Amino acid dipepetide frequency for Mycoplasma phage MAV1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.17AlaAla: 3.17 ± 1.304
0.423AlaCys: 0.423 ± 0.406
2.113AlaAsp: 2.113 ± 0.573
1.902AlaGlu: 1.902 ± 0.566
3.593AlaPhe: 3.593 ± 0.736
1.902AlaGly: 1.902 ± 0.742
0.211AlaHis: 0.211 ± 0.203
4.861AlaIle: 4.861 ± 1.216
4.861AlaLys: 4.861 ± 0.991
3.381AlaLeu: 3.381 ± 0.852
0.423AlaMet: 0.423 ± 0.259
3.804AlaAsn: 3.804 ± 1.313
0.211AlaPro: 0.211 ± 0.183
1.268AlaGln: 1.268 ± 0.69
2.113AlaArg: 2.113 ± 0.668
4.227AlaSer: 4.227 ± 0.847
1.902AlaThr: 1.902 ± 0.48
1.691AlaVal: 1.691 ± 0.54
0.845AlaTrp: 0.845 ± 0.421
2.325AlaTyr: 2.325 ± 0.587
0.0AlaXaa: 0.0 ± 0.0
Cys
0.211CysAla: 0.211 ± 0.234
0.0CysCys: 0.0 ± 0.0
0.634CysAsp: 0.634 ± 0.326
0.423CysGlu: 0.423 ± 0.273
0.211CysPhe: 0.211 ± 0.196
0.423CysGly: 0.423 ± 0.316
0.211CysHis: 0.211 ± 0.194
0.423CysIle: 0.423 ± 0.299
0.0CysLys: 0.0 ± 0.0
1.268CysLeu: 1.268 ± 0.586
0.211CysMet: 0.211 ± 0.196
0.0CysAsn: 0.0 ± 0.0
0.634CysPro: 0.634 ± 0.363
0.423CysGln: 0.423 ± 0.357
1.057CysArg: 1.057 ± 0.392
0.845CysSer: 0.845 ± 0.408
0.211CysThr: 0.211 ± 0.183
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.211CysTyr: 0.211 ± 0.227
0.0CysXaa: 0.0 ± 0.0
Asp
2.747AspAla: 2.747 ± 0.566
0.423AspCys: 0.423 ± 0.291
3.17AspAsp: 3.17 ± 0.744
3.593AspGlu: 3.593 ± 0.85
3.593AspPhe: 3.593 ± 0.82
1.479AspGly: 1.479 ± 0.394
0.634AspHis: 0.634 ± 0.292
4.649AspIle: 4.649 ± 0.845
7.396AspLys: 7.396 ± 1.474
5.495AspLeu: 5.495 ± 0.852
0.423AspMet: 0.423 ± 0.288
4.227AspAsn: 4.227 ± 1.125
1.479AspPro: 1.479 ± 0.452
1.691AspGln: 1.691 ± 0.791
1.057AspArg: 1.057 ± 0.579
2.959AspSer: 2.959 ± 0.742
2.747AspThr: 2.747 ± 0.692
2.747AspVal: 2.747 ± 0.759
1.057AspTrp: 1.057 ± 0.392
3.593AspTyr: 3.593 ± 0.889
0.0AspXaa: 0.0 ± 0.0
Glu
2.113GluAla: 2.113 ± 0.616
0.423GluCys: 0.423 ± 0.263
2.113GluAsp: 2.113 ± 0.711
5.495GluGlu: 5.495 ± 1.72
4.861GluPhe: 4.861 ± 1.051
1.691GluGly: 1.691 ± 0.406
1.691GluHis: 1.691 ± 0.523
6.762GluIle: 6.762 ± 1.619
7.185GluLys: 7.185 ± 1.198
8.664GluLeu: 8.664 ± 1.229
2.113GluMet: 2.113 ± 0.675
6.34GluAsn: 6.34 ± 1.258
1.691GluPro: 1.691 ± 0.883
2.536GluGln: 2.536 ± 0.572
1.902GluArg: 1.902 ± 0.839
3.381GluSer: 3.381 ± 0.827
4.861GluThr: 4.861 ± 1.859
2.959GluVal: 2.959 ± 0.947
0.845GluTrp: 0.845 ± 0.402
2.959GluTyr: 2.959 ± 1.026
0.0GluXaa: 0.0 ± 0.0
Phe
2.959PheAla: 2.959 ± 0.748
0.634PheCys: 0.634 ± 0.289
2.959PheAsp: 2.959 ± 0.764
5.706PheGlu: 5.706 ± 0.963
3.17PhePhe: 3.17 ± 0.697
1.902PheGly: 1.902 ± 0.473
0.634PheHis: 0.634 ± 0.351
3.804PheIle: 3.804 ± 0.852
7.396PheLys: 7.396 ± 1.169
5.917PheLeu: 5.917 ± 1.465
0.211PheMet: 0.211 ± 0.284
4.227PheAsn: 4.227 ± 0.663
1.479PhePro: 1.479 ± 0.369
2.536PheGln: 2.536 ± 0.829
2.536PheArg: 2.536 ± 0.482
3.593PheSer: 3.593 ± 0.744
2.325PheThr: 2.325 ± 0.435
3.381PheVal: 3.381 ± 0.698
0.845PheTrp: 0.845 ± 0.464
3.17PheTyr: 3.17 ± 0.757
0.0PheXaa: 0.0 ± 0.0
Gly
2.113GlyAla: 2.113 ± 0.544
0.211GlyCys: 0.211 ± 0.234
0.634GlyAsp: 0.634 ± 0.292
1.268GlyGlu: 1.268 ± 0.395
1.691GlyPhe: 1.691 ± 0.671
1.902GlyGly: 1.902 ± 0.493
0.423GlyHis: 0.423 ± 0.469
3.381GlyIle: 3.381 ± 0.668
3.804GlyLys: 3.804 ± 1.295
2.959GlyLeu: 2.959 ± 1.062
1.057GlyMet: 1.057 ± 0.518
4.015GlyAsn: 4.015 ± 0.788
0.634GlyPro: 0.634 ± 0.331
1.479GlyGln: 1.479 ± 0.445
2.113GlyArg: 2.113 ± 0.436
2.747GlySer: 2.747 ± 0.721
1.691GlyThr: 1.691 ± 0.738
1.479GlyVal: 1.479 ± 0.582
0.211GlyTrp: 0.211 ± 0.19
1.479GlyTyr: 1.479 ± 0.414
0.0GlyXaa: 0.0 ± 0.0
His
0.634HisAla: 0.634 ± 0.376
0.423HisCys: 0.423 ± 0.364
0.634HisAsp: 0.634 ± 0.511
0.634HisGlu: 0.634 ± 0.404
0.845HisPhe: 0.845 ± 0.421
0.634HisGly: 0.634 ± 0.339
0.423HisHis: 0.423 ± 0.317
1.268HisIle: 1.268 ± 0.546
0.634HisLys: 0.634 ± 0.373
1.479HisLeu: 1.479 ± 0.458
0.211HisMet: 0.211 ± 0.194
1.057HisAsn: 1.057 ± 0.277
1.268HisPro: 1.268 ± 0.596
0.423HisGln: 0.423 ± 0.237
0.634HisArg: 0.634 ± 0.367
0.845HisSer: 0.845 ± 0.381
0.0HisThr: 0.0 ± 0.0
1.479HisVal: 1.479 ± 0.674
0.211HisTrp: 0.211 ± 0.183
0.845HisTyr: 0.845 ± 0.388
0.0HisXaa: 0.0 ± 0.0
Ile
2.959IleAla: 2.959 ± 0.561
0.634IleCys: 0.634 ± 0.334
7.185IleAsp: 7.185 ± 0.991
5.706IleGlu: 5.706 ± 0.975
4.015IlePhe: 4.015 ± 0.521
1.902IleGly: 1.902 ± 0.419
1.691IleHis: 1.691 ± 0.522
7.396IleIle: 7.396 ± 0.999
9.721IleLys: 9.721 ± 1.97
6.34IleLeu: 6.34 ± 1.263
1.057IleMet: 1.057 ± 0.539
6.762IleAsn: 6.762 ± 1.122
2.113IlePro: 2.113 ± 0.702
2.325IleGln: 2.325 ± 0.804
3.804IleArg: 3.804 ± 0.786
6.974IleSer: 6.974 ± 1.19
6.34IleThr: 6.34 ± 1.312
5.917IleVal: 5.917 ± 1.343
0.423IleTrp: 0.423 ± 0.292
3.593IleTyr: 3.593 ± 1.118
0.0IleXaa: 0.0 ± 0.0
Lys
4.227LysAla: 4.227 ± 1.306
0.634LysCys: 0.634 ± 0.387
6.128LysAsp: 6.128 ± 0.754
9.51LysGlu: 9.51 ± 1.457
8.664LysPhe: 8.664 ± 1.74
2.747LysGly: 2.747 ± 0.623
2.325LysHis: 2.325 ± 0.469
10.144LysIle: 10.144 ± 1.303
9.087LysLys: 9.087 ± 2.0
12.468LysLeu: 12.468 ± 2.382
1.268LysMet: 1.268 ± 0.372
11.834LysAsn: 11.834 ± 1.585
4.015LysPro: 4.015 ± 1.117
2.959LysGln: 2.959 ± 0.779
2.325LysArg: 2.325 ± 0.471
6.762LysSer: 6.762 ± 1.012
7.608LysThr: 7.608 ± 1.296
4.227LysVal: 4.227 ± 1.178
1.268LysTrp: 1.268 ± 0.487
4.438LysTyr: 4.438 ± 1.172
0.0LysXaa: 0.0 ± 0.0
Leu
6.551LeuAla: 6.551 ± 1.248
1.057LeuCys: 1.057 ± 0.509
4.861LeuAsp: 4.861 ± 1.224
8.664LeuGlu: 8.664 ± 1.717
4.015LeuPhe: 4.015 ± 0.846
5.072LeuGly: 5.072 ± 1.356
0.634LeuHis: 0.634 ± 0.413
10.355LeuIle: 10.355 ± 1.869
12.257LeuLys: 12.257 ± 1.627
5.917LeuLeu: 5.917 ± 1.231
1.691LeuMet: 1.691 ± 0.581
8.03LeuAsn: 8.03 ± 1.636
2.959LeuPro: 2.959 ± 0.712
2.959LeuGln: 2.959 ± 0.703
1.902LeuArg: 1.902 ± 0.637
6.974LeuSer: 6.974 ± 1.415
4.861LeuThr: 4.861 ± 0.85
4.861LeuVal: 4.861 ± 0.927
0.423LeuTrp: 0.423 ± 0.214
3.17LeuTyr: 3.17 ± 0.587
0.0LeuXaa: 0.0 ± 0.0
Met
0.634MetAla: 0.634 ± 0.249
0.211MetCys: 0.211 ± 0.196
1.268MetAsp: 1.268 ± 0.477
1.057MetGlu: 1.057 ± 0.36
1.268MetPhe: 1.268 ± 0.589
0.845MetGly: 0.845 ± 0.42
0.423MetHis: 0.423 ± 0.237
0.211MetIle: 0.211 ± 0.196
2.113MetLys: 2.113 ± 0.633
2.325MetLeu: 2.325 ± 0.673
0.0MetMet: 0.0 ± 0.0
1.902MetAsn: 1.902 ± 0.616
0.211MetPro: 0.211 ± 0.234
0.0MetGln: 0.0 ± 0.0
0.211MetArg: 0.211 ± 0.234
1.902MetSer: 1.902 ± 0.77
0.211MetThr: 0.211 ± 0.167
0.0MetVal: 0.0 ± 0.0
0.423MetTrp: 0.423 ± 0.234
0.423MetTyr: 0.423 ± 0.366
0.0MetXaa: 0.0 ± 0.0
Asn
2.959AsnAla: 2.959 ± 0.587
0.423AsnCys: 0.423 ± 0.299
4.227AsnAsp: 4.227 ± 0.615
7.608AsnGlu: 7.608 ± 1.403
6.128AsnPhe: 6.128 ± 1.105
2.959AsnGly: 2.959 ± 0.516
1.691AsnHis: 1.691 ± 0.542
4.438AsnIle: 4.438 ± 0.681
8.242AsnLys: 8.242 ± 1.023
8.664AsnLeu: 8.664 ± 1.185
1.691AsnMet: 1.691 ± 0.762
6.128AsnAsn: 6.128 ± 1.751
3.804AsnPro: 3.804 ± 0.817
4.861AsnGln: 4.861 ± 1.05
2.113AsnArg: 2.113 ± 0.632
4.227AsnSer: 4.227 ± 0.665
4.438AsnThr: 4.438 ± 1.023
2.959AsnVal: 2.959 ± 0.682
2.113AsnTrp: 2.113 ± 0.592
5.283AsnTyr: 5.283 ± 1.137
0.0AsnXaa: 0.0 ± 0.0
Pro
1.902ProAla: 1.902 ± 0.657
0.211ProCys: 0.211 ± 0.194
1.691ProAsp: 1.691 ± 0.613
1.691ProGlu: 1.691 ± 0.659
1.268ProPhe: 1.268 ± 0.444
0.423ProGly: 0.423 ± 0.238
0.423ProHis: 0.423 ± 0.214
3.17ProIle: 3.17 ± 0.736
2.747ProLys: 2.747 ± 0.679
2.747ProLeu: 2.747 ± 0.592
0.845ProMet: 0.845 ± 0.438
1.479ProAsn: 1.479 ± 0.464
0.423ProPro: 0.423 ± 0.273
0.423ProGln: 0.423 ± 0.272
1.057ProArg: 1.057 ± 0.455
2.325ProSer: 2.325 ± 0.785
2.325ProThr: 2.325 ± 0.582
0.845ProVal: 0.845 ± 0.433
0.634ProTrp: 0.634 ± 0.47
0.423ProTyr: 0.423 ± 0.257
0.0ProXaa: 0.0 ± 0.0
Gln
1.268GlnAla: 1.268 ± 0.489
0.0GlnCys: 0.0 ± 0.0
2.113GlnAsp: 2.113 ± 0.563
2.113GlnGlu: 2.113 ± 0.578
2.113GlnPhe: 2.113 ± 0.644
1.268GlnGly: 1.268 ± 0.49
0.423GlnHis: 0.423 ± 0.317
3.593GlnIle: 3.593 ± 0.954
4.438GlnLys: 4.438 ± 1.241
3.381GlnLeu: 3.381 ± 0.802
0.845GlnMet: 0.845 ± 0.399
3.381GlnAsn: 3.381 ± 0.983
0.845GlnPro: 0.845 ± 0.276
1.057GlnGln: 1.057 ± 0.626
0.211GlnArg: 0.211 ± 0.234
2.113GlnSer: 2.113 ± 0.748
2.113GlnThr: 2.113 ± 0.681
1.057GlnVal: 1.057 ± 0.541
1.057GlnTrp: 1.057 ± 0.588
1.057GlnTyr: 1.057 ± 0.443
0.0GlnXaa: 0.0 ± 0.0
Arg
1.479ArgAla: 1.479 ± 0.525
0.0ArgCys: 0.0 ± 0.0
1.902ArgAsp: 1.902 ± 0.934
1.902ArgGlu: 1.902 ± 0.738
1.691ArgPhe: 1.691 ± 0.496
0.423ArgGly: 0.423 ± 0.272
0.211ArgHis: 0.211 ± 0.196
2.747ArgIle: 2.747 ± 0.752
3.17ArgLys: 3.17 ± 0.886
3.381ArgLeu: 3.381 ± 0.7
0.211ArgMet: 0.211 ± 0.194
2.747ArgAsn: 2.747 ± 0.559
0.845ArgPro: 0.845 ± 0.273
1.268ArgGln: 1.268 ± 0.436
1.268ArgArg: 1.268 ± 0.674
1.268ArgSer: 1.268 ± 0.469
2.325ArgThr: 2.325 ± 0.519
1.268ArgVal: 1.268 ± 0.861
0.0ArgTrp: 0.0 ± 0.0
0.845ArgTyr: 0.845 ± 0.379
0.0ArgXaa: 0.0 ± 0.0
Ser
2.747SerAla: 2.747 ± 0.6
0.845SerCys: 0.845 ± 0.457
4.227SerAsp: 4.227 ± 0.776
3.804SerGlu: 3.804 ± 1.282
2.325SerPhe: 2.325 ± 0.684
2.959SerGly: 2.959 ± 0.85
0.845SerHis: 0.845 ± 0.499
4.649SerIle: 4.649 ± 1.089
8.876SerLys: 8.876 ± 1.372
6.974SerLeu: 6.974 ± 1.197
1.057SerMet: 1.057 ± 0.536
6.128SerAsn: 6.128 ± 1.105
0.845SerPro: 0.845 ± 0.367
2.113SerGln: 2.113 ± 0.659
0.845SerArg: 0.845 ± 0.461
4.861SerSer: 4.861 ± 1.357
4.227SerThr: 4.227 ± 0.953
2.325SerVal: 2.325 ± 0.739
0.845SerTrp: 0.845 ± 0.505
3.804SerTyr: 3.804 ± 0.854
0.0SerXaa: 0.0 ± 0.0
Thr
1.902ThrAla: 1.902 ± 0.588
0.0ThrCys: 0.0 ± 0.0
1.902ThrAsp: 1.902 ± 0.647
3.381ThrGlu: 3.381 ± 0.956
4.227ThrPhe: 4.227 ± 0.918
2.959ThrGly: 2.959 ± 0.959
0.211ThrHis: 0.211 ± 0.203
4.861ThrIle: 4.861 ± 1.0
8.242ThrLys: 8.242 ± 1.515
5.706ThrLeu: 5.706 ± 1.071
0.634ThrMet: 0.634 ± 0.368
4.649ThrAsn: 4.649 ± 1.016
1.902ThrPro: 1.902 ± 0.828
1.057ThrGln: 1.057 ± 0.326
2.113ThrArg: 2.113 ± 0.628
2.325ThrSer: 2.325 ± 0.4
4.649ThrThr: 4.649 ± 1.143
2.536ThrVal: 2.536 ± 0.519
0.845ThrTrp: 0.845 ± 0.582
1.902ThrTyr: 1.902 ± 0.428
0.0ThrXaa: 0.0 ± 0.0
Val
1.902ValAla: 1.902 ± 0.486
0.211ValCys: 0.211 ± 0.196
3.593ValAsp: 3.593 ± 1.222
2.325ValGlu: 2.325 ± 0.709
3.381ValPhe: 3.381 ± 0.702
1.902ValGly: 1.902 ± 0.74
0.423ValHis: 0.423 ± 0.253
3.804ValIle: 3.804 ± 1.138
5.495ValLys: 5.495 ± 1.207
4.861ValLeu: 4.861 ± 1.477
0.211ValMet: 0.211 ± 0.196
3.593ValAsn: 3.593 ± 0.984
1.057ValPro: 1.057 ± 0.401
2.536ValGln: 2.536 ± 0.51
0.634ValArg: 0.634 ± 0.392
2.536ValSer: 2.536 ± 0.689
1.479ValThr: 1.479 ± 0.536
3.593ValVal: 3.593 ± 1.273
0.845ValTrp: 0.845 ± 0.482
1.691ValTyr: 1.691 ± 0.498
0.0ValXaa: 0.0 ± 0.0
Trp
0.423TrpAla: 0.423 ± 0.296
0.423TrpCys: 0.423 ± 0.366
0.423TrpAsp: 0.423 ± 0.214
1.057TrpGlu: 1.057 ± 0.371
0.211TrpPhe: 0.211 ± 0.227
0.423TrpGly: 0.423 ± 0.379
0.211TrpHis: 0.211 ± 0.167
2.747TrpIle: 2.747 ± 0.79
1.691TrpLys: 1.691 ± 0.912
1.268TrpLeu: 1.268 ± 0.605
0.423TrpMet: 0.423 ± 0.299
1.902TrpAsn: 1.902 ± 0.844
0.211TrpPro: 0.211 ± 0.203
0.423TrpGln: 0.423 ± 0.234
0.0TrpArg: 0.0 ± 0.0
0.634TrpSer: 0.634 ± 0.347
0.211TrpThr: 0.211 ± 0.196
0.634TrpVal: 0.634 ± 0.423
0.211TrpTrp: 0.211 ± 0.19
0.211TrpTyr: 0.211 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.325TyrAla: 2.325 ± 0.657
0.211TyrCys: 0.211 ± 0.196
3.381TyrAsp: 3.381 ± 0.967
2.747TyrGlu: 2.747 ± 0.867
2.325TyrPhe: 2.325 ± 0.817
1.479TyrGly: 1.479 ± 0.648
0.845TyrHis: 0.845 ± 0.389
3.593TyrIle: 3.593 ± 0.878
5.283TyrLys: 5.283 ± 1.395
4.015TyrLeu: 4.015 ± 1.223
0.845TyrMet: 0.845 ± 0.392
2.747TyrAsn: 2.747 ± 0.831
0.423TyrPro: 0.423 ± 0.273
2.113TyrGln: 2.113 ± 0.728
1.057TyrArg: 1.057 ± 0.404
3.804TyrSer: 3.804 ± 0.883
1.479TyrThr: 1.479 ± 0.493
2.113TyrVal: 2.113 ± 0.549
0.634TyrTrp: 0.634 ± 0.354
2.113TyrTyr: 2.113 ± 0.521
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (4733 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski