Amino acid dipepetide frequency for Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.808AlaAla: 7.808 ± 0.128
1.033AlaCys: 1.033 ± 0.021
4.134AlaAsp: 4.134 ± 0.048
4.669AlaGlu: 4.669 ± 0.051
3.104AlaPhe: 3.104 ± 0.04
4.814AlaGly: 4.814 ± 0.056
1.881AlaHis: 1.881 ± 0.03
3.694AlaIle: 3.694 ± 0.043
4.429AlaLys: 4.429 ± 0.049
7.883AlaLeu: 7.883 ± 0.065
1.587AlaMet: 1.587 ± 0.029
2.976AlaAsn: 2.976 ± 0.035
4.14AlaPro: 4.14 ± 0.061
3.1AlaGln: 3.1 ± 0.037
4.328AlaArg: 4.328 ± 0.049
6.485AlaSer: 6.485 ± 0.061
4.061AlaThr: 4.061 ± 0.047
4.987AlaVal: 4.987 ± 0.057
0.761AlaTrp: 0.761 ± 0.018
2.1AlaTyr: 2.1 ± 0.033
0.0AlaXaa: 0.0 ± 0.0
Cys
0.904CysAla: 0.904 ± 0.019
0.263CysCys: 0.263 ± 0.01
0.734CysAsp: 0.734 ± 0.018
0.711CysGlu: 0.711 ± 0.019
0.766CysPhe: 0.766 ± 0.019
0.971CysGly: 0.971 ± 0.023
0.363CysHis: 0.363 ± 0.014
0.739CysIle: 0.739 ± 0.02
0.644CysLys: 0.644 ± 0.015
1.514CysLeu: 1.514 ± 0.026
0.292CysMet: 0.292 ± 0.011
0.5CysAsn: 0.5 ± 0.017
0.596CysPro: 0.596 ± 0.013
0.426CysGln: 0.426 ± 0.013
0.631CysArg: 0.631 ± 0.019
0.99CysSer: 0.99 ± 0.021
0.641CysThr: 0.641 ± 0.015
0.918CysVal: 0.918 ± 0.022
0.159CysTrp: 0.159 ± 0.008
0.422CysTyr: 0.422 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.419AspAla: 4.419 ± 0.055
0.664AspCys: 0.664 ± 0.019
4.075AspAsp: 4.075 ± 0.066
4.472AspGlu: 4.472 ± 0.054
2.908AspPhe: 2.908 ± 0.032
3.099AspGly: 3.099 ± 0.042
1.27AspHis: 1.27 ± 0.023
3.334AspIle: 3.334 ± 0.04
2.885AspLys: 2.885 ± 0.034
6.231AspLeu: 6.231 ± 0.053
1.268AspMet: 1.268 ± 0.022
2.113AspAsn: 2.113 ± 0.032
2.679AspPro: 2.679 ± 0.036
1.796AspGln: 1.796 ± 0.027
2.369AspArg: 2.369 ± 0.035
4.557AspSer: 4.557 ± 0.05
2.885AspThr: 2.885 ± 0.033
3.779AspVal: 3.779 ± 0.043
0.667AspTrp: 0.667 ± 0.017
1.924AspTyr: 1.924 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
4.45GluAla: 4.45 ± 0.045
0.669GluCys: 0.669 ± 0.019
3.946GluAsp: 3.946 ± 0.055
4.734GluGlu: 4.734 ± 0.065
2.622GluPhe: 2.622 ± 0.03
2.757GluGly: 2.757 ± 0.037
1.435GluHis: 1.435 ± 0.026
3.836GluIle: 3.836 ± 0.049
4.602GluLys: 4.602 ± 0.047
6.369GluLeu: 6.369 ± 0.064
1.363GluMet: 1.363 ± 0.022
3.482GluAsn: 3.482 ± 0.041
2.421GluPro: 2.421 ± 0.035
2.354GluGln: 2.354 ± 0.032
2.993GluArg: 2.993 ± 0.036
4.581GluSer: 4.581 ± 0.051
3.556GluThr: 3.556 ± 0.04
3.374GluVal: 3.374 ± 0.043
0.641GluTrp: 0.641 ± 0.015
2.037GluTyr: 2.037 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.18PheAla: 3.18 ± 0.034
0.69PheCys: 0.69 ± 0.017
2.825PheAsp: 2.825 ± 0.033
2.739PheGlu: 2.739 ± 0.034
2.193PhePhe: 2.193 ± 0.036
2.927PheGly: 2.927 ± 0.044
1.108PheHis: 1.108 ± 0.02
2.192PheIle: 2.192 ± 0.032
2.457PheLys: 2.457 ± 0.033
4.711PheLeu: 4.711 ± 0.049
0.955PheMet: 0.955 ± 0.021
1.987PheAsn: 1.987 ± 0.03
1.897PhePro: 1.897 ± 0.028
1.715PheGln: 1.715 ± 0.027
2.037PheArg: 2.037 ± 0.027
3.773PheSer: 3.773 ± 0.052
2.281PheThr: 2.281 ± 0.029
3.102PheVal: 3.102 ± 0.036
0.584PheTrp: 0.584 ± 0.016
1.462PheTyr: 1.462 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
4.631GlyAla: 4.631 ± 0.055
0.82GlyCys: 0.82 ± 0.022
3.126GlyAsp: 3.126 ± 0.042
3.122GlyGlu: 3.122 ± 0.039
2.745GlyPhe: 2.745 ± 0.035
3.841GlyGly: 3.841 ± 0.057
1.493GlyHis: 1.493 ± 0.029
3.137GlyIle: 3.137 ± 0.042
3.397GlyLys: 3.397 ± 0.046
5.855GlyLeu: 5.855 ± 0.057
1.137GlyMet: 1.137 ± 0.026
2.424GlyAsn: 2.424 ± 0.037
2.643GlyPro: 2.643 ± 0.039
1.865GlyGln: 1.865 ± 0.033
2.87GlyArg: 2.87 ± 0.045
4.819GlySer: 4.819 ± 0.049
3.034GlyThr: 3.034 ± 0.038
3.767GlyVal: 3.767 ± 0.041
0.667GlyTrp: 0.667 ± 0.017
1.774GlyTyr: 1.774 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
1.763HisAla: 1.763 ± 0.027
0.348HisCys: 0.348 ± 0.011
1.357HisAsp: 1.357 ± 0.024
1.492HisGlu: 1.492 ± 0.025
1.101HisPhe: 1.101 ± 0.02
1.521HisGly: 1.521 ± 0.027
0.723HisHis: 0.723 ± 0.021
1.317HisIle: 1.317 ± 0.023
1.342HisLys: 1.342 ± 0.025
2.586HisLeu: 2.586 ± 0.035
0.546HisMet: 0.546 ± 0.014
1.009HisAsn: 1.009 ± 0.021
1.255HisPro: 1.255 ± 0.025
1.012HisGln: 1.012 ± 0.022
1.247HisArg: 1.247 ± 0.024
1.847HisSer: 1.847 ± 0.03
1.303HisThr: 1.303 ± 0.024
1.734HisVal: 1.734 ± 0.029
0.265HisTrp: 0.265 ± 0.01
0.779HisTyr: 0.779 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
3.679IleAla: 3.679 ± 0.042
0.811IleCys: 0.811 ± 0.018
3.374IleAsp: 3.374 ± 0.042
3.295IleGlu: 3.295 ± 0.042
2.367IlePhe: 2.367 ± 0.034
2.82IleGly: 2.82 ± 0.04
1.345IleHis: 1.345 ± 0.023
2.763IleIle: 2.763 ± 0.041
3.117IleLys: 3.117 ± 0.04
5.536IleLeu: 5.536 ± 0.055
1.131IleMet: 1.131 ± 0.024
2.439IleAsn: 2.439 ± 0.036
2.641IlePro: 2.641 ± 0.038
1.925IleGln: 1.925 ± 0.028
2.593IleArg: 2.593 ± 0.037
4.667IleSer: 4.667 ± 0.046
2.82IleThr: 2.82 ± 0.035
3.488IleVal: 3.488 ± 0.037
0.585IleTrp: 0.585 ± 0.015
1.727IleTyr: 1.727 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.269LysAla: 4.269 ± 0.048
0.677LysCys: 0.677 ± 0.017
3.303LysAsp: 3.303 ± 0.042
3.796LysGlu: 3.796 ± 0.045
2.571LysPhe: 2.571 ± 0.037
2.659LysGly: 2.659 ± 0.034
1.522LysHis: 1.522 ± 0.026
3.602LysIle: 3.602 ± 0.039
4.913LysLys: 4.913 ± 0.064
6.433LysLeu: 6.433 ± 0.059
1.263LysMet: 1.263 ± 0.024
3.051LysAsn: 3.051 ± 0.035
2.738LysPro: 2.738 ± 0.036
2.411LysGln: 2.411 ± 0.036
3.294LysArg: 3.294 ± 0.04
4.556LysSer: 4.556 ± 0.057
3.529LysThr: 3.529 ± 0.035
3.508LysVal: 3.508 ± 0.043
0.671LysTrp: 0.671 ± 0.016
2.129LysTyr: 2.129 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
8.681LeuAla: 8.681 ± 0.078
1.48LeuCys: 1.48 ± 0.028
5.954LeuAsp: 5.954 ± 0.049
6.327LeuGlu: 6.327 ± 0.065
4.392LeuPhe: 4.392 ± 0.048
5.818LeuGly: 5.818 ± 0.052
2.51LeuHis: 2.51 ± 0.038
5.036LeuIle: 5.036 ± 0.057
6.437LeuLys: 6.437 ± 0.067
10.937LeuLeu: 10.937 ± 0.093
2.135LeuMet: 2.135 ± 0.033
4.576LeuAsn: 4.576 ± 0.048
5.079LeuPro: 5.079 ± 0.051
4.412LeuGln: 4.412 ± 0.048
5.831LeuArg: 5.831 ± 0.047
8.501LeuSer: 8.501 ± 0.068
5.166LeuThr: 5.166 ± 0.051
6.897LeuVal: 6.897 ± 0.063
1.058LeuTrp: 1.058 ± 0.023
3.071LeuTyr: 3.071 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
1.872MetAla: 1.872 ± 0.028
0.293MetCys: 0.293 ± 0.011
1.234MetAsp: 1.234 ± 0.025
1.193MetGlu: 1.193 ± 0.023
0.878MetPhe: 0.878 ± 0.016
1.285MetGly: 1.285 ± 0.025
0.427MetHis: 0.427 ± 0.013
1.053MetIle: 1.053 ± 0.023
1.317MetLys: 1.317 ± 0.023
1.99MetLeu: 1.99 ± 0.027
0.497MetMet: 0.497 ± 0.016
0.975MetAsn: 0.975 ± 0.022
1.017MetPro: 1.017 ± 0.02
0.671MetGln: 0.671 ± 0.019
1.07MetArg: 1.07 ± 0.019
1.974MetSer: 1.974 ± 0.027
1.106MetThr: 1.106 ± 0.021
1.287MetVal: 1.287 ± 0.023
0.204MetTrp: 0.204 ± 0.011
0.667MetTyr: 0.667 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.056AsnAla: 3.056 ± 0.036
0.565AsnCys: 0.565 ± 0.017
2.545AsnAsp: 2.545 ± 0.034
2.822AsnGlu: 2.822 ± 0.039
2.136AsnPhe: 2.136 ± 0.033
2.62AsnGly: 2.62 ± 0.038
1.054AsnHis: 1.054 ± 0.021
2.593AsnIle: 2.593 ± 0.033
2.499AsnLys: 2.499 ± 0.037
4.543AsnLeu: 4.543 ± 0.046
1.007AsnMet: 1.007 ± 0.022
1.986AsnAsn: 1.986 ± 0.044
2.235AsnPro: 2.235 ± 0.036
1.48AsnGln: 1.48 ± 0.029
1.868AsnArg: 1.868 ± 0.028
3.653AsnSer: 3.653 ± 0.047
2.519AsnThr: 2.519 ± 0.031
2.787AsnVal: 2.787 ± 0.031
0.521AsnTrp: 0.521 ± 0.016
1.564AsnTyr: 1.564 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
4.305ProAla: 4.305 ± 0.061
0.465ProCys: 0.465 ± 0.014
2.552ProAsp: 2.552 ± 0.032
3.516ProGlu: 3.516 ± 0.041
1.971ProPhe: 1.971 ± 0.029
3.103ProGly: 3.103 ± 0.047
1.253ProHis: 1.253 ± 0.024
2.211ProIle: 2.211 ± 0.031
2.742ProLys: 2.742 ± 0.037
4.574ProLeu: 4.574 ± 0.05
0.882ProMet: 0.882 ± 0.019
1.908ProAsn: 1.908 ± 0.031
3.024ProPro: 3.024 ± 0.07
2.185ProGln: 2.185 ± 0.038
2.575ProArg: 2.575 ± 0.036
4.013ProSer: 4.013 ± 0.052
2.447ProThr: 2.447 ± 0.036
3.28ProVal: 3.28 ± 0.037
0.48ProTrp: 0.48 ± 0.013
1.328ProTyr: 1.328 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
2.943GlnAla: 2.943 ± 0.039
0.405GlnCys: 0.405 ± 0.013
1.963GlnAsp: 1.963 ± 0.026
2.339GlnGlu: 2.339 ± 0.036
1.63GlnPhe: 1.63 ± 0.022
1.869GlnGly: 1.869 ± 0.029
0.975GlnHis: 0.975 ± 0.023
2.276GlnIle: 2.276 ± 0.033
2.616GlnLys: 2.616 ± 0.036
4.053GlnLeu: 4.053 ± 0.045
0.897GlnMet: 0.897 ± 0.022
1.986GlnAsn: 1.986 ± 0.03
1.768GlnPro: 1.768 ± 0.032
2.163GlnGln: 2.163 ± 0.079
1.966GlnArg: 1.966 ± 0.029
2.632GlnSer: 2.632 ± 0.036
2.144GlnThr: 2.144 ± 0.032
2.17GlnVal: 2.17 ± 0.029
0.396GlnTrp: 0.396 ± 0.013
1.247GlnTyr: 1.247 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
3.9ArgAla: 3.9 ± 0.045
0.641ArgCys: 0.641 ± 0.017
2.763ArgAsp: 2.763 ± 0.039
2.993ArgGlu: 2.993 ± 0.035
2.263ArgPhe: 2.263 ± 0.031
2.721ArgGly: 2.721 ± 0.039
1.363ArgHis: 1.363 ± 0.024
2.649ArgIle: 2.649 ± 0.032
3.534ArgLys: 3.534 ± 0.045
5.544ArgLeu: 5.544 ± 0.043
1.063ArgMet: 1.063 ± 0.017
2.329ArgAsn: 2.329 ± 0.029
2.51ArgPro: 2.51 ± 0.039
2.065ArgGln: 2.065 ± 0.036
3.433ArgArg: 3.433 ± 0.047
3.696ArgSer: 3.696 ± 0.04
2.496ArgThr: 2.496 ± 0.031
3.139ArgVal: 3.139 ± 0.033
0.542ArgTrp: 0.542 ± 0.015
1.488ArgTyr: 1.488 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
6.116SerAla: 6.116 ± 0.056
0.974SerCys: 0.974 ± 0.021
4.453SerAsp: 4.453 ± 0.052
4.793SerGlu: 4.793 ± 0.06
3.701SerPhe: 3.701 ± 0.044
4.876SerGly: 4.876 ± 0.052
1.99SerHis: 1.99 ± 0.032
4.326SerIle: 4.326 ± 0.049
4.783SerLys: 4.783 ± 0.054
8.676SerLeu: 8.676 ± 0.075
1.72SerMet: 1.72 ± 0.029
3.33SerAsn: 3.33 ± 0.04
4.087SerPro: 4.087 ± 0.05
3.076SerGln: 3.076 ± 0.042
4.102SerArg: 4.102 ± 0.04
7.986SerSer: 7.986 ± 0.104
4.542SerThr: 4.542 ± 0.052
5.207SerVal: 5.207 ± 0.049
0.851SerTrp: 0.851 ± 0.02
2.26SerTyr: 2.26 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
3.942ThrAla: 3.942 ± 0.044
0.757ThrCys: 0.757 ± 0.02
2.73ThrAsp: 2.73 ± 0.034
3.008ThrGlu: 3.008 ± 0.037
2.275ThrPhe: 2.275 ± 0.033
3.409ThrGly: 3.409 ± 0.046
1.274ThrHis: 1.274 ± 0.025
2.886ThrIle: 2.886 ± 0.038
3.119ThrLys: 3.119 ± 0.037
5.338ThrLeu: 5.338 ± 0.051
1.027ThrMet: 1.027 ± 0.018
2.31ThrAsn: 2.31 ± 0.034
3.033ThrPro: 3.033 ± 0.041
1.993ThrGln: 1.993 ± 0.035
2.692ThrArg: 2.692 ± 0.033
4.55ThrSer: 4.55 ± 0.047
2.981ThrThr: 2.981 ± 0.044
3.385ThrVal: 3.385 ± 0.044
0.58ThrTrp: 0.58 ± 0.014
1.614ThrTyr: 1.614 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
5.171ValAla: 5.171 ± 0.062
0.942ValCys: 0.942 ± 0.02
3.797ValAsp: 3.797 ± 0.034
3.679ValGlu: 3.679 ± 0.041
3.123ValPhe: 3.123 ± 0.04
3.489ValGly: 3.489 ± 0.04
1.519ValHis: 1.519 ± 0.026
3.201ValIle: 3.201 ± 0.039
3.572ValLys: 3.572 ± 0.039
6.967ValLeu: 6.967 ± 0.065
1.297ValMet: 1.297 ± 0.022
2.65ValAsn: 2.65 ± 0.031
3.382ValPro: 3.382 ± 0.042
2.22ValGln: 2.22 ± 0.03
3.119ValArg: 3.119 ± 0.034
5.44ValSer: 5.44 ± 0.046
3.218ValThr: 3.218 ± 0.035
4.577ValVal: 4.577 ± 0.049
0.732ValTrp: 0.732 ± 0.019
2.033ValTyr: 2.033 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
0.801TrpAla: 0.801 ± 0.02
0.229TrpCys: 0.229 ± 0.01
0.656TrpAsp: 0.656 ± 0.018
0.579TrpGlu: 0.579 ± 0.016
0.507TrpPhe: 0.507 ± 0.014
0.653TrpGly: 0.653 ± 0.016
0.26TrpHis: 0.26 ± 0.01
0.579TrpIle: 0.579 ± 0.016
0.715TrpLys: 0.715 ± 0.018
1.187TrpLeu: 1.187 ± 0.024
0.231TrpMet: 0.231 ± 0.01
0.547TrpAsn: 0.547 ± 0.015
0.407TrpPro: 0.407 ± 0.013
0.378TrpGln: 0.378 ± 0.012
0.643TrpArg: 0.643 ± 0.018
0.769TrpSer: 0.769 ± 0.016
0.558TrpThr: 0.558 ± 0.014
0.689TrpVal: 0.689 ± 0.018
0.189TrpTrp: 0.189 ± 0.008
0.362TrpTyr: 0.362 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.084TyrAla: 2.084 ± 0.036
0.458TyrCys: 0.458 ± 0.015
1.872TyrAsp: 1.872 ± 0.028
1.944TyrGlu: 1.944 ± 0.031
1.564TyrPhe: 1.564 ± 0.029
1.913TyrGly: 1.913 ± 0.036
0.778TyrHis: 0.778 ± 0.018
1.702TyrIle: 1.702 ± 0.033
1.777TyrLys: 1.777 ± 0.029
3.372TyrLeu: 3.372 ± 0.04
0.71TyrMet: 0.71 ± 0.017
1.476TyrAsn: 1.476 ± 0.026
1.265TyrPro: 1.265 ± 0.027
1.189TyrGln: 1.189 ± 0.019
1.468TyrArg: 1.468 ± 0.025
2.362TyrSer: 2.362 ± 0.039
1.616TyrThr: 1.616 ± 0.023
2.052TyrVal: 2.052 ± 0.028
0.386TyrTrp: 0.386 ± 0.012
1.14TyrTyr: 1.14 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5827 proteins (2545319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski