Amino acid dipepetide frequency for Rotavirus G pigeon/HK18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.211AlaAla: 4.211 ± 1.0
0.526AlaCys: 0.526 ± 0.289
2.982AlaAsp: 2.982 ± 0.817
4.386AlaGlu: 4.386 ± 0.884
2.807AlaPhe: 2.807 ± 0.377
0.877AlaGly: 0.877 ± 0.402
0.175AlaHis: 0.175 ± 0.145
5.614AlaIle: 5.614 ± 1.031
3.86AlaLys: 3.86 ± 1.108
5.088AlaLeu: 5.088 ± 0.589
1.93AlaMet: 1.93 ± 0.544
3.509AlaAsn: 3.509 ± 0.963
1.579AlaPro: 1.579 ± 0.265
2.105AlaGln: 2.105 ± 0.489
2.281AlaArg: 2.281 ± 0.669
4.561AlaSer: 4.561 ± 1.103
2.807AlaThr: 2.807 ± 0.653
4.561AlaVal: 4.561 ± 0.805
0.702AlaTrp: 0.702 ± 0.223
2.281AlaTyr: 2.281 ± 0.533
0.0AlaXaa: 0.0 ± 0.0
Cys
0.351CysAla: 0.351 ± 0.252
0.0CysCys: 0.0 ± 0.0
0.526CysAsp: 0.526 ± 0.428
1.053CysGlu: 1.053 ± 0.571
0.702CysPhe: 0.702 ± 0.312
1.404CysGly: 1.404 ± 0.795
0.0CysHis: 0.0 ± 0.0
0.526CysIle: 0.526 ± 0.289
0.877CysLys: 0.877 ± 0.348
0.702CysLeu: 0.702 ± 0.394
0.0CysMet: 0.0 ± 0.0
0.526CysAsn: 0.526 ± 0.234
0.351CysPro: 0.351 ± 0.45
0.702CysGln: 0.702 ± 0.303
0.526CysArg: 0.526 ± 0.494
0.877CysSer: 0.877 ± 0.332
0.351CysThr: 0.351 ± 0.209
0.877CysVal: 0.877 ± 0.366
0.0CysTrp: 0.0 ± 0.0
0.351CysTyr: 0.351 ± 0.269
0.0CysXaa: 0.0 ± 0.0
Asp
3.86AspAla: 3.86 ± 0.586
0.351AspCys: 0.351 ± 0.264
4.386AspAsp: 4.386 ± 0.969
5.088AspGlu: 5.088 ± 1.001
3.158AspPhe: 3.158 ± 1.045
2.456AspGly: 2.456 ± 0.446
0.877AspHis: 0.877 ± 0.296
7.018AspIle: 7.018 ± 1.385
5.263AspLys: 5.263 ± 0.764
6.316AspLeu: 6.316 ± 0.7
2.281AspMet: 2.281 ± 0.618
4.386AspAsn: 4.386 ± 0.778
1.579AspPro: 1.579 ± 0.509
2.807AspGln: 2.807 ± 0.772
2.807AspArg: 2.807 ± 0.496
2.456AspSer: 2.456 ± 0.591
3.509AspThr: 3.509 ± 0.938
5.263AspVal: 5.263 ± 0.724
0.702AspTrp: 0.702 ± 0.333
2.281AspTyr: 2.281 ± 0.532
0.0AspXaa: 0.0 ± 0.0
Glu
3.158GluAla: 3.158 ± 0.662
0.175GluCys: 0.175 ± 0.168
4.561GluAsp: 4.561 ± 1.274
6.14GluGlu: 6.14 ± 0.828
3.158GluPhe: 3.158 ± 0.455
1.754GluGly: 1.754 ± 0.446
2.105GluHis: 2.105 ± 0.759
7.368GluIle: 7.368 ± 0.793
4.561GluLys: 4.561 ± 0.875
5.789GluLeu: 5.789 ± 1.299
2.281GluMet: 2.281 ± 0.729
5.789GluAsn: 5.789 ± 1.193
1.93GluPro: 1.93 ± 0.732
2.105GluGln: 2.105 ± 0.558
3.158GluArg: 3.158 ± 0.575
4.561GluSer: 4.561 ± 0.921
3.509GluThr: 3.509 ± 0.495
3.158GluVal: 3.158 ± 0.649
0.351GluTrp: 0.351 ± 0.3
2.807GluTyr: 2.807 ± 0.59
0.0GluXaa: 0.0 ± 0.0
Phe
1.93PheAla: 1.93 ± 1.08
1.053PheCys: 1.053 ± 0.875
3.158PheAsp: 3.158 ± 1.002
3.158PheGlu: 3.158 ± 0.683
1.228PhePhe: 1.228 ± 0.649
1.404PheGly: 1.404 ± 0.372
0.526PheHis: 0.526 ± 0.299
2.281PheIle: 2.281 ± 0.688
2.982PheLys: 2.982 ± 0.637
3.158PheLeu: 3.158 ± 0.606
1.228PheMet: 1.228 ± 0.459
2.807PheAsn: 2.807 ± 0.795
1.053PhePro: 1.053 ± 0.595
1.404PheGln: 1.404 ± 0.455
1.579PheArg: 1.579 ± 0.459
3.333PheSer: 3.333 ± 0.695
3.158PheThr: 3.158 ± 0.826
1.754PheVal: 1.754 ± 0.492
0.0PheTrp: 0.0 ± 0.0
1.579PheTyr: 1.579 ± 0.644
0.0PheXaa: 0.0 ± 0.0
Gly
3.684GlyAla: 3.684 ± 0.659
0.0GlyCys: 0.0 ± 0.0
1.754GlyAsp: 1.754 ± 0.814
1.579GlyGlu: 1.579 ± 0.438
1.404GlyPhe: 1.404 ± 0.306
2.281GlyGly: 2.281 ± 0.484
1.053GlyHis: 1.053 ± 0.49
2.807GlyIle: 2.807 ± 0.522
2.807GlyLys: 2.807 ± 0.439
2.281GlyLeu: 2.281 ± 0.582
0.526GlyMet: 0.526 ± 0.215
2.632GlyAsn: 2.632 ± 0.588
0.702GlyPro: 0.702 ± 0.268
1.93GlyGln: 1.93 ± 0.617
2.456GlyArg: 2.456 ± 0.534
1.579GlySer: 1.579 ± 0.409
2.281GlyThr: 2.281 ± 0.799
2.807GlyVal: 2.807 ± 0.449
0.351GlyTrp: 0.351 ± 0.31
1.93GlyTyr: 1.93 ± 0.468
0.0GlyXaa: 0.0 ± 0.0
His
1.228HisAla: 1.228 ± 0.421
0.0HisCys: 0.0 ± 0.0
1.053HisAsp: 1.053 ± 0.495
0.702HisGlu: 0.702 ± 0.305
0.877HisPhe: 0.877 ± 0.373
0.702HisGly: 0.702 ± 0.466
0.175HisHis: 0.175 ± 0.145
1.754HisIle: 1.754 ± 1.061
0.351HisLys: 0.351 ± 0.272
1.404HisLeu: 1.404 ± 0.484
0.351HisMet: 0.351 ± 0.193
0.877HisAsn: 0.877 ± 0.238
0.526HisPro: 0.526 ± 0.283
0.175HisGln: 0.175 ± 0.227
1.053HisArg: 1.053 ± 0.408
0.702HisSer: 0.702 ± 0.394
1.228HisThr: 1.228 ± 0.346
1.579HisVal: 1.579 ± 0.41
0.0HisTrp: 0.0 ± 0.0
0.877HisTyr: 0.877 ± 0.32
0.0HisXaa: 0.0 ± 0.0
Ile
4.035IleAla: 4.035 ± 0.864
1.404IleCys: 1.404 ± 0.875
6.667IleAsp: 6.667 ± 1.118
6.14IleGlu: 6.14 ± 1.183
4.035IlePhe: 4.035 ± 0.838
3.509IleGly: 3.509 ± 0.609
0.877IleHis: 0.877 ± 0.322
5.789IleIle: 5.789 ± 0.801
6.842IleLys: 6.842 ± 1.227
6.316IleLeu: 6.316 ± 0.881
2.281IleMet: 2.281 ± 0.909
5.789IleAsn: 5.789 ± 0.842
4.386IlePro: 4.386 ± 0.916
2.982IleGln: 2.982 ± 0.71
3.509IleArg: 3.509 ± 0.794
5.088IleSer: 5.088 ± 0.968
5.263IleThr: 5.263 ± 0.801
5.789IleVal: 5.789 ± 1.471
0.351IleTrp: 0.351 ± 0.194
2.105IleTyr: 2.105 ± 0.48
0.0IleXaa: 0.0 ± 0.0
Lys
3.509LysAla: 3.509 ± 0.725
0.877LysCys: 0.877 ± 0.427
5.439LysAsp: 5.439 ± 1.196
6.491LysGlu: 6.491 ± 1.186
2.105LysPhe: 2.105 ± 0.904
1.404LysGly: 1.404 ± 0.307
0.877LysHis: 0.877 ± 0.39
7.544LysIle: 7.544 ± 1.471
8.947LysLys: 8.947 ± 1.273
5.965LysLeu: 5.965 ± 0.977
3.86LysMet: 3.86 ± 1.159
5.965LysAsn: 5.965 ± 0.948
2.632LysPro: 2.632 ± 0.72
3.509LysGln: 3.509 ± 0.705
3.684LysArg: 3.684 ± 0.786
4.035LysSer: 4.035 ± 0.945
3.684LysThr: 3.684 ± 0.864
3.333LysVal: 3.333 ± 0.732
1.228LysTrp: 1.228 ± 0.547
3.158LysTyr: 3.158 ± 1.236
0.0LysXaa: 0.0 ± 0.0
Leu
5.088LeuAla: 5.088 ± 0.866
0.877LeuCys: 0.877 ± 0.296
4.561LeuAsp: 4.561 ± 0.933
5.439LeuGlu: 5.439 ± 1.547
2.281LeuPhe: 2.281 ± 0.439
3.509LeuGly: 3.509 ± 1.119
1.754LeuHis: 1.754 ± 0.432
6.14LeuIle: 6.14 ± 0.886
6.316LeuLys: 6.316 ± 0.907
6.14LeuLeu: 6.14 ± 0.504
2.456LeuMet: 2.456 ± 0.729
4.386LeuAsn: 4.386 ± 0.632
2.456LeuPro: 2.456 ± 0.588
4.035LeuGln: 4.035 ± 1.071
4.912LeuArg: 4.912 ± 0.704
7.368LeuSer: 7.368 ± 1.201
3.684LeuThr: 3.684 ± 0.586
3.509LeuVal: 3.509 ± 0.56
0.351LeuTrp: 0.351 ± 0.236
2.807LeuTyr: 2.807 ± 1.024
0.0LeuXaa: 0.0 ± 0.0
Met
2.105MetAla: 2.105 ± 0.448
0.175MetCys: 0.175 ± 0.145
2.982MetAsp: 2.982 ± 0.573
1.93MetGlu: 1.93 ± 0.632
0.702MetPhe: 0.702 ± 0.392
1.404MetGly: 1.404 ± 0.316
0.351MetHis: 0.351 ± 0.193
2.105MetIle: 2.105 ± 0.746
2.807MetLys: 2.807 ± 0.589
2.982MetLeu: 2.982 ± 0.625
0.702MetMet: 0.702 ± 0.253
2.982MetAsn: 2.982 ± 0.712
0.877MetPro: 0.877 ± 0.316
1.754MetGln: 1.754 ± 0.705
1.754MetArg: 1.754 ± 0.513
2.105MetSer: 2.105 ± 0.534
2.281MetThr: 2.281 ± 0.409
0.877MetVal: 0.877 ± 0.316
0.175MetTrp: 0.175 ± 0.213
1.404MetTyr: 1.404 ± 0.699
0.0MetXaa: 0.0 ± 0.0
Asn
4.386AsnAla: 4.386 ± 0.896
0.702AsnCys: 0.702 ± 0.267
4.737AsnAsp: 4.737 ± 1.255
4.211AsnGlu: 4.211 ± 0.803
3.684AsnPhe: 3.684 ± 0.995
2.807AsnGly: 2.807 ± 0.548
0.877AsnHis: 0.877 ± 0.324
6.491AsnIle: 6.491 ± 0.814
2.807AsnLys: 2.807 ± 0.603
3.684AsnLeu: 3.684 ± 0.716
2.105AsnMet: 2.105 ± 0.677
3.684AsnAsn: 3.684 ± 1.043
2.105AsnPro: 2.105 ± 0.793
1.754AsnGln: 1.754 ± 0.449
3.684AsnArg: 3.684 ± 1.213
5.614AsnSer: 5.614 ± 0.657
3.86AsnThr: 3.86 ± 0.644
5.965AsnVal: 5.965 ± 1.152
1.053AsnTrp: 1.053 ± 0.543
3.86AsnTyr: 3.86 ± 0.652
0.0AsnXaa: 0.0 ± 0.0
Pro
1.228ProAla: 1.228 ± 0.38
0.526ProCys: 0.526 ± 0.254
1.93ProAsp: 1.93 ± 0.46
2.632ProGlu: 2.632 ± 0.422
0.526ProPhe: 0.526 ± 0.289
1.228ProGly: 1.228 ± 0.435
0.526ProHis: 0.526 ± 0.249
1.579ProIle: 1.579 ± 0.451
1.404ProLys: 1.404 ± 0.4
2.281ProLeu: 2.281 ± 0.559
1.404ProMet: 1.404 ± 0.4
2.281ProAsn: 2.281 ± 0.807
0.526ProPro: 0.526 ± 0.224
0.526ProGln: 0.526 ± 0.185
0.877ProArg: 0.877 ± 0.365
2.982ProSer: 2.982 ± 0.915
3.333ProThr: 3.333 ± 0.813
1.93ProVal: 1.93 ± 0.671
0.526ProTrp: 0.526 ± 0.205
2.281ProTyr: 2.281 ± 0.498
0.0ProXaa: 0.0 ± 0.0
Gln
1.754GlnAla: 1.754 ± 0.394
0.351GlnCys: 0.351 ± 0.278
1.404GlnAsp: 1.404 ± 0.323
1.579GlnGlu: 1.579 ± 0.725
1.93GlnPhe: 1.93 ± 0.644
2.456GlnGly: 2.456 ± 0.595
0.702GlnHis: 0.702 ± 0.343
2.632GlnIle: 2.632 ± 0.54
2.982GlnLys: 2.982 ± 0.916
4.035GlnLeu: 4.035 ± 1.186
2.281GlnMet: 2.281 ± 0.495
2.632GlnAsn: 2.632 ± 0.719
1.579GlnPro: 1.579 ± 0.425
1.404GlnGln: 1.404 ± 0.288
2.456GlnArg: 2.456 ± 0.664
2.807GlnSer: 2.807 ± 0.804
2.632GlnThr: 2.632 ± 0.74
1.93GlnVal: 1.93 ± 0.604
0.175GlnTrp: 0.175 ± 0.15
2.105GlnTyr: 2.105 ± 0.689
0.0GlnXaa: 0.0 ± 0.0
Arg
2.456ArgAla: 2.456 ± 0.508
0.702ArgCys: 0.702 ± 0.487
2.982ArgAsp: 2.982 ± 0.475
2.982ArgGlu: 2.982 ± 0.677
2.105ArgPhe: 2.105 ± 0.621
1.404ArgGly: 1.404 ± 0.662
0.351ArgHis: 0.351 ± 0.32
3.86ArgIle: 3.86 ± 0.882
3.86ArgLys: 3.86 ± 0.908
4.211ArgLeu: 4.211 ± 0.542
2.105ArgMet: 2.105 ± 0.749
2.632ArgAsn: 2.632 ± 0.503
1.579ArgPro: 1.579 ± 0.464
2.632ArgGln: 2.632 ± 0.944
3.684ArgArg: 3.684 ± 0.78
2.105ArgSer: 2.105 ± 0.551
3.158ArgThr: 3.158 ± 0.983
5.439ArgVal: 5.439 ± 0.906
0.526ArgTrp: 0.526 ± 0.229
1.93ArgTyr: 1.93 ± 0.434
0.175ArgXaa: 0.175 ± 0.145
Ser
5.088SerAla: 5.088 ± 1.399
1.228SerCys: 1.228 ± 0.4
6.14SerAsp: 6.14 ± 1.186
3.509SerGlu: 3.509 ± 0.761
2.456SerPhe: 2.456 ± 0.651
3.158SerGly: 3.158 ± 0.693
1.053SerHis: 1.053 ± 0.525
4.386SerIle: 4.386 ± 0.826
6.491SerLys: 6.491 ± 0.781
4.561SerLeu: 4.561 ± 0.943
1.579SerMet: 1.579 ± 0.813
3.684SerAsn: 3.684 ± 0.851
1.404SerPro: 1.404 ± 0.5
3.158SerGln: 3.158 ± 0.998
3.509SerArg: 3.509 ± 0.646
5.614SerSer: 5.614 ± 1.484
3.509SerThr: 3.509 ± 0.644
4.561SerVal: 4.561 ± 0.882
0.351SerTrp: 0.351 ± 0.193
4.561SerTyr: 4.561 ± 1.465
0.0SerXaa: 0.0 ± 0.0
Thr
2.281ThrAla: 2.281 ± 0.48
0.526ThrCys: 0.526 ± 0.302
4.211ThrAsp: 4.211 ± 0.771
4.035ThrGlu: 4.035 ± 1.021
1.579ThrPhe: 1.579 ± 0.359
2.281ThrGly: 2.281 ± 0.463
1.228ThrHis: 1.228 ± 0.34
5.789ThrIle: 5.789 ± 0.741
5.263ThrLys: 5.263 ± 0.631
4.737ThrLeu: 4.737 ± 0.971
1.053ThrMet: 1.053 ± 0.295
5.439ThrAsn: 5.439 ± 0.661
1.579ThrPro: 1.579 ± 0.436
2.807ThrGln: 2.807 ± 0.798
2.632ThrArg: 2.632 ± 0.644
4.737ThrSer: 4.737 ± 0.832
3.333ThrThr: 3.333 ± 0.822
3.684ThrVal: 3.684 ± 0.521
0.0ThrTrp: 0.0 ± 0.0
2.982ThrTyr: 2.982 ± 0.787
0.0ThrXaa: 0.0 ± 0.0
Val
2.807ValAla: 2.807 ± 0.785
0.877ValCys: 0.877 ± 0.395
4.386ValAsp: 4.386 ± 1.124
4.035ValGlu: 4.035 ± 0.78
2.456ValPhe: 2.456 ± 0.799
1.053ValGly: 1.053 ± 0.438
0.526ValHis: 0.526 ± 0.324
4.737ValIle: 4.737 ± 1.327
4.912ValLys: 4.912 ± 1.033
5.965ValLeu: 5.965 ± 0.894
2.105ValMet: 2.105 ± 0.668
4.561ValAsn: 4.561 ± 1.235
1.93ValPro: 1.93 ± 0.533
2.281ValGln: 2.281 ± 0.388
3.684ValArg: 3.684 ± 0.411
5.263ValSer: 5.263 ± 0.825
4.386ValThr: 4.386 ± 0.609
2.982ValVal: 2.982 ± 0.564
0.526ValTrp: 0.526 ± 0.231
2.632ValTyr: 2.632 ± 0.635
0.0ValXaa: 0.0 ± 0.0
Trp
1.053TrpAla: 1.053 ± 0.457
0.0TrpCys: 0.0 ± 0.0
0.175TrpAsp: 0.175 ± 0.15
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.175TrpGly: 0.175 ± 0.145
0.0TrpHis: 0.0 ± 0.0
0.351TrpIle: 0.351 ± 0.193
1.93TrpLys: 1.93 ± 0.658
0.526TrpLeu: 0.526 ± 0.34
0.175TrpMet: 0.175 ± 0.213
0.702TrpAsn: 0.702 ± 0.435
0.175TrpPro: 0.175 ± 0.213
0.702TrpGln: 0.702 ± 0.289
0.526TrpArg: 0.526 ± 0.183
0.175TrpSer: 0.175 ± 0.15
0.702TrpThr: 0.702 ± 0.277
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.351TrpTyr: 0.351 ± 0.191
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.632TyrAla: 2.632 ± 0.509
0.351TyrCys: 0.351 ± 0.253
2.807TyrAsp: 2.807 ± 0.589
3.333TyrGlu: 3.333 ± 0.706
1.754TyrPhe: 1.754 ± 0.749
1.579TyrGly: 1.579 ± 0.462
1.579TyrHis: 1.579 ± 0.354
4.386TyrIle: 4.386 ± 1.036
2.982TyrLys: 2.982 ± 0.724
1.93TyrLeu: 1.93 ± 0.462
1.579TyrMet: 1.579 ± 0.406
2.807TyrAsn: 2.807 ± 0.581
1.579TyrPro: 1.579 ± 0.417
1.053TyrGln: 1.053 ± 0.454
2.105TyrArg: 2.105 ± 0.633
4.035TyrSer: 4.035 ± 1.31
3.509TyrThr: 3.509 ± 1.026
2.105TyrVal: 2.105 ± 0.555
0.175TyrTrp: 0.175 ± 0.135
2.281TyrTyr: 2.281 ± 0.586
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.175XaaTrp: 0.175 ± 0.145
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (5701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski