 1.331 ± 0.451
1.996ArgAsn: 1.996 ± 0.768
1.331ArgPro: 1.331 ± 0.541
0.887ArgGln: 0.887 ± 0.28
3.549ArgArg: 3.549 ± 1.384
6.655ArgSer: 6.655 ± 1.166
1.775ArgThr: 1.775 ± 0.325
2.44ArgVal: 2.44 ± 0.522
0.444ArgTrp: 0.444 ± 0.277
1.775ArgTyr: 1.775 ± 0.628
0.0ArgXaa: 0.0 ± 0.0
Ser
4.88SerAla: 4.88 ± 0.765
1.109SerCys: 1.109 ± 0.549
3.771SerAsp: 3.771 ± 0.734
4.437SerGlu: 4.437 ± 1.036
4.658SerPhe: 4.658 ± 1.12
4.437SerGly: 4.437 ± 0.564
2.884SerHis: 2.884 ± 0.61
7.098SerIle: 7.098 ± 1.081
4.658SerLys: 4.658 ± 0.809
9.539SerLeu: 9.539 ± 1.353
0.665SerMet: 0.665 ± 0.378
4.658SerAsn: 4.658 ± 0.747
3.327SerPro: 3.327 ± 0.659
2.218SerGln: 2.218 ± 0.545
4.437SerArg: 4.437 ± 1.327
5.546SerSer: 5.546 ± 0.987
3.993SerThr: 3.993 ± 1.231
4.215SerVal: 4.215 ± 0.709
2.662SerTrp: 2.662 ± 0.74
2.44SerTyr: 2.44 ± 0.66
0.0SerXaa: 0.0 ± 0.0
Thr
2.218ThrAla: 2.218 ± 0.489
1.331ThrCys: 1.331 ± 0.538
1.775ThrAsp: 1.775 ± 0.612
2.44ThrGlu: 2.44 ± 0.776
1.109ThrPhe: 1.109 ± 0.657
3.106ThrGly: 3.106 ± 0.524
0.665ThrHis: 0.665 ± 0.269
4.437ThrIle: 4.437 ± 0.982
3.106ThrLys: 3.106 ± 0.786
3.327ThrLeu: 3.327 ± 1.434
1.775ThrMet: 1.775 ± 0.676
3.106ThrAsn: 3.106 ± 0.756
1.553ThrPro: 1.553 ± 0.786
1.553ThrGln: 1.553 ± 0.952
1.775ThrArg: 1.775 ± 0.511
4.215ThrSer: 4.215 ± 0.696
2.218ThrThr: 2.218 ± 0.53
1.996ThrVal: 1.996 ± 0.512
1.553ThrTrp: 1.553 ± 0.348
1.996ThrTyr: 1.996 ± 0.789
0.0ThrXaa: 0.0 ± 0.0
Val
3.993ValAla: 3.993 ± 0.838
1.109ValCys: 1.109 ± 0.463
2.218ValAsp: 2.218 ± 0.642
3.106ValGlu: 3.106 ± 0.997
2.884ValPhe: 2.884 ± 0.57
1.996ValGly: 1.996 ± 0.965
1.331ValHis: 1.331 ± 0.665
2.44ValIle: 2.44 ± 0.391
2.218ValLys: 2.218 ± 0.501
5.768ValLeu: 5.768 ± 0.934
1.331ValMet: 1.331 ± 0.542
3.993ValAsn: 3.993 ± 0.854
3.771ValPro: 3.771 ± 1.172
0.887ValGln: 0.887 ± 0.54
2.44ValArg: 2.44 ± 1.026
4.88ValSer: 4.88 ± 1.027
1.996ValThr: 1.996 ± 1.044
2.662ValVal: 2.662 ± 0.58
0.222ValTrp: 0.222 ± 0.131
2.662ValTyr: 2.662 ± 1.054
0.0ValXaa: 0.0 ± 0.0
Trp
1.331TrpAla: 1.331 ± 0.771
0.665TrpCys: 0.665 ± 0.49
0.887TrpAsp: 0.887 ± 0.373
0.887TrpGlu: 0.887 ± 0.324
1.331TrpPhe: 1.331 ± 0.464
2.218TrpGly: 2.218 ± 0.705
0.222TrpHis: 0.222 ± 0.131
1.775TrpIle: 1.775 ± 0.82
1.775TrpLys: 1.775 ± 0.646
1.331TrpLeu: 1.331 ± 0.768
1.109TrpMet: 1.109 ± 0.96
1.331TrpAsn: 1.331 ± 0.457
0.222TrpPro: 0.222 ± 0.131
1.331TrpGln: 1.331 ± 0.364
0.665TrpArg: 0.665 ± 0.376
1.775TrpSer: 1.775 ± 0.638
0.444TrpThr: 0.444 ± 0.262
0.665TrpVal: 0.665 ± 0.3
0.444TrpTrp: 0.444 ± 0.452
0.665TrpTyr: 0.665 ± 0.53
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.996TyrAla: 1.996 ± 0.484
0.887TyrCys: 0.887 ± 0.318
2.662TyrAsp: 2.662 ± 1.073
2.44TyrGlu: 2.44 ± 0.673
2.662TyrPhe: 2.662 ± 0.665
2.218TyrGly: 2.218 ± 0.48
1.553TyrHis: 1.553 ± 0.52
2.884TyrIle: 2.884 ± 0.897
3.549TyrLys: 3.549 ± 1.074
5.102TyrLeu: 5.102 ± 1.08
0.665TyrMet: 0.665 ± 0.318
3.106TyrAsn: 3.106 ± 0.807
3.106TyrPro: 3.106 ± 1.064
1.331TyrGln: 1.331 ± 0.52
1.109TyrArg: 1.109 ± 0.504
3.771TyrSer: 3.771 ± 0.509
2.218TyrThr: 2.218 ± 0.683
1.331TyrVal: 1.331 ± 0.363
0.887TyrTrp: 0.887 ± 0.682
1.775TyrTyr: 1.775 ± 0.518
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (4509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski