Amino acid dipepetide frequency for Histidinibacterium sp. 176SS1-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.629AlaAla: 16.629 ± 0.179	1.066AlaCys: 1.066 ± 0.034	6.49AlaAsp: 6.49 ± 0.083	9.768AlaGlu: 9.768 ± 0.136	4.104AlaPhe: 4.104 ± 0.068	10.982AlaGly: 10.982 ± 0.1	2.147AlaHis: 2.147 ± 0.047	5.358AlaIle: 5.358 ± 0.066	2.936AlaLys: 2.936 ± 0.064	14.011AlaLeu: 14.011 ± 0.168	3.493AlaMet: 3.493 ± 0.064	2.279AlaAsn: 2.279 ± 0.047	6.02AlaPro: 6.02 ± 0.086	3.817AlaGln: 3.817 ± 0.059	9.54AlaArg: 9.54 ± 0.122	5.631AlaSer: 5.631 ± 0.078	5.886AlaThr: 5.886 ± 0.08	8.849AlaVal: 8.849 ± 0.115	1.613AlaTrp: 1.613 ± 0.038	2.422AlaTyr: 2.422 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.995CysAla: 0.995 ± 0.037	0.094CysCys: 0.094 ± 0.01	0.539CysAsp: 0.539 ± 0.023	0.51CysGlu: 0.51 ± 0.024	0.277CysPhe: 0.277 ± 0.016	0.958CysGly: 0.958 ± 0.031	0.255CysHis: 0.255 ± 0.015	0.367CysIle: 0.367 ± 0.018	0.137CysLys: 0.137 ± 0.011	0.853CysLeu: 0.853 ± 0.026	0.131CysMet: 0.131 ± 0.01	0.157CysAsn: 0.157 ± 0.013	0.504CysPro: 0.504 ± 0.024	0.195CysGln: 0.195 ± 0.013	0.619CysArg: 0.619 ± 0.025	0.394CysSer: 0.394 ± 0.019	0.399CysThr: 0.399 ± 0.017	0.559CysVal: 0.559 ± 0.023	0.1CysTrp: 0.1 ± 0.01	0.19CysTyr: 0.19 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.805AspAla: 6.805 ± 0.078	0.527AspCys: 0.527 ± 0.021	3.416AspAsp: 3.416 ± 0.085	4.097AspGlu: 4.097 ± 0.07	2.198AspPhe: 2.198 ± 0.046	5.495AspGly: 5.495 ± 0.098	1.247AspHis: 1.247 ± 0.037	2.721AspIle: 2.721 ± 0.056	1.28AspLys: 1.28 ± 0.033	6.601AspLeu: 6.601 ± 0.087	1.541AspMet: 1.541 ± 0.037	1.064AspAsn: 1.064 ± 0.034	3.952AspPro: 3.952 ± 0.066	1.591AspGln: 1.591 ± 0.037	5.27AspArg: 5.27 ± 0.08	2.135AspSer: 2.135 ± 0.051	2.669AspThr: 2.669 ± 0.071	3.926AspVal: 3.926 ± 0.08	1.296AspTrp: 1.296 ± 0.035	1.51AspTyr: 1.51 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	9.871GluAla: 9.871 ± 0.14	0.335GluCys: 0.335 ± 0.019	4.016GluAsp: 4.016 ± 0.066	5.194GluGlu: 5.194 ± 0.105	1.764GluPhe: 1.764 ± 0.035	6.433GluGly: 6.433 ± 0.092	1.251GluHis: 1.251 ± 0.036	3.953GluIle: 3.953 ± 0.061	1.839GluLys: 1.839 ± 0.044	5.926GluLeu: 5.926 ± 0.08	1.987GluMet: 1.987 ± 0.043	1.635GluAsn: 1.635 ± 0.035	3.32GluPro: 3.32 ± 0.061	1.959GluGln: 1.959 ± 0.044	5.505GluArg: 5.505 ± 0.092	2.909GluSer: 2.909 ± 0.045	4.738GluThr: 4.738 ± 0.073	5.225GluVal: 5.225 ± 0.084	0.771GluTrp: 0.771 ± 0.028	1.015GluTyr: 1.015 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.24PheAla: 4.24 ± 0.067	0.398PheCys: 0.398 ± 0.018	2.724PheAsp: 2.724 ± 0.057	2.373PheGlu: 2.373 ± 0.052	1.379PhePhe: 1.379 ± 0.043	3.602PheGly: 3.602 ± 0.066	0.702PheHis: 0.702 ± 0.024	1.397PheIle: 1.397 ± 0.039	0.619PheLys: 0.619 ± 0.023	3.348PheLeu: 3.348 ± 0.052	0.735PheMet: 0.735 ± 0.024	0.853PheAsn: 0.853 ± 0.029	1.549PhePro: 1.549 ± 0.041	0.922PheGln: 0.922 ± 0.028	2.325PheArg: 2.325 ± 0.046	2.03PheSer: 2.03 ± 0.042	1.925PheThr: 1.925 ± 0.045	2.604PheVal: 2.604 ± 0.049	0.58PheTrp: 0.58 ± 0.023	0.849PheTyr: 0.849 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.369GlyAla: 10.369 ± 0.115	0.828GlyCys: 0.828 ± 0.028	4.749GlyAsp: 4.749 ± 0.115	5.882GlyGlu: 5.882 ± 0.088	3.531GlyPhe: 3.531 ± 0.062	7.918GlyGly: 7.918 ± 0.166	1.924GlyHis: 1.924 ± 0.04	4.395GlyIle: 4.395 ± 0.067	2.439GlyLys: 2.439 ± 0.047	9.92GlyLeu: 9.92 ± 0.125	2.419GlyMet: 2.419 ± 0.043	1.891GlyAsn: 1.891 ± 0.052	4.466GlyPro: 4.466 ± 0.065	2.993GlyGln: 2.993 ± 0.053	6.856GlyArg: 6.856 ± 0.094	4.423GlySer: 4.423 ± 0.099	5.148GlyThr: 5.148 ± 0.09	6.359GlyVal: 6.359 ± 0.08	1.574GlyTrp: 1.574 ± 0.038	2.322GlyTyr: 2.322 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.195HisAla: 2.195 ± 0.045	0.204HisCys: 0.204 ± 0.015	1.155HisAsp: 1.155 ± 0.037	1.22HisGlu: 1.22 ± 0.033	0.742HisPhe: 0.742 ± 0.024	1.889HisGly: 1.889 ± 0.047	0.531HisHis: 0.531 ± 0.023	0.835HisIle: 0.835 ± 0.027	0.384HisLys: 0.384 ± 0.019	2.071HisLeu: 2.071 ± 0.044	0.515HisMet: 0.515 ± 0.023	0.351HisAsn: 0.351 ± 0.016	1.363HisPro: 1.363 ± 0.034	0.535HisGln: 0.535 ± 0.022	1.519HisArg: 1.519 ± 0.038	0.832HisSer: 0.832 ± 0.027	0.719HisThr: 0.719 ± 0.025	1.505HisVal: 1.505 ± 0.036	0.335HisTrp: 0.335 ± 0.016	0.555HisTyr: 0.555 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.46IleAla: 6.46 ± 0.076	0.495IleCys: 0.495 ± 0.02	3.318IleAsp: 3.318 ± 0.064	3.598IleGlu: 3.598 ± 0.053	1.644IlePhe: 1.644 ± 0.036	4.615IleGly: 4.615 ± 0.073	0.865IleHis: 0.865 ± 0.027	1.729IleIle: 1.729 ± 0.049	0.974IleLys: 0.974 ± 0.028	4.549IleLeu: 4.549 ± 0.074	0.895IleMet: 0.895 ± 0.028	1.013IleAsn: 1.013 ± 0.03	2.16IlePro: 2.16 ± 0.04	1.001IleGln: 1.001 ± 0.032	3.196IleArg: 3.196 ± 0.052	2.595IleSer: 2.595 ± 0.053	2.357IleThr: 2.357 ± 0.051	3.861IleVal: 3.861 ± 0.063	0.636IleTrp: 0.636 ± 0.021	1.089IleTyr: 1.089 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.973LysAla: 2.973 ± 0.055	0.125LysCys: 0.125 ± 0.009	1.393LysAsp: 1.393 ± 0.042	1.423LysGlu: 1.423 ± 0.039	0.661LysPhe: 0.661 ± 0.024	2.181LysGly: 2.181 ± 0.046	0.449LysHis: 0.449 ± 0.02	1.204LysIle: 1.204 ± 0.032	0.93LysLys: 0.93 ± 0.041	2.323LysLeu: 2.323 ± 0.048	0.646LysMet: 0.646 ± 0.024	0.569LysAsn: 0.569 ± 0.023	1.363LysPro: 1.363 ± 0.04	0.663LysGln: 0.663 ± 0.028	1.933LysArg: 1.933 ± 0.047	1.474LysSer: 1.474 ± 0.037	1.573LysThr: 1.573 ± 0.037	1.927LysVal: 1.927 ± 0.046	0.308LysTrp: 0.308 ± 0.018	0.458LysTyr: 0.458 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.478LeuAla: 13.478 ± 0.172	0.966LeuCys: 0.966 ± 0.031	6.201LeuAsp: 6.201 ± 0.073	6.116LeuGlu: 6.116 ± 0.09	3.533LeuPhe: 3.533 ± 0.072	9.02LeuGly: 9.02 ± 0.106	1.831LeuHis: 1.831 ± 0.045	4.573LeuIle: 4.573 ± 0.076	2.705LeuLys: 2.705 ± 0.059	9.602LeuLeu: 9.602 ± 0.137	2.474LeuMet: 2.474 ± 0.047	2.149LeuAsn: 2.149 ± 0.045	5.725LeuPro: 5.725 ± 0.086	2.585LeuGln: 2.585 ± 0.053	7.665LeuArg: 7.665 ± 0.095	6.798LeuSer: 6.798 ± 0.085	6.102LeuThr: 6.102 ± 0.077	7.557LeuVal: 7.557 ± 0.098	1.453LeuTrp: 1.453 ± 0.044	2.044LeuTyr: 2.044 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.162MetAla: 3.162 ± 0.058	0.146MetCys: 0.146 ± 0.01	1.303MetAsp: 1.303 ± 0.037	1.51MetGlu: 1.51 ± 0.039	0.648MetPhe: 0.648 ± 0.024	2.148MetGly: 2.148 ± 0.044	0.414MetHis: 0.414 ± 0.017	1.377MetIle: 1.377 ± 0.038	0.851MetLys: 0.851 ± 0.028	2.343MetLeu: 2.343 ± 0.043	0.643MetMet: 0.643 ± 0.026	0.674MetAsn: 0.674 ± 0.027	1.479MetPro: 1.479 ± 0.036	0.837MetGln: 0.837 ± 0.026	1.904MetArg: 1.904 ± 0.042	1.705MetSer: 1.705 ± 0.037	2.116MetThr: 2.116 ± 0.045	1.705MetVal: 1.705 ± 0.041	0.224MetTrp: 0.224 ± 0.014	0.272MetTyr: 0.272 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.549AsnAla: 2.549 ± 0.047	0.223AsnCys: 0.223 ± 0.015	1.201AsnAsp: 1.201 ± 0.037	1.195AsnGlu: 1.195 ± 0.034	0.831AsnPhe: 0.831 ± 0.027	1.972AsnGly: 1.972 ± 0.049	0.434AsnHis: 0.434 ± 0.019	1.05AsnIle: 1.05 ± 0.035	0.407AsnLys: 0.407 ± 0.021	2.191AsnLeu: 2.191 ± 0.043	0.565AsnMet: 0.565 ± 0.022	0.537AsnAsn: 0.537 ± 0.026	1.57AsnPro: 1.57 ± 0.044	0.576AsnGln: 0.576 ± 0.025	1.64AsnArg: 1.64 ± 0.038	0.989AsnSer: 0.989 ± 0.031	1.049AsnThr: 1.049 ± 0.031	1.642AsnVal: 1.642 ± 0.042	0.361AsnTrp: 0.361 ± 0.018	0.544AsnTyr: 0.544 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.933ProAla: 5.933 ± 0.088	0.325ProCys: 0.325 ± 0.016	4.039ProAsp: 4.039 ± 0.064	5.285ProGlu: 5.285 ± 0.082	1.898ProPhe: 1.898 ± 0.04	5.191ProGly: 5.191 ± 0.071	1.025ProHis: 1.025 ± 0.031	2.0ProIle: 2.0 ± 0.043	1.383ProLys: 1.383 ± 0.038	4.867ProLeu: 4.867 ± 0.073	1.271ProMet: 1.271 ± 0.037	1.1ProAsn: 1.1 ± 0.033	2.852ProPro: 2.852 ± 0.069	1.572ProGln: 1.572 ± 0.038	3.331ProArg: 3.331 ± 0.065	2.574ProSer: 2.574 ± 0.045	2.379ProThr: 2.379 ± 0.045	4.526ProVal: 4.526 ± 0.072	0.75ProTrp: 0.75 ± 0.03	1.125ProTyr: 1.125 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.564GlnAla: 3.564 ± 0.064	0.17GlnCys: 0.17 ± 0.012	1.52GlnAsp: 1.52 ± 0.046	1.897GlnGlu: 1.897 ± 0.048	0.88GlnPhe: 0.88 ± 0.03	2.482GlnGly: 2.482 ± 0.056	0.494GlnHis: 0.494 ± 0.022	1.62GlnIle: 1.62 ± 0.037	0.812GlnLys: 0.812 ± 0.029	2.578GlnLeu: 2.578 ± 0.051	0.875GlnMet: 0.875 ± 0.028	0.707GlnAsn: 0.707 ± 0.03	1.486GlnPro: 1.486 ± 0.039	0.957GlnGln: 0.957 ± 0.034	2.111GlnArg: 2.111 ± 0.047	1.621GlnSer: 1.621 ± 0.038	1.647GlnThr: 1.647 ± 0.035	2.301GlnVal: 2.301 ± 0.046	0.374GlnTrp: 0.374 ± 0.019	0.51GlnTyr: 0.51 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.793ArgAla: 8.793 ± 0.104	0.497ArgCys: 0.497 ± 0.021	4.54ArgAsp: 4.54 ± 0.068	4.94ArgGlu: 4.94 ± 0.076	2.711ArgPhe: 2.711 ± 0.049	5.361ArgGly: 5.361 ± 0.067	1.714ArgHis: 1.714 ± 0.045	4.129ArgIle: 4.129 ± 0.06	1.984ArgLys: 1.984 ± 0.052	8.566ArgLeu: 8.566 ± 0.111	2.059ArgMet: 2.059 ± 0.042	1.601ArgAsn: 1.601 ± 0.041	3.969ArgPro: 3.969 ± 0.065	2.366ArgGln: 2.366 ± 0.044	6.328ArgArg: 6.328 ± 0.106	3.815ArgSer: 3.815 ± 0.063	3.638ArgThr: 3.638 ± 0.053	5.256ArgVal: 5.256 ± 0.069	1.05ArgTrp: 1.05 ± 0.03	1.602ArgTyr: 1.602 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.907SerAla: 5.907 ± 0.078	0.41SerCys: 0.41 ± 0.018	3.256SerAsp: 3.256 ± 0.06	3.485SerGlu: 3.485 ± 0.059	2.079SerPhe: 2.079 ± 0.046	5.61SerGly: 5.61 ± 0.101	1.044SerHis: 1.044 ± 0.033	2.283SerIle: 2.283 ± 0.046	1.196SerLys: 1.196 ± 0.034	5.125SerLeu: 5.125 ± 0.073	1.241SerMet: 1.241 ± 0.033	1.16SerAsn: 1.16 ± 0.035	2.691SerPro: 2.691 ± 0.048	1.461SerGln: 1.461 ± 0.035	3.699SerArg: 3.699 ± 0.065	2.6SerSer: 2.6 ± 0.062	2.436SerThr: 2.436 ± 0.052	3.916SerVal: 3.916 ± 0.069	0.744SerTrp: 0.744 ± 0.025	1.283SerTyr: 1.283 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.191ThrAla: 6.191 ± 0.076	0.447ThrCys: 0.447 ± 0.02	3.242ThrAsp: 3.242 ± 0.054	3.641ThrGlu: 3.641 ± 0.058	1.991ThrPhe: 1.991 ± 0.043	5.676ThrGly: 5.676 ± 0.088	0.986ThrHis: 0.986 ± 0.029	2.631ThrIle: 2.631 ± 0.061	1.111ThrLys: 1.111 ± 0.032	6.037ThrLeu: 6.037 ± 0.069	1.21ThrMet: 1.21 ± 0.03	1.083ThrAsn: 1.083 ± 0.034	3.242ThrPro: 3.242 ± 0.057	1.382ThrGln: 1.382 ± 0.032	3.699ThrArg: 3.699 ± 0.063	2.629ThrSer: 2.629 ± 0.058	2.699ThrThr: 2.699 ± 0.06	4.576ThrVal: 4.576 ± 0.069	0.763ThrTrp: 0.763 ± 0.028	1.201ThrTyr: 1.201 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.988ValAla: 8.988 ± 0.094	0.621ValCys: 0.621 ± 0.025	4.01ValAsp: 4.01 ± 0.067	5.28ValGlu: 5.28 ± 0.072	2.844ValPhe: 2.844 ± 0.054	5.732ValGly: 5.732 ± 0.079	1.296ValHis: 1.296 ± 0.032	3.838ValIle: 3.838 ± 0.054	1.791ValLys: 1.791 ± 0.039	7.781ValLeu: 7.781 ± 0.11	1.94ValMet: 1.94 ± 0.044	1.834ValAsn: 1.834 ± 0.048	3.86ValPro: 3.86 ± 0.069	2.001ValGln: 2.001 ± 0.041	4.894ValArg: 4.894 ± 0.075	4.456ValSer: 4.456 ± 0.079	5.048ValThr: 5.048 ± 0.079	5.905ValVal: 5.905 ± 0.086	0.994ValTrp: 0.994 ± 0.03	1.534ValTyr: 1.534 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.464TrpAla: 1.464 ± 0.039	0.138TrpCys: 0.138 ± 0.011	0.773TrpAsp: 0.773 ± 0.029	0.792TrpGlu: 0.792 ± 0.026	0.569TrpPhe: 0.569 ± 0.026	1.053TrpGly: 1.053 ± 0.029	0.344TrpHis: 0.344 ± 0.021	0.764TrpIle: 0.764 ± 0.027	0.369TrpLys: 0.369 ± 0.017	1.689TrpLeu: 1.689 ± 0.046	0.392TrpMet: 0.392 ± 0.019	0.384TrpAsn: 0.384 ± 0.017	0.777TrpPro: 0.777 ± 0.027	0.599TrpGln: 0.599 ± 0.022	1.242TrpArg: 1.242 ± 0.038	0.881TrpSer: 0.881 ± 0.026	0.87TrpThr: 0.87 ± 0.031	0.945TrpVal: 0.945 ± 0.031	0.257TrpTrp: 0.257 ± 0.014	0.254TrpTyr: 0.254 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.477TyrAla: 2.477 ± 0.048	0.218TyrCys: 0.218 ± 0.013	1.457TyrAsp: 1.457 ± 0.038	1.44TyrGlu: 1.44 ± 0.035	0.871TyrPhe: 0.871 ± 0.032	2.088TyrGly: 2.088 ± 0.046	0.501TyrHis: 0.501 ± 0.022	0.826TyrIle: 0.826 ± 0.028	0.429TyrLys: 0.429 ± 0.019	2.197TyrLeu: 2.197 ± 0.047	0.427TyrMet: 0.427 ± 0.021	0.484TyrAsn: 0.484 ± 0.019	1.081TyrPro: 1.081 ± 0.034	0.592TyrGln: 0.592 ± 0.025	1.643TyrArg: 1.643 ± 0.04	1.135TyrSer: 1.135 ± 0.029	1.038TyrThr: 1.038 ± 0.035	1.503TyrVal: 1.503 ± 0.041	0.372TyrTrp: 0.372 ± 0.017	0.533TyrTyr: 0.533 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3759 proteins (1173173 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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