Amino acid dipepetide frequency for Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.174AlaAla: 19.174 ± 0.32	0.854AlaCys: 0.854 ± 0.036	12.742AlaAsp: 12.742 ± 0.203	7.584AlaGlu: 7.584 ± 0.142	4.313AlaPhe: 4.313 ± 0.079	11.205AlaGly: 11.205 ± 0.154	2.473AlaHis: 2.473 ± 0.063	4.614AlaIle: 4.614 ± 0.086	1.88AlaLys: 1.88 ± 0.062	11.146AlaLeu: 11.146 ± 0.184	2.275AlaMet: 2.275 ± 0.066	2.544AlaAsn: 2.544 ± 0.058	4.807AlaPro: 4.807 ± 0.109	2.664AlaGln: 2.664 ± 0.063	6.976AlaArg: 6.976 ± 0.122	6.206AlaSer: 6.206 ± 0.115	8.135AlaThr: 8.135 ± 0.132	12.86AlaVal: 12.86 ± 0.229	1.306AlaTrp: 1.306 ± 0.05	2.81AlaTyr: 2.81 ± 0.074	0.0AlaXaa: 0.0 ± 0.0
Cys	0.647CysAla: 0.647 ± 0.033	0.087CysCys: 0.087 ± 0.011	0.558CysAsp: 0.558 ± 0.024	0.57CysGlu: 0.57 ± 0.026	0.181CysPhe: 0.181 ± 0.016	0.926CysGly: 0.926 ± 0.044	0.191CysHis: 0.191 ± 0.017	0.26CysIle: 0.26 ± 0.019	0.1CysLys: 0.1 ± 0.012	0.513CysLeu: 0.513 ± 0.03	0.125CysMet: 0.125 ± 0.015	0.187CysAsn: 0.187 ± 0.017	0.597CysPro: 0.597 ± 0.031	0.215CysGln: 0.215 ± 0.018	0.501CysArg: 0.501 ± 0.029	0.47CysSer: 0.47 ± 0.03	0.457CysThr: 0.457 ± 0.026	0.623CysVal: 0.623 ± 0.034	0.112CysTrp: 0.112 ± 0.011	0.173CysTyr: 0.173 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	14.287AspAla: 14.287 ± 0.201	0.742AspCys: 0.742 ± 0.041	8.72AspAsp: 8.72 ± 0.151	6.387AspGlu: 6.387 ± 0.125	1.871AspPhe: 1.871 ± 0.055	8.082AspGly: 8.082 ± 0.131	2.294AspHis: 2.294 ± 0.068	3.402AspIle: 3.402 ± 0.075	0.976AspLys: 0.976 ± 0.036	6.622AspLeu: 6.622 ± 0.127	1.268AspMet: 1.268 ± 0.041	1.377AspAsn: 1.377 ± 0.056	4.426AspPro: 4.426 ± 0.085	1.913AspGln: 1.913 ± 0.06	6.395AspArg: 6.395 ± 0.094	3.727AspSer: 3.727 ± 0.079	5.856AspThr: 5.856 ± 0.095	8.085AspVal: 8.085 ± 0.136	1.06AspTrp: 1.06 ± 0.04	1.937AspTyr: 1.937 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	7.255GluAla: 7.255 ± 0.133	0.506GluCys: 0.506 ± 0.031	4.954GluAsp: 4.954 ± 0.123	4.275GluGlu: 4.275 ± 0.123	2.57GluPhe: 2.57 ± 0.07	3.799GluGly: 3.799 ± 0.085	2.068GluHis: 2.068 ± 0.049	3.226GluIle: 3.226 ± 0.095	1.5GluLys: 1.5 ± 0.054	6.504GluLeu: 6.504 ± 0.122	1.614GluMet: 1.614 ± 0.052	1.716GluAsn: 1.716 ± 0.052	3.014GluPro: 3.014 ± 0.071	2.691GluGln: 2.691 ± 0.076	6.225GluArg: 6.225 ± 0.129	3.874GluSer: 3.874 ± 0.083	5.321GluThr: 5.321 ± 0.104	4.686GluVal: 4.686 ± 0.103	0.905GluTrp: 0.905 ± 0.046	2.319GluTyr: 2.319 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	3.639PheAla: 3.639 ± 0.084	0.262PheCys: 0.262 ± 0.021	3.227PheAsp: 3.227 ± 0.07	2.708PheGlu: 2.708 ± 0.074	0.901PhePhe: 0.901 ± 0.036	2.96PheGly: 2.96 ± 0.067	0.597PheHis: 0.597 ± 0.033	0.986PheIle: 0.986 ± 0.051	0.529PheLys: 0.529 ± 0.024	2.492PheLeu: 2.492 ± 0.061	0.508PheMet: 0.508 ± 0.027	0.679PheAsn: 0.679 ± 0.029	1.327PhePro: 1.327 ± 0.046	0.861PheGln: 0.861 ± 0.036	1.768PheArg: 1.768 ± 0.054	1.618PheSer: 1.618 ± 0.047	1.875PheThr: 1.875 ± 0.051	3.049PheVal: 3.049 ± 0.083	0.366PheTrp: 0.366 ± 0.027	0.799PheTyr: 0.799 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.983GlyAla: 8.983 ± 0.162	0.779GlyCys: 0.779 ± 0.035	7.596GlyAsp: 7.596 ± 0.12	5.49GlyGlu: 5.49 ± 0.113	3.12GlyPhe: 3.12 ± 0.066	7.365GlyGly: 7.365 ± 0.159	1.84GlyHis: 1.84 ± 0.053	3.625GlyIle: 3.625 ± 0.074	1.711GlyLys: 1.711 ± 0.056	6.883GlyLeu: 6.883 ± 0.106	1.646GlyMet: 1.646 ± 0.054	1.758GlyAsn: 1.758 ± 0.05	3.126GlyPro: 3.126 ± 0.067	1.997GlyGln: 1.997 ± 0.061	4.905GlyArg: 4.905 ± 0.092	4.67GlySer: 4.67 ± 0.081	5.527GlyThr: 5.527 ± 0.092	8.844GlyVal: 8.844 ± 0.131	1.055GlyTrp: 1.055 ± 0.038	2.414GlyTyr: 2.414 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.676HisAla: 2.676 ± 0.07	0.226HisCys: 0.226 ± 0.017	2.337HisAsp: 2.337 ± 0.07	1.616HisGlu: 1.616 ± 0.052	0.529HisPhe: 0.529 ± 0.029	2.081HisGly: 2.081 ± 0.063	0.651HisHis: 0.651 ± 0.028	0.807HisIle: 0.807 ± 0.032	0.307HisLys: 0.307 ± 0.021	1.762HisLeu: 1.762 ± 0.053	0.295HisMet: 0.295 ± 0.022	0.457HisAsn: 0.457 ± 0.026	1.398HisPro: 1.398 ± 0.048	0.548HisGln: 0.548 ± 0.027	1.465HisArg: 1.465 ± 0.048	0.933HisSer: 0.933 ± 0.037	1.384HisThr: 1.384 ± 0.046	2.146HisVal: 2.146 ± 0.06	0.207HisTrp: 0.207 ± 0.018	0.583HisTyr: 0.583 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	4.742IleAla: 4.742 ± 0.095	0.215IleCys: 0.215 ± 0.019	3.863IleAsp: 3.863 ± 0.088	3.709IleGlu: 3.709 ± 0.082	0.723IlePhe: 0.723 ± 0.038	3.387IleGly: 3.387 ± 0.083	0.763IleHis: 0.763 ± 0.028	1.24IleIle: 1.24 ± 0.046	0.663IleLys: 0.663 ± 0.036	2.417IleLeu: 2.417 ± 0.072	0.456IleMet: 0.456 ± 0.028	0.911IleAsn: 0.911 ± 0.037	1.937IlePro: 1.937 ± 0.053	1.209IleGln: 1.209 ± 0.045	2.275IleArg: 2.275 ± 0.058	1.947IleSer: 1.947 ± 0.056	2.636IleThr: 2.636 ± 0.066	3.171IleVal: 3.171 ± 0.078	0.272IleTrp: 0.272 ± 0.019	0.72IleTyr: 0.72 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	1.646LysAla: 1.646 ± 0.058	0.119LysCys: 0.119 ± 0.015	1.132LysAsp: 1.132 ± 0.048	1.054LysGlu: 1.054 ± 0.037	0.46LysPhe: 0.46 ± 0.028	1.159LysGly: 1.159 ± 0.044	0.504LysHis: 0.504 ± 0.029	0.71LysIle: 0.71 ± 0.036	0.448LysLys: 0.448 ± 0.028	1.627LysLeu: 1.627 ± 0.051	0.347LysMet: 0.347 ± 0.02	0.492LysAsn: 0.492 ± 0.027	0.943LysPro: 0.943 ± 0.042	0.868LysGln: 0.868 ± 0.042	1.556LysArg: 1.556 ± 0.05	1.109LysSer: 1.109 ± 0.046	1.381LysThr: 1.381 ± 0.047	1.036LysVal: 1.036 ± 0.041	0.219LysTrp: 0.219 ± 0.02	0.607LysTyr: 0.607 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.996LeuAla: 11.996 ± 0.178	0.52LeuCys: 0.52 ± 0.026	7.786LeuAsp: 7.786 ± 0.111	4.946LeuGlu: 4.946 ± 0.105	2.682LeuPhe: 2.682 ± 0.071	7.22LeuGly: 7.22 ± 0.126	1.709LeuHis: 1.709 ± 0.057	2.473LeuIle: 2.473 ± 0.066	1.537LeuLys: 1.537 ± 0.057	7.487LeuLeu: 7.487 ± 0.136	1.278LeuMet: 1.278 ± 0.045	1.813LeuAsn: 1.813 ± 0.056	4.003LeuPro: 4.003 ± 0.089	2.215LeuGln: 2.215 ± 0.054	5.42LeuArg: 5.42 ± 0.092	5.279LeuSer: 5.279 ± 0.096	5.326LeuThr: 5.326 ± 0.092	8.093LeuVal: 8.093 ± 0.127	0.792LeuTrp: 0.792 ± 0.034	2.034LeuTyr: 2.034 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.919MetAla: 1.919 ± 0.051	0.118MetCys: 0.118 ± 0.013	1.361MetAsp: 1.361 ± 0.047	1.002MetGlu: 1.002 ± 0.04	0.472MetPhe: 0.472 ± 0.028	1.368MetGly: 1.368 ± 0.045	0.42MetHis: 0.42 ± 0.021	0.544MetIle: 0.544 ± 0.029	0.356MetLys: 0.356 ± 0.028	1.481MetLeu: 1.481 ± 0.046	0.292MetMet: 0.292 ± 0.023	0.517MetAsn: 0.517 ± 0.027	0.936MetPro: 0.936 ± 0.039	0.605MetGln: 0.605 ± 0.028	1.284MetArg: 1.284 ± 0.044	1.462MetSer: 1.462 ± 0.05	1.458MetThr: 1.458 ± 0.048	1.289MetVal: 1.289 ± 0.043	0.144MetTrp: 0.144 ± 0.015	0.366MetTyr: 0.366 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.72AsnAla: 2.72 ± 0.067	0.203AsnCys: 0.203 ± 0.021	1.733AsnAsp: 1.733 ± 0.054	1.521AsnGlu: 1.521 ± 0.053	0.608AsnPhe: 0.608 ± 0.029	1.803AsnGly: 1.803 ± 0.051	0.488AsnHis: 0.488 ± 0.03	0.901AsnIle: 0.901 ± 0.039	0.439AsnLys: 0.439 ± 0.028	1.702AsnLeu: 1.702 ± 0.048	0.416AsnMet: 0.416 ± 0.025	0.554AsnAsn: 0.554 ± 0.031	1.428AsnPro: 1.428 ± 0.047	0.638AsnGln: 0.638 ± 0.032	1.427AsnArg: 1.427 ± 0.045	1.035AsnSer: 1.035 ± 0.049	1.492AsnThr: 1.492 ± 0.053	2.118AsnVal: 2.118 ± 0.066	0.266AsnTrp: 0.266 ± 0.024	0.629AsnTyr: 0.629 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.821ProAla: 5.821 ± 0.113	0.253ProCys: 0.253 ± 0.02	4.78ProAsp: 4.78 ± 0.092	3.627ProGlu: 3.627 ± 0.077	1.483ProPhe: 1.483 ± 0.046	3.974ProGly: 3.974 ± 0.088	1.024ProHis: 1.024 ± 0.042	1.634ProIle: 1.634 ± 0.055	0.791ProLys: 0.791 ± 0.027	3.487ProLeu: 3.487 ± 0.075	0.844ProMet: 0.844 ± 0.04	1.083ProAsn: 1.083 ± 0.036	2.337ProPro: 2.337 ± 0.069	1.104ProGln: 1.104 ± 0.043	2.438ProArg: 2.438 ± 0.066	2.735ProSer: 2.735 ± 0.068	3.489ProThr: 3.489 ± 0.071	4.439ProVal: 4.439 ± 0.084	0.503ProTrp: 0.503 ± 0.027	1.06ProTyr: 1.06 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.085GlnAla: 3.085 ± 0.065	0.193GlnCys: 0.193 ± 0.018	1.715GlnAsp: 1.715 ± 0.053	1.624GlnGlu: 1.624 ± 0.058	1.093GlnPhe: 1.093 ± 0.044	1.59GlnGly: 1.59 ± 0.048	0.666GlnHis: 0.666 ± 0.027	0.961GlnIle: 0.961 ± 0.042	0.557GlnLys: 0.557 ± 0.028	2.422GlnLeu: 2.422 ± 0.063	0.605GlnMet: 0.605 ± 0.03	0.694GlnAsn: 0.694 ± 0.032	1.59GlnPro: 1.59 ± 0.056	1.336GlnGln: 1.336 ± 0.065	2.425GlnArg: 2.425 ± 0.069	1.899GlnSer: 1.899 ± 0.048	1.772GlnThr: 1.772 ± 0.055	1.716GlnVal: 1.716 ± 0.05	0.404GlnTrp: 0.404 ± 0.026	0.933GlnTyr: 0.933 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	7.487ArgAla: 7.487 ± 0.134	0.533ArgCys: 0.533 ± 0.031	5.577ArgAsp: 5.577 ± 0.109	5.63ArgGlu: 5.63 ± 0.133	2.057ArgPhe: 2.057 ± 0.056	4.604ArgGly: 4.604 ± 0.087	1.43ArgHis: 1.43 ± 0.045	2.799ArgIle: 2.799 ± 0.057	1.333ArgLys: 1.333 ± 0.046	5.858ArgLeu: 5.858 ± 0.091	1.211ArgMet: 1.211 ± 0.043	1.537ArgAsn: 1.537 ± 0.048	2.575ArgPro: 2.575 ± 0.073	1.859ArgGln: 1.859 ± 0.057	4.97ArgArg: 4.97 ± 0.131	3.409ArgSer: 3.409 ± 0.079	4.065ArgThr: 4.065 ± 0.076	5.79ArgVal: 5.79 ± 0.105	0.736ArgTrp: 0.736 ± 0.033	1.753ArgTyr: 1.753 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.791SerAla: 5.791 ± 0.098	0.409SerCys: 0.409 ± 0.026	4.057SerAsp: 4.057 ± 0.074	3.785SerGlu: 3.785 ± 0.08	1.894SerPhe: 1.894 ± 0.052	5.032SerGly: 5.032 ± 0.098	1.13SerHis: 1.13 ± 0.035	2.093SerIle: 2.093 ± 0.06	1.264SerLys: 1.264 ± 0.05	4.666SerLeu: 4.666 ± 0.091	1.104SerMet: 1.104 ± 0.041	1.308SerAsn: 1.308 ± 0.049	2.563SerPro: 2.563 ± 0.074	1.593SerGln: 1.593 ± 0.054	3.336SerArg: 3.336 ± 0.079	2.824SerSer: 2.824 ± 0.09	3.647SerThr: 3.647 ± 0.077	5.234SerVal: 5.234 ± 0.098	0.62SerTrp: 0.62 ± 0.031	1.37SerTyr: 1.37 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	8.608ThrAla: 8.608 ± 0.141	0.348ThrCys: 0.348 ± 0.023	6.081ThrAsp: 6.081 ± 0.111	4.334ThrGlu: 4.334 ± 0.088	1.884ThrPhe: 1.884 ± 0.055	5.941ThrGly: 5.941 ± 0.092	1.544ThrHis: 1.544 ± 0.048	2.901ThrIle: 2.901 ± 0.074	1.011ThrLys: 1.011 ± 0.039	5.808ThrLeu: 5.808 ± 0.094	1.101ThrMet: 1.101 ± 0.044	1.487ThrAsn: 1.487 ± 0.049	3.946ThrPro: 3.946 ± 0.077	1.74ThrGln: 1.74 ± 0.048	3.675ThrArg: 3.675 ± 0.084	2.979ThrSer: 2.979 ± 0.068	5.378ThrThr: 5.378 ± 0.131	7.229ThrVal: 7.229 ± 0.114	0.58ThrTrp: 0.58 ± 0.028	1.687ThrTyr: 1.687 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	12.178ValAla: 12.178 ± 0.199	0.776ValCys: 0.776 ± 0.033	7.962ValAsp: 7.962 ± 0.101	6.356ValGlu: 6.356 ± 0.13	3.161ValPhe: 3.161 ± 0.073	7.844ValGly: 7.844 ± 0.139	1.802ValHis: 1.802 ± 0.054	2.963ValIle: 2.963 ± 0.075	1.371ValLys: 1.371 ± 0.047	8.323ValLeu: 8.323 ± 0.15	1.377ValMet: 1.377 ± 0.043	2.031ValAsn: 2.031 ± 0.062	4.388ValPro: 4.388 ± 0.078	2.093ValGln: 2.093 ± 0.057	5.514ValArg: 5.514 ± 0.101	5.78ValSer: 5.78 ± 0.107	6.653ValThr: 6.653 ± 0.122	10.382ValVal: 10.382 ± 0.197	0.839ValTrp: 0.839 ± 0.036	2.193ValTyr: 2.193 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	1.076TrpAla: 1.076 ± 0.044	0.107TrpCys: 0.107 ± 0.013	0.699TrpAsp: 0.699 ± 0.039	0.702TrpGlu: 0.702 ± 0.036	0.406TrpPhe: 0.406 ± 0.026	0.802TrpGly: 0.802 ± 0.036	0.222TrpHis: 0.222 ± 0.017	0.373TrpIle: 0.373 ± 0.024	0.245TrpLys: 0.245 ± 0.021	1.179TrpLeu: 1.179 ± 0.044	0.241TrpMet: 0.241 ± 0.019	0.27TrpAsn: 0.27 ± 0.021	0.419TrpPro: 0.419 ± 0.027	0.394TrpGln: 0.394 ± 0.025	0.889TrpArg: 0.889 ± 0.036	0.564TrpSer: 0.564 ± 0.029	0.86TrpThr: 0.86 ± 0.04	0.935TrpVal: 0.935 ± 0.039	0.204TrpTrp: 0.204 ± 0.019	0.32TrpTyr: 0.32 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.839TyrAla: 2.839 ± 0.065	0.244TyrCys: 0.244 ± 0.017	2.547TyrAsp: 2.547 ± 0.064	2.1TyrGlu: 2.1 ± 0.061	0.744TyrPhe: 0.744 ± 0.033	2.191TyrGly: 2.191 ± 0.048	0.594TyrHis: 0.594 ± 0.032	0.745TyrIle: 0.745 ± 0.038	0.401TyrLys: 0.401 ± 0.026	2.229TyrLeu: 2.229 ± 0.064	0.391TyrMet: 0.391 ± 0.025	0.704TyrAsn: 0.704 ± 0.033	1.145TyrPro: 1.145 ± 0.042	0.736TyrGln: 0.736 ± 0.032	1.769TyrArg: 1.769 ± 0.052	1.201TyrSer: 1.201 ± 0.042	1.55TyrThr: 1.55 ± 0.049	2.26TyrVal: 2.26 ± 0.057	0.317TyrTrp: 0.317 ± 0.023	0.827TyrTyr: 0.827 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2426 proteins (680494 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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