Amino acid dipepetide frequency for bacterium I07

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.444AlaAla: 5.444 ± 0.176
0.717AlaCys: 0.717 ± 0.061
3.536AlaAsp: 3.536 ± 0.129
4.209AlaGlu: 4.209 ± 0.128
2.968AlaPhe: 2.968 ± 0.107
5.231AlaGly: 5.231 ± 0.144
1.349AlaHis: 1.349 ± 0.068
4.577AlaIle: 4.577 ± 0.139
3.041AlaLys: 3.041 ± 0.1
5.981AlaLeu: 5.981 ± 0.154
1.673AlaMet: 1.673 ± 0.081
2.54AlaAsn: 2.54 ± 0.094
2.06AlaPro: 2.06 ± 0.095
2.006AlaGln: 2.006 ± 0.084
3.6AlaArg: 3.6 ± 0.116
3.854AlaSer: 3.854 ± 0.125
2.66AlaThr: 2.66 ± 0.102
4.777AlaVal: 4.777 ± 0.144
0.971AlaTrp: 0.971 ± 0.065
2.105AlaTyr: 2.105 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.603CysAla: 0.603 ± 0.043
0.162CysCys: 0.162 ± 0.025
0.559CysAsp: 0.559 ± 0.046
0.536CysGlu: 0.536 ± 0.043
0.527CysPhe: 0.527 ± 0.04
0.917CysGly: 0.917 ± 0.067
0.314CysHis: 0.314 ± 0.035
0.686CysIle: 0.686 ± 0.045
0.467CysLys: 0.467 ± 0.036
1.032CysLeu: 1.032 ± 0.06
0.222CysMet: 0.222 ± 0.027
0.4CysAsn: 0.4 ± 0.043
0.502CysPro: 0.502 ± 0.047
0.387CysGln: 0.387 ± 0.034
0.73CysArg: 0.73 ± 0.047
0.667CysSer: 0.667 ± 0.055
0.59CysThr: 0.59 ± 0.042
0.692CysVal: 0.692 ± 0.049
0.21CysTrp: 0.21 ± 0.025
0.324CysTyr: 0.324 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
3.314AspAla: 3.314 ± 0.115
0.54AspCys: 0.54 ± 0.045
3.136AspAsp: 3.136 ± 0.116
3.939AspGlu: 3.939 ± 0.118
2.997AspPhe: 2.997 ± 0.108
5.022AspGly: 5.022 ± 0.209
1.346AspHis: 1.346 ± 0.067
4.676AspIle: 4.676 ± 0.124
2.628AspLys: 2.628 ± 0.094
5.787AspLeu: 5.787 ± 0.156
1.314AspMet: 1.314 ± 0.069
2.479AspAsn: 2.479 ± 0.094
2.895AspPro: 2.895 ± 0.094
1.924AspGln: 1.924 ± 0.081
3.346AspArg: 3.346 ± 0.1
3.635AspSer: 3.635 ± 0.121
2.762AspThr: 2.762 ± 0.127
3.555AspVal: 3.555 ± 0.108
0.93AspTrp: 0.93 ± 0.053
2.295AspTyr: 2.295 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
4.501GluAla: 4.501 ± 0.126
0.448GluCys: 0.448 ± 0.041
3.327GluAsp: 3.327 ± 0.102
4.085GluGlu: 4.085 ± 0.134
2.4GluPhe: 2.4 ± 0.088
4.339GluGly: 4.339 ± 0.127
1.232GluHis: 1.232 ± 0.057
5.133GluIle: 5.133 ± 0.145
5.263GluLys: 5.263 ± 0.154
5.641GluLeu: 5.641 ± 0.158
1.898GluMet: 1.898 ± 0.082
3.505GluAsn: 3.505 ± 0.117
2.155GluPro: 2.155 ± 0.08
2.267GluGln: 2.267 ± 0.08
3.289GluArg: 3.289 ± 0.128
4.098GluSer: 4.098 ± 0.119
3.409GluThr: 3.409 ± 0.116
3.638GluVal: 3.638 ± 0.126
0.962GluTrp: 0.962 ± 0.06
2.327GluTyr: 2.327 ± 0.089
0.0GluXaa: 0.0 ± 0.0
Phe
2.4PheAla: 2.4 ± 0.1
0.508PheCys: 0.508 ± 0.032
2.813PheAsp: 2.813 ± 0.112
2.844PheGlu: 2.844 ± 0.11
2.009PhePhe: 2.009 ± 0.091
3.209PheGly: 3.209 ± 0.11
0.978PheHis: 0.978 ± 0.061
3.184PheIle: 3.184 ± 0.108
2.425PheLys: 2.425 ± 0.087
4.311PheLeu: 4.311 ± 0.122
1.016PheMet: 1.016 ± 0.065
2.174PheAsn: 2.174 ± 0.084
1.927PhePro: 1.927 ± 0.088
1.692PheGln: 1.692 ± 0.075
2.517PheArg: 2.517 ± 0.096
3.508PheSer: 3.508 ± 0.109
2.498PheThr: 2.498 ± 0.095
2.365PheVal: 2.365 ± 0.081
0.724PheTrp: 0.724 ± 0.043
1.613PheTyr: 1.613 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
4.025GlyAla: 4.025 ± 0.138
0.886GlyCys: 0.886 ± 0.061
4.095GlyAsp: 4.095 ± 0.134
4.736GlyGlu: 4.736 ± 0.144
3.343GlyPhe: 3.343 ± 0.107
5.292GlyGly: 5.292 ± 0.198
1.762GlyHis: 1.762 ± 0.069
5.584GlyIle: 5.584 ± 0.146
4.847GlyLys: 4.847 ± 0.147
6.495GlyLeu: 6.495 ± 0.148
2.07GlyMet: 2.07 ± 0.077
3.165GlyAsn: 3.165 ± 0.104
2.174GlyPro: 2.174 ± 0.092
2.52GlyGln: 2.52 ± 0.092
4.028GlyArg: 4.028 ± 0.13
5.089GlySer: 5.089 ± 0.131
3.968GlyThr: 3.968 ± 0.127
4.387GlyVal: 4.387 ± 0.109
1.178GlyTrp: 1.178 ± 0.057
2.654GlyTyr: 2.654 ± 0.104
0.0GlyXaa: 0.0 ± 0.0
His
1.505HisAla: 1.505 ± 0.075
0.308HisCys: 0.308 ± 0.03
1.292HisAsp: 1.292 ± 0.057
1.289HisGlu: 1.289 ± 0.073
1.317HisPhe: 1.317 ± 0.068
1.289HisGly: 1.289 ± 0.062
0.663HisHis: 0.663 ± 0.05
1.673HisIle: 1.673 ± 0.069
1.019HisLys: 1.019 ± 0.063
2.111HisLeu: 2.111 ± 0.077
0.441HisMet: 0.441 ± 0.039
0.898HisAsn: 0.898 ± 0.061
1.34HisPro: 1.34 ± 0.069
0.848HisGln: 0.848 ± 0.056
1.292HisArg: 1.292 ± 0.061
1.425HisSer: 1.425 ± 0.076
1.009HisThr: 1.009 ± 0.052
1.587HisVal: 1.587 ± 0.065
0.375HisTrp: 0.375 ± 0.035
0.968HisTyr: 0.968 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
4.549IleAla: 4.549 ± 0.134
0.965IleCys: 0.965 ± 0.057
4.504IleAsp: 4.504 ± 0.136
4.927IleGlu: 4.927 ± 0.143
2.949IlePhe: 2.949 ± 0.103
4.895IleGly: 4.895 ± 0.138
1.994IleHis: 1.994 ± 0.086
5.139IleIle: 5.139 ± 0.148
4.362IleLys: 4.362 ± 0.121
7.117IleLeu: 7.117 ± 0.161
1.606IleMet: 1.606 ± 0.086
3.117IleAsn: 3.117 ± 0.109
3.673IlePro: 3.673 ± 0.096
3.047IleGln: 3.047 ± 0.104
4.231IleArg: 4.231 ± 0.106
5.06IleSer: 5.06 ± 0.125
3.857IleThr: 3.857 ± 0.121
4.784IleVal: 4.784 ± 0.124
1.079IleTrp: 1.079 ± 0.06
2.784IleTyr: 2.784 ± 0.131
0.0IleXaa: 0.0 ± 0.0
Lys
4.136LysAla: 4.136 ± 0.126
0.438LysCys: 0.438 ± 0.036
3.355LysAsp: 3.355 ± 0.117
3.949LysGlu: 3.949 ± 0.131
1.911LysPhe: 1.911 ± 0.07
4.066LysGly: 4.066 ± 0.134
1.209LysHis: 1.209 ± 0.075
4.603LysIle: 4.603 ± 0.143
4.489LysLys: 4.489 ± 0.148
5.343LysLeu: 5.343 ± 0.14
1.806LysMet: 1.806 ± 0.082
2.803LysAsn: 2.803 ± 0.089
2.555LysPro: 2.555 ± 0.098
2.168LysGln: 2.168 ± 0.077
3.787LysArg: 3.787 ± 0.142
4.117LysSer: 4.117 ± 0.113
3.505LysThr: 3.505 ± 0.1
3.454LysVal: 3.454 ± 0.106
0.933LysTrp: 0.933 ± 0.064
2.006LysTyr: 2.006 ± 0.084
0.0LysXaa: 0.0 ± 0.0
Leu
5.901LeuAla: 5.901 ± 0.159
0.968LeuCys: 0.968 ± 0.061
5.003LeuAsp: 5.003 ± 0.126
5.803LeuGlu: 5.803 ± 0.154
4.33LeuPhe: 4.33 ± 0.146
6.523LeuGly: 6.523 ± 0.168
1.924LeuHis: 1.924 ± 0.071
6.85LeuIle: 6.85 ± 0.162
6.771LeuLys: 6.771 ± 0.171
8.584LeuLeu: 8.584 ± 0.215
2.247LeuMet: 2.247 ± 0.088
4.368LeuAsn: 4.368 ± 0.137
4.041LeuPro: 4.041 ± 0.119
3.073LeuGln: 3.073 ± 0.098
4.346LeuArg: 4.346 ± 0.129
6.565LeuSer: 6.565 ± 0.156
5.32LeuThr: 5.32 ± 0.123
5.282LeuVal: 5.282 ± 0.143
1.219LeuTrp: 1.219 ± 0.057
3.159LeuTyr: 3.159 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.721MetAla: 1.721 ± 0.073
0.203MetCys: 0.203 ± 0.026
1.517MetAsp: 1.517 ± 0.07
1.575MetGlu: 1.575 ± 0.068
0.803MetPhe: 0.803 ± 0.051
1.949MetGly: 1.949 ± 0.088
0.47MetHis: 0.47 ± 0.034
2.047MetIle: 2.047 ± 0.084
2.105MetLys: 2.105 ± 0.092
2.016MetLeu: 2.016 ± 0.088
0.66MetMet: 0.66 ± 0.043
1.336MetAsn: 1.336 ± 0.073
1.006MetPro: 1.006 ± 0.053
0.79MetGln: 0.79 ± 0.052
1.317MetArg: 1.317 ± 0.065
1.619MetSer: 1.619 ± 0.077
1.416MetThr: 1.416 ± 0.068
1.533MetVal: 1.533 ± 0.067
0.238MetTrp: 0.238 ± 0.027
0.594MetTyr: 0.594 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.724AsnAla: 2.724 ± 0.106
0.508AsnCys: 0.508 ± 0.045
2.473AsnAsp: 2.473 ± 0.092
2.666AsnGlu: 2.666 ± 0.099
1.648AsnPhe: 1.648 ± 0.071
3.136AsnGly: 3.136 ± 0.119
1.032AsnHis: 1.032 ± 0.048
3.416AsnIle: 3.416 ± 0.111
2.514AsnLys: 2.514 ± 0.092
4.222AsnLeu: 4.222 ± 0.123
1.092AsnMet: 1.092 ± 0.064
2.181AsnAsn: 2.181 ± 0.108
2.863AsnPro: 2.863 ± 0.104
1.99AsnGln: 1.99 ± 0.077
2.847AsnArg: 2.847 ± 0.106
2.73AsnSer: 2.73 ± 0.128
2.2AsnThr: 2.2 ± 0.085
2.774AsnVal: 2.774 ± 0.098
0.857AsnTrp: 0.857 ± 0.055
1.667AsnTyr: 1.667 ± 0.086
0.0AsnXaa: 0.0 ± 0.0
Pro
2.686ProAla: 2.686 ± 0.106
0.368ProCys: 0.368 ± 0.032
3.622ProAsp: 3.622 ± 0.104
3.822ProGlu: 3.822 ± 0.103
2.4ProPhe: 2.4 ± 0.085
3.292ProGly: 3.292 ± 0.118
0.908ProHis: 0.908 ± 0.058
2.657ProIle: 2.657 ± 0.107
2.067ProLys: 2.067 ± 0.091
3.425ProLeu: 3.425 ± 0.109
0.882ProMet: 0.882 ± 0.052
1.911ProAsn: 1.911 ± 0.08
1.695ProPro: 1.695 ± 0.09
1.178ProGln: 1.178 ± 0.062
1.717ProArg: 1.717 ± 0.076
2.581ProSer: 2.581 ± 0.084
1.778ProThr: 1.778 ± 0.075
3.682ProVal: 3.682 ± 0.12
0.584ProTrp: 0.584 ± 0.044
1.463ProTyr: 1.463 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
2.514GlnAla: 2.514 ± 0.101
0.336GlnCys: 0.336 ± 0.032
1.968GlnAsp: 1.968 ± 0.08
1.955GlnGlu: 1.955 ± 0.088
1.6GlnPhe: 1.6 ± 0.065
2.181GlnGly: 2.181 ± 0.083
0.654GlnHis: 0.654 ± 0.046
2.933GlnIle: 2.933 ± 0.091
2.447GlnLys: 2.447 ± 0.092
3.19GlnLeu: 3.19 ± 0.106
0.952GlnMet: 0.952 ± 0.054
1.924GlnAsn: 1.924 ± 0.072
1.197GlnPro: 1.197 ± 0.058
1.222GlnGln: 1.222 ± 0.067
1.651GlnArg: 1.651 ± 0.075
2.406GlnSer: 2.406 ± 0.095
2.006GlnThr: 2.006 ± 0.082
2.365GlnVal: 2.365 ± 0.086
0.546GlnTrp: 0.546 ± 0.042
1.365GlnTyr: 1.365 ± 0.07
0.0GlnXaa: 0.0 ± 0.0
Arg
2.863ArgAla: 2.863 ± 0.088
0.581ArgCys: 0.581 ± 0.053
3.032ArgAsp: 3.032 ± 0.097
3.327ArgGlu: 3.327 ± 0.097
2.72ArgPhe: 2.72 ± 0.093
3.397ArgGly: 3.397 ± 0.111
1.165ArgHis: 1.165 ± 0.06
4.67ArgIle: 4.67 ± 0.114
3.666ArgLys: 3.666 ± 0.12
5.057ArgLeu: 5.057 ± 0.135
1.521ArgMet: 1.521 ± 0.063
2.565ArgAsn: 2.565 ± 0.099
2.082ArgPro: 2.082 ± 0.09
1.968ArgGln: 1.968 ± 0.088
2.895ArgArg: 2.895 ± 0.121
3.574ArgSer: 3.574 ± 0.108
2.774ArgThr: 2.774 ± 0.095
3.238ArgVal: 3.238 ± 0.124
0.917ArgTrp: 0.917 ± 0.06
2.133ArgTyr: 2.133 ± 0.087
0.003ArgXaa: 0.003 ± 0.003
Ser
4.047SerAla: 4.047 ± 0.11
0.746SerCys: 0.746 ± 0.049
4.019SerAsp: 4.019 ± 0.121
4.108SerGlu: 4.108 ± 0.112
3.032SerPhe: 3.032 ± 0.099
5.498SerGly: 5.498 ± 0.157
1.635SerHis: 1.635 ± 0.079
4.72SerIle: 4.72 ± 0.127
3.393SerLys: 3.393 ± 0.101
6.063SerLeu: 6.063 ± 0.144
1.444SerMet: 1.444 ± 0.064
2.993SerAsn: 2.993 ± 0.111
3.333SerPro: 3.333 ± 0.144
2.174SerGln: 2.174 ± 0.079
3.73SerArg: 3.73 ± 0.115
4.587SerSer: 4.587 ± 0.154
3.397SerThr: 3.397 ± 0.112
4.206SerVal: 4.206 ± 0.124
1.149SerTrp: 1.149 ± 0.061
2.406SerTyr: 2.406 ± 0.097
0.0SerXaa: 0.0 ± 0.0
Thr
3.546ThrAla: 3.546 ± 0.105
0.492ThrCys: 0.492 ± 0.035
3.279ThrAsp: 3.279 ± 0.101
3.06ThrGlu: 3.06 ± 0.088
2.378ThrPhe: 2.378 ± 0.107
4.752ThrGly: 4.752 ± 0.139
1.197ThrHis: 1.197 ± 0.062
3.819ThrIle: 3.819 ± 0.12
2.501ThrLys: 2.501 ± 0.101
5.041ThrLeu: 5.041 ± 0.113
1.108ThrMet: 1.108 ± 0.062
1.987ThrAsn: 1.987 ± 0.078
2.324ThrPro: 2.324 ± 0.099
1.594ThrGln: 1.594 ± 0.072
2.419ThrArg: 2.419 ± 0.077
3.038ThrSer: 3.038 ± 0.117
2.559ThrThr: 2.559 ± 0.116
4.0ThrVal: 4.0 ± 0.152
0.819ThrTrp: 0.819 ± 0.061
1.746ThrTyr: 1.746 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
3.851ValAla: 3.851 ± 0.118
0.663ValCys: 0.663 ± 0.049
3.803ValAsp: 3.803 ± 0.114
4.079ValGlu: 4.079 ± 0.112
2.968ValPhe: 2.968 ± 0.09
3.901ValGly: 3.901 ± 0.12
1.508ValHis: 1.508 ± 0.063
4.793ValIle: 4.793 ± 0.13
3.762ValLys: 3.762 ± 0.098
6.066ValLeu: 6.066 ± 0.139
1.682ValMet: 1.682 ± 0.085
2.838ValAsn: 2.838 ± 0.101
2.635ValPro: 2.635 ± 0.09
2.355ValGln: 2.355 ± 0.086
3.343ValArg: 3.343 ± 0.116
4.4ValSer: 4.4 ± 0.107
3.425ValThr: 3.425 ± 0.124
4.285ValVal: 4.285 ± 0.135
0.816ValTrp: 0.816 ± 0.054
2.53ValTyr: 2.53 ± 0.102
0.0ValXaa: 0.0 ± 0.0
Trp
0.93TrpAla: 0.93 ± 0.055
0.222TrpCys: 0.222 ± 0.028
1.032TrpAsp: 1.032 ± 0.068
0.898TrpGlu: 0.898 ± 0.051
0.66TrpPhe: 0.66 ± 0.045
0.978TrpGly: 0.978 ± 0.055
0.397TrpHis: 0.397 ± 0.042
1.232TrpIle: 1.232 ± 0.078
1.0TrpLys: 1.0 ± 0.059
1.314TrpLeu: 1.314 ± 0.066
0.441TrpMet: 0.441 ± 0.037
0.749TrpAsn: 0.749 ± 0.061
0.609TrpPro: 0.609 ± 0.041
0.559TrpGln: 0.559 ± 0.046
0.765TrpArg: 0.765 ± 0.057
1.124TrpSer: 1.124 ± 0.077
0.781TrpThr: 0.781 ± 0.047
0.902TrpVal: 0.902 ± 0.059
0.254TrpTrp: 0.254 ± 0.03
0.508TrpTyr: 0.508 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.041TyrAla: 2.041 ± 0.088
0.47TyrCys: 0.47 ± 0.04
2.152TyrAsp: 2.152 ± 0.09
2.108TyrGlu: 2.108 ± 0.103
1.755TyrPhe: 1.755 ± 0.074
2.428TyrGly: 2.428 ± 0.096
0.914TyrHis: 0.914 ± 0.053
2.247TyrIle: 2.247 ± 0.094
1.867TyrLys: 1.867 ± 0.078
3.482TyrLeu: 3.482 ± 0.118
0.835TyrMet: 0.835 ± 0.059
1.606TyrAsn: 1.606 ± 0.089
1.651TyrPro: 1.651 ± 0.071
1.651TyrGln: 1.651 ± 0.085
2.298TyrArg: 2.298 ± 0.095
2.606TyrSer: 2.606 ± 0.096
1.743TyrThr: 1.743 ± 0.081
2.197TyrVal: 2.197 ± 0.089
0.594TyrTrp: 0.594 ± 0.047
1.736TyrTyr: 1.736 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.003XaaAsp: 0.003 ± 0.003
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.006
Statistics based on 1024 proteins (315021 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski