Amino acid dipepetide frequency for gamma proteobacterium HTCC2207

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.676AlaAla: 10.676 ± 0.149	0.943AlaCys: 0.943 ± 0.037	6.251AlaAsp: 6.251 ± 0.095	6.852AlaGlu: 6.852 ± 0.103	3.365AlaPhe: 3.365 ± 0.077	7.562AlaGly: 7.562 ± 0.122	1.545AlaHis: 1.545 ± 0.046	5.929AlaIle: 5.929 ± 0.096	4.154AlaLys: 4.154 ± 0.091	10.279AlaLeu: 10.279 ± 0.132	2.782AlaMet: 2.782 ± 0.061	3.483AlaAsn: 3.483 ± 0.075	3.476AlaPro: 3.476 ± 0.078	3.866AlaGln: 3.866 ± 0.073	4.382AlaArg: 4.382 ± 0.074	5.897AlaSer: 5.897 ± 0.095	5.04AlaThr: 5.04 ± 0.099	7.091AlaVal: 7.091 ± 0.111	0.959AlaTrp: 0.959 ± 0.038	2.331AlaTyr: 2.331 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.975CysAla: 0.975 ± 0.036	0.154CysCys: 0.154 ± 0.014	0.605CysAsp: 0.605 ± 0.029	0.578CysGlu: 0.578 ± 0.028	0.417CysPhe: 0.417 ± 0.024	1.051CysGly: 1.051 ± 0.039	0.306CysHis: 0.306 ± 0.023	0.521CysIle: 0.521 ± 0.027	0.342CysLys: 0.342 ± 0.024	0.962CysLeu: 0.962 ± 0.037	0.225CysMet: 0.225 ± 0.017	0.376CysAsn: 0.376 ± 0.023	0.456CysPro: 0.456 ± 0.027	0.419CysGln: 0.419 ± 0.022	0.532CysArg: 0.532 ± 0.029	0.701CysSer: 0.701 ± 0.032	0.506CysThr: 0.506 ± 0.025	0.602CysVal: 0.602 ± 0.029	0.113CysTrp: 0.113 ± 0.012	0.311CysTyr: 0.311 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	5.289AspAla: 5.289 ± 0.09	0.606AspCys: 0.606 ± 0.029	3.17AspAsp: 3.17 ± 0.059	3.536AspGlu: 3.536 ± 0.086	2.544AspPhe: 2.544 ± 0.061	4.524AspGly: 4.524 ± 0.105	1.242AspHis: 1.242 ± 0.042	4.132AspIle: 4.132 ± 0.062	2.689AspLys: 2.689 ± 0.065	5.939AspLeu: 5.939 ± 0.099	1.603AspMet: 1.603 ± 0.044	2.42AspAsn: 2.42 ± 0.052	2.454AspPro: 2.454 ± 0.063	2.737AspGln: 2.737 ± 0.065	2.869AspArg: 2.869 ± 0.057	4.03AspSer: 4.03 ± 0.085	2.663AspThr: 2.663 ± 0.066	3.831AspVal: 3.831 ± 0.075	0.97AspTrp: 0.97 ± 0.038	2.136AspTyr: 2.136 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.689GluAla: 5.689 ± 0.09	0.426GluCys: 0.426 ± 0.023	2.994GluAsp: 2.994 ± 0.07	3.626GluGlu: 3.626 ± 0.082	2.271GluPhe: 2.271 ± 0.056	3.967GluGly: 3.967 ± 0.072	1.318GluHis: 1.318 ± 0.043	4.122GluIle: 4.122 ± 0.077	3.118GluLys: 3.118 ± 0.062	6.555GluLeu: 6.555 ± 0.103	1.638GluMet: 1.638 ± 0.045	2.298GluAsn: 2.298 ± 0.064	2.227GluPro: 2.227 ± 0.057	3.59GluGln: 3.59 ± 0.081	3.433GluArg: 3.433 ± 0.072	3.694GluSer: 3.694 ± 0.073	3.316GluThr: 3.316 ± 0.071	4.205GluVal: 4.205 ± 0.087	0.712GluTrp: 0.712 ± 0.032	1.474GluTyr: 1.474 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.554PheAla: 3.554 ± 0.072	0.492PheCys: 0.492 ± 0.023	2.842PheAsp: 2.842 ± 0.059	2.267PheGlu: 2.267 ± 0.056	1.585PhePhe: 1.585 ± 0.057	3.3PheGly: 3.3 ± 0.069	0.715PheHis: 0.715 ± 0.031	2.345PheIle: 2.345 ± 0.063	1.677PheLys: 1.677 ± 0.037	3.409PheLeu: 3.409 ± 0.075	0.998PheMet: 0.998 ± 0.038	1.71PheAsn: 1.71 ± 0.047	1.501PhePro: 1.501 ± 0.048	1.23PheGln: 1.23 ± 0.043	1.585PheArg: 1.585 ± 0.044	3.185PheSer: 3.185 ± 0.075	2.172PheThr: 2.172 ± 0.052	2.678PheVal: 2.678 ± 0.064	0.48PheTrp: 0.48 ± 0.025	1.305PheTyr: 1.305 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	6.785GlyAla: 6.785 ± 0.127	0.931GlyCys: 0.931 ± 0.038	4.499GlyAsp: 4.499 ± 0.093	4.665GlyGlu: 4.665 ± 0.085	3.508GlyPhe: 3.508 ± 0.07	5.984GlyGly: 5.984 ± 0.097	1.595GlyHis: 1.595 ± 0.046	4.868GlyIle: 4.868 ± 0.082	3.524GlyLys: 3.524 ± 0.084	7.912GlyLeu: 7.912 ± 0.111	2.257GlyMet: 2.257 ± 0.058	2.652GlyAsn: 2.652 ± 0.068	2.258GlyPro: 2.258 ± 0.065	2.919GlyGln: 2.919 ± 0.063	3.723GlyArg: 3.723 ± 0.078	5.063GlySer: 5.063 ± 0.103	3.929GlyThr: 3.929 ± 0.08	5.549GlyVal: 5.549 ± 0.103	1.085GlyTrp: 1.085 ± 0.039	2.52GlyTyr: 2.52 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.518HisAla: 1.518 ± 0.049	0.325HisCys: 0.325 ± 0.021	0.914HisAsp: 0.914 ± 0.035	0.885HisGlu: 0.885 ± 0.039	0.909HisPhe: 0.909 ± 0.029	1.557HisGly: 1.557 ± 0.051	0.533HisHis: 0.533 ± 0.03	1.279HisIle: 1.279 ± 0.038	0.818HisLys: 0.818 ± 0.033	2.068HisLeu: 2.068 ± 0.058	0.484HisMet: 0.484 ± 0.024	0.799HisAsn: 0.799 ± 0.028	1.134HisPro: 1.134 ± 0.041	0.999HisGln: 0.999 ± 0.036	1.126HisArg: 1.126 ± 0.04	1.534HisSer: 1.534 ± 0.046	0.823HisThr: 0.823 ± 0.035	1.099HisVal: 1.099 ± 0.039	0.329HisTrp: 0.329 ± 0.022	0.687HisTyr: 0.687 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.681IleAla: 6.681 ± 0.098	0.748IleCys: 0.748 ± 0.036	4.332IleAsp: 4.332 ± 0.077	4.386IleGlu: 4.386 ± 0.087	2.205IlePhe: 2.205 ± 0.071	4.711IleGly: 4.711 ± 0.093	1.079IleHis: 1.079 ± 0.033	3.415IleIle: 3.415 ± 0.085	2.724IleLys: 2.724 ± 0.054	5.19IleLeu: 5.19 ± 0.09	1.283IleMet: 1.283 ± 0.036	2.999IleAsn: 2.999 ± 0.072	2.731IlePro: 2.731 ± 0.058	1.887IleGln: 1.887 ± 0.056	2.829IleArg: 2.829 ± 0.063	4.553IleSer: 4.553 ± 0.081	3.461IleThr: 3.461 ± 0.073	4.027IleVal: 4.027 ± 0.076	0.64IleTrp: 0.64 ± 0.031	1.689IleTyr: 1.689 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.258LysAla: 4.258 ± 0.09	0.289LysCys: 0.289 ± 0.021	2.155LysAsp: 2.155 ± 0.053	2.037LysGlu: 2.037 ± 0.059	1.32LysPhe: 1.32 ± 0.041	2.904LysGly: 2.904 ± 0.081	0.868LysHis: 0.868 ± 0.039	2.715LysIle: 2.715 ± 0.062	2.205LysLys: 2.205 ± 0.072	4.607LysLeu: 4.607 ± 0.071	1.218LysMet: 1.218 ± 0.038	1.745LysAsn: 1.745 ± 0.05	2.049LysPro: 2.049 ± 0.06	2.138LysGln: 2.138 ± 0.059	2.421LysArg: 2.421 ± 0.061	2.637LysSer: 2.637 ± 0.055	2.697LysThr: 2.697 ± 0.062	3.165LysVal: 3.165 ± 0.075	0.442LysTrp: 0.442 ± 0.023	1.106LysTyr: 1.106 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	10.348LeuAla: 10.348 ± 0.128	1.102LeuCys: 1.102 ± 0.041	6.049LeuAsp: 6.049 ± 0.091	6.169LeuGlu: 6.169 ± 0.096	3.894LeuPhe: 3.894 ± 0.076	7.569LeuGly: 7.569 ± 0.112	1.897LeuHis: 1.897 ± 0.053	6.133LeuIle: 6.133 ± 0.087	4.517LeuLys: 4.517 ± 0.079	10.325LeuLeu: 10.325 ± 0.148	2.706LeuMet: 2.706 ± 0.064	3.917LeuAsn: 3.917 ± 0.067	4.671LeuPro: 4.671 ± 0.066	4.141LeuGln: 4.141 ± 0.085	5.27LeuArg: 5.27 ± 0.091	7.684LeuSer: 7.684 ± 0.121	5.254LeuThr: 5.254 ± 0.09	7.268LeuVal: 7.268 ± 0.114	1.207LeuTrp: 1.207 ± 0.037	2.453LeuTyr: 2.453 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.837MetAla: 2.837 ± 0.057	0.163MetCys: 0.163 ± 0.014	1.451MetAsp: 1.451 ± 0.043	1.336MetGlu: 1.336 ± 0.042	0.848MetPhe: 0.848 ± 0.037	1.932MetGly: 1.932 ± 0.057	0.561MetHis: 0.561 ± 0.026	1.5MetIle: 1.5 ± 0.043	1.134MetLys: 1.134 ± 0.036	2.751MetLeu: 2.751 ± 0.066	0.655MetMet: 0.655 ± 0.031	0.926MetAsn: 0.926 ± 0.035	1.297MetPro: 1.297 ± 0.041	1.105MetGln: 1.105 ± 0.04	1.379MetArg: 1.379 ± 0.039	1.952MetSer: 1.952 ± 0.05	1.686MetThr: 1.686 ± 0.055	1.932MetVal: 1.932 ± 0.046	0.203MetTrp: 0.203 ± 0.015	0.475MetTyr: 0.475 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.339AsnAla: 3.339 ± 0.066	0.489AsnCys: 0.489 ± 0.027	2.023AsnAsp: 2.023 ± 0.059	1.843AsnGlu: 1.843 ± 0.045	1.501AsnPhe: 1.501 ± 0.049	2.868AsnGly: 2.868 ± 0.061	0.765AsnHis: 0.765 ± 0.031	2.567AsnIle: 2.567 ± 0.065	1.629AsnLys: 1.629 ± 0.046	3.779AsnLeu: 3.779 ± 0.078	0.97AsnMet: 0.97 ± 0.035	1.694AsnAsn: 1.694 ± 0.056	2.16AsnPro: 2.16 ± 0.056	1.819AsnGln: 1.819 ± 0.052	2.096AsnArg: 2.096 ± 0.055	2.719AsnSer: 2.719 ± 0.069	1.936AsnThr: 1.936 ± 0.068	2.314AsnVal: 2.314 ± 0.054	0.593AsnTrp: 0.593 ± 0.028	1.246AsnTyr: 1.246 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	3.983ProAla: 3.983 ± 0.08	0.34ProCys: 0.34 ± 0.022	2.535ProAsp: 2.535 ± 0.068	3.478ProGlu: 3.478 ± 0.072	1.654ProPhe: 1.654 ± 0.05	3.063ProGly: 3.063 ± 0.071	0.792ProHis: 0.792 ± 0.033	2.413ProIle: 2.413 ± 0.06	1.78ProLys: 1.78 ± 0.051	4.272ProLeu: 4.272 ± 0.076	1.031ProMet: 1.031 ± 0.037	1.549ProAsn: 1.549 ± 0.044	1.323ProPro: 1.323 ± 0.044	1.792ProGln: 1.792 ± 0.052	1.713ProArg: 1.713 ± 0.049	2.82ProSer: 2.82 ± 0.068	2.1ProThr: 2.1 ± 0.053	3.288ProVal: 3.288 ± 0.072	0.53ProTrp: 0.53 ± 0.03	1.043ProTyr: 1.043 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.21GlnAla: 4.21 ± 0.094	0.357GlnCys: 0.357 ± 0.023	1.869GlnAsp: 1.869 ± 0.054	2.025GlnGlu: 2.025 ± 0.059	1.683GlnPhe: 1.683 ± 0.045	3.072GlnGly: 3.072 ± 0.079	0.98GlnHis: 0.98 ± 0.041	2.515GlnIle: 2.515 ± 0.05	1.557GlnLys: 1.557 ± 0.048	5.179GlnLeu: 5.179 ± 0.113	1.138GlnMet: 1.138 ± 0.037	1.343GlnAsn: 1.343 ± 0.045	1.969GlnPro: 1.969 ± 0.057	2.858GlnGln: 2.858 ± 0.093	2.916GlnArg: 2.916 ± 0.062	2.828GlnSer: 2.828 ± 0.059	2.082GlnThr: 2.082 ± 0.048	3.1GlnVal: 3.1 ± 0.064	0.645GlnTrp: 0.645 ± 0.031	1.061GlnTyr: 1.061 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.125ArgAla: 4.125 ± 0.081	0.509ArgCys: 0.509 ± 0.03	3.034ArgAsp: 3.034 ± 0.067	3.387ArgGlu: 3.387 ± 0.072	2.349ArgPhe: 2.349 ± 0.058	3.532ArgGly: 3.532 ± 0.06	1.134ArgHis: 1.134 ± 0.042	3.131ArgIle: 3.131 ± 0.059	2.144ArgLys: 2.144 ± 0.053	5.459ArgLeu: 5.459 ± 0.095	1.257ArgMet: 1.257 ± 0.038	1.898ArgAsn: 1.898 ± 0.053	1.977ArgPro: 1.977 ± 0.055	2.461ArgGln: 2.461 ± 0.063	2.926ArgArg: 2.926 ± 0.069	3.219ArgSer: 3.219 ± 0.07	2.095ArgThr: 2.095 ± 0.048	3.392ArgVal: 3.392 ± 0.073	0.727ArgTrp: 0.727 ± 0.029	1.608ArgTyr: 1.608 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.774SerAla: 6.774 ± 0.116	0.669SerCys: 0.669 ± 0.033	4.342SerAsp: 4.342 ± 0.071	4.027SerGlu: 4.027 ± 0.083	2.727SerPhe: 2.727 ± 0.065	5.956SerGly: 5.956 ± 0.093	1.347SerHis: 1.347 ± 0.043	4.138SerIle: 4.138 ± 0.08	2.706SerLys: 2.706 ± 0.063	7.018SerLeu: 7.018 ± 0.114	1.772SerMet: 1.772 ± 0.052	2.555SerAsn: 2.555 ± 0.071	2.723SerPro: 2.723 ± 0.062	2.845SerGln: 2.845 ± 0.062	3.292SerArg: 3.292 ± 0.063	4.766SerSer: 4.766 ± 0.1	3.306SerThr: 3.306 ± 0.07	4.765SerVal: 4.765 ± 0.083	0.885SerTrp: 0.885 ± 0.038	1.901SerTyr: 1.901 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	5.331ThrAla: 5.331 ± 0.098	0.446ThrCys: 0.446 ± 0.029	3.342ThrAsp: 3.342 ± 0.081	3.145ThrGlu: 3.145 ± 0.072	1.911ThrPhe: 1.911 ± 0.058	4.384ThrGly: 4.384 ± 0.101	0.966ThrHis: 0.966 ± 0.036	3.05ThrIle: 3.05 ± 0.071	1.797ThrLys: 1.797 ± 0.049	5.647ThrLeu: 5.647 ± 0.091	1.2ThrMet: 1.2 ± 0.034	1.812ThrAsn: 1.812 ± 0.045	2.594ThrPro: 2.594 ± 0.066	1.99ThrGln: 1.99 ± 0.051	2.222ThrArg: 2.222 ± 0.057	3.305ThrSer: 3.305 ± 0.074	2.741ThrThr: 2.741 ± 0.077	4.235ThrVal: 4.235 ± 0.097	0.518ThrTrp: 0.518 ± 0.024	1.333ThrTyr: 1.333 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.255ValAla: 7.255 ± 0.106	0.673ValCys: 0.673 ± 0.029	4.737ValAsp: 4.737 ± 0.086	4.509ValGlu: 4.509 ± 0.085	2.61ValPhe: 2.61 ± 0.071	5.235ValGly: 5.235 ± 0.096	1.248ValHis: 1.248 ± 0.04	4.629ValIle: 4.629 ± 0.084	2.849ValLys: 2.849 ± 0.059	6.577ValLeu: 6.577 ± 0.107	1.894ValMet: 1.894 ± 0.05	2.72ValAsn: 2.72 ± 0.057	2.76ValPro: 2.76 ± 0.064	2.273ValGln: 2.273 ± 0.049	3.278ValArg: 3.278 ± 0.059	4.989ValSer: 4.989 ± 0.086	4.287ValThr: 4.287 ± 0.109	5.624ValVal: 5.624 ± 0.101	0.715ValTrp: 0.715 ± 0.03	1.685ValTyr: 1.685 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.866TrpAla: 0.866 ± 0.036	0.158TrpCys: 0.158 ± 0.016	0.705TrpAsp: 0.705 ± 0.031	0.529TrpGlu: 0.529 ± 0.027	0.518TrpPhe: 0.518 ± 0.027	0.866TrpGly: 0.866 ± 0.036	0.316TrpHis: 0.316 ± 0.02	0.704TrpIle: 0.704 ± 0.03	0.459TrpLys: 0.459 ± 0.025	1.641TrpLeu: 1.641 ± 0.044	0.375TrpMet: 0.375 ± 0.025	0.478TrpAsn: 0.478 ± 0.025	0.493TrpPro: 0.493 ± 0.026	0.868TrpGln: 0.868 ± 0.038	0.697TrpArg: 0.697 ± 0.031	0.759TrpSer: 0.759 ± 0.032	0.561TrpThr: 0.561 ± 0.028	0.845TrpVal: 0.845 ± 0.033	0.18TrpTrp: 0.18 ± 0.017	0.329TrpTyr: 0.329 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.368TyrAla: 2.368 ± 0.058	0.331TyrCys: 0.331 ± 0.022	1.534TyrAsp: 1.534 ± 0.051	1.394TyrGlu: 1.394 ± 0.037	1.211TyrPhe: 1.211 ± 0.041	2.191TyrGly: 2.191 ± 0.061	0.613TyrHis: 0.613 ± 0.029	1.463TyrIle: 1.463 ± 0.052	1.153TyrLys: 1.153 ± 0.035	3.008TyrLeu: 3.008 ± 0.066	0.637TyrMet: 0.637 ± 0.026	0.976TyrAsn: 0.976 ± 0.036	1.248TyrPro: 1.248 ± 0.045	1.45TyrGln: 1.45 ± 0.044	1.672TyrArg: 1.672 ± 0.05	2.178TyrSer: 2.178 ± 0.056	1.313TyrThr: 1.313 ± 0.052	1.539TyrVal: 1.539 ± 0.049	0.414TyrTrp: 0.414 ± 0.023	0.925TyrTyr: 0.925 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2388 proteins (778587 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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